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Protein

Serine/threonine-protein kinase TAO2

Gene

Taok2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57ATPPROSITE-ProRule annotation1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 42ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase TAO2 (EC:2.7.11.1)
Alternative name(s):
Thousand and one amino acid protein 2
Gene namesi
Name:Taok2
Synonyms:Kiaa0881
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915919. Taok2.

Subcellular locationi

Isoform 2 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei972 – 992HelicalSequence analysisAdd BLAST21
Transmembranei994 – 1014HelicalSequence analysisAdd BLAST21
Transmembranei1019 – 1039HelicalSequence analysisAdd BLAST21
Transmembranei1045 – 1065HelicalSequence analysisAdd BLAST21
Transmembranei1175 – 1195HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867341 – 1240Serine/threonine-protein kinase TAO2Add BLAST1240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei181PhosphoserineBy similarity1
Modified residuei422PhosphoserineBy similarity1
Modified residuei663PhosphoserineCombined sources1
Modified residuei782PhosphoserineBy similarity1
Modified residuei830PhosphoserineBy similarity1
Modified residuei832PhosphoserineBy similarity1
Isoform 2 (identifier: Q6ZQ29-2)
Modified residuei999Omega-N-methylarginineCombined sourcesBy similarity1
Modified residuei1037PhosphoserineCombined sourcesBy similarity1

Post-translational modificationi

Autophosphorylated. Phosphorylated by ATM (By similarity).By similarity
Isoform 2: Phosphorylated on Ser-1037 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ6ZQ29.
PaxDbiQ6ZQ29.
PeptideAtlasiQ6ZQ29.
PRIDEiQ6ZQ29.

PTM databases

iPTMnetiQ6ZQ29.
PhosphoSitePlusiQ6ZQ29.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059981.
CleanExiMM_TAOK2.
GenevisibleiQ6ZQ29. MM.

Interactioni

Subunit structurei

Interacts with MAP2K3 and MAP2K6 (By similarity). Self-associates. Interacts with tubulins. Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation (By similarity). Isoform 2 interacts with PCDH8; this complex may also include CDH2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi238152. 6 interactors.
IntActiQ6ZQ29. 6 interactors.
STRINGi10090.ENSMUSP00000112963.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQ29.
SMRiQ6ZQ29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 281Protein kinasePROSITE-ProRule annotationAdd BLAST254

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili493 – 528Sequence analysisAdd BLAST36
Coiled coili581 – 608Sequence analysisAdd BLAST28
Coiled coili688 – 720Sequence analysisAdd BLAST33
Coiled coili805 – 934Sequence analysisAdd BLAST130

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi353 – 376Ser-richAdd BLAST24
Compositional biasi384 – 414Glu-richAdd BLAST31
Compositional biasi990 – 1083Pro-richAdd BLAST94

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0577. Eukaryota.
ENOG410Y259. LUCA.
GeneTreeiENSGT00810000125351.
HOGENOMiHOG000236358.
HOVERGENiHBG088996.
InParanoidiQ6ZQ29.
KOiK04429.
OMAiLNHRFLC.
OrthoDBiEOG091G01CN.
PhylomeDBiQ6ZQ29.
TreeFamiTF351444.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZQ29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAGGRAGSL KDPDVAELFF KDDPEKLFSD LREIGHGSFG AVYFARDVRN
60 70 80 90 100
SEVVAIKKMS YSGKQSNEKW QDIIKEVRFL QKLRHPNTIQ YRGCYLREHT
110 120 130 140 150
AWLVMEYCLG SASDLLEVHK KPLQEVEIAA VTHGALQGLA YLHSHNMIHR
160 170 180 190 200
DVKAGNILLS EPGLVKLGDF GSASIMAPAN SFVGTPYWMA PEVILAMDEG
210 220 230 240 250
QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN ESPALQSGHW
260 270 280 290 300
SEYFRNFVDS CLQKIPQDRP TSEVLLKHRF VLRERPPTVI MDLIQRTKDA
310 320 330 340 350
VRELDNLQYR KMKKILFQEA PNGPGAEAPE EEELTPCSQE AEPYTHRAGT
360 370 380 390 400
LTSLESSHSV PSMSISASSQ SSSVNSLADA SDNEEEEEEE EEEEEEEEEE
410 420 430 440 450
GPESREMAMM QEGEHTVTSH SSIIHRLPGS DNLYDDPYQP EMTPGPLQPP
460 470 480 490 500
AAPPTSTSSS ARRRAYCRNR DHFATIRTAS LVSRQIQEHE QDSALREQLS
510 520 530 540 550
GYKRMRRQHQ KQLLALESRL RGEREEHSGR LQRELEAQRA GFGTEAEKLA
560 570 580 590 600
RRHQAIGEKE ARAAQAEERK FQQHILGQQK KELAALLEAQ KRTYKLRKEQ
610 620 630 640 650
LKEELQENPS TPKREKAEWL LRQKEQLQQC QAEEEAGLLR RQRQYFELQC
660 670 680 690 700
RQYKRKMLLA RHSLDQDLLR EDLNKKQTQK DLECALLLRQ HEATRELELR
710 720 730 740 750
QLQAVQRTRA ELTRLQHQTE LGNQLEYNKR REQELRQKHA AQVRQQPKSL
760 770 780 790 800
KVRAGQLPMG LPATGALGPL STGTPSEEQP CSSGQEAILD QRMLGEEEEA
810 820 830 840 850
VPERRILGKE GTTLEPEEQR ILGEEMGTFS SSPQKHRSLA NEEDWDISEE
860 870 880 890 900
MKEIRVPSLA SQERNIIGQE EAAAWSLWEK EGGNLVDVEF KLGWVQGPVL
910 920 930 940 950
TPVPEEEEEE EEEGGAPIGT HRDPGDGCPS PDIPPEPPPS HLRQYPTSQL
960 970 980 990 1000
PGLLSHGLLA GLSFAVGSSS GLLPLLLLLL LPLLAAQGGG GLQAALLALE
1010 1020 1030 1040 1050
VGLVGLGASY LFLCTALHLP PGLFLLLAQG TALLAVLSLS WRRGLMGVPL
1060 1070 1080 1090 1100
GLGAAWLLAW PSLALPLAAM AAGGKWVRQQ GPQMRRGISR LWLRILLRLS
1110 1120 1130 1140 1150
PMVFRALQGC GAVGDRGLFA LYPKTNKNGF RSRLPVPWPR QGNPRTTQHP
1160 1170 1180 1190 1200
LAQLTRVWAV CKGWNWRLAR ASHRLASCLP PWAVHILASW GLLKGERPSR
1210 1220 1230 1240
IPRLLPRSQR RLGLSASRQL PPGTVAGRRS QTRRTLPPWR
Length:1,240
Mass (Da):139,297
Last modified:February 8, 2011 - v3
Checksum:iE6A989CD16B1AE54
GO
Isoform 2 (identifier: Q6ZQ29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     752-1055: VRAGQLPMGL...MGVPLGLGAA → SKELQIKKQF...ILNGSSHFYS
     1056-1240: Missing.

