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Q6ZQ93

- UBP34_MOUSE

UniProt

Q6ZQ93 - UBP34_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase 34

Gene

Usp34

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 3 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1940 – 19401NucleophilePROSITE-ProRule annotation
    Active sitei2201 – 22011Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
    2. protein K48-linked deubiquitination Source: UniProtKB
    3. ubiquitin-dependent protein catabolic process Source: InterPro
    4. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway, Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_207044. TCF dependent signaling in response to WNT.

    Protein family/group databases

    MEROPSiC19.067.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 34 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 34
    Ubiquitin thioesterase 34
    Ubiquitin-specific-processing protease 34
    Gene namesi
    Name:Usp34
    Synonyms:Kiaa0570, Murr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:109473. Usp34.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 35823582Ubiquitin carboxyl-terminal hydrolase 34PRO_0000249520Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei352 – 3521PhosphoserineBy similarity
    Modified residuei2525 – 25251Phosphoserine1 Publication
    Modified residuei3395 – 33951PhosphoserineBy similarity
    Modified residuei3396 – 33961PhosphoserineBy similarity
    Modified residuei3443 – 34431PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6ZQ93.
    PaxDbiQ6ZQ93.
    PRIDEiQ6ZQ93.

    PTM databases

    PhosphoSiteiQ6ZQ93.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZQ93.
    BgeeiQ6ZQ93.
    CleanExiMM_USP34.
    GenevestigatoriQ6ZQ93.

