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Q6ZQ38

- CAND1_MOUSE

UniProt

Q6ZQ38 - CAND1_MOUSE

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Protein

Cullin-associated NEDD8-dissociated protein 1

Gene

Cand1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity).By similarity

GO - Biological processi

  1. cell differentiation Source: UniProtKB
  2. negative regulation of catalytic activity Source: UniProtKB
  3. positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: Ensembl
  4. positive regulation of transcription, DNA-templated Source: UniProtKB
  5. protein ubiquitination Source: UniProtKB
  6. SCF complex assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Cullin-associated NEDD8-dissociated protein 1
Alternative name(s):
Cullin-associated and neddylation-dissociated protein 1
p120 CAND1
Gene namesi
Name:Cand1
Synonyms:D10Ertd516e, Kiaa0829
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1261820. Cand1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Predominantly cytoplasmic.By similarity

GO - Cellular componenti

  1. cullin-RING ubiquitin ligase complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. extracellular vesicular exosome Source: Ensembl
  4. nucleus Source: UniProtKB
  5. ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 12301229Cullin-associated NEDD8-dissociated protein 1PRO_0000089294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei335 – 3351PhosphoserineBy similarity
Modified residuei971 – 9711N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6ZQ38.
PaxDbiQ6ZQ38.
PRIDEiQ6ZQ38.

PTM databases

PhosphoSiteiQ6ZQ38.

Expressioni

Gene expression databases

BgeeiQ6ZQ38.
CleanExiMM_CAND1.
ExpressionAtlasiQ6ZQ38. baseline and differential.
GenevestigatoriQ6ZQ38.

Interactioni

Subunit structurei

Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins (By similarity).By similarity

Protein-protein interaction databases

BioGridi215017. 3 interactions.
IntActiQ6ZQ38. 5 interactions.
MINTiMINT-1862433.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQ38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3938HEAT 1Add
BLAST
Repeati44 – 8138HEAT 2Add
BLAST
Repeati83 – 11937HEAT 3Add
BLAST
Repeati131 – 16535HEAT 4Add
BLAST
Repeati171 – 20838HEAT 5Add
BLAST
Repeati210 – 24738HEAT 6Add
BLAST
Repeati248 – 28235HEAT 7Add
BLAST
Repeati289 – 36678HEAT 8Add
BLAST
Repeati370 – 40738HEAT 9Add
BLAST
Repeati424 – 46744HEAT 10Add
BLAST
Repeati471 – 51040HEAT 11Add
BLAST
Repeati515 – 55238HEAT 12Add
BLAST
Repeati563 – 60240HEAT 13Add
BLAST
Repeati606 – 64338HEAT 14Add
BLAST
Repeati646 – 68338HEAT 15Add
BLAST
Repeati688 – 72538HEAT 16Add
BLAST
Repeati729 – 76840HEAT 17Add
BLAST
Repeati770 – 80839HEAT 18Add
BLAST
Repeati809 – 84537HEAT 19Add
BLAST
Repeati852 – 88938HEAT 20Add
BLAST
Repeati890 – 92738HEAT 21Add
BLAST
Repeati928 – 96033HEAT 22Add
BLAST
Repeati961 – 99838HEAT 23Add
BLAST
Repeati1002 – 103938HEAT 24Add
BLAST
Repeati1043 – 109755HEAT 25Add
BLAST
Repeati1099 – 113335HEAT 26Add
BLAST
Repeati1140 – 118950HEAT 27Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi314 – 34431Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the CAND family.Curated
Contains 27 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG278162.
GeneTreeiENSGT00390000017740.
HOGENOMiHOG000264713.
HOVERGENiHBG053467.
InParanoidiQ6ZQ38.
KOiK17263.
OMAiTRPAQSW.
OrthoDBiEOG77HDCZ.
PhylomeDBiQ6ZQ38.
TreeFamiTF300355.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013932. TATA-bd_TIP120.
[Graphical view]
PfamiPF08623. TIP120. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZQ38-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASASYHISN LLEKMTSSDK DFRFMATNDL MTELQKDSIK LDDDSERKVV
60 70 80 90 100
KMILRLLEDK NGEVQNLAVK CLGPLVSKVK EYQVETIVDT LCTNMLSDKE
110 120 130 140 150
QLRDISSIGL KTVIGELPPA SSGSALAANV CKKITGRLTS AIAKQEDVSV
160 170 180 190 200
QLEALDIMAD MLSRQGGLLV NFHPSILTCL LPQLTSPRLA VRKRTIIALG
210 220 230 240 250
HLVMSCGNIV FVDLIEHLLS ELSKNDSMST TRTYIQCIAA ISRQAGHRIG
260 270 280 290 300
EYLEKIIPLV VKFCNVDDDE LREYCIQAFE SFVRRCPKEV YPHVSTIINI
310 320 330 340 350
CLKYLTYDPN YNYDDEDEDE NAMDADGGDD DDQGSDDEYS DDDDMSWKVR
360 370 380 390 400
RAAAKCLDAV VSTRHEMLPE FYKTVSPALI ARFKEREENV KADVFHAYLS
410 420 430 440 450
LLKQTRPVQS WLCDPDAMEQ GDTPLTMLQS QVPNIVKALH KQMKEKSVKT
460 470 480 490 500
RQCCFNMLTE LVNVLPGALT QHIPVLVPGI IFSLNDKSSS SNLKIDALSC
510 520 530 540 550
LYVILCNHSP QVFHPHVQAL VPPVVACVGD PFYKITSEAL LVTQQLVKVI
560 570 580 590 600
RPLDQPSSFD ATPYIKDLFT CTIKRLKAAD IDQEVKERAI SCMGQIICNL
610 620 630 640 650
GDNLGPDLSN TLQIFLERLK NEITRLTTVK ALTLIAGSPL KIDLRPVLGE
660 670 680 690 700
GVPILASFLR KNQRALKLGT LSALDILIKN YSDSLTAAMI DAVLDELPPL
710 720 730 740 750
ISESDMHVSQ MAISFLTTLA KVYPSSLSKI SGSILNELIG LVRSPLLQGG
760 770 780 790 800
ALSAMLDFFQ ALVVTGTNNL GYMDLLRMLT GPVYSQSTAL THKQSYYSIA
810 820 830 840 850
KCVAALTRAC PKEGPAVVGQ FIQDVKNSRS TDSIRLLALL SLGEVGHHID
860 870 880 890 900
LSGQLELKSV ILEAFSSPSE EVKSAASYAL GSISVGNLPE YLPFVLQEIT
910 920 930 940 950
SQPKRQYLLL HSLKEIISSA SVAGLKPYVE NIWALLLKHC ECAEEGTRNV
960 970 980 990 1000
VAECLGKLTL IDPETLLPRL KGYLISGSSY ARSSVVTAVK FTISDHPQPI
1010 1020 1030 1040 1050
DPLLKNCIGD FLKTLEDPDL NVRRVALVTF NSAAHNKPSL IRDLLDSVLP
1060 1070 1080 1090 1100
HLYNETKVRK ELIREVEMGP FKHTVDDGLD IRKAAFECMY TLLDSCLDRL
1110 1120 1130 1140 1150
DIFEFLNHVE DGLKDHYDIK MLTFLMLVRL STLCPSAVLQ RLDRLVEPLR
1160 1170 1180 1190 1200
ATCTTKVKAN SVKQEFEKQD ELKRSAMRAV AALLTIPEAE KSPLMSEFQS
1210 1220 1230
QISSNPELAA IFESIQKDSS STNLESMDTS
Length:1,230
Mass (Da):136,332
Last modified:June 7, 2005 - v2
Checksum:i20B6BFB4ED250825
GO

