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Protein

Neurobeachin-like protein 2

Gene

Nbeal2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: MGI
  • megakaryocyte development Source: MGI
  • platelet alpha granule organization Source: MGI
  • platelet formation Source: UniProtKB
  • wound healing Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neurobeachin-like protein 2
Gene namesi
Name:Nbeal2
Synonyms:Kiaa0540
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2448554. Nbeal2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27422742Neurobeachin-like protein 2PRO_0000333255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1855 – 18551PhosphothreonineBy similarity
Modified residuei2727 – 27271PhosphoserineCombined sources
Modified residuei2730 – 27301PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZQA0.
MaxQBiQ6ZQA0.
PaxDbiQ6ZQA0.
PRIDEiQ6ZQA0.

PTM databases

iPTMnetiQ6ZQA0.
PhosphoSiteiQ6ZQA0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056724.
ExpressionAtlasiQ6ZQA0. baseline and differential.
GenevisibleiQ6ZQA0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128586.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQA0.
SMRiQ6ZQA0. Positions 1910-2333, 2449-2606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1511 – 155141WD 1Add
BLAST
Domaini1903 – 2028126BEACH-type PHPROSITE-ProRule annotationAdd
BLAST
Domaini2041 – 2333293BEACHPROSITE-ProRule annotationAdd
BLAST
Repeati2445 – 248743WD 2Add
BLAST
Repeati2488 – 252740WD 3Add
BLAST
Repeati2539 – 258042WD 4Add
BLAST
Repeati2673 – 271240WD 5Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat neurobeachin family.Curated
Contains 1 BEACH domain.PROSITE-ProRule annotation
Contains 1 BEACH-type PH domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1787. Eukaryota.
ENOG410XNQC. LUCA.
GeneTreeiENSGT00760000119083.
HOVERGENiHBG108176.
InParanoidiQ6ZQA0.

