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Q6ZQ82

- RHG26_MOUSE

UniProt

Q6ZQ82 - RHG26_MOUSE

Protein

Rho GTPase-activating protein 26

Gene

Arhgap26

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    GTPase-activating protein for RHOA and CDC42.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. filopodium assembly Source: InterPro
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Enzyme and pathway databases

    ReactomeiREACT_210090. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho GTPase-activating protein 26
    Alternative name(s):
    Rho-type GTPase-activating protein 26
    Gene namesi
    Name:Arhgap26
    Synonyms:Kiaa0621
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1918552. Arhgap26.

    Subcellular locationi

    Cell junctionfocal adhesion By similarity. Cytoplasmcytoskeleton By similarity
    Note: Colocalizes with actin stress fibers and cortical actin structures.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. focal adhesion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 814814Rho GTPase-activating protein 26PRO_0000355553Add
    BLAST

    Proteomic databases

    MaxQBiQ6ZQ82.
    PaxDbiQ6ZQ82.
    PRIDEiQ6ZQ82.

    PTM databases

    PhosphoSiteiQ6ZQ82.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZQ82.
    BgeeiQ6ZQ82.
    GenevestigatoriQ6ZQ82.

    Interactioni

    Subunit structurei

    Binds to the C-terminus of PTK2/FAK1 By similarity. Interacts with NYAP1, NYAP2 and MYO16.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ6ZQ82. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZQ82.
    SMRiQ6ZQ82. Positions 383-573, 754-814.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini265 – 369105PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini383 – 568186Rho-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini756 – 81459SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi584 – 701118Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG311191.
    GeneTreeiENSGT00730000110511.
    HOGENOMiHOG000018767.
    HOVERGENiHBG067993.
    InParanoidiQ6ZQ82.
    OMAiKDFGDFK.
    OrthoDBiEOG71VSS5.
    TreeFamiTF316851.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR013606. IRSp53/MIM_homology_IMD.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF08397. IMD. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 2 hits.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZQ82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLPALEFSD CCLDSPHFRE TLKSHEAELD KTNKFIKELI KDGKSLISAL    50
    KNLSSAKRKF ADSLNEFKFQ CIGDAETDDE MCIARSLQEF AAVLRNLEDE 100
    RSRMIENASE VLITPLEKFR KEQIGAAREA KKKYDKETEK YCGTLEKHLN 150
    LSSKKKESQL QEADSQVDLV RQHFYEVSLE YVFKVQEVQE RKMFEFVEPL 200
    LAFLQGLFTF YHHGYELAKD FGDFKTQLTI SIQNTRNRFE GTRSEVESLM 250
    KKMKENPLEH KTISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRDSKQITM 300
    VPFDQKSGGK GGEDESVTLK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ 350
    ALSEEDRRLW MEAMDGREPV YNSNRDSQSE GTAQLDSIGF SIIRKCIHAV 400
    ETRGINEQGL YRIVGVNSRV QKLLSVLMDP KAASETETDI CAEWEIKTVT 450
    SALKTYLRML PGPLMMYQFQ RSFIKAAKLE NQETRVSEIH SLVHRLPEKN 500
    RQMLQLLMNH LANVANNHKQ NLMTVANLGV VFGPTLLRPQ EETVAAIMDI 550
    KFQNIVIEIL IENHEKIFNT VPDVPLTNAQ LHLSRKKSSD SKPPSCSKRP 600
    LTLFHAVPST EKQEQRNSII NSSLESVSSS ANSILNSSSS LQPNLNSSDS 650
    NLDVVKPSRP SSLPPNPSPT SPLSPSWPMF SAPSSPMPTS STSSDSSPIR 700
    SVAGFVWFSV AAVVLSLAWS SLHAVFSLLV NFVPCHPNLH LLFDRPEEAV 750
    REDSSTPFRK AKALYACQAE HDSELSFTAG TVFDNVHPSQ EPGWLEGTLN 800
    GKTGLIPENY VEFL 814
    Length:814
    Mass (Da):92,071
    Last modified:July 27, 2011 - v3
    Checksum:iB1BA51634549C891
    GO

    Sequence cautioni

    The sequence BAC97986.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti598 – 5981K → E in BAC97986. (PubMed:14621295)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129176 mRNA. Translation: BAC97986.1. Different initiation.
    AC110730 Genomic DNA. No translation available.
    AC129603 Genomic DNA. No translation available.
    AC132098 Genomic DNA. No translation available.
    AC132450 Genomic DNA. No translation available.
    AC133601 Genomic DNA. No translation available.
    AC151409 Genomic DNA. No translation available.
    AC151580 Genomic DNA. No translation available.
    CCDSiCCDS29205.1.
    RefSeqiNP_780373.3. NM_175164.4.
    UniGeneiMm.329396.

    Genome annotation databases

    EnsembliENSMUST00000097593; ENSMUSP00000095200; ENSMUSG00000036452.
    GeneIDi71302.
    KEGGimmu:71302.
    UCSCiuc008esr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129176 mRNA. Translation: BAC97986.1 . Different initiation.
    AC110730 Genomic DNA. No translation available.
    AC129603 Genomic DNA. No translation available.
    AC132098 Genomic DNA. No translation available.
    AC132450 Genomic DNA. No translation available.
    AC133601 Genomic DNA. No translation available.
    AC151409 Genomic DNA. No translation available.
    AC151580 Genomic DNA. No translation available.
    CCDSi CCDS29205.1.
    RefSeqi NP_780373.3. NM_175164.4.
    UniGenei Mm.329396.

    3D structure databases

    ProteinModelPortali Q6ZQ82.
    SMRi Q6ZQ82. Positions 383-573, 754-814.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6ZQ82. 2 interactions.

    PTM databases

    PhosphoSitei Q6ZQ82.

    Proteomic databases

    MaxQBi Q6ZQ82.
    PaxDbi Q6ZQ82.
    PRIDEi Q6ZQ82.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000097593 ; ENSMUSP00000095200 ; ENSMUSG00000036452 .
    GeneIDi 71302.
    KEGGi mmu:71302.
    UCSCi uc008esr.1. mouse.

    Organism-specific databases

    CTDi 23092.
    MGIi MGI:1918552. Arhgap26.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG311191.
    GeneTreei ENSGT00730000110511.
    HOGENOMi HOG000018767.
    HOVERGENi HBG067993.
    InParanoidi Q6ZQ82.
    OMAi KDFGDFK.
    OrthoDBi EOG71VSS5.
    TreeFami TF316851.

    Enzyme and pathway databases

    Reactomei REACT_210090. Rho GTPase cycle.

    Miscellaneous databases

    NextBioi 333497.
    PROi Q6ZQ82.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZQ82.
    Bgeei Q6ZQ82.
    Genevestigatori Q6ZQ82.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR013606. IRSp53/MIM_homology_IMD.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF08397. IMD. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 2 hits.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons."
      Yokoyama K., Tezuka T., Kotani M., Nakazawa T., Hoshina N., Shimoda Y., Kakuta S., Sudo K., Watanabe K., Iwakura Y., Yamamoto T.
      EMBO J. 30:4739-4754(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NYAP1; NYAP2 AND MYO16.

    Entry informationi

    Entry nameiRHG26_MOUSE
    AccessioniPrimary (citable) accession number: Q6ZQ82
    Secondary accession number(s): E9QLL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 83 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3