    Interactioni

    Subunit structurei

    Interacts with AXIN1 and AXIN2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZQ93.
    SMRiQ6ZQ93. Positions 1930-2275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1931 – 2276346USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    GeneTreeiENSGT00740000115055.
    HOVERGENiHBG092616.
    InParanoidiQ6ZQ93.
    KOiK11853.
    PhylomeDBiQ6ZQ93.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 6 hits.
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZQ93-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCENCADLVE VLNEISDIEG GDGLQLRKEH TLKIFAYINS WTQRQCLCCF     50
    KEYKHLEIFN QVVCALINLV IAQVQVLRDQ LCKHCTTINI DSTWQDESNQ 100
    AEEPLSIDRE CNEGNTERQK SIEKKSNSTR TCNLTEEESS KSSDPFSLWN 150
    TDEKEKLLLC VAKIFQIQFP LYTAYKHNTH PTIEDISTQE SNILGAFCDM 200
    NDVEVPLHLL RYVCLFCGKN GLSLMKDCFE YGTPETLPFL IAHAFITVVS 250
    NIRIWLHIPA VMQHIIPFRT YVIRYLCKLS DQELRQSAAR NMADLMWSTV 300
    KEPLDTTLCF DKESLDLAFK YFMSPTLTMR LAGLSQITNQ LHTFNDVCNN 350
    ESLVSDTETS IAKELADWLI SNNVVEHIFG PNLHIEIIKQ CQVILNFLAA 400
    EGRLSTQHID CIWAAAQLKH CSRYIHDLFP SLIKNLDPVP LRHLLNLVSA 450
    LEPGVHTEQT LYLASMLIKA LWNNALAAKA QLSKQSSFAS LLNTNMPIGN 500
    KKEEEELRRA APSPWSPAAS PQSSDNSDTH QSGASDIEMD EQLINRNKHV 550
    QQRLSDTEES MQGSSDETAN SGEDGSSGPG SSSGHSDGSS NEVNSSHASQ 600
    SAGSPGSEVQ SEDIADIEAL KEEEEEEEEE EEEEEEEDDE EEEDEEEDDD 650
    DDDDHGHNPA KNTCGTELRN RKLENPAGIC LGESQGTSER NGTNSGTGKD 700
    LVFNTEPLPS VDNRIRMLDA CAHSEDPEHG ISGEVSSAHL AQGSQEACIT 750
    RSGDFLGETI GNELFNCRQF IGPQHHHHHH HHHHHHHHHH HHHHHHHDGH 800
    MVDDMLSADD VSCSSSQVSA KSEKNMADFD GEESGCEEEL VQINSHAELT 850
    SHLQQHLPNL ASIYHEHLSQ GPAVHKHQFS SNAVTDINLD NVCKKGNTLL 900
    WDIVQDDDAI NLSEGLINEA EKLLCSLVCW FTDRQIRMRF IEGCLENLGN 950
    NRSVVISLRL LPKLFGTFQQ FGSSYDTHWI TMWAEKELNM MKLFFDNLVY 1000
    YIQGIREGRQ KHALYSHSAE VQVRLQFLTC VFSTLGSPDH FRLSLEQVDI 1050
    LWHCLVEDSE CYDDALHWFL NQVRSKDQHA MGMETYKHLF LEKMPQLKPE 1100
    TISMTGLNLF QHLCNLARLA TSAYDGGSNS ELCGMDQFWG IALRAQSGDV 1150
    SRAAIQYINS YYINGKTGLE KEQEFISKCM ESLMIASSSL EQESHSSLTV 1200
    IERGLLMLKT HLEAFRRRFA YHLRQWQIEG TGISSHLKAL SDKQSLPLRV 1250
    VCQPAGLPDK MTIEMYPSDQ VADLRAEVTH WYENLQKEQI NQQAQLQEFG 1300
    QSSRKGEFPG GLMGPVRMIS SGHELTTDYD EKALHELGFK DMQMVFVSLG 1350
    APRRERKGEG VQLPASCLPP PQKDNIPMLL LLQEPHLTTL FDLLEMLASF 1400
    KPPSGKVAVD DSESLKCEEL HLHAENLSRR VWELLMLLPT CPNMLTAFQN 1450
    VSDEQSNDGL NWKELLKIKS AHKLLYALEI IEALGKPNRR IRRESTGSYS 1500
    DLYPDSDDSS EDQVENSKNS WTCKFVAAGG LQQLLEIFNS AILEPKEQES 1550
    WTVWQLDCLA CLLKLICQFA VDPSDLDLAY HDVFAWSGIA ESHRKRTWPG 1600
    KSRKAAGDHA KSLHIPRLTE VFLVLVQGTS LIQRLMSVAY TYDNLAPRVL 1650
    KAQSDHRSRH EVSHYSMWLL VSWAHCCSLV KSSLADSDHL QDWLKQLTLL 1700
    IPETAVRHES CNGLYKLSLS GLDGGDSIHR SFLLLAASTL LKFLPDAQAL 1750
    KPPRIDDYEE EPLLKPGCKE YFWLLCKLVD NIHIKDASQT TLLDLDALAR 1800
    HLADCIRSRE ILDHLDGSIE DDGLSGLLRL ATSVIKHKPP FKFSREGQEF 1850
    LRDIFNLLFL LPSLKDRRQP KCKSHSCRAA AYDLLVEMVK GSVENYRLIH 1900
    NWVMAQHMQS HAPYKWDYWP HEDVRAECRF VGLTNLGATC YLASTIQQLY 1950
    MIPEARQAVF TAKYSEDMKH KTTLLELQKM FTYLMESECK AYNPRPFCKT 2000
    YTMDKQPLNT GEQKDMTEFF TDLITKVEEM SPELKNTVKS LFGGVITNNV 2050
    VSLDCEHVSQ TAEEFYTVRC QVADMKNIYE SLDEVTIKDT LEGDNMYTCS 2100
    HCGKKVRAEK RACFKKLPRI LSFNTMRYTF NMVTMMKEKV NTHFSFPLRL 2150
    DMTPYTEDFL MGKSDRKEGF KDVGDRSKDT ESYEYDLIGV TVHTGTADGG 2200
    HYYSFIRDIV NPHAYKNNKW YLFNDAEVKP FDSAQLASEC FGGEMTTKTY 2250
    DSVTDKFMDF SFEKTHSAYM LFYKRMEPEE ENGREYKFDV SSELLEWIWH 2300
    DNMQFLQDKN IFEHTYFGFM WQLCSCIPST LPDPKAVSLM TAKLSTSFVL 2350
    ETFIHSKEKP TMLQWIELLT KQFNNSQAAC EWFLDRMADD DWWPMQILIK 2400
    CPNQIVRQMF QRLCIHVIQR LRPVHAHLYL QPGMEDGSDD MDASVEDIGG 2450
    RSCVTRFVRT LLLIMEHGVK PHSKHLTEYF AFLYEFAKMG EEESQFLLSL 2500
    QAISTMVHFY MGTKGPENPQ VEVLSEEEGE EEEEEEDILS LAEEKYRPAA 2550
    LEKMIALVAL LVEQSRSERH LTLSQTDMAA LTGGKGFPFL FQHIRDGINI 2600
    RQTCNLIFSL CRYNNRLAEH IVSMLFTSIA KLTPEAANPF FKLLTMLMEF 2650
    AGGPPGMPPF ASYILQRIWE VIEYNPSQCL DWLAVQTPRN KLAHSWVLQN 2700
    MENWVERFLL AHNYPRVRTS AAYLLVSLIP SNSFRQMFRS TRSLHIPTRD 2750
    LPLSPDTTVV LHQVYNVLLG LLSRAKLYVD AAVHGTTKLV PYLSFMTYCL 2800
    ISKTEKLMFS TYFMDLWNLF QPKLSEPAIA TNHNKQALLS FWYNVCADCP 2850
    ENIRLIVQNP VVTKNIAFNY ILADHDDQDV VLFNRGMLPA YYGILRLCCE 2900
    QSPAFTRQLA SHQNIQWAFK NLTPHASQYP GAVEELFNLM QLFIAQRPDM 2950
    REEELEDIKQ FKKTTISCYL RCLDGRSCWT TLISAFRILL ESDEDRLLVV 3000
    FNRGLILMTE SFNTLHMMYH EATACHVTGD LVELLSIFLS VLKSTRPYLQ 3050
    RKDVKQALIQ WQERIEFAHK LLTLLNSYSP PELRNACIDV LKELVLLSPH 3100
    DFLHTLVPFL QHNHCTYHHS NIPMSLGPYF PCRENIKLIG GKSNIRPPRP 3150
    ELNMCLLPTM VETSKGKDDV YDRMLLDYFF SYHQFIHLLC RVAINCEKFT 3200
    ETLVKLSVLV AYEGLPLHLA LFPKLWTELC QTQSAMSKNC IKLLCEDPVF 3250
    AEYIKCILMD ERTFLNNNIV YTFMTHFLLK VQSQVFSEAN CASLISTLIT 3300
    NLINQYQNLQ SDFTNRVEIS KASAALNGDL RALALLLSVH TPKQLNPALI 3350
    PTLQELLNKC RTCLQQRNSL QEQEAKERKT KDDEGATPVK RRRVSSDEEH 3400
    TVDSCIGDIK TETREVLTPT STSDNETRDS SIIDPGTEQD LPSPENSSVK 3450
    EYRMEGPSSF SEDGSHIRSQ HAEEQSNNGR FDDCKEFKDH CSKDTTLAED 3500
    ESEFPSTSIS AVLSDLADLR SCDGQALSSQ DPEAAVSLSC GHSRGLISHM 3550
    QQHDILDTLC RTIESTIHVV TRISGKGNQA AS 3582
    Length:3,582
    Mass (Da):408,214
    Last modified:November 4, 2008 - v3
    Checksum:i27BA0032ED7E06A2
    GO
    Isoform 2 (identifier: Q6ZQ93-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-151: Missing.
         152-160: DEKEKLLLC → MRRKNYYYV

