Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CCR4-NOT transcription complex subunit 1

Gene

Cnot1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiR-MMU-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 1
Alternative name(s):
CCR4-associated factor 1
Gene namesi
Name:Cnot1
Synonyms:Kiaa1007
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2442402. Cnot1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23752375CCR4-NOT transcription complex subunit 1PRO_0000315542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei318 – 3181PhosphoserineBy similarity
Modified residuei1060 – 10601PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZQ08.
MaxQBiQ6ZQ08.
PaxDbiQ6ZQ08.
PeptideAtlasiQ6ZQ08.
PRIDEiQ6ZQ08.

PTM databases

iPTMnetiQ6ZQ08.
PhosphoSiteiQ6ZQ08.

Expressioni

Developmental stagei

Expressed in embryonic stem (ES) cells and in inner cell mass (ICM) of the blastocyst.1 Publication

Gene expression databases

BgeeiQ6ZQ08.
CleanExiMM_CNOT1.
ExpressionAtlasiQ6ZQ08. baseline and differential.
GenevisibleiQ6ZQ08. MM.

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits (By similarity). In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or CNOT8. Interacts in a ligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2, TOB1 and ZFP36. Interacts with TNRC6A, TNRC6B and TNRC6C; the interactions are direct.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nanos2P603223EBI-682479,EBI-6507212

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231545. 4 interactions.
DIPiDIP-46845N.
IntActiQ6ZQ08. 13 interactions.
MINTiMINT-1670031.
STRINGi10090.ENSMUSP00000063565.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQ08.
SMRiQ6ZQ08. Positions 826-1003, 1068-1309, 1351-1587, 1841-2352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni799 – 1014216Interaction with ZFP36By similarityAdd
BLAST
Regioni1089 – 1604516Interaction with CNOT6, CNOT6L, CNOT7 and CNOT8By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi153 – 1575LXXLL
Motifi181 – 1855LXXLL
Motifi223 – 2275LXXLL
Motifi570 – 5745LXXLL
Motifi1638 – 16425LXXLL
Motifi1941 – 19455LXXLL
Motifi2095 – 20995LXXLL

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1332 – 134918Thr-richAdd
BLAST

Domaini

Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the CNOT1 family.Curated

Phylogenomic databases

eggNOGiKOG1831. Eukaryota.
COG5103. LUCA.
GeneTreeiENSGT00390000014869.
HOVERGENiHBG060834.
InParanoidiQ6ZQ08.
KOiK12604.
OMAiPNVFAND.
OrthoDBiEOG744T85.
PhylomeDBiQ6ZQ08.
TreeFamiTF105630.

