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Protein

Neurobeachin-like protein 2

Gene

Nbeal2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis (By similarity).By similarity

GO - Biological processi

  • blood coagulation Source: MGI
  • megakaryocyte development Source: MGI
  • platelet alpha granule organization Source: MGI
  • platelet formation Source: UniProtKB
  • wound healing Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurobeachin-like protein 2
Gene namesi
Name:Nbeal2
Synonyms:Kiaa0540
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2448554 Nbeal2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332551 – 2742Neurobeachin-like protein 2Add BLAST2742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1855PhosphothreonineBy similarity1
Modified residuei2727PhosphoserineCombined sources1
Modified residuei2730PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZQA0
PaxDbiQ6ZQA0
PRIDEiQ6ZQA0

PTM databases

iPTMnetiQ6ZQA0
PhosphoSitePlusiQ6ZQA0

Expressioni

Gene expression databases

BgeeiENSMUSG00000056724
ExpressionAtlasiQ6ZQA0 baseline and differential
GenevisibleiQ6ZQA0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128586

Structurei

3D structure databases

ProteinModelPortaliQ6ZQA0
SMRiQ6ZQA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1903 – 2028BEACH-type PHPROSITE-ProRule annotationAdd BLAST126
Domaini2041 – 2333BEACHPROSITE-ProRule annotationAdd BLAST293
Repeati2374 – 2412WD 1Add BLAST39
Repeati2436 – 2479WD 2Add BLAST44
Repeati2482 – 2519WD 3Add BLAST38
Repeati2532 – 2570WD 4Add BLAST39
Repeati2577 – 2619WD 5Add BLAST43
Repeati2627 – 2662WD 6Add BLAST36
Repeati2670 – 2705WD 7Add BLAST36

Sequence similaritiesi

Belongs to the WD repeat neurobeachin family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1787 Eukaryota
ENOG410XNQC LUCA
GeneTreeiENSGT00760000119083
HOVERGENiHBG108176
InParanoidiQ6ZQA0

