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Protein

Zinc finger CCCH domain-containing protein 4

Gene

Zc3h4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri389 – 41628C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44528C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46924C3H1-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 4
Gene namesi
Name:Zc3h4
Synonyms:Kiaa1064
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2682314. Zc3h4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13041304Zinc finger CCCH domain-containing protein 4PRO_0000234069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei92 – 921PhosphoserineBy similarity
Modified residuei94 – 941PhosphoserineBy similarity
Modified residuei155 – 1551PhosphotyrosineBy similarity
Modified residuei816 – 8161PhosphoserineCombined sources
Modified residuei817 – 8171PhosphoserineCombined sources
Modified residuei913 – 9131PhosphoserineBy similarity
Modified residuei916 – 9161PhosphoserineBy similarity
Modified residuei917 – 9171PhosphoserineCombined sources
Modified residuei1104 – 11041PhosphoserineCombined sources
Modified residuei1109 – 11091PhosphoserineCombined sources
Modified residuei1115 – 11151PhosphoserineCombined sources
Modified residuei1119 – 11191PhosphothreonineCombined sources
Modified residuei1270 – 12701PhosphoserineCombined sources
Modified residuei1276 – 12761PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZPZ3.
MaxQBiQ6ZPZ3.
PaxDbiQ6ZPZ3.
PRIDEiQ6ZPZ3.

PTM databases

iPTMnetiQ6ZPZ3.
PhosphoSiteiQ6ZPZ3.

Expressioni

Gene expression databases

CleanExiMM_ZC3H4.

Interactioni

Protein-protein interaction databases

DIPiDIP-61658N.
STRINGi10090.ENSMUSP00000096386.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPZ3.
SMRiQ6ZPZ3. Positions 416-502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili94 – 12835Sequence analysisAdd
BLAST
Coiled coili778 – 80932Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 5147Pro-richAdd
BLAST
Compositional biasi233 – 373141Gly-richAdd
BLAST
Compositional biasi505 – 773269Pro-richAdd
BLAST
Compositional biasi988 – 1124137Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri389 – 41628C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44528C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46924C3H1-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1040. Eukaryota.
ENOG410Y9BS. LUCA.
HOGENOMiHOG000231733.
HOVERGENiHBG108366.
InParanoidiQ6ZPZ3.
PhylomeDBiQ6ZPZ3.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 3 hits.
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZPZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAVPGTPPP PPSESPPPPS PPPPSTPSPP PCSPDGRAAT PHLLHHRLPL
60 70 80 90 100
PDDREDGELE EGELEDDGAE EVQDPPGGQE RSRKEKGEKH HSDSEEEKSH
110 120 130 140 150
RRLKRKRKKE REKEKRRSKK RRKSKHKRHA SSSDDFSDFS DDSDFSPSEK
160 170 180 190 200
SHRKYRDYSP PYAPSHQQYS SSHNAPLPKK SYSKMDSKGY SMYEDYENEQ
210 220 230 240 250
YGEYEGDEEE DMGKEDYDDF TKELNQYRRA KEGSSRGRGS RGRGRGYRGR
260 270 280 290 300
GSRGGSRGRG MGRGSRGRGR GSMGEHPEDE EDLYEEEIEY GESEEPMGDD
310 320 330 340 350
DYDDYSKELN QYRRSKDSRG RGLSRGRGRG SRGGRGKGMG RGRGRGGRGG
360 370 380 390 400
MSKGGMNDDE DFYDDDMGDG GGGSYRRSDH DKPHQQSDKK GKVICKYFVE
410 420 430 440 450
GRCTWGDHCN FSHDIELPKK RELCKFYITG FCARAENCPY MHGDFPCKLY
460 470 480 490 500
HTTGNCINGD DCMFSHDPLT EETRELLDKM LADDAEAGAE DEKEVEELKK
510 520 530 540 550
QGINPLPKPP PGVGLLPTPP RPPGPPAPTS PNGRPMQGGP PPPPPPPPPP
560 570 580 590 600
PGPPQMSLPT HEPLSPQQLQ QDMYNKKIPS LFEIVVRPTG QLAEKLGVRF
610 620 630 640 650
PGPGGPSGPM GPGPNMGPPG PMGGPMHPDM HPDMHPDMHP DMHPDMHPDM
660 670 680 690 700
HPDMHPDMHP DMPMGPGMNP GPPMGPGGPP MMPYGPGDSP HSGMMPPIPP
710 720 730 740 750
AQNFYENFYP QQEGMEMEPG LVGDAEDYGH YEELPGQPGE PLFPEHPLEP
760 770 780 790 800
DSFPEGGPPG RPKAGAGVPD FLPSAQRALY LRIQQKQQEE ERARRLAESS
810 820 830 840 850
KQDRENEEGD TGNWYSSDED EGGSSVTSIL KTLRQQTSSR PQASVGEPSS
860 870 880 890 900
SGLGDPRLQK GHPTGSRLSD PRLSRDPRLS RHAETSGGSG PGDSGPSDPR
910 920 930 940 950
LARALPTSKA EGSLHSSPAG PSSSKGQPPA EEEEGERALR EKAVNIPLDP
960 970 980 990 1000
LPGHPLRDPR SQLQQFSHIK KDVTLSKPSF ARTVLWNPED LIPLPIPKQD
1010 1020 1030 1040 1050
VPPVPAALQS LPALDPRLHR STPPGPPNTR QRPGSTDPST SGSNLPDFEL
1060 1070 1080 1090 1100
LSRILKTVNV NTPGQSEKPS DPRVRKTPTD PRLQKPADPV AASRAAKPCP
1110 1120 1130 1140 1150
TEASPPAASP SGDSSPPATA PYDPRVLAAG GLGQGSSSGQ SSVLSGISLY
1160 1170 1180 1190 1200
DPRTPNAGGK TAEPASDTSA QPKGPEGNGK GSASKAKEPP FVRKSALEQP
1210 1220 1230 1240 1250
ETGKASTDGA TATDRYNSYN RPRPKATAAP TAASSTPPPE GATPQPGVHN
1260 1270 1280 1290 1300
LPVPTLFGTV KPAPKTGTGS PFAGNSPARE GEQDAGSLKD VFKGFDPTAS

