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Protein

Rho GTPase-activating protein 26

Gene

Arhgap26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein for RHOA and CDC42.By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. phospholipid binding Source: Ensembl

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
  2. plasma membrane organization Source: InterPro
  3. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_297947. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 26
Alternative name(s):
Rho-type GTPase-activating protein 26
Gene namesi
Name:Arhgap26
Synonyms:Kiaa0621
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1918552. Arhgap26.

Subcellular locationi

  1. Cell junctionfocal adhesion By similarity
  2. Cytoplasmcytoskeleton By similarity

  3. Note: Colocalizes with actin stress fibers and cortical actin structures.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. focal adhesion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 814814Rho GTPase-activating protein 26PRO_0000355553Add
BLAST

Proteomic databases

MaxQBiQ6ZQ82.
PaxDbiQ6ZQ82.
PRIDEiQ6ZQ82.

PTM databases

PhosphoSiteiQ6ZQ82.

Expressioni

Gene expression databases

BgeeiQ6ZQ82.
ExpressionAtlasiQ6ZQ82. baseline and differential.
GenevestigatoriQ6ZQ82.

Interactioni

Subunit structurei

Binds to the C-terminus of PTK2/FAK1 (By similarity). Interacts with NYAP1, NYAP2 and MYO16.By similarity1 Publication

Protein-protein interaction databases

IntActiQ6ZQ82. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQ82.
SMRiQ6ZQ82. Positions 383-573, 754-814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini265 – 369105PHPROSITE-ProRule annotationAdd
BLAST
Domaini383 – 568186Rho-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini756 – 81459SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi584 – 701118Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG311191.
GeneTreeiENSGT00780000121833.
HOGENOMiHOG000018767.
HOVERGENiHBG067993.
InParanoidiQ6ZQ82.
OMAiKDFGDFK.
OrthoDBiEOG71VSS5.
TreeFamiTF316851.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR013606. I-BAR_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR030061. RHG26.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR12552:SF4. PTHR12552:SF4. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZQ82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPALEFSD CCLDSPHFRE TLKSHEAELD KTNKFIKELI KDGKSLISAL
60 70 80 90 100
KNLSSAKRKF ADSLNEFKFQ CIGDAETDDE MCIARSLQEF AAVLRNLEDE
110 120 130 140 150
RSRMIENASE VLITPLEKFR KEQIGAAREA KKKYDKETEK YCGTLEKHLN
160 170 180 190 200
LSSKKKESQL QEADSQVDLV RQHFYEVSLE YVFKVQEVQE RKMFEFVEPL
210 220 230 240 250
LAFLQGLFTF YHHGYELAKD FGDFKTQLTI SIQNTRNRFE GTRSEVESLM
260 270 280 290 300
KKMKENPLEH KTISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRDSKQITM
310 320 330 340 350
VPFDQKSGGK GGEDESVTLK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ
360 370 380 390 400
ALSEEDRRLW MEAMDGREPV YNSNRDSQSE GTAQLDSIGF SIIRKCIHAV
410 420 430 440 450
ETRGINEQGL YRIVGVNSRV QKLLSVLMDP KAASETETDI CAEWEIKTVT
460 470 480 490 500
SALKTYLRML PGPLMMYQFQ RSFIKAAKLE NQETRVSEIH SLVHRLPEKN
510 520 530 540 550
RQMLQLLMNH LANVANNHKQ NLMTVANLGV VFGPTLLRPQ EETVAAIMDI
560 570 580 590 600
KFQNIVIEIL IENHEKIFNT VPDVPLTNAQ LHLSRKKSSD SKPPSCSKRP
610 620 630 640 650
LTLFHAVPST EKQEQRNSII NSSLESVSSS ANSILNSSSS LQPNLNSSDS
660 670 680 690 700
NLDVVKPSRP SSLPPNPSPT SPLSPSWPMF SAPSSPMPTS STSSDSSPIR
710 720 730 740 750
SVAGFVWFSV AAVVLSLAWS SLHAVFSLLV NFVPCHPNLH LLFDRPEEAV
760 770 780 790 800
REDSSTPFRK AKALYACQAE HDSELSFTAG TVFDNVHPSQ EPGWLEGTLN
810
GKTGLIPENY VEFL
Length:814
Mass (Da):92,071
Last modified:July 27, 2011 - v3
Checksum:iB1BA51634549C891
GO

Sequence cautioni

The sequence BAC97986.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti598 – 5981K → E in BAC97986 (PubMed:14621295).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129176 mRNA. Translation: BAC97986.1. Different initiation.
AC110730 Genomic DNA. No translation available.
AC129603 Genomic DNA. No translation available.
AC132098 Genomic DNA. No translation available.
AC132450 Genomic DNA. No translation available.
AC133601 Genomic DNA. No translation available.
AC151409 Genomic DNA. No translation available.
AC151580 Genomic DNA. No translation available.
CCDSiCCDS29205.1.
RefSeqiNP_780373.3. NM_175164.4.
UniGeneiMm.329396.

Genome annotation databases

EnsembliENSMUST00000097593; ENSMUSP00000095200; ENSMUSG00000036452.
GeneIDi71302.
KEGGimmu:71302.
UCSCiuc008esr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129176 mRNA. Translation: BAC97986.1. Different initiation.
AC110730 Genomic DNA. No translation available.
AC129603 Genomic DNA. No translation available.
AC132098 Genomic DNA. No translation available.
AC132450 Genomic DNA. No translation available.
AC133601 Genomic DNA. No translation available.
AC151409 Genomic DNA. No translation available.
AC151580 Genomic DNA. No translation available.
CCDSiCCDS29205.1.
RefSeqiNP_780373.3. NM_175164.4.
UniGeneiMm.329396.

3D structure databases

ProteinModelPortaliQ6ZQ82.
SMRiQ6ZQ82. Positions 383-573, 754-814.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6ZQ82. 2 interactions.

PTM databases

PhosphoSiteiQ6ZQ82.

Proteomic databases

MaxQBiQ6ZQ82.
PaxDbiQ6ZQ82.
PRIDEiQ6ZQ82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097593; ENSMUSP00000095200; ENSMUSG00000036452.
GeneIDi71302.
KEGGimmu:71302.
UCSCiuc008esr.1. mouse.

Organism-specific databases

CTDi23092.
MGIiMGI:1918552. Arhgap26.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG311191.
GeneTreeiENSGT00780000121833.
HOGENOMiHOG000018767.
HOVERGENiHBG067993.
InParanoidiQ6ZQ82.
OMAiKDFGDFK.
OrthoDBiEOG71VSS5.
TreeFamiTF316851.

Enzyme and pathway databases

ReactomeiREACT_297947. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiArhgap26. mouse.
NextBioi333497.
PROiQ6ZQ82.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZQ82.
ExpressionAtlasiQ6ZQ82. baseline and differential.
GenevestigatoriQ6ZQ82.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR013606. I-BAR_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR030061. RHG26.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR12552:SF4. PTHR12552:SF4. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons."
    Yokoyama K., Tezuka T., Kotani M., Nakazawa T., Hoshina N., Shimoda Y., Kakuta S., Sudo K., Watanabe K., Iwakura Y., Yamamoto T.
    EMBO J. 30:4739-4754(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NYAP1; NYAP2 AND MYO16.

Entry informationi

Entry nameiRHG26_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQ82
Secondary accession number(s): E9QLL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 27, 2011
Last modified: April 29, 2015
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.