Family and domain databases

InterProiIPR007196. CCR4-Not_Not1_C.
IPR024557. CCR4-Not_Not1su_DUF3819.
IPR032191. CNOT1_CAF1_bind.
IPR032194. CNOT1_HEAT.
IPR032193. CNOT1_TTP_bind.
[Graphical view]
PfamiPF16415. CNOT1_CAF1_bind. 1 hit.
PF16418. CNOT1_HEAT. 1 hit.
PF16417. CNOT1_TTP_bind. 1 hit.
PF12842. DUF3819. 1 hit.
PF04054. Not1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZQ08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC
60 70 80 90 100
LFSHVDFSGD GKSSGKDFHQ TQFLIQECAS LITKPNFIST LSYAIDNPLH
110 120 130 140 150
YQKSLKPAPH LFAQLSKVLK LSKVQEVIFG LALLNSSSPD LRGFAAQFIK
160 170 180 190 200
QKLPDLLRSY IDADVSGNQE GGFQDIAIEV LHLLLSHLLF GQKGAFGVGQ
210 220 230 240 250
EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL PDSGGVAKTM
260 270 280 290 300
MESSLADFMQ EVGYGFCASI EECRNIIMQF GVREVTAAQV ARVLGMMART
310 320 330 340 350
HSGLTDGIPL QSISAPGSGI WSDGKDKSEG AQAHTWNVEV LIDVLKELNP
360 370 380 390 400
SLNFKEVTYE LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDFIYRPWK
410 420 430 440 450
HAEGQLSFIQ HSLINPEVFC FADYPCHTVA TDILKAPPED DNREIATWKS
460 470 480 490 500
LDLIESLLRL AEVGQYEQVK QLFSFPIKHC PDMLVLALLQ INTSWHTLRH
510 520 530 540 550
ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH AMAEWYMRGE
560 570 580 590 600
QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW
610 620 630 640 650
LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPAETLAT
660 670 680 690 700
MLACLQACAG SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA
710 720 730 740 750
SSLDAISPVQ IDPLAGMASL SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP
760 770 780 790 800
AKAFPPLSTP NQTTAFSGIG GLSSQLPGGL GTGSLTGIGT GALGLPAVNN
810 820 830 840 850
DPFVQRKLGT SGLNQPTFQQ SKMKPSDLSQ VWPEANQHFS KEIDDEANSY
860 870 880 890 900
FQRIYNHPPH PTMSVDEVLE MLQRFKDSTI KREREVFNCM LRNLFEEYRF
910 920 930 940 950
FPQYPDKELH ITACLFGGII EKGLVTYMAL GLALRYVLEA LRKPFGSKMY
960 970 980 990 1000
YFGIAALDRF KNRLKDYPQY CQHLASISHF MQFPHHLQEY IEYGQQSRDP
1010 1020 1030 1040 1050
PVKMQGSITT PGSIALAQAQ AQAQVPAKAP LAGQVNTMVT TSTTTTVAKT
1060 1070 1080 1090 1100
VTVTKPTGVS FKKDVPPSIN TTNIDTLLVA TDQTERIVEP PENIQEKIAF
1110 1120 1130 1140 1150
IFNNLSQSNM TQKVEELKET VKEEFMPWVS QYLVMKRVSI EPNFHSLYSN
1160 1170 1180 1190 1200
FLDTLKNPEF NKMVLNETYR NIKVLLTSDK AAANFSDRSL LKNLGHWLGM
1210 1220 1230 1240 1250
ITLAKNKPIL HTDLDVKSLL LEAYVKGQQE LLYVVPFVAK VLESSIRSLV
1260 1270 1280 1290 1300
FRPPNPWTMA IMNVLAELHQ EHDLKLNLKF EIEVLCKNLA LDINELKPGN
1310 1320 1330 1340 1350
LLKDKDRLKN LDEQLSAPKK DVKQPEELPA ITTTTTSTTP ATSTTCTATV
1360 1370 1380 1390 1400
PPQPQYSYHD INVYSLAGLA PHITLNPTIP LFQAHPQLKQ CVRQAIERAV
1410 1420 1430 1440 1450
QELVHPVVDR SIKIAMTTCE QIVRKDFALD SEESRMRIAA HHMMRNLTAG
1460 1470 1480 1490 1500
MAMITCREPL LMSISTNLKN SFASALRTAS PQQREMMDQA AAQLAQDNCE
1510 1520 1530 1540 1550
LACCFIQKTA VEKAGPEMDK RLATEFELRK HARQEGRRYC DPVVLTYQAE
1560 1570 1580 1590 1600
RMPEQIRLKV GGVDPKQLAV YEEFARNVPG FLPTNDLSQP TGFLAQPMKQ
1610 1620 1630 1640 1650
AWATDDVAQI YDKCITELEQ HLHAIPPTLA MNPQAQALRS LLEVVVLSRN
1660 1670 1680 1690 1700
SRDAIAALGL LQKAVEGLLD ATSGADADLL LRYRECHLLV LKALQDGRAY
1710 1720 1730 1740 1750
GSPWCNKQIT RCLIECRDEY KYNVEAVELL IRNHLVNMQQ YDLHLAQSME
1760 1770 1780 1790 1800
NGLNYMAVAF AMQLVKILLV DERSVAHITE ADLFHTIETL MRINAHSRGN
1810 1820 1830 1840 1850
APEGLPQLME VVRSNYEAMI DRAHGGPNFM MHSGISQASE YDDPPGLREK
1860 1870 1880 1890 1900
AEYLLREWVN LYHSAAAGRD STKAFSAFVG QMHQQGILKT DDLITRFFRL
1910 1920 1930 1940 1950
CTEMCVEISY RAQAEQQHNP AANPTMIRAK CYHNLDAFVR LIALLVKHSG
1960 1970 1980 1990 2000
EATNTVTKIN LLNKVLGIVV GVLLQDHDVR QSEFQQLPYH RIFIMLLLEL
2010 2020 2030 2040 2050
NAPEHVLETI NFQTLTAFCN TFHILRPTKA PGFVYAWLEL ISHRIFIARM
2060 2070 2080 2090 2100
LAHTPQQKGW PMYAQLLIDL FKYLAPFLRN VELTKPMQIL YKGTLRVLLV
2110 2120 2130 2140 2150
LLHDFPEFLC DYHYGFCDVI PPNCIQLRNL ILSAFPRNMR LPDPFTPNLK
2160 2170 2180 2190 2200
VDMLSEINIA PRILTNFTGV MPPQFKKDLD SYLKTRSPVT FLSDLRSNLQ
2210 2220 2230 2240 2250
VSNEPGNRYN LQLINALVLY VGTQAIAHIH NKGSTPSMST ITHSAHMDIF
2260 2270 2280 2290 2300
QNLAVDLDTE GRYLFLNAIA NQLRYPNSHT HYFSCTMLYL FAEANTEAIQ
2310 2320 2330 2340 2350
EQITRVLLER LIVNRPHPWG LLITFIELIK NPAFKFWNHE FVHCAPEIEK
2360 2370
LFQSVAQCCM GQKQAQQVME GTGAS
Length:2,375
Mass (Da):266,808
Last modified:January 15, 2008 - v2
Checksum:i7771515027BA4B60
GO
Isoform 2 (identifier: Q6ZQ08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     777-777: P → PV
     821-826: SKMKPS → T