Family and domain databases

CDDicd06071 Beach, 1 hit
cd01201 PH_BEACH, 1 hit
Gene3Di1.10.1540.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR013320 ConA-like_dom_sf
IPR031570 DUF4704
IPR026916 NBEAL2
IPR023362 PH-BEACH_dom
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13743:SF111 PTHR13743:SF111, 1 hit
PfamiView protein in Pfam
PF02138 Beach, 1 hit
PF15787 DUF4704, 1 hit
PF14844 PH_BEACH, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM01026 Beach, 1 hit
SM00320 WD40, 3 hits
SUPFAMiSSF48371 SSF48371, 2 hits
SSF49899 SSF49899, 1 hit
SSF50978 SSF50978, 1 hit
SSF81837 SSF81837, 1 hit
PROSITEiView protein in PROSITE
PS50197 BEACH, 1 hit
PS51783 PH_BEACH, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZQA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASERLYEL WLLYYAQKDL GYLQQWLKAF VGVFEKTISL SSLEPRRPEE
60 70 80 90 100
AGAEVPLLPL DALHALAEQL DQDDLDQALL LLKLFIILCR NLENVEAGWG
110 120 130 140 150
QVLVPRVLAL LTVLMAELKG SSQESHGTQL ENVALHALLL CEGLFDPYQT
160 170 180 190 200
WRRQLTGEVI SSKEKSKYKF PPAALPCEFG AFFQENLQDA ERLPPTLLLR
210 220 230 240 250
LIHLFGAILA GGKANGQMAV SAGSVQGLLG VVRGWGRGPA QDPQQVPLAL
260 270 280 290 300
RALVGAVHVL HASRAPPRGP ELRTLLEGYF HILNADWPTS PSSSPEEALV
310 320 330 340 350
TLRVSMLDAI PMMLACEDRP VLQATFLSNN CFEHLIRLIQ NSKLYLQARA
360 370 380 390 400
PPEGDSDLAT WLLTEPDVQK VLDQDTDAIA VHVVRVLTCI MSGSPSAKEV
410 420 430 440 450
FKERIGYQHL QEVLQSHGPP THRLLQELLN MAVEGDHSMH PPPPIRNEQP
460 470 480 490 500
VLVLMQWLPA LPTAELRLFL AQRLWWLCDS CPASRTTCVQ AGLVGYLLET
510 520 530 540 550
LNTGTALGAR CQEQLLALLQ ALGRVSLRPL ELRRLLRPPP GLDSESSGNE
560 570 580 590 600
SQKARHAGAV IRALSGMARH RGPARALRYF DLTPSMAGIM VPPVQRWPGA
610 620 630 640 650
GFTFHAWLCL QSSEAVPTSA PSRPLQRKQL YSFFTSSGSG FEAFFTAAGT
660 670 680 690 700
LVVAVCTRKE YVTVNLPEVS FADSAWHCVA IVHVPGRRPF SQNLVNVFKD
710 720 730 740 750
GHLVKTVPFR FPSLSEPFSS CCIGSAGHRT TTTTTGLPAS SVSTALAHTH
760 770 780 790 800
PSLTRSQSVP ASTGLGWGPG LGTPLQEGSV SSTLAGTQDT RWGSPTSLEG
810 820 830 840 850
ELGAVAIFHE ALQPSALRVL CSLGPNEPAP FKPEGELHEF GTKLLLHYSP
860 870 880 890 900
QACKNNICLD LSPGHGLDGR LTGHRVETWD VKDVVNCVGG MGVLLPLLER
910 920 930 940 950
VAVQPQEAEA GPCETHDLVG PELTSGRNTQ GLLLPLGKSS EDRMERNAVA
960 970 980 990 1000
AFLLMLRNFL QNHTVNQESL VQCQGPAIIG ALLRKVPSSA MDMNVLMSAQ
1010 1020 1030 1040 1050
LLMEQAAADG GGPLLYLLYQ HLLFNFHLWT LSDFAVRLGH IQYMSSMVRE
1060 1070 1080 1090 1100
HRQKLRKKYG VQFLLDALRT HYSPQRERPL AADDLRTVQT SLLGLVREFL
1110 1120 1130 1140 1150
VRNFSVEDMQ VVLNFLAATG DDGQVVGTLE LLLTLLQGSP VQDPLAAFLL
1160 1170 1180 1190 1200
ELGNLEVLLA LLVRPKSTPL LTDRVCKILR RLQQNERLPE RNRQRIRLHD
1210 1220 1230 1240 1250
CGLQGLVASL SEESISPQLC QGLYKLFVGT DCLNLSDLLA VVQLSLQADL
1260 1270 1280 1290 1300
SVRLDICRQL FYLIYGQPDV VRLLARQAGW QDVLTRLYVL EAATDSSPPR
1310 1320 1330 1340 1350
FLPELPISSE LALSPPPTEL PADSSDVFLP SESPCPDQDA FYQALSPFST
1360 1370 1380 1390 1400
PFDLGLERAS IGSGNTAGGG SSNGTVTPAS QPGTPSPLDG PRPFPTAQGR
1410 1420 1430 1440 1450
