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Protein

La-related protein 1

Gene

Larp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
La-related protein 1
Alternative name(s):
La ribonucleoprotein domain family member 1
Gene namesi
Name:Larp1
Synonyms:Kiaa0731, Larp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1890165. Larp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 10721071La-related protein 1PRO_0000207610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei68 – 681PhosphoserineCombined sources
Modified residuei81 – 811PhosphoserineCombined sources
Modified residuei138 – 1381PhosphoserineBy similarity
Modified residuei188 – 1881PhosphoserineBy similarity
Modified residuei193 – 1931PhosphoserineBy similarity
Modified residuei196 – 1961PhosphothreonineCombined sources
Modified residuei198 – 1981PhosphoserineCombined sources
Modified residuei201 – 2011PhosphoserineCombined sources
Cross-linki286 – 286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei299 – 2991PhosphoserineCombined sources
Modified residuei302 – 3021PhosphoserineCombined sources
Modified residuei351 – 3511PhosphothreonineBy similarity
Modified residuei494 – 4941PhosphoserineBy similarity
Modified residuei498 – 4981PhosphoserineBy similarity
Modified residuei503 – 5031PhosphothreonineCombined sources
Modified residuei525 – 5251PhosphoserineCombined sources
Modified residuei568 – 5681PhosphoserineBy similarity
Modified residuei604 – 6041PhosphoserineCombined sources
Modified residuei608 – 6081PhosphoserineCombined sources
Modified residuei626 – 6261PhosphothreonineCombined sources
Modified residuei701 – 7011PhosphothreonineBy similarity
Modified residuei743 – 7431PhosphoserineCombined sources
Modified residuei751 – 7511PhosphoserineCombined sources
Modified residuei754 – 7541PhosphotyrosineBy similarity
Modified residuei762 – 7621PhosphothreonineBy similarity
Modified residuei765 – 7651PhosphothreonineBy similarity
Modified residuei801 – 8011PhosphoserineBy similarity
Modified residuei822 – 8221PhosphothreonineBy similarity
Modified residuei828 – 8281PhosphoserineBy similarity
Modified residuei830 – 8301PhosphoserineCombined sources
Modified residuei842 – 8421PhosphothreonineCombined sources
Modified residuei845 – 8451PhosphoserineCombined sources
Modified residuei869 – 8691N6-acetyllysineBy similarity
Modified residuei994 – 9941N6-acetyllysineBy similarity
Modified residuei1065 – 10651PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6ZQ58.
MaxQBiQ6ZQ58.
PaxDbiQ6ZQ58.
PeptideAtlasiQ6ZQ58.
PRIDEiQ6ZQ58.

PTM databases

iPTMnetiQ6ZQ58.
PhosphoSiteiQ6ZQ58.

Expressioni

Developmental stagei

At E10.5, expressed in dorsal root ganglia, spinal cord, and branchial arches. At E14.5, expressed in olfactory epithelium and cranial sensory ganglia. Also expressed in salivary glands, lungs, gut, kidney, teeth and vibrissae.1 Publication

Gene expression databases

BgeeiQ6ZQ58.
CleanExiMM_LARP1.
ExpressionAtlasiQ6ZQ58. baseline and differential.
GenevisibleiQ6ZQ58. MM.

Interactioni

Subunit structurei

Interacts with PABPC1/PABP. Associates with the mTORC1 complex. Interacts with EIF4E. Found in a complex with PABPC1 and RYDEN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215803. 1 interaction.
IntActiQ6ZQ58. 2 interactions.
STRINGi10090.ENSMUSP00000136673.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQ58.
SMRiQ6ZQ58. Positions 382-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini372 – 46291HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 17581Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the LARP family.Curated
Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2590. Eukaryota.
COG5193. LUCA.
GeneTreeiENSGT00390000000523.
HOGENOMiHOG000113283.
HOVERGENiHBG054322.
InParanoidiQ6ZQ58.
KOiK18757.
OrthoDBiEOG7HB59K.
TreeFamiTF314516.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR006607. DM15.
IPR006630. Lupus_La_RNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
[Graphical view]
SMARTiSM00684. DM15. 3 hits.
SM00715. LA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZQ58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATQVEPLLP AGAPLLQAEE HGLARKKPAP DAQAESGPGD GGGEPDGGVR
60 70 80 90 100
RPRPACARPG RDGAERESPR PPAAAEAPAG SDGEDGGRRD FVEAPPPKVN
110 120 130 140 150
PWTKHAPPPA AVNGQPPPEP SAPAKVVRAA APKPRKGSKV GDFGDAVNWP
160 170 180 190 200
TPGEIAHKSV QPQSHKPQPA RKLPPKKDMK EQEKGDGSDS KESPKTKSDE
210 220 230 240 250
SGEEKNGDED CQRGGQKKKG SKHKWVPLQI DMKPEVPREK LASRPTRPQE
260 270 280 290 300
PRHTPAVRGE MKGSEPATYM PVSVAPPTPA WQPETKVEPA WHDQDETSSV
310 320 330 340 350
KSDGAGGARA SFRGRGRGRG RGRGRGRGGT RTHFDYQFGY RKFDGTEGPR
360 370 380 390 400
THKYMNNITY YFDNVSSNEI YSMDQELLKD YIKRQIEYYF SVDNLERDFF
410 420 430 440 450
LRRKMDADGF LPITLIASFH RVQALTTDIS LIFAALKDSK VVEMVEEKVR
460 470 480 490 500
RREEPEKWPL PGPPIVDYSQ TDFSQLLNCP EFVPRQHYQK ETESAPGSPR
510 520 530 540 550
AVTPVPTKTE EVSNLKTLPK GLSASLPDLD SESWIEVKKR PRPSPARPKK
560 570 580 590 600
PEEPRFSHPT ALPQQLPSQQ LMSKDQDEQE ELDFLFDEEM EQMDGRKNTF
610 620 630 640 650
TAWSEEDSDY EIDDRDVNKI LIVTQTPPYM RRHPGGDRTG NHTSRAKMSA
660 670 680 690 700
ELAKVINDGL FYYEQDLWTE KFEPEYSQIK QEVENFKKVN MISREQFDTL
710 720 730 740 750
TPEPPVDPNQ EVPPGPPRFQ QVPTDALANK LFGAPEPSTI ARSLPTTVPE
760 770 780 790 800
SPNYRNARTP RTPRTPQLKD SSQTPRFYPV VKEGRTLDAK MPRKRKTRHS
810 820 830 840 850
SNPPLESHVG WVMDSREHRP RTASISSSPS EGTPAVGSYG CTPQSLPKFQ
860 870 880 890 900
HPSHELLKEN GFTQHVYHKY RRRCLNERKR LGIGQSQEMN TLFRFWSFFL
910 920 930 940 950
RDHFNKKMYE EFKQLALEDA KEGYRYGLEC LFRYYSYGLE KKFRLDIFKD
960 970 980 990 1000
FQEETVKDYE AGQLYGLEKF WAFLKYSKAK NLDIDPKLQE YLGKFRRLED
1010 1020 1030 1040 1050
FRVDPPMGEE GNHKRHPVVA GGSGEGRKRC PSQSSSRPAT GISQPPTTPT
1060 1070
GQATREDAKW TSQHSDTLTL RK
Length:1,072
Mass (Da):121,125
Last modified:April 16, 2014 - v3
Checksum:iBAFCE019DF683870
GO
Isoform 2 (identifier: Q6ZQ58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1006: Missing.