Show »
Length:2,371
Mass (Da):266,349
Checksum:iA7F33BDEF22E68D5
GO
Isoform 3 (identifier: Q6ZQ08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1881: Missing.

Show »
Length:494
Mass (Da):56,802
Checksum:i647E40938B0BE420
GO
Isoform 4 (identifier: Q6ZQ08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     777-777: P → PV

Show »
Length:2,376
Mass (Da):266,907
Checksum:i6122235C002F3CE7
GO

Sequence cautioni

The sequence BAC27364.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC28830.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE25479.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2089 – 20891I → F in AAH18281 (PubMed:15489334).Curated
Sequence conflicti2203 – 22031N → S in BAC33267 (PubMed:16141072).Curated
Sequence conflicti2233 – 22331G → D in BAC27364 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 18811881Missing in isoform 3. 1 PublicationVSP_030564Add
BLAST
Alternative sequencei777 – 7771P → PV in isoform 2 and isoform 4. 2 PublicationsVSP_030565
Alternative sequencei821 – 8266SKMKPS → T in isoform 2. 2 PublicationsVSP_030566

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113951 Genomic DNA. No translation available.
AC127300 Genomic DNA. No translation available.
AK031357 mRNA. Translation: BAC27364.1. Different initiation.
AK034776 mRNA. Translation: BAC28830.1. Different initiation.
AK048177 mRNA. Translation: BAC33267.1.
AK143651 mRNA. Translation: BAE25479.1. Different initiation.
BC018281 mRNA. Translation: AAH18281.2.
BC158073 mRNA. Translation: AAI58074.1.
AK129258 Transcribed RNA. Translation: BAC98068.2.
RefSeqiNP_835179.1. NM_178078.2. [Q6ZQ08-2]
XP_006530937.1. XM_006530874.1. [Q6ZQ08-4]
UniGeneiMm.259220.

