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Protein

Cullin-associated NEDD8-dissociated protein 2

Gene

Cand2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.By similarity

GO - Molecular functioni

  • TBP-class protein binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Cullin-associated NEDD8-dissociated protein 2
Alternative name(s):
Cullin-associated and neddylation-dissociated protein 2
TBP-interacting protein of 120 kDa B
Short name:
TBP-interacting protein 120B
p120 CAND2
Gene namesi
Name:Cand2
Synonyms:Kiaa0667, Tip120b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914338. Cand2.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000892982 – 1235Cullin-associated NEDD8-dissociated protein 2Add BLAST1234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Post-translational modificationi

Ubiquitinated and targeted for proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiQ6ZQ73.
MaxQBiQ6ZQ73.
PaxDbiQ6ZQ73.
PeptideAtlasiQ6ZQ73.
PRIDEiQ6ZQ73.

PTM databases

iPTMnetiQ6ZQ73.
PhosphoSitePlusiQ6ZQ73.

Expressioni

Tissue specificityi

Highly expressed in embryonic limb buds.1 Publication

Gene expression databases

BgeeiENSMUSG00000030319.
GenevisibleiQ6ZQ73. MM.

Interactioni

Subunit structurei

Binds TBP, CNOT3 and UBE3C.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CNOT3O75175-12EBI-6504831,EBI-6504867From a different organism.

GO - Molecular functioni

  • TBP-class protein binding Source: MGI

Protein-protein interaction databases

BioGridi211931. 5 interactors.
IntActiQ6ZQ73. 1 interactor.
STRINGi10090.ENSMUSP00000075377.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQ73.
SMRiQ6ZQ73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 39HEAT 1Add BLAST38
Repeati44 – 81HEAT 2Add BLAST38
Repeati83 – 119HEAT 3Add BLAST37
Repeati129 – 167HEAT 4Add BLAST39
Repeati171 – 208HEAT 5Add BLAST38
Repeati210 – 246HEAT 6Add BLAST37
Repeati254 – 291HEAT 7Add BLAST38
Repeati326 – 367HEAT 8Add BLAST42
Repeati371 – 408HEAT 9Add BLAST38
Repeati431 – 468HEAT 10Add BLAST38
Repeati516 – 553HEAT 11Add BLAST38
Repeati564 – 603HEAT 12Add BLAST40
Repeati607 – 644HEAT 13Add BLAST38
Repeati647 – 684HEAT 14Add BLAST38
Repeati689 – 726HEAT 15Add BLAST38
Repeati730 – 769HEAT 16Add BLAST40
Repeati771 – 812HEAT 17Add BLAST42
Repeati856 – 893HEAT 18Add BLAST38
Repeati895 – 930HEAT 19Add BLAST36
Repeati932 – 965HEAT 20Add BLAST34
Repeati966 – 1002HEAT 21Add BLAST37
Repeati1006 – 1043HEAT 22Add BLAST38
Repeati1047 – 1083HEAT 23Add BLAST37
Repeati1104 – 1140HEAT 24Add BLAST37
Repeati1156 – 1193HEAT 25Add BLAST38
Repeati1203 – 1235HEAT 26Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi342 – 345Poly-Asp4
Compositional biasi489 – 492Poly-Ser4