Note: No experimental confirmation available.
Show »
Length:66
Mass (Da):7,040
Checksum:i9134EA00889FA520
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10061006Missing in isoform 2. 1 PublicationVSP_015116Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672182 Genomic DNA. Translation: CAM19966.1.
BC053449 mRNA. Translation: AAH53449.1.
AK129202 mRNA. Translation: BAC98012.1.
CCDSiCCDS56771.1. [Q6ZQ58-1]
RefSeqiNP_082727.1. NM_028451.1. [Q6ZQ58-1]
UniGeneiMm.248843.

Genome annotation databases

EnsembliENSMUST00000178636; ENSMUSP00000136673; ENSMUSG00000037331. [Q6ZQ58-1]
GeneIDi73158.
KEGGimmu:73158.
UCSCiuc007jah.2. mouse. [Q6ZQ58-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672182 Genomic DNA. Translation: CAM19966.1.
BC053449 mRNA. Translation: AAH53449.1.
AK129202 mRNA. Translation: BAC98012.1.
CCDSiCCDS56771.1. [Q6ZQ58-1]
RefSeqiNP_082727.1. NM_028451.1. [Q6ZQ58-1]
UniGeneiMm.248843.

3D structure databases

ProteinModelPortaliQ6ZQ58.
SMRiQ6ZQ58. Positions 382-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215803. 1 interaction.
IntActiQ6ZQ58. 2 interactions.
STRINGi10090.ENSMUSP00000136673.

PTM databases

iPTMnetiQ6ZQ58.
PhosphoSiteiQ6ZQ58.

Proteomic databases

EPDiQ6ZQ58.
MaxQBiQ6ZQ58.
PaxDbiQ6ZQ58.
PeptideAtlasiQ6ZQ58.
PRIDEiQ6ZQ58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000178636; ENSMUSP00000136673; ENSMUSG00000037331. [Q6ZQ58-1]
GeneIDi73158.
KEGGimmu:73158.
UCSCiuc007jah.2. mouse. [Q6ZQ58-1]

Organism-specific databases

CTDi23367.
MGIiMGI:1890165. Larp1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2590. Eukaryota.
COG5193. LUCA.
GeneTreeiENSGT00390000000523.
HOGENOMiHOG000113283.
HOVERGENiHBG054322.
InParanoidiQ6ZQ58.
KOiK18757.
OrthoDBiEOG7HB59K.
TreeFamiTF314516.

Miscellaneous databases

ChiTaRSiLarp1. mouse.
PROiQ6ZQ58.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZQ58.
CleanExiMM_LARP1.
ExpressionAtlasiQ6ZQ58. baseline and differential.
GenevisibleiQ6ZQ58. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR006607. DM15.
IPR006630. Lupus_La_RNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
[Graphical view]
SMARTiSM00684. DM15. 3 hits.
SM00715. LA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Limb.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 709-1072 (ISOFORM 1).
    Tissue: Embryonic tail.
  4. "dlarp, a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions."
    Chauvet S., Maurel-Zaffran C., Miassod R., Jullien N., Pradel J., Aragnol D.
    Dev. Dyn. 218:401-413(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-503; SER-604; SER-608; THR-626 AND SER-751, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-503; SER-604 AND SER-608, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299; SER-302; THR-503 AND SER-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68; SER-81; THR-196; SER-198; SER-201; SER-299; SER-302; THR-503; SER-525; SER-604; SER-608; THR-626; SER-743; SER-830; THR-842 AND SER-845, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiLARP1_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQ58
Secondary accession number(s): A2AFQ8, J3QNB1, Q7TSF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: April 16, 2014
Last modified: July 6, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.