Genome annotation databases

EnsembliENSMUST00000098473; ENSMUSP00000096073; ENSMUSG00000036550. [Q6ZQ08-4]
GeneIDi234594.
KEGGimmu:234594.
UCSCiuc009myy.1. mouse. [Q6ZQ08-3]
uc009myz.3. mouse. [Q6ZQ08-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113951 Genomic DNA. No translation available.
AC127300 Genomic DNA. No translation available.
AK031357 mRNA. Translation: BAC27364.1. Different initiation.
AK034776 mRNA. Translation: BAC28830.1. Different initiation.
AK048177 mRNA. Translation: BAC33267.1.
AK143651 mRNA. Translation: BAE25479.1. Different initiation.
BC018281 mRNA. Translation: AAH18281.2.
BC158073 mRNA. Translation: AAI58074.1.
AK129258 Transcribed RNA. Translation: BAC98068.2.
RefSeqiNP_835179.1. NM_178078.2. [Q6ZQ08-2]
XP_006530937.1. XM_006530874.1. [Q6ZQ08-4]
UniGeneiMm.259220.

3D structure databases

ProteinModelPortaliQ6ZQ08.
SMRiQ6ZQ08. Positions 826-1003, 1068-1309, 1351-1587, 1841-2352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231545. 4 interactions.
DIPiDIP-46845N.
IntActiQ6ZQ08. 13 interactions.
MINTiMINT-1670031.
STRINGi10090.ENSMUSP00000063565.

PTM databases

iPTMnetiQ6ZQ08.
PhosphoSiteiQ6ZQ08.

Proteomic databases

EPDiQ6ZQ08.
MaxQBiQ6ZQ08.
PaxDbiQ6ZQ08.
PeptideAtlasiQ6ZQ08.
PRIDEiQ6ZQ08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098473; ENSMUSP00000096073; ENSMUSG00000036550. [Q6ZQ08-4]
GeneIDi234594.
KEGGimmu:234594.
UCSCiuc009myy.1. mouse. [Q6ZQ08-3]
uc009myz.3. mouse. [Q6ZQ08-2]

Organism-specific databases

CTDi23019.
MGIiMGI:2442402. Cnot1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1831. Eukaryota.
COG5103. LUCA.
GeneTreeiENSGT00390000014869.
HOVERGENiHBG060834.
InParanoidiQ6ZQ08.
KOiK12604.
OMAiPNVFAND.
OrthoDBiEOG744T85.
PhylomeDBiQ6ZQ08.
TreeFamiTF105630.

Enzyme and pathway databases

ReactomeiR-MMU-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Miscellaneous databases

ChiTaRSiCnot1. mouse.
PROiQ6ZQ08.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZQ08.
CleanExiMM_CNOT1.
ExpressionAtlasiQ6ZQ08. baseline and differential.
GenevisibleiQ6ZQ08. MM.

Family and domain databases

InterProiIPR007196. CCR4-Not_Not1_C.
IPR024557. CCR4-Not_Not1su_DUF3819.
IPR032191. CNOT1_CAF1_bind.
IPR032194. CNOT1_HEAT.
IPR032193. CNOT1_TTP_bind.
[Graphical view]
PfamiPF16415. CNOT1_CAF1_bind. 1 hit.
PF16418. CNOT1_HEAT. 1 hit.
PF16417. CNOT1_TTP_bind. 1 hit.
PF12842. DUF3819. 1 hit.
PF04054. Not1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-2305 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-847 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 533-1302 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1819-2375 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo, Head, Spleen and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1247-2375 (ISOFORM 1/2).
    Strain: Czech II.
    Tissue: Brain and Mammary tumor.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 918-2375 (ISOFORM 1).
    Tissue: Embryonic tail.
  5. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  7. "NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs."
    Suzuki A., Igarashi K., Aisaki K., Kanno J., Saga Y.
    Proc. Natl. Acad. Sci. U.S.A. 107:3594-3599(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH NANOS2.
  8. "Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation."
    Zheng X., Dumitru R., Lackford B.L., Freudenberg J.M., Singh A.P., Archer T.K., Jothi R., Hu G.
    Stem Cells 30:910-922(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCNOT1_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQ08
Secondary accession number(s): B2RY28
, Q3UPB7, Q8BSB4, Q8BXB2, Q8C0H2, Q8K3D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 6, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.