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Q6ZQ89

- MARH6_MOUSE

UniProt

Q6ZQ89 - MARH6_MOUSE

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Protein
E3 ubiquitin-protein ligase MARCH6
Gene
March6, Kiaa0597
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 6262RING-CH-type
Add
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. ubiquitin-protein transferase activity Source: Ensembl
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein K48-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MARCH6 (EC:6.3.2.-)
Alternative name(s):
Membrane-associated RING finger protein 6
Membrane-associated RING-CH protein VI
Short name:
MARCH-VI
Gene namesi
Name:March6
Synonyms:Kiaa0597
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2442773. March6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9191Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei92 – 11221Helical; Reviewed prediction
Add
BLAST
Topological domaini113 – 14230Extracellular Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Topological domaini164 – 283120Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei284 – 30421Helical; Reviewed prediction
Add
BLAST
Topological domaini305 – 33632Extracellular Reviewed prediction
Add
BLAST
Transmembranei337 – 35721Helical; Reviewed prediction
Add
BLAST
Topological domaini358 – 37619Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei377 – 39721Helical; Reviewed prediction
Add
BLAST
Topological domaini398 – 42124Extracellular Reviewed prediction
Add
BLAST
Transmembranei422 – 44221Helical; Reviewed prediction
Add
BLAST
Topological domaini443 – 48038Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei481 – 50121Helical; Reviewed prediction
Add
BLAST
Topological domaini502 – 51918Extracellular Reviewed prediction
Add
BLAST
Transmembranei520 – 54021Helical; Reviewed prediction
Add
BLAST
Topological domaini541 – 63191Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei632 – 65221Helical; Reviewed prediction
Add
BLAST
Topological domaini653 – 67725Extracellular Reviewed prediction
Add
BLAST
Transmembranei678 – 69821Helical; Reviewed prediction
Add
BLAST
Topological domaini699 – 72022Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei721 – 74121Helical; Reviewed prediction
Add
BLAST
Topological domaini742 – 76322Extracellular Reviewed prediction
Add
BLAST
Transmembranei764 – 78421Helical; Reviewed prediction
Add
BLAST
Topological domaini785 – 81430Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei815 – 83521Helical; Reviewed prediction
Add
BLAST
Topological domaini836 – 84712Extracellular Reviewed prediction
Add
BLAST
Transmembranei848 – 86821Helical; Reviewed prediction
Add
BLAST
Topological domaini869 – 90941Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of endoplasmic reticulum membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 909909E3 ubiquitin-protein ligase MARCH6
PRO_0000274299Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Post-translational modificationi

Auto-ubiquitinated, which results in proteasomal degradation By similarity.

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PaxDbiQ6ZQ89.
PRIDEiQ6ZQ89.

PTM databases

PhosphoSiteiQ6ZQ89.

Expressioni

Gene expression databases

ArrayExpressiQ6ZQ89.
BgeeiQ6ZQ89.
CleanExiMM_MARCH6.
GenevestigatoriQ6ZQ89.

Interactioni

Subunit structurei

Interacts with DIO2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQ89.
SMRiQ6ZQ89. Positions 4-59.

Family & Domainsi

Domaini

The RING-CH-type zinc finger domain is required for E3 ligase activity By similarity.

Sequence similaritiesi

Belongs to the DOA10/MARCH6 family.

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5183.
GeneTreeiENSGT00730000110355.
HOGENOMiHOG000286005.
HOVERGENiHBG080753.
InParanoidiQ6ZQ89.
KOiK10661.
OMAiDNLLADC.
OrthoDBiEOG7J4464.
PhylomeDBiQ6ZQ89.
TreeFamiTF105777.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011016. Znf_RING-CH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF12906. RINGv. 1 hit.
[Graphical view]
SMARTiSM00744. RINGv. 1 hit.
[Graphical view]
PROSITEiPS51292. ZF_RING_CH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZQ89-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDTAEEDICR VCRSEGTPEK PLYHPCVCTG SIKFIHQECL VQWLKHSRKE    50
YCELCKHRFA FTPIYSPDMP SRLPIQDIFA GLVTSIGTAI RYWFHYTLVA 100
FAWLGVVPLT ACRIYKCLFT GSVSSLLTLP LDMLSTENLL ADCLQGCFVV 150
TCTLCAFISL VWLREQIVHG GAPIWLEHAA PPFNAAGHHQ NEAPVGGNGA 200
ENPAADQPAN PAGENAVLGE NPDAQDGQAE EEEEDNEEED DAGVEDAADA 250
NNGAQDDMNW NALEWDRAAE ELTWERMLGL DGSLVFLEHV FWVVSLNTLF 300
ILVFAFCPYH IGHFSLVGLG FEEHVQASHF EGLITTIVGY ILLAITLIIC 350
HALATLVKFH RSRRLLGVCY IVVKVSLLVV VEIGVFPLIC GWWLDICSLE 400
MFDATLKDRE LSFQSAPGTT MFLHWLVGMV YVFYFASFIL LLREVLRPGV 450
LWFLRNLNDP DFNPVQEMIH LPIYRHLRRF ILSVIVFGSI VLLMLWLPIR 500
IIKSLLPNFL PYNVMLYSDA PVSELSLELL LLQVVLPALL EQGHTRQWLK 550
GLVRAWTVTA GYLLDLHSYL LGDQEENENS ANQQVNNNQP ARNNNAVPAG 600
EGLHAAHQAI LQQGGPVGFQ PYRRPLNFPL RIFLLIVFMC ITLLIASLIC 650
LTLPVFAGRW LMSFWTGTAK IHELYTAACG LYVCWLTIRA VTVLVAWMPQ 700
GRRVIFQKVK EWSLMIMKTL IVAVLLAGVV PLLLGLLFEL VIVAPLRVPL 750
DQTPLFYPWQ DWALGVLHAK IIAAITLMGP QWWLKTVIEQ VYANGIRNID 800
LHYIIRKLAA PVISVLLLSL CVPYVIASGA VPLLGVTAEM QNLVHRRIYP 850
FLLMVVVLMG ILSFQVRQFK RLYEHIKNDK YLVGQRLVNY ERKSGKQGPS 900
TPPPVSSQE 909
Length:909
Mass (Da):102,273
Last modified:February 6, 2007 - v2
Checksum:iDC46CB2A34B6F749
GO
Isoform 2 (identifier: Q6ZQ89-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     625-821: PLNFPLRIFL...VISVLLLSLC → LPRWAPSHWQ...SWGFIVHNIC
     822-909: Missing.

