Q6ZQ82 (RHG26_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho GTPase-activating protein 26

Alternative name(s):
Rho-type GTPase-activating protein 26

Gene names

Name:	Arhgap26
Synonyms:	Kiaa0621

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	814 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTPase-activating protein for RHOA and CDC42 By similarity.
Subunit structure	Binds to the C-terminus of PTK2/FAK1 By similarity. Interacts with NYAP1, NYAP2 and MYO16. Ref.3
Subcellular location	Cell junction › focal adhesion By similarity. Cytoplasm › cytoskeleton By similarity. Note: Colocalizes with actin stress fibers and cortical actin structures By similarity.
Sequence similarities	Contains 1 PH domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain.
Sequence caution	The sequence BAC97986.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasm Cytoskeleton
Domain	SH3 domain
Molecular function	GTPase activation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	filopodium assembly Inferred from electronic annotation. Source: InterPro positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell focal adhesion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 814	814	Rho GTPase-activating protein 26		PRO_0000355553
Regions
	Domain	265 – 369	105	PH
	Domain	383 – 568	186	Rho-GAP
	Domain	756 – 814	59	SH3
	Compositional bias	584 – 701	118	Ser-rich
Experimental info
	Sequence conflict	598	1	K → E in BAC97986. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6ZQ82 [UniParc]. Last modified July 27, 2011. Version 3. Checksum: B1BA51634549C891	FASTA	814	92,071
	10 20 30 40 50 60 MGLPALEFSD CCLDSPHFRE TLKSHEAELD KTNKFIKELI KDGKSLISAL KNLSSAKRKF 70 80 90 100 110 120 ADSLNEFKFQ CIGDAETDDE MCIARSLQEF AAVLRNLEDE RSRMIENASE VLITPLEKFR 130 140 150 160 170 180 KEQIGAAREA KKKYDKETEK YCGTLEKHLN LSSKKKESQL QEADSQVDLV RQHFYEVSLE 190 200 210 220 230 240 YVFKVQEVQE RKMFEFVEPL LAFLQGLFTF YHHGYELAKD FGDFKTQLTI SIQNTRNRFE 250 260 270 280 290 300 GTRSEVESLM KKMKENPLEH KTISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRDSKQITM 310 320 330 340 350 360 VPFDQKSGGK GGEDESVTLK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ ALSEEDRRLW 370 380 390 400 410 420 MEAMDGREPV YNSNRDSQSE GTAQLDSIGF SIIRKCIHAV ETRGINEQGL YRIVGVNSRV 430 440 450 460 470 480 QKLLSVLMDP KAASETETDI CAEWEIKTVT SALKTYLRML PGPLMMYQFQ RSFIKAAKLE 490 500 510 520 530 540 NQETRVSEIH SLVHRLPEKN RQMLQLLMNH LANVANNHKQ NLMTVANLGV VFGPTLLRPQ 550 560 570 580 590 600 EETVAAIMDI KFQNIVIEIL IENHEKIFNT VPDVPLTNAQ LHLSRKKSSD SKPPSCSKRP 610 620 630 640 650 660 LTLFHAVPST EKQEQRNSII NSSLESVSSS ANSILNSSSS LQPNLNSSDS NLDVVKPSRP 670 680 690 700 710 720 SSLPPNPSPT SPLSPSWPMF SAPSSPMPTS STSSDSSPIR SVAGFVWFSV AAVVLSLAWS 730 740 750 760 770 780 SLHAVFSLLV NFVPCHPNLH LLFDRPEEAV REDSSTPFRK AKALYACQAE HDSELSFTAG 790 800 810 TVFDNVHPSQ EPGWLEGTLN GKTGLIPENY VEFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons." Yokoyama K., Tezuka T., Kotani M., Nakazawa T., Hoshina N., Shimoda Y., Kakuta S., Sudo K., Watanabe K., Iwakura Y., Yamamoto T. EMBO J. 30:4739-4754(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NYAP1; NYAP2 AND MYO16.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK129176 mRNA. Translation: BAC97986.1. Different initiation. AC110730 Genomic DNA. No translation available. AC129603 Genomic DNA. No translation available. AC132098 Genomic DNA. No translation available. AC132450 Genomic DNA. No translation available. AC133601 Genomic DNA. No translation available. AC151409 Genomic DNA. No translation available. AC151580 Genomic DNA. No translation available.
IPI	IPI00620960.
RefSeq	NP_780373.3. NM_175164.4.
UniGene	Mm.329396.
3D structure databases
HSSP	HSSP built from PDB template 1UGV based on UniProtKB Q9UNA1.
ProteinModelPortal	Q6ZQ82.
SMR	Q6ZQ82. Positions 383-573, 754-814.
ModBase	Search...
PTM databases
PhosphoSite	Q6ZQ82.
Proteomic databases
PaxDb	Q6ZQ82.
PRIDE	Q6ZQ82.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000097593; ENSMUSP00000095200; ENSMUSG00000036452.
GeneID	71302.
KEGG	mmu:71302.
UCSC	uc008esr.1. mouse.
Organism-specific databases
CTD	23092.
MGI	MGI:1918552. Arhgap26.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG311191.
GeneTree	ENSGT00700000104048.
HOGENOM	HOG000018767.
HOVERGEN	HBG067993.
InParanoid	Q6ZQ82.
OMA	KDFGDFK.
Gene expression databases
ArrayExpress	Q6ZQ82.
Bgee	Q6ZQ82.
Genevestigator	Q6ZQ82.
Family and domain databases
Gene3D	1.10.555.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR013606. IRSp53/MIM_homology_IMD. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. IPR001452. SH3_domain. [Graphical view]
Pfam	PF08397. IMD. 1 hit. PF00620. RhoGAP. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. SM00324. RhoGAP. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF48350. Rho_GAP. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS50003. PH_DOMAIN. 1 hit. PS50238. RHOGAP. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	333497.
SOURCE	Search...

Entry information

Entry name

RHG26_MOUSE

Accession

Primary (citable) accession number: Q6ZQ82
Secondary accession number(s): E9QLL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 69 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program