Sequence similaritiesi

Belongs to the CAND family.Curated
Contains 26 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1824. Eukaryota.
ENOG410XPK4. LUCA.
GeneTreeiENSGT00390000017740.
HOGENOMiHOG000264713.
HOVERGENiHBG053467.
InParanoidiQ6ZQ73.
OMAiCNLDDDE.
OrthoDBiEOG091G017Q.
PhylomeDBiQ6ZQ73.
TreeFamiTF300355.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013932. TATA-bd_TIP120.
[Graphical view]
PfamiPF08623. TIP120. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZQ73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGAFYISS LLEKMTSSDK DFRFMATSDL MSELQKDSIQ LDEDSERKVV
60 70 80 90 100
RTLLRLLEDR SGEVQNLAVK CLGPLVGKVK EYQVENIVDT LCANMRSDKE
110 120 130 140 150
QLRDIAGIGL KTVLSELPPA ATGSGLAINV CRKITGQLTS AIAQQEDVAV
160 170 180 190 200
QLEALDILSD MLSRLGAPLG TFHASLLHCL LPQLSSPRLA VRKRTVVALG
210 220 230 240 250
HLAAACSTDL FVELADHLVD RLPGPRAPAS PAAIRTLIQC LGSVGRQAGH
260 270 280 290 300
RLGAHLDRLV PMVEEFCNLD DDELRESCLQ AFEAFLRKCP KEMDPHVPNV
310 320 330 340 350
TSLCLQYMKH DPNYDHDSDD EEQMETEDSE FSEQESEDEY SDDDDMSWKV
360 370 380 390 400
RRAAAKCMAA LISSRPDLLP DFHCTLAPAL IRRFKEREEN VKADIFGAYI
410 420 430 440 450
MLLRHTRPPK GWLEAVEEPT QTGRNLNMLR AQVPLVIKAL QRQLKDRNVR
460 470 480 490 500
TRQGCFNLFT ELAGVLPGSL AEHMAVLVSG IVFSLADYSS SSTIRMDALA
510 520 530 540 550
FLQGLLGTEP AEAFHPHLPT LLPPVMACVA DPFYKVAAEA LLVLQELVRT
560 570 580 590 600
LWPLDRPRLL DPEPYVGEMS TATLARLRAT DLDQEVKERA ISCVGHLVGH
610 620 630 640 650
LGDRLGDDLE PTLMLLLDRL RNEITRLPAV KALTLVAMSP LRLDLQPILA
660 670 680 690 700
EALPILASFL RKNQRALRLA TLAALDALAQ SQGLGLPPPA VRTVLTELPA
710 720 730 740 750
LVSENDMHVA QLAVDFLTTV TQTQPSSLVE VSGPVLGELL QLLHSPLLPA
760 770 780 790 800
GVLAATEGFL QALVGTRPPC VEYSELISLL TAPVYNQVGD GGPGLHKQVF
810 820 830 840 850
HSLARCVAAL SAACPQEAAG TASRLVCDAK SPHSSTGVKV LAFLSLAEVG
860 870 880 890 900
QVAGPGPQRE LKTVLLEALG SPSEDVRAAA AYALGRVGAG NLPDFLPFLL
910 920 930 940 950
AQIEAQPRRQ YLLLHALREA LGAAQPDNLK PYVEDVWALL FQRCESPEEG
960 970 980 990 1000
TRCVVAECIG KLVFVNPPYL LPRFRKQLAA GQPYTRSTVI TAVKFLISDQ
1010 1020 1030 1040 1050
PHSIDPLLKS FIAEFMESLQ DPDLNVRRAT LTFFNSAVHN KPSLVRDLLD
1060 1070 1080 1090 1100
DILPLLYQET KIRRDLIREV EMGPFKHTVD DGLDVRKAAF ECMYSLLESC
1110 1120 1130 1140 1150
LGQLDMCEFL NHVEDGLKDH YDIRMLTFIM LARLATLCPA PVLQRVDRLI
1160 1170 1180 1190 1200
EPLRATCTAK VKAGSVKQEL EKQEELKRSA MRAVAALLTN PEVRKSPTVA
1210 1220 1230
DFSAQIRSNP ELTTLFESIQ KDTASGPSTD SMELS
Length:1,235
Mass (Da):135,633
Last modified:June 7, 2005 - v2
Checksum:i534AC3D3633E0899
GO

Sequence cautioni

The sequence BAC97996 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1129I → F in AAH56365 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129186 mRNA. Translation: BAC97996.1. Different initiation.
BC056365 mRNA. Translation: AAH56365.1.
CCDSiCCDS20442.1.
RefSeqiNP_080234.2. NM_025958.2.
UniGeneiMm.277683.

Genome annotation databases

EnsembliENSMUST00000075995; ENSMUSP00000075377; ENSMUSG00000030319.
GeneIDi67088.
KEGGimmu:67088.
UCSCiuc009djb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129186 mRNA. Translation: BAC97996.1. Different initiation.
BC056365 mRNA. Translation: AAH56365.1.
CCDSiCCDS20442.1.
RefSeqiNP_080234.2. NM_025958.2.
UniGeneiMm.277683.

3D structure databases

ProteinModelPortaliQ6ZQ73.
SMRiQ6ZQ73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211931. 5 interactors.
IntActiQ6ZQ73. 1 interactor.
STRINGi10090.ENSMUSP00000075377.

PTM databases

iPTMnetiQ6ZQ73.
PhosphoSitePlusiQ6ZQ73.

Proteomic databases

EPDiQ6ZQ73.
MaxQBiQ6ZQ73.
PaxDbiQ6ZQ73.
PeptideAtlasiQ6ZQ73.
PRIDEiQ6ZQ73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075995; ENSMUSP00000075377; ENSMUSG00000030319.
GeneIDi67088.
KEGGimmu:67088.
UCSCiuc009djb.2. mouse.

Organism-specific databases

CTDi23066.
MGIiMGI:1914338. Cand2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1824. Eukaryota.
ENOG410XPK4. LUCA.
GeneTreeiENSGT00390000017740.
HOGENOMiHOG000264713.
HOVERGENiHBG053467.
InParanoidiQ6ZQ73.
OMAiCNLDDDE.
OrthoDBiEOG091G017Q.
PhylomeDBiQ6ZQ73.
TreeFamiTF300355.

Miscellaneous databases

ChiTaRSiCand2. mouse.
PROiQ6ZQ73.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030319.
GenevisibleiQ6ZQ73. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013932. TATA-bd_TIP120.
[Graphical view]
PfamiPF08623. TIP120. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAND2_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQ73
Secondary accession number(s): Q6PHT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.