    Show »
    Length:3,431
    Mass (Da):391,068
    Checksum:iE7D7BECDEA86331D
    GO
    Isoform 3 (identifier: Q6ZQ93-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-151: Missing.
         152-160: DEKEKLLLC → MRRKNYYYV
         3124-3206: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:3,348
    Mass (Da):381,386
    Checksum:iB03CEBA62999D4CE
    GO
    Isoform 4 (identifier: Q6ZQ93-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-151: Missing.
         152-160: DEKEKLLLC → MRRKNYYYV
         2569-3582: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:2,417
    Mass (Da):275,543
    Checksum:i3C4C2FC2CB1FDB6C
    GO

    Sequence cautioni

    The sequence AAH55938.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence CAM20294.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2163 – 21631K → Q in BAE25365. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 151151Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_035641Add
    BLAST
    Alternative sequencei152 – 1609DEKEKLLLC → MRRKNYYYV in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_035642
    Alternative sequencei2569 – 35821014Missing in isoform 4. 1 PublicationVSP_020464Add
    BLAST
    Alternative sequencei3124 – 320683Missing in isoform 3. 1 PublicationVSP_020465Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672049 Genomic DNA. Translation: CAM16931.1.
    AL672049
    , AL672004, AL772359, AL928722 Genomic DNA. Translation: CAM16940.1.
    AL672004 Genomic DNA. Translation: CAM17339.1.
    AL672004
    , AL672049, AL772359, AL928722 Genomic DNA. Translation: CAM17340.1.
    AL772359
    , AL672004, AL672049, AL928722 Genomic DNA. Translation: CAM20294.1. Different initiation.
    AL928722
    , AL672004, AL672049, AL772359 Genomic DNA. Translation: CAO77877.1.
    AK033182 mRNA. Translation: BAC28186.1.
    AK143407 mRNA. Translation: BAE25365.1.
    AK148805 mRNA. Translation: BAE28668.1.
    AK129165 mRNA. Translation: BAC97975.1.
    BC055938 mRNA. Translation: AAH55938.1. Sequence problems.
    BC063062 mRNA. Translation: AAH63062.1.
    CCDSiCCDS56763.1. [Q6ZQ93-1]
    RefSeqiNP_001177330.2. NM_001190401.2. [Q6ZQ93-1]
    UniGeneiMm.119155.