Sequence cautioni

The sequence AAH57457.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB26438.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC98035.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129225 mRNA. Translation: BAC98035.1. Different initiation.
BC057457 mRNA. Translation: AAH57457.1. Different initiation.
AK009683 mRNA. Translation: BAB26438.1. Different initiation.
CCDSiCCDS48701.1.
RefSeqiNP_082270.1. NM_027994.1.
UniGeneiMm.203965.

Genome annotation databases

EnsembliENSMUST00000020315; ENSMUSP00000020315; ENSMUSG00000020114.
GeneIDi71902.
KEGGimmu:71902.
UCSCiuc007hec.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129225 mRNA. Translation: BAC98035.1 . Different initiation.
BC057457 mRNA. Translation: AAH57457.1 . Different initiation.
AK009683 mRNA. Translation: BAB26438.1 . Different initiation.
CCDSi CCDS48701.1.
RefSeqi NP_082270.1. NM_027994.1.
UniGenei Mm.203965.

3D structure databases

ProteinModelPortali Q6ZQ38.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 215017. 3 interactions.
IntActi Q6ZQ38. 5 interactions.
MINTi MINT-1862433.

PTM databases

PhosphoSitei Q6ZQ38.

Proteomic databases

MaxQBi Q6ZQ38.
PaxDbi Q6ZQ38.
PRIDEi Q6ZQ38.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020315 ; ENSMUSP00000020315 ; ENSMUSG00000020114 .
GeneIDi 71902.
KEGGi mmu:71902.
UCSCi uc007hec.2. mouse.

Organism-specific databases

CTDi 55832.
MGIi MGI:1261820. Cand1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG278162.
GeneTreei ENSGT00390000017740.
HOGENOMi HOG000264713.
HOVERGENi HBG053467.
InParanoidi Q6ZQ38.
KOi K17263.
OMAi TRPAQSW.
OrthoDBi EOG77HDCZ.
PhylomeDBi Q6ZQ38.
TreeFami TF300355.

Miscellaneous databases

NextBioi 334892.
PROi Q6ZQ38.
SOURCEi Search...

Gene expression databases

Bgeei Q6ZQ38.
CleanExi MM_CAND1.
ExpressionAtlasi Q6ZQ38. baseline and differential.
Genevestigatori Q6ZQ38.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013932. TATA-bd_TIP120.
[Graphical view ]
Pfami PF08623. TIP120. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 342-1230.
    Strain: FVB/N.
    Tissue: Kidney.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1007-1230.
    Strain: C57BL/6J.
    Tissue: Tongue.

Entry informationi

Entry nameiCAND1_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQ38
Secondary accession number(s): Q6PFR0, Q9CV45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3