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Q6ZQ38

- CAND1_MOUSE

UniProt

Q6ZQ38 - CAND1_MOUSE

Protein

Cullin-associated NEDD8-dissociated protein 1

Gene

Cand1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. cell differentiation Source: UniProtKB
    2. negative regulation of catalytic activity Source: UniProtKB
    3. positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: Ensembl
    4. positive regulation of transcription, DNA-templated Source: UniProtKB
    5. protein ubiquitination Source: UniProtKB
    6. SCF complex assembly Source: UniProtKB

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cullin-associated NEDD8-dissociated protein 1
    Alternative name(s):
    Cullin-associated and neddylation-dissociated protein 1
    p120 CAND1
    Gene namesi
    Name:Cand1
    Synonyms:D10Ertd516e, Kiaa0829
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1261820. Cand1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Predominantly cytoplasmic.By similarity

    GO - Cellular componenti

    1. cullin-RING ubiquitin ligase complex Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 12301229Cullin-associated NEDD8-dissociated protein 1PRO_0000089294Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei335 – 3351PhosphoserineBy similarity
    Modified residuei971 – 9711N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ6ZQ38.
    PaxDbiQ6ZQ38.
    PRIDEiQ6ZQ38.

    PTM databases

    PhosphoSiteiQ6ZQ38.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZQ38.
    BgeeiQ6ZQ38.
    CleanExiMM_CAND1.
    GenevestigatoriQ6ZQ38.

    Interactioni

    Subunit structurei

    Interacts with TBP By similarity. Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins By similarity.By similarity

    Protein-protein interaction databases

    BioGridi215017. 3 interactions.
    IntActiQ6ZQ38. 5 interactions.
    MINTiMINT-1862433.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZQ38.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati2 – 3938HEAT 1Add
    BLAST
    Repeati44 – 8138HEAT 2Add
    BLAST
    Repeati83 – 11937HEAT 3Add
    BLAST
    Repeati131 – 16535HEAT 4Add
    BLAST
    Repeati171 – 20838HEAT 5Add
    BLAST
    Repeati210 – 24738HEAT 6Add
    BLAST
    Repeati248 – 28235HEAT 7Add
    BLAST
    Repeati289 – 36678HEAT 8Add
    BLAST
    Repeati370 – 40738HEAT 9Add
    BLAST
    Repeati424 – 46744HEAT 10Add
    BLAST
    Repeati471 – 51040HEAT 11Add
    BLAST
    Repeati515 – 55238HEAT 12Add
    BLAST
    Repeati563 – 60240HEAT 13Add
    BLAST
    Repeati606 – 64338HEAT 14Add
    BLAST
    Repeati646 – 68338HEAT 15Add
    BLAST
    Repeati688 – 72538HEAT 16Add
    BLAST
    Repeati729 – 76840HEAT 17Add
    BLAST
    Repeati770 – 80839HEAT 18Add
    BLAST
    Repeati809 – 84537HEAT 19Add
    BLAST
    Repeati852 – 88938HEAT 20Add
    BLAST
    Repeati890 – 92738HEAT 21Add
    BLAST
    Repeati928 – 96033HEAT 22Add
    BLAST
    Repeati961 – 99838HEAT 23Add
    BLAST
    Repeati1002 – 103938HEAT 24Add
    BLAST
    Repeati1043 – 109755HEAT 25Add
    BLAST
    Repeati1099 – 113335HEAT 26Add
    BLAST
    Repeati1140 – 118950HEAT 27Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi314 – 34431Asp-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CAND family.Curated
    Contains 27 HEAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG278162.
    GeneTreeiENSGT00390000017740.
    HOGENOMiHOG000264713.
    HOVERGENiHBG053467.
    InParanoidiQ6ZQ38.
    KOiK17263.
    OMAiTRPAQSW.
    OrthoDBiEOG77HDCZ.
    PhylomeDBiQ6ZQ38.
    TreeFamiTF300355.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013932. TATA-bd_TIP120.
    [Graphical view]
    PfamiPF08623. TIP120. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6ZQ38-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASASYHISN LLEKMTSSDK DFRFMATNDL MTELQKDSIK LDDDSERKVV     50
    KMILRLLEDK NGEVQNLAVK CLGPLVSKVK EYQVETIVDT LCTNMLSDKE 100
    QLRDISSIGL KTVIGELPPA SSGSALAANV CKKITGRLTS AIAKQEDVSV 150
    QLEALDIMAD MLSRQGGLLV NFHPSILTCL LPQLTSPRLA VRKRTIIALG 200
    HLVMSCGNIV FVDLIEHLLS ELSKNDSMST TRTYIQCIAA ISRQAGHRIG 250
    EYLEKIIPLV VKFCNVDDDE LREYCIQAFE SFVRRCPKEV YPHVSTIINI 300
    CLKYLTYDPN YNYDDEDEDE NAMDADGGDD DDQGSDDEYS DDDDMSWKVR 350
    RAAAKCLDAV VSTRHEMLPE FYKTVSPALI ARFKEREENV KADVFHAYLS 400
    LLKQTRPVQS WLCDPDAMEQ GDTPLTMLQS QVPNIVKALH KQMKEKSVKT 450
    RQCCFNMLTE LVNVLPGALT QHIPVLVPGI IFSLNDKSSS SNLKIDALSC 500
    LYVILCNHSP QVFHPHVQAL VPPVVACVGD PFYKITSEAL LVTQQLVKVI 550
    RPLDQPSSFD ATPYIKDLFT CTIKRLKAAD IDQEVKERAI SCMGQIICNL 600
    GDNLGPDLSN TLQIFLERLK NEITRLTTVK ALTLIAGSPL KIDLRPVLGE 650
    GVPILASFLR KNQRALKLGT LSALDILIKN YSDSLTAAMI DAVLDELPPL 700
    ISESDMHVSQ MAISFLTTLA KVYPSSLSKI SGSILNELIG LVRSPLLQGG 750
    ALSAMLDFFQ ALVVTGTNNL GYMDLLRMLT GPVYSQSTAL THKQSYYSIA 800
    KCVAALTRAC PKEGPAVVGQ FIQDVKNSRS TDSIRLLALL SLGEVGHHID 850
    LSGQLELKSV ILEAFSSPSE EVKSAASYAL GSISVGNLPE YLPFVLQEIT 900
    SQPKRQYLLL HSLKEIISSA SVAGLKPYVE NIWALLLKHC ECAEEGTRNV 950
    VAECLGKLTL IDPETLLPRL KGYLISGSSY ARSSVVTAVK FTISDHPQPI 1000
    DPLLKNCIGD FLKTLEDPDL NVRRVALVTF NSAAHNKPSL IRDLLDSVLP 1050
    HLYNETKVRK ELIREVEMGP FKHTVDDGLD IRKAAFECMY TLLDSCLDRL 1100
    DIFEFLNHVE DGLKDHYDIK MLTFLMLVRL STLCPSAVLQ RLDRLVEPLR 1150
    ATCTTKVKAN SVKQEFEKQD ELKRSAMRAV AALLTIPEAE KSPLMSEFQS 1200
    QISSNPELAA IFESIQKDSS STNLESMDTS 1230
    Length:1,230
    Mass (Da):136,332
    Last modified:June 7, 2005 - v2
    Checksum:i20B6BFB4ED250825
    GO

    Sequence cautioni

    The sequence AAH57457.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB26438.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC98035.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129225 mRNA. Translation: BAC98035.1. Different initiation.
    BC057457 mRNA. Translation: AAH57457.1. Different initiation.
    AK009683 mRNA. Translation: BAB26438.1. Different initiation.
    CCDSiCCDS48701.1.
    RefSeqiNP_082270.1. NM_027994.1.
    UniGeneiMm.203965.

    Genome annotation databases

    EnsembliENSMUST00000020315; ENSMUSP00000020315; ENSMUSG00000020114.
    GeneIDi71902.
    KEGGimmu:71902.
    UCSCiuc007hec.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129225 mRNA. Translation: BAC98035.1 . Different initiation.
    BC057457 mRNA. Translation: AAH57457.1 . Different initiation.
    AK009683 mRNA. Translation: BAB26438.1 . Different initiation.
    CCDSi CCDS48701.1.
    RefSeqi NP_082270.1. NM_027994.1.
    UniGenei Mm.203965.

    3D structure databases

    ProteinModelPortali Q6ZQ38.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 215017. 3 interactions.
    IntActi Q6ZQ38. 5 interactions.
    MINTi MINT-1862433.

    PTM databases

    PhosphoSitei Q6ZQ38.

    Proteomic databases

    MaxQBi Q6ZQ38.
    PaxDbi Q6ZQ38.
    PRIDEi Q6ZQ38.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020315 ; ENSMUSP00000020315 ; ENSMUSG00000020114 .
    GeneIDi 71902.
    KEGGi mmu:71902.
    UCSCi uc007hec.2. mouse.

    Organism-specific databases

    CTDi 55832.
    MGIi MGI:1261820. Cand1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG278162.
    GeneTreei ENSGT00390000017740.
    HOGENOMi HOG000264713.
    HOVERGENi HBG053467.
    InParanoidi Q6ZQ38.
    KOi K17263.
    OMAi TRPAQSW.
    OrthoDBi EOG77HDCZ.
    PhylomeDBi Q6ZQ38.
    TreeFami TF300355.

    Miscellaneous databases

    NextBioi 334892.
    PROi Q6ZQ38.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZQ38.
    Bgeei Q6ZQ38.
    CleanExi MM_CAND1.
    Genevestigatori Q6ZQ38.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013932. TATA-bd_TIP120.
    [Graphical view ]
    Pfami PF08623. TIP120. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryonic tail.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 342-1230.
      Strain: FVB/N.
      Tissue: Kidney.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1007-1230.
      Strain: C57BL/6J.
      Tissue: Tongue.

    Entry informationi

    Entry nameiCAND1_MOUSE
    AccessioniPrimary (citable) accession number: Q6ZQ38
    Secondary accession number(s): Q6PFR0, Q9CV45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3