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Q6ZQ82

- RHG26_MOUSE

UniProt

Q6ZQ82 - RHG26_MOUSE

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Protein
Rho GTPase-activating protein 26
Gene
Arhgap26, Kiaa0621
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GTPase-activating protein for RHOA and CDC42 By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. filopodium assembly Source: InterPro
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_210090. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 26
Alternative name(s):
Rho-type GTPase-activating protein 26
Gene namesi
Name:Arhgap26
Synonyms:Kiaa0621
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1918552. Arhgap26.

Subcellular locationi

Cell junctionfocal adhesion By similarity. Cytoplasmcytoskeleton By similarity
Note: Colocalizes with actin stress fibers and cortical actin structures By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. focal adhesion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 814814Rho GTPase-activating protein 26
PRO_0000355553Add
BLAST

Proteomic databases

MaxQBiQ6ZQ82.
PaxDbiQ6ZQ82.
PRIDEiQ6ZQ82.

PTM databases

PhosphoSiteiQ6ZQ82.

Expressioni

Gene expression databases

ArrayExpressiQ6ZQ82.
BgeeiQ6ZQ82.
GenevestigatoriQ6ZQ82.

Interactioni

Subunit structurei

Binds to the C-terminus of PTK2/FAK1 By similarity. Interacts with NYAP1, NYAP2 and MYO16.1 Publication

Protein-protein interaction databases

IntActiQ6ZQ82. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQ82.
SMRiQ6ZQ82. Positions 383-573, 754-814.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini265 – 369105PH
Add
BLAST
Domaini383 – 568186Rho-GAP
Add
BLAST
Domaini756 – 81459SH3
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi584 – 701118Ser-rich
Add
BLAST

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 Rho-GAP domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG311191.
GeneTreeiENSGT00730000110511.
HOGENOMiHOG000018767.
HOVERGENiHBG067993.
InParanoidiQ6ZQ82.
OMAiKDFGDFK.
OrthoDBiEOG71VSS5.
TreeFamiTF316851.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR013606. IRSp53/MIM_homology_IMD.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08397. IMD. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZQ82-1 [UniParc]FASTAAdd to Basket

« Hide

MGLPALEFSD CCLDSPHFRE TLKSHEAELD KTNKFIKELI KDGKSLISAL    50
KNLSSAKRKF ADSLNEFKFQ CIGDAETDDE MCIARSLQEF AAVLRNLEDE 100
RSRMIENASE VLITPLEKFR KEQIGAAREA KKKYDKETEK YCGTLEKHLN 150
LSSKKKESQL QEADSQVDLV RQHFYEVSLE YVFKVQEVQE RKMFEFVEPL 200
LAFLQGLFTF YHHGYELAKD FGDFKTQLTI SIQNTRNRFE GTRSEVESLM 250
KKMKENPLEH KTISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRDSKQITM 300
VPFDQKSGGK GGEDESVTLK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ 350
ALSEEDRRLW MEAMDGREPV YNSNRDSQSE GTAQLDSIGF SIIRKCIHAV 400
ETRGINEQGL YRIVGVNSRV QKLLSVLMDP KAASETETDI CAEWEIKTVT 450
SALKTYLRML PGPLMMYQFQ RSFIKAAKLE NQETRVSEIH SLVHRLPEKN 500
RQMLQLLMNH LANVANNHKQ NLMTVANLGV VFGPTLLRPQ EETVAAIMDI 550
KFQNIVIEIL IENHEKIFNT VPDVPLTNAQ LHLSRKKSSD SKPPSCSKRP 600
LTLFHAVPST EKQEQRNSII NSSLESVSSS ANSILNSSSS LQPNLNSSDS 650
NLDVVKPSRP SSLPPNPSPT SPLSPSWPMF SAPSSPMPTS STSSDSSPIR 700
SVAGFVWFSV AAVVLSLAWS SLHAVFSLLV NFVPCHPNLH LLFDRPEEAV 750
REDSSTPFRK AKALYACQAE HDSELSFTAG TVFDNVHPSQ EPGWLEGTLN 800
GKTGLIPENY VEFL 814
Length:814
Mass (Da):92,071
Last modified:July 27, 2011 - v3
Checksum:iB1BA51634549C891
GO

Sequence cautioni

The sequence BAC97986.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti598 – 5981K → E in BAC97986. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129176 mRNA. Translation: BAC97986.1. Different initiation.
AC110730 Genomic DNA. No translation available.
AC129603 Genomic DNA. No translation available.
AC132098 Genomic DNA. No translation available.
AC132450 Genomic DNA. No translation available.
AC133601 Genomic DNA. No translation available.
AC151409 Genomic DNA. No translation available.
AC151580 Genomic DNA. No translation available.
CCDSiCCDS29205.1.
RefSeqiNP_780373.3. NM_175164.4.
UniGeneiMm.329396.

Genome annotation databases

EnsembliENSMUST00000097593; ENSMUSP00000095200; ENSMUSG00000036452.
GeneIDi71302.
KEGGimmu:71302.
UCSCiuc008esr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129176 mRNA. Translation: BAC97986.1 . Different initiation.
AC110730 Genomic DNA. No translation available.
AC129603 Genomic DNA. No translation available.
AC132098 Genomic DNA. No translation available.
AC132450 Genomic DNA. No translation available.
AC133601 Genomic DNA. No translation available.
AC151409 Genomic DNA. No translation available.
AC151580 Genomic DNA. No translation available.
CCDSi CCDS29205.1.
RefSeqi NP_780373.3. NM_175164.4.
UniGenei Mm.329396.

3D structure databases

ProteinModelPortali Q6ZQ82.
SMRi Q6ZQ82. Positions 383-573, 754-814.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6ZQ82. 2 interactions.

PTM databases

PhosphoSitei Q6ZQ82.

Proteomic databases

MaxQBi Q6ZQ82.
PaxDbi Q6ZQ82.
PRIDEi Q6ZQ82.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000097593 ; ENSMUSP00000095200 ; ENSMUSG00000036452 .
GeneIDi 71302.
KEGGi mmu:71302.
UCSCi uc008esr.1. mouse.

Organism-specific databases

CTDi 23092.
MGIi MGI:1918552. Arhgap26.
Rougei Search...

Phylogenomic databases

eggNOGi NOG311191.
GeneTreei ENSGT00730000110511.
HOGENOMi HOG000018767.
HOVERGENi HBG067993.
InParanoidi Q6ZQ82.
OMAi KDFGDFK.
OrthoDBi EOG71VSS5.
TreeFami TF316851.

Enzyme and pathway databases

Reactomei REACT_210090. Rho GTPase cycle.

Miscellaneous databases

NextBioi 333497.
PROi Q6ZQ82.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6ZQ82.
Bgeei Q6ZQ82.
Genevestigatori Q6ZQ82.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR013606. IRSp53/MIM_homology_IMD.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF08397. IMD. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons."
    Yokoyama K., Tezuka T., Kotani M., Nakazawa T., Hoshina N., Shimoda Y., Kakuta S., Sudo K., Watanabe K., Iwakura Y., Yamamoto T.
    EMBO J. 30:4739-4754(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NYAP1; NYAP2 AND MYO16.

Entry informationi

Entry nameiRHG26_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQ82
Secondary accession number(s): E9QLL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi