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Protein

Zinc finger CCCH domain-containing protein 4

Gene

Zc3h4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri389 – 416C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri418 – 445C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri446 – 469C3H1-type 3PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 4
Gene namesi
Name:Zc3h4
Synonyms:Kiaa1064
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2682314. Zc3h4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340691 – 1304Zinc finger CCCH domain-containing protein 4Add BLAST1304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92PhosphoserineBy similarity1
Modified residuei94PhosphoserineBy similarity1
Modified residuei155PhosphotyrosineBy similarity1
Modified residuei599Asymmetric dimethylarginineCombined sources1
Modified residuei816PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei913PhosphoserineBy similarity1
Modified residuei916PhosphoserineBy similarity1
Modified residuei917PhosphoserineCombined sources1
Modified residuei1104PhosphoserineCombined sources1
Modified residuei1109PhosphoserineCombined sources1
Modified residuei1111PhosphoserineBy similarity1
Modified residuei1115PhosphoserineCombined sources1
Modified residuei1119PhosphothreonineCombined sources1
Modified residuei1270PhosphoserineCombined sources1
Modified residuei1276PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ6ZPZ3.
PeptideAtlasiQ6ZPZ3.
PRIDEiQ6ZPZ3.

PTM databases

iPTMnetiQ6ZPZ3.
PhosphoSitePlusiQ6ZPZ3.

Expressioni

Gene expression databases

CleanExiMM_ZC3H4.

Interactioni

Protein-protein interaction databases

DIPiDIP-61658N.
STRINGi10090.ENSMUSP00000096386.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPZ3.
SMRiQ6ZPZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 128Sequence analysisAdd BLAST35
Coiled coili778 – 809Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 51Pro-richAdd BLAST47
Compositional biasi233 – 373Gly-richAdd BLAST141
Compositional biasi505 – 773Pro-richAdd BLAST269
Compositional biasi988 – 1124Pro-richAdd BLAST137

Sequence similaritiesi

Contains 3 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri389 – 416C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri418 – 445C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri446 – 469C3H1-type 3PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1040. Eukaryota.
ENOG410Y9BS. LUCA.
HOGENOMiHOG000231733.
HOVERGENiHBG108366.
InParanoidiQ6ZPZ3.
PhylomeDBiQ6ZPZ3.

Family and domain databases

Gene3Di4.10.1000.10. 3 hits.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 3 hits.
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZPZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAVPGTPPP PPSESPPPPS PPPPSTPSPP PCSPDGRAAT PHLLHHRLPL
60 70 80 90 100
PDDREDGELE EGELEDDGAE EVQDPPGGQE RSRKEKGEKH HSDSEEEKSH
110 120 130 140 150
RRLKRKRKKE REKEKRRSKK RRKSKHKRHA SSSDDFSDFS DDSDFSPSEK
160 170 180 190 200
SHRKYRDYSP PYAPSHQQYS SSHNAPLPKK SYSKMDSKGY SMYEDYENEQ
210 220 230 240 250
YGEYEGDEEE DMGKEDYDDF TKELNQYRRA KEGSSRGRGS RGRGRGYRGR
260 270 280 290 300
GSRGGSRGRG MGRGSRGRGR GSMGEHPEDE EDLYEEEIEY GESEEPMGDD
310 320 330 340 350
DYDDYSKELN QYRRSKDSRG RGLSRGRGRG SRGGRGKGMG RGRGRGGRGG
360 370 380 390 400
MSKGGMNDDE DFYDDDMGDG GGGSYRRSDH DKPHQQSDKK GKVICKYFVE
410 420 430 440 450
GRCTWGDHCN FSHDIELPKK RELCKFYITG FCARAENCPY MHGDFPCKLY
460 470 480 490 500
HTTGNCINGD DCMFSHDPLT EETRELLDKM LADDAEAGAE DEKEVEELKK
510 520 530 540 550
QGINPLPKPP PGVGLLPTPP RPPGPPAPTS PNGRPMQGGP PPPPPPPPPP
560 570 580 590 600
PGPPQMSLPT HEPLSPQQLQ QDMYNKKIPS LFEIVVRPTG QLAEKLGVRF
610 620 630 640 650
PGPGGPSGPM GPGPNMGPPG PMGGPMHPDM HPDMHPDMHP DMHPDMHPDM
660 670 680 690 700
HPDMHPDMHP DMPMGPGMNP GPPMGPGGPP MMPYGPGDSP HSGMMPPIPP
710 720 730 740 750
AQNFYENFYP QQEGMEMEPG LVGDAEDYGH YEELPGQPGE PLFPEHPLEP
760 770 780 790 800
DSFPEGGPPG RPKAGAGVPD FLPSAQRALY LRIQQKQQEE ERARRLAESS
810 820 830 840 850
KQDRENEEGD TGNWYSSDED EGGSSVTSIL KTLRQQTSSR PQASVGEPSS
860 870 880 890 900
SGLGDPRLQK GHPTGSRLSD PRLSRDPRLS RHAETSGGSG PGDSGPSDPR
910 920 930 940 950
LARALPTSKA EGSLHSSPAG PSSSKGQPPA EEEEGERALR EKAVNIPLDP
960 970 980 990 1000
LPGHPLRDPR SQLQQFSHIK KDVTLSKPSF ARTVLWNPED LIPLPIPKQD
1010 1020 1030 1040 1050
VPPVPAALQS LPALDPRLHR STPPGPPNTR QRPGSTDPST SGSNLPDFEL
1060 1070 1080 1090 1100
LSRILKTVNV NTPGQSEKPS DPRVRKTPTD PRLQKPADPV AASRAAKPCP
1110 1120 1130 1140 1150
TEASPPAASP SGDSSPPATA PYDPRVLAAG GLGQGSSSGQ SSVLSGISLY
1160 1170 1180 1190 1200
DPRTPNAGGK TAEPASDTSA QPKGPEGNGK GSASKAKEPP FVRKSALEQP
1210 1220 1230 1240 1250
ETGKASTDGA TATDRYNSYN RPRPKATAAP TAASSTPPPE GATPQPGVHN
1260 1270 1280 1290 1300
LPVPTLFGTV KPAPKTGTGS PFAGNSPARE GEQDAGSLKD VFKGFDPTAS