    Genome annotation databases

    EnsembliENSMUST00000180046; ENSMUSP00000137430; ENSMUSG00000056342. [Q6ZQ93-1]
    GeneIDi17847.
    KEGGimmu:17847.
    UCSCiuc029rkw.1. mouse. [Q6ZQ93-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672049 Genomic DNA. Translation: CAM16931.1 .
    AL672049
    , AL672004 , AL772359 , AL928722 Genomic DNA. Translation: CAM16940.1 .
    AL672004 Genomic DNA. Translation: CAM17339.1 .
    AL672004
    , AL672049 , AL772359 , AL928722 Genomic DNA. Translation: CAM17340.1 .
    AL772359
    , AL672004 , AL672049 , AL928722 Genomic DNA. Translation: CAM20294.1 . Different initiation.
    AL928722
    , AL672004 , AL672049 , AL772359 Genomic DNA. Translation: CAO77877.1 .
    AK033182 mRNA. Translation: BAC28186.1 .
    AK143407 mRNA. Translation: BAE25365.1 .
    AK148805 mRNA. Translation: BAE28668.1 .
    AK129165 mRNA. Translation: BAC97975.1 .
    BC055938 mRNA. Translation: AAH55938.1 . Sequence problems.
    BC063062 mRNA. Translation: AAH63062.1 .
    CCDSi CCDS56763.1. [Q6ZQ93-1 ]
    RefSeqi NP_001177330.2. NM_001190401.2. [Q6ZQ93-1 ]
    UniGenei Mm.119155.

    3D structure databases

    ProteinModelPortali Q6ZQ93.
    SMRi Q6ZQ93. Positions 1930-2275.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.067.

    PTM databases

    PhosphoSitei Q6ZQ93.

    Proteomic databases

    MaxQBi Q6ZQ93.
    PaxDbi Q6ZQ93.
    PRIDEi Q6ZQ93.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000180046 ; ENSMUSP00000137430 ; ENSMUSG00000056342 . [Q6ZQ93-1 ]
    GeneIDi 17847.
    KEGGi mmu:17847.
    UCSCi uc029rkw.1. mouse. [Q6ZQ93-1 ]

    Organism-specific databases

    CTDi 9736.
    MGIi MGI:109473. Usp34.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5077.
    GeneTreei ENSGT00740000115055.
    HOVERGENi HBG092616.
    InParanoidi Q6ZQ93.
    KOi K11853.
    PhylomeDBi Q6ZQ93.

    Enzyme and pathway databases

    Reactomei REACT_207044. TCF dependent signaling in response to WNT.

    Miscellaneous databases

    NextBioi 292585.
    PROi Q6ZQ93.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZQ93.
    Bgeei Q6ZQ93.
    CleanExi MM_USP34.
    Genevestigatori Q6ZQ93.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 6 hits.
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 225-639; 2096-2278 AND 2437-3582 (ISOFORM 4).
      Strain: C57BL/6J.
      Tissue: Ovary, Sympathetic ganglion and Testis.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2279-3582 (ISOFORM 3).
      Tissue: Embryonic tail.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2346-2569 AND 3160-3376.
      Strain: C57BL/6 and Czech II.
      Tissue: Brain and Mammary tumor.
    5. "Mouse U2af1-rs1 is a neomorphic imprinted gene."
      Nabetani A., Hatada I., Morisaki H., Oshimura M., Mukai T.
      Mol. Cell. Biol. 17:789-798(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.

    Entry informationi

    Entry nameiUBP34_MOUSE
    AccessioniPrimary (citable) accession number: Q6ZQ93
    Secondary accession number(s): A2AF26
    , A2AF27, A2AF77, Q3UF93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 82 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3