Family and domain databases

CDDicd06071. Beach. 1 hit.
Gene3Di1.10.1540.10. 1 hit.
1.25.10.10. 7 hits.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR031570. DUF4704.
IPR026916. NBEAL2.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR13743:SF50. PTHR13743:SF50. 2 hits.
PfamiPF02138. Beach. 1 hit.
PF15787. DUF4704. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZQA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASERLYEL WLLYYAQKDL GYLQQWLKAF VGVFEKTISL SSLEPRRPEE
60 70 80 90 100
AGAEVPLLPL DALHALAEQL DQDDLDQALL LLKLFIILCR NLENVEAGWG
110 120 130 140 150
QVLVPRVLAL LTVLMAELKG SSQESHGTQL ENVALHALLL CEGLFDPYQT
160 170 180 190 200
WRRQLTGEVI SSKEKSKYKF PPAALPCEFG AFFQENLQDA ERLPPTLLLR
210 220 230 240 250
LIHLFGAILA GGKANGQMAV SAGSVQGLLG VVRGWGRGPA QDPQQVPLAL
260 270 280 290 300
RALVGAVHVL HASRAPPRGP ELRTLLEGYF HILNADWPTS PSSSPEEALV
310 320 330 340 350
TLRVSMLDAI PMMLACEDRP VLQATFLSNN CFEHLIRLIQ NSKLYLQARA
360 370 380 390 400
PPEGDSDLAT WLLTEPDVQK VLDQDTDAIA VHVVRVLTCI MSGSPSAKEV
410 420 430 440 450
FKERIGYQHL QEVLQSHGPP THRLLQELLN MAVEGDHSMH PPPPIRNEQP
460 470 480 490 500
VLVLMQWLPA LPTAELRLFL AQRLWWLCDS CPASRTTCVQ AGLVGYLLET
510 520 530 540 550
LNTGTALGAR CQEQLLALLQ ALGRVSLRPL ELRRLLRPPP GLDSESSGNE
560 570 580 590 600
SQKARHAGAV IRALSGMARH RGPARALRYF DLTPSMAGIM VPPVQRWPGA
610 620 630 640 650
GFTFHAWLCL QSSEAVPTSA PSRPLQRKQL YSFFTSSGSG FEAFFTAAGT
660 670 680 690 700
LVVAVCTRKE YVTVNLPEVS FADSAWHCVA IVHVPGRRPF SQNLVNVFKD
710 720 730 740 750
GHLVKTVPFR FPSLSEPFSS CCIGSAGHRT TTTTTGLPAS SVSTALAHTH
760 770 780 790 800
PSLTRSQSVP ASTGLGWGPG LGTPLQEGSV SSTLAGTQDT RWGSPTSLEG
810 820 830 840 850
ELGAVAIFHE ALQPSALRVL CSLGPNEPAP FKPEGELHEF GTKLLLHYSP
860 870 880 890 900
QACKNNICLD LSPGHGLDGR LTGHRVETWD VKDVVNCVGG MGVLLPLLER
910 920 930 940 950
VAVQPQEAEA GPCETHDLVG PELTSGRNTQ GLLLPLGKSS EDRMERNAVA
960 970 980 990 1000
AFLLMLRNFL QNHTVNQESL VQCQGPAIIG ALLRKVPSSA MDMNVLMSAQ
1010 1020 1030 1040 1050
LLMEQAAADG GGPLLYLLYQ HLLFNFHLWT LSDFAVRLGH IQYMSSMVRE
1060 1070 1080 1090 1100
HRQKLRKKYG VQFLLDALRT HYSPQRERPL AADDLRTVQT SLLGLVREFL
1110 1120 1130 1140 1150
VRNFSVEDMQ VVLNFLAATG DDGQVVGTLE LLLTLLQGSP VQDPLAAFLL
1160 1170 1180 1190 1200
ELGNLEVLLA LLVRPKSTPL LTDRVCKILR RLQQNERLPE RNRQRIRLHD
1210 1220 1230 1240 1250
CGLQGLVASL SEESISPQLC QGLYKLFVGT DCLNLSDLLA VVQLSLQADL
1260 1270 1280 1290 1300
SVRLDICRQL FYLIYGQPDV VRLLARQAGW QDVLTRLYVL EAATDSSPPR
1310 1320 1330 1340 1350
FLPELPISSE LALSPPPTEL PADSSDVFLP SESPCPDQDA FYQALSPFST
1360 1370 1380 1390 1400
PFDLGLERAS IGSGNTAGGG SSNGTVTPAS QPGTPSPLDG PRPFPTAQGR
1410 1420 1430 1440 1450
HSSSLSNVLE DGSLLEPNIS GDDTSNTSNP QQTPEEELCN LLTNVLFSVT
1460 1470 1480 1490 1500
WRGVEGSAEA AWRERGQVFS VLTQLGASAT LVRPPDCIKR SLLEMMLESA
1510 1520 1530 1540 1550
LTDIKEAPPG GLANLSQQAL WLLRLLQDFL CAEGHGNQEL WSEKLFEGVC
1560 1570 1580 1590 1600
NLLDRLGAWP HLANSTADLR EMAQIGLRLV LGYILLEDPQ LHAQAYVKLH
1610 1620 1630 1640 1650
TLLQTAVPTR REEACYVLSK LEAALSRALT TSSSETEHAS TAVAASERCS
1660 1670 1680 1690 1700
WLVPLVRTLL DRAYGPLGLQ WGLPSLPPTN GSPTFFEDFQ AFCATAEWRH
1710 1720 1730 1740 1750
FIDKQVQPTM SKFEMDTYAK SHDLMSGFWN ACYDTLMSSG QRHQRDRIQS
1760 1770 1780 1790 1800
RRAFKELVLE PAQRRARVEG LRYASVLKQQ AAQHSTALLH WGALWRQLSS
1810 1820 1830 1840 1850
PCGAWALRIP PAPHWKLSSA ETYSRMRLKL VPNHHFDPHL EASALRDNLG
1860 1870 1880 1890 1900
EAPMTPTEET SLPLAVTKEA KISAPPEELP EEQLGEEDLA ALESLMEAAE
1910 1920 1930 1940 1950
LDEKREKLVL SAECQLVTVV AVVPGLLEIT TQHVYFYDGS TERVETEEGI
1960 1970 1980 1990 2000
GHDFRRPLAQ LREVHLRRFN LRRSALELFF IDQSNYFLNF PHKVAASSAS
2010 2020 2030 2040 2050
SPCQAPRPQL YPIPSHTQLR NQVYSLLLRL RPPTQGYLSS RSPLEMLRAS
2060 2070 2080 2090 2100
GLTQKWVQRE ISNFEYLMQL NTIAGRTYND LSQYPVFPWV LQDYVSPVLD
2110 2120 2130 2140 2150
LSNPAVFRDL SKPIGVVNPK HAQLVREKYE SFEDPAGTID KFHYGTHYSN
2160 2170 2180 2190 2200
AAGVMHYLIR VEPFTSLHVQ LQSGRFDCSD RQFHSVAAAW QARLESPADV
2210 2220 2230 2240 2250
KELIPEFFYF PDFLENQNGF DLGCLQLTNE KVGDVVLPPW AGSPEDFIQK
2260 2270 2280 2290 2300
HRQALESEYV STHLHEWIDL IFGYKQRGPA AEEALNVFYY CTYEGAVDLD
2310 2320 2330 2340 2350
HVADERERKA LEGIISNFGQ TPCQLLKEPH PPRLSAEEAA NRLARLDTNS
2360 2370 2380 2390 2400
PSIFQNLNQL KAFFAEVVSE AVPLVLALVP HRQSHSFITQ SSSDMLVTVS
2410 2420 2430 2440 2450
ASGLLGTHTW LPYDRNINNY FTFSKDPTMG SPKVQKLLSG PWVSDSGVSA
2460 2470 2480 2490 2500
QALAVAPDGK LLFSGGHWDG SLRVTSLPRG RLLNQLSRHL DIVTCLALDT
2510 2520 2530 2540 2550
CGIYLISGSR DTTCMVWRLL QQSGLSAGLA PKPVQVLYGH VAAVSCVAIS
2560 2570 2580 2590 2600
TELDMAVSGS EDGTVIIHTV RRGQFVAALR PPGATLPGPI SHLALGAEGQ
2610 2620 2630 2640 2650
IVVQSSACER PGAQVTYSLH LYSVNGRLRA SVTLTEQPTA LTVAEDFVLL
2660 2670 2680 2690 2700
GTAQCSLHIL HLNKLRPAVP PLPMKVPVHS VSVTKERSHV LVGLEDGKLI
2710 2720 2730 2740
VVGAGQPSEV RSSQFARRLW RSSRRISQVS SGETEYNPGE AR
Length:2,742
Mass (Da):301,924
Last modified:May 20, 2008 - v2
Checksum:iC1345C9E4A40204A
GO
Isoform 2 (identifier: Q6ZQA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1896-1896: M → ME