PFCQ
Note: No experimental confirmation available.
Length:1,304
Mass (Da):140,967
Last modified:May 2, 2006 - v2
Checksum:iF2D02AAC15148C8B
GO
Isoform 2 (identifier: Q6ZPZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     726-808: Missing.

Note: No experimental confirmation available.
Show »
Length:1,221
Mass (Da):131,604
Checksum:i63DCFF84DD5DB81B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018209726 – 808Missing in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148972 Genomic DNA. No translation available.
AK129275 mRNA. Translation: BAC98085.1.
RefSeqiNP_941033.2. NM_198631.2.
XP_006540165.1. XM_006540102.3. [Q6ZPZ3-1]
XP_006540169.1. XM_006540106.3. [Q6ZPZ3-2]
XP_006540170.1. XM_006540107.3. [Q6ZPZ3-1]
XP_006540171.1. XM_006540108.3. [Q6ZPZ3-1]
XP_017177799.1. XM_017322310.1. [Q6ZPZ3-1]
UniGeneiMm.333594.
Mm.490954.

Genome annotation databases

GeneIDi330474.
KEGGimmu:330474.
UCSCiuc009fht.1. mouse. [Q6ZPZ3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148972 Genomic DNA. No translation available.
AK129275 mRNA. Translation: BAC98085.1.
RefSeqiNP_941033.2. NM_198631.2.
XP_006540165.1. XM_006540102.3. [Q6ZPZ3-1]
XP_006540169.1. XM_006540106.3. [Q6ZPZ3-2]
XP_006540170.1. XM_006540107.3. [Q6ZPZ3-1]
XP_006540171.1. XM_006540108.3. [Q6ZPZ3-1]
XP_017177799.1. XM_017322310.1. [Q6ZPZ3-1]
UniGeneiMm.333594.
Mm.490954.

3D structure databases

ProteinModelPortaliQ6ZPZ3.
SMRiQ6ZPZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61658N.
STRINGi10090.ENSMUSP00000096386.

PTM databases

iPTMnetiQ6ZPZ3.
PhosphoSitePlusiQ6ZPZ3.

Proteomic databases

PaxDbiQ6ZPZ3.
PeptideAtlasiQ6ZPZ3.
PRIDEiQ6ZPZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi330474.
KEGGimmu:330474.
UCSCiuc009fht.1. mouse. [Q6ZPZ3-2]

Organism-specific databases

CTDi23211.