PFCQ
Note: No experimental confirmation available.
Length:1,304
Mass (Da):140,967
Last modified:May 2, 2006 - v2
Checksum:iF2D02AAC15148C8B
GO
Isoform 2 (identifier: Q6ZPZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     726-808: Missing.

Note: No experimental confirmation available.
Show »
Length:1,221
Mass (Da):131,604
Checksum:i63DCFF84DD5DB81B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei726 – 80883Missing in isoform 2. 1 PublicationVSP_018209Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148972 Genomic DNA. No translation available.
AK129275 mRNA. Translation: BAC98085.1.
RefSeqiNP_941033.2. NM_198631.2.
XP_006540165.1. XM_006540102.2. [Q6ZPZ3-1]
XP_006540169.1. XM_006540106.2. [Q6ZPZ3-2]
XP_006540170.1. XM_006540107.2. [Q6ZPZ3-1]
XP_006540171.1. XM_006540108.2. [Q6ZPZ3-1]
UniGeneiMm.333594.
Mm.490954.

Genome annotation databases

GeneIDi330474.
KEGGimmu:330474.
UCSCiuc009fht.1. mouse. [Q6ZPZ3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148972 Genomic DNA. No translation available.
AK129275 mRNA. Translation: BAC98085.1.
RefSeqiNP_941033.2. NM_198631.2.
XP_006540165.1. XM_006540102.2. [Q6ZPZ3-1]
XP_006540169.1. XM_006540106.2. [Q6ZPZ3-2]
XP_006540170.1. XM_006540107.2. [Q6ZPZ3-1]
XP_006540171.1. XM_006540108.2. [Q6ZPZ3-1]
UniGeneiMm.333594.
Mm.490954.

3D structure databases

ProteinModelPortaliQ6ZPZ3.
SMRiQ6ZPZ3. Positions 416-502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61658N.
STRINGi10090.ENSMUSP00000096386.

PTM databases

iPTMnetiQ6ZPZ3.
PhosphoSiteiQ6ZPZ3.

Proteomic databases

EPDiQ6ZPZ3.
MaxQBiQ6ZPZ3.
PaxDbiQ6ZPZ3.
PRIDEiQ6ZPZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi330474.
KEGGimmu:330474.
UCSCiuc009fht.1. mouse. [Q6ZPZ3-2]

Organism-specific databases

CTDi23211.
MGIiMGI:2682314. Zc3h4.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1040. Eukaryota.
ENOG410Y9BS. LUCA.
HOGENOMiHOG000231733.
HOVERGENiHBG108366.
InParanoidiQ6ZPZ3.
PhylomeDBiQ6ZPZ3.

Miscellaneous databases

PROiQ6ZPZ3.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ZC3H4.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 3 hits.
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-1304 (ISOFORM 2).
    Tissue: Embryonic tail.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1104; SER-1109 AND SER-1276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-816; SER-817; SER-917; SER-1104; SER-1109; SER-1115; THR-1119; SER-1270 AND SER-1276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiZC3H4_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: June 8, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.