HSSSLSNVLE DGSLLEPNIS GDDTSNTSNP QQTPEEELCN LLTNVLFSVT
1460 1470 1480 1490 1500
WRGVEGSAEA AWRERGQVFS VLTQLGASAT LVRPPDCIKR SLLEMMLESA
1510 1520 1530 1540 1550
LTDIKEAPPG GLANLSQQAL WLLRLLQDFL CAEGHGNQEL WSEKLFEGVC
1560 1570 1580 1590 1600
NLLDRLGAWP HLANSTADLR EMAQIGLRLV LGYILLEDPQ LHAQAYVKLH
1610 1620 1630 1640 1650
TLLQTAVPTR REEACYVLSK LEAALSRALT TSSSETEHAS TAVAASERCS
1660 1670 1680 1690 1700
WLVPLVRTLL DRAYGPLGLQ WGLPSLPPTN GSPTFFEDFQ AFCATAEWRH
1710 1720 1730 1740 1750
FIDKQVQPTM SKFEMDTYAK SHDLMSGFWN ACYDTLMSSG QRHQRDRIQS
1760 1770 1780 1790 1800
RRAFKELVLE PAQRRARVEG LRYASVLKQQ AAQHSTALLH WGALWRQLSS
1810 1820 1830 1840 1850
PCGAWALRIP PAPHWKLSSA ETYSRMRLKL VPNHHFDPHL EASALRDNLG
1860 1870 1880 1890 1900
EAPMTPTEET SLPLAVTKEA KISAPPEELP EEQLGEEDLA ALESLMEAAE
1910 1920 1930 1940 1950
LDEKREKLVL SAECQLVTVV AVVPGLLEIT TQHVYFYDGS TERVETEEGI
1960 1970 1980 1990 2000
GHDFRRPLAQ LREVHLRRFN LRRSALELFF IDQSNYFLNF PHKVAASSAS
2010 2020 2030 2040 2050
SPCQAPRPQL YPIPSHTQLR NQVYSLLLRL RPPTQGYLSS RSPLEMLRAS
2060 2070 2080 2090 2100
GLTQKWVQRE ISNFEYLMQL NTIAGRTYND LSQYPVFPWV LQDYVSPVLD
2110 2120 2130 2140 2150
LSNPAVFRDL SKPIGVVNPK HAQLVREKYE SFEDPAGTID KFHYGTHYSN
2160 2170 2180 2190 2200
AAGVMHYLIR VEPFTSLHVQ LQSGRFDCSD RQFHSVAAAW QARLESPADV
2210 2220 2230 2240 2250
KELIPEFFYF PDFLENQNGF DLGCLQLTNE KVGDVVLPPW AGSPEDFIQK
2260 2270 2280 2290 2300
HRQALESEYV STHLHEWIDL IFGYKQRGPA AEEALNVFYY CTYEGAVDLD
2310 2320 2330 2340 2350
HVADERERKA LEGIISNFGQ TPCQLLKEPH PPRLSAEEAA NRLARLDTNS
2360 2370 2380 2390 2400
PSIFQNLNQL KAFFAEVVSE AVPLVLALVP HRQSHSFITQ SSSDMLVTVS
2410 2420 2430 2440 2450
ASGLLGTHTW LPYDRNINNY FTFSKDPTMG SPKVQKLLSG PWVSDSGVSA
2460 2470 2480 2490 2500
QALAVAPDGK LLFSGGHWDG SLRVTSLPRG RLLNQLSRHL DIVTCLALDT
2510 2520 2530 2540 2550
CGIYLISGSR DTTCMVWRLL QQSGLSAGLA PKPVQVLYGH VAAVSCVAIS
2560 2570 2580 2590 2600
TELDMAVSGS EDGTVIIHTV RRGQFVAALR PPGATLPGPI SHLALGAEGQ
2610 2620 2630 2640 2650
IVVQSSACER PGAQVTYSLH LYSVNGRLRA SVTLTEQPTA LTVAEDFVLL
2660 2670 2680 2690 2700
GTAQCSLHIL HLNKLRPAVP PLPMKVPVHS VSVTKERSHV LVGLEDGKLI
2710 2720 2730 2740
VVGAGQPSEV RSSQFARRLW RSSRRISQVS SGETEYNPGE AR
Length:2,742
Mass (Da):301,924
Last modified:May 20, 2008 - v2
Checksum:iC1345C9E4A40204A
GO
Isoform 2 (identifier: Q6ZQA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1896-1896: M → ME

Show »
Length:2,743
Mass (Da):302,053
Checksum:iE09D7342A5D6FF41
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0335081896M → ME in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132103 Genomic DNA No translation available.
AK129158 mRNA Translation: BAC97968.2
UniGeneiMm.335481

Genome annotation databases

EnsembliENSMUST00000133191; ENSMUSP00000121373; ENSMUSG00000056724 [Q6ZQA0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNBEL2_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: March 28, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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