Show »
Length:1,055
Mass (Da):119,958
Checksum:i5A0E9DF896CAC39F
GO

Sequence cautioni

The sequence AAH52933 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N- and C-terminal parts.Curated
The sequence BAC98045 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040543752 – 1055VRAGQ…GLGAA → SKELQIKKQFQETCKIQTRQ YKALRAHLLETTPKAQHKSL LKRLKEEQTRKLAILAEQYD QSISEMLSSQALRLDETQEA EFQALRQQLQQELELLNAYQ SKIKIRTESQHERELRELEQ RVALRRALLEQRVEEELLAL QTGRSERIRSLLERQAREIE AFDAESMRLGFSSMALGGIP AEAAAQGYPAPPPAPAWPSR PVPRSGAHWSHGPPPPGMPP PAWRQPALLAPPGPPNWLGP PTQSGTPRGGALLLLRNSPQ PLRRAASGGSSGENVGPPAA VPGPLSRSTSVASHILNGSS HFYS in isoform 2. 1 PublicationAdd BLAST304
Alternative sequenceiVSP_0405441056 – 1240Missing in isoform 2. 1 PublicationAdd BLAST185

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129235 mRNA. Translation: BAC98045.1. Different initiation.
BC052933 mRNA. Translation: AAH52933.1. Sequence problems.
BC085152 mRNA. No translation available.
CCDSiCCDS52403.1. [Q6ZQ29-1]
CCDS52404.1. [Q6ZQ29-2]
RefSeqiNP_001157246.1. NM_001163774.1. [Q6ZQ29-2]
NP_001157247.1. NM_001163775.1. [Q6ZQ29-1]
UniGeneiMm.259634.

Genome annotation databases

EnsembliENSMUST00000071268; ENSMUSP00000071246; ENSMUSG00000059981. [Q6ZQ29-2]
ENSMUST00000117394; ENSMUSP00000112963; ENSMUSG00000059981. [Q6ZQ29-1]
GeneIDi381921.
KEGGimmu:381921.
UCSCiuc009jtg.2. mouse. [Q6ZQ29-2]
uc009jth.2. mouse. [Q6ZQ29-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129235 mRNA. Translation: BAC98045.1. Different initiation.
BC052933 mRNA. Translation: AAH52933.1. Sequence problems.
BC085152 mRNA. No translation available.
CCDSiCCDS52403.1. [Q6ZQ29-1]
CCDS52404.1. [Q6ZQ29-2]
RefSeqiNP_001157246.1. NM_001163774.1. [Q6ZQ29-2]
NP_001157247.1. NM_001163775.1. [Q6ZQ29-1]
UniGeneiMm.259634.

3D structure databases

ProteinModelPortaliQ6ZQ29.
SMRiQ6ZQ29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi238152. 6 interactors.
IntActiQ6ZQ29. 6 interactors.
STRINGi10090.ENSMUSP00000112963.

PTM databases

iPTMnetiQ6ZQ29.
PhosphoSitePlusiQ6ZQ29.

Proteomic databases

EPDiQ6ZQ29.
PaxDbiQ6ZQ29.
PeptideAtlasiQ6ZQ29.
PRIDEiQ6ZQ29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071268; ENSMUSP00000071246; ENSMUSG00000059981. [Q6ZQ29-2]
ENSMUST00000117394; ENSMUSP00000112963; ENSMUSG00000059981. [Q6ZQ29-1]
GeneIDi381921.
KEGGimmu:381921.
UCSCiuc009jtg.2. mouse. [Q6ZQ29-2]
uc009jth.2. mouse. [Q6ZQ29-1]

Organism-specific databases

CTDi9344.
MGIiMGI:1915919. Taok2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0577. Eukaryota.
ENOG410Y259. LUCA.
GeneTreeiENSGT00810000125351.
HOGENOMiHOG000236358.
HOVERGENiHBG088996.
InParanoidiQ6ZQ29.
KOiK04429.
OMAiLNHRFLC.
OrthoDBiEOG091G01CN.
PhylomeDBiQ6ZQ29.
TreeFamiTF351444.

Miscellaneous databases

PROiQ6ZQ29.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059981.
CleanExiMM_TAOK2.
GenevisibleiQ6ZQ29. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAOK2_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQ29
Secondary accession number(s): Q7TSS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: February 8, 2011
Last modified: November 2, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.