Show »
Length:2,743
Mass (Da):302,053
Checksum:iE09D7342A5D6FF41
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1896 – 18961M → ME in isoform 2. 1 PublicationVSP_033508

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132103 Genomic DNA. No translation available.
AK129158 mRNA. Translation: BAC97968.2.
UniGeneiMm.335481.

Genome annotation databases

EnsembliENSMUST00000133191; ENSMUSP00000121373; ENSMUSG00000056724. [Q6ZQA0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132103 Genomic DNA. No translation available.
AK129158 mRNA. Translation: BAC97968.2.
UniGeneiMm.335481.

3D structure databases

ProteinModelPortaliQ6ZQA0.
SMRiQ6ZQA0. Positions 1910-2333, 2449-2606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128586.

PTM databases

iPTMnetiQ6ZQA0.
PhosphoSiteiQ6ZQA0.

Proteomic databases

EPDiQ6ZQA0.
MaxQBiQ6ZQA0.
PaxDbiQ6ZQA0.
PRIDEiQ6ZQA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000133191; ENSMUSP00000121373; ENSMUSG00000056724. [Q6ZQA0-2]

Organism-specific databases

MGIiMGI:2448554. Nbeal2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1787. Eukaryota.
ENOG410XNQC. LUCA.
GeneTreeiENSGT00760000119083.
HOVERGENiHBG108176.
InParanoidiQ6ZQA0.

Miscellaneous databases

PROiQ6ZQA0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056724.
ExpressionAtlasiQ6ZQA0. baseline and differential.
GenevisibleiQ6ZQA0. MM.

Family and domain databases

CDDicd06071. Beach. 1 hit.
Gene3Di1.10.1540.10. 1 hit.
1.25.10.10. 7 hits.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR031570. DUF4704.
IPR026916. NBEAL2.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR13743:SF50. PTHR13743:SF50. 2 hits.
PfamiPF02138. Beach. 1 hit.
PF15787. DUF4704. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNBEL2_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.