Note: No experimental confirmation available.

Show »
Length:661
Mass (Da):74,274
Checksum:iC73C562C44B0DAF4
GO
Isoform 3 (identifier: Q6ZQ89-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     683-708: Missing.

Note: No experimental confirmation available.

Show »
Length:883
Mass (Da):99,219
Checksum:i5DB1C80612C77827
GO

Sequence cautioni

The sequence AAH37454.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei625 – 821197PLNFP…LLSLC → LPRWAPSHWQGLLSCVLCPV AFRKMMSSWGFIVHNIC in isoform 2.
VSP_022702Add
BLAST
Alternative sequencei683 – 70826Missing in isoform 3.
VSP_022704Add
BLAST
Alternative sequencei822 – 90988Missing in isoform 2.
VSP_022703Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti476 – 4761H → N in BAC31427. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK042980 mRNA. Translation: BAC31427.1.
AK089827 mRNA. Translation: BAC40971.1.
AK129169 Transcribed RNA. Translation: BAC97979.1.
BC037454 mRNA. Translation: AAH37454.1. Different initiation.
BC048816 mRNA. Translation: AAH48816.1.
BC059190 mRNA. Translation: AAH59190.2.
CCDSiCCDS37054.1. [Q6ZQ89-1]
RefSeqiNP_766194.2. NM_172606.2. [Q6ZQ89-1]
UniGeneiMm.272185.

Genome annotation databases

EnsembliENSMUST00000090227; ENSMUSP00000087694; ENSMUSG00000039100. [Q6ZQ89-1]
GeneIDi223455.
KEGGimmu:223455.
UCSCiuc007vkh.1. mouse. [Q6ZQ89-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK042980 mRNA. Translation: BAC31427.1 .
AK089827 mRNA. Translation: BAC40971.1 .
AK129169 Transcribed RNA. Translation: BAC97979.1 .
BC037454 mRNA. Translation: AAH37454.1 . Different initiation.
BC048816 mRNA. Translation: AAH48816.1 .
BC059190 mRNA. Translation: AAH59190.2 .
CCDSi CCDS37054.1. [Q6ZQ89-1 ]
RefSeqi NP_766194.2. NM_172606.2. [Q6ZQ89-1 ]
UniGenei Mm.272185.

3D structure databases

ProteinModelPortali Q6ZQ89.
SMRi Q6ZQ89. Positions 4-59.
ModBasei Search...

PTM databases

PhosphoSitei Q6ZQ89.

Proteomic databases

PaxDbi Q6ZQ89.
PRIDEi Q6ZQ89.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090227 ; ENSMUSP00000087694 ; ENSMUSG00000039100 . [Q6ZQ89-1 ]
GeneIDi 223455.
KEGGi mmu:223455.
UCSCi uc007vkh.1. mouse. [Q6ZQ89-1 ]

Organism-specific databases

CTDi 10299.
MGIi MGI:2442773. March6.
Rougei Search...

Phylogenomic databases

eggNOGi COG5183.
GeneTreei ENSGT00730000110355.
HOGENOMi HOG000286005.
HOVERGENi HBG080753.
InParanoidi Q6ZQ89.
KOi K10661.
OMAi DNLLADC.
OrthoDBi EOG7J4464.
PhylomeDBi Q6ZQ89.
TreeFami TF105777.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi MARCH6. mouse.
NextBioi 376726.
PROi Q6ZQ89.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6ZQ89.
Bgeei Q6ZQ89.
CleanExi MM_MARCH6.
Genevestigatori Q6ZQ89.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR011016. Znf_RING-CH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF12906. RINGv. 1 hit.
[Graphical view ]
SMARTi SM00744. RINGv. 1 hit.
[Graphical view ]
PROSITEi PS51292. ZF_RING_CH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 476-909 (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum and Spleen.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 348-883 (ISOFORM 3).
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 383-909 (ISOFORM 1).
    Strain: Czech II and FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiMARH6_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQ89
Secondary accession number(s): Q6PCS1
, Q80V02, Q80VC7, Q8BJA0, Q8BXX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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