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Q6ZQ82 (RHG26_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho GTPase-activating protein 26
Alternative name(s):
Rho-type GTPase-activating protein 26
Gene names
Name:Arhgap26
Synonyms:Kiaa0621
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length814 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GTPase-activating protein for RHOA and CDC42 By similarity.

Subunit structure

Binds to the C-terminus of PTK2/FAK1 By similarity. Interacts with NYAP1, NYAP2 and MYO16. Ref.3

Subcellular location

Cell junctionfocal adhesion By similarity. Cytoplasmcytoskeleton By similarity. Note: Colocalizes with actin stress fibers and cortical actin structures By similarity.

Sequence similarities

Contains 1 PH domain.

Contains 1 Rho-GAP domain.

Contains 1 SH3 domain.

Sequence caution

The sequence BAC97986.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentCell junction
Cytoplasm
Cytoskeleton
   DomainSH3 domain
   Molecular functionGTPase activation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfilopodium assembly

Inferred from electronic annotation. Source: InterPro

signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

focal adhesion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTPase activator activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction Ref.3. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 814814Rho GTPase-activating protein 26
PRO_0000355553

Regions

Domain265 – 369105PH
Domain383 – 568186Rho-GAP
Domain756 – 81459SH3
Compositional bias584 – 701118Ser-rich

Experimental info

Sequence conflict5981K → E in BAC97986. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6ZQ82 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: B1BA51634549C891

FASTA81492,071
        10         20         30         40         50         60 
MGLPALEFSD CCLDSPHFRE TLKSHEAELD KTNKFIKELI KDGKSLISAL KNLSSAKRKF 

        70         80         90        100        110        120 
ADSLNEFKFQ CIGDAETDDE MCIARSLQEF AAVLRNLEDE RSRMIENASE VLITPLEKFR 

       130        140        150        160        170        180 
KEQIGAAREA KKKYDKETEK YCGTLEKHLN LSSKKKESQL QEADSQVDLV RQHFYEVSLE 

       190        200        210        220        230        240 
YVFKVQEVQE RKMFEFVEPL LAFLQGLFTF YHHGYELAKD FGDFKTQLTI SIQNTRNRFE 

       250        260        270        280        290        300 
GTRSEVESLM KKMKENPLEH KTISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRDSKQITM 

       310        320        330        340        350        360 
VPFDQKSGGK GGEDESVTLK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ ALSEEDRRLW 

       370        380        390        400        410        420 
MEAMDGREPV YNSNRDSQSE GTAQLDSIGF SIIRKCIHAV ETRGINEQGL YRIVGVNSRV 

       430        440        450        460        470        480 
QKLLSVLMDP KAASETETDI CAEWEIKTVT SALKTYLRML PGPLMMYQFQ RSFIKAAKLE 

       490        500        510        520        530        540 
NQETRVSEIH SLVHRLPEKN RQMLQLLMNH LANVANNHKQ NLMTVANLGV VFGPTLLRPQ 

       550        560        570        580        590        600 
EETVAAIMDI KFQNIVIEIL IENHEKIFNT VPDVPLTNAQ LHLSRKKSSD SKPPSCSKRP 

       610        620        630        640        650        660 
LTLFHAVPST EKQEQRNSII NSSLESVSSS ANSILNSSSS LQPNLNSSDS NLDVVKPSRP 

       670        680        690        700        710        720 
SSLPPNPSPT SPLSPSWPMF SAPSSPMPTS STSSDSSPIR SVAGFVWFSV AAVVLSLAWS 

       730        740        750        760        770        780 
SLHAVFSLLV NFVPCHPNLH LLFDRPEEAV REDSSTPFRK AKALYACQAE HDSELSFTAG 

       790        800        810 
TVFDNVHPSQ EPGWLEGTLN GKTGLIPENY VEFL 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons."
Yokoyama K., Tezuka T., Kotani M., Nakazawa T., Hoshina N., Shimoda Y., Kakuta S., Sudo K., Watanabe K., Iwakura Y., Yamamoto T.
EMBO J. 30:4739-4754(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NYAP1; NYAP2 AND MYO16.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK129176 mRNA. Translation: BAC97986.1. Different initiation.
AC110730 Genomic DNA. No translation available.
AC129603 Genomic DNA. No translation available.
AC132098 Genomic DNA. No translation available.
AC132450 Genomic DNA. No translation available.
AC133601 Genomic DNA. No translation available.
AC151409 Genomic DNA. No translation available.
AC151580 Genomic DNA. No translation available.
CCDSCCDS29205.1.
RefSeqNP_780373.3. NM_175164.4.
UniGeneMm.329396.

3D structure databases

ProteinModelPortalQ6ZQ82.
SMRQ6ZQ82. Positions 383-573, 754-814.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6ZQ82. 2 interactions.

PTM databases

PhosphoSiteQ6ZQ82.

Proteomic databases

MaxQBQ6ZQ82.
PaxDbQ6ZQ82.
PRIDEQ6ZQ82.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000097593; ENSMUSP00000095200; ENSMUSG00000036452.
GeneID71302.
KEGGmmu:71302.
UCSCuc008esr.1. mouse.

Organism-specific databases

CTD23092.
MGIMGI:1918552. Arhgap26.
RougeSearch...

Phylogenomic databases

eggNOGNOG311191.
GeneTreeENSGT00730000110511.
HOGENOMHOG000018767.
HOVERGENHBG067993.
InParanoidQ6ZQ82.
OMAKDFGDFK.
OrthoDBEOG71VSS5.
TreeFamTF316851.

Gene expression databases

ArrayExpressQ6ZQ82.
BgeeQ6ZQ82.
GenevestigatorQ6ZQ82.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR013606. IRSp53/MIM_homology_IMD.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamPF08397. IMD. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio333497.
PROQ6ZQ82.
SOURCESearch...

Entry information

Entry nameRHG26_MOUSE
AccessionPrimary (citable) accession number: Q6ZQ82
Secondary accession number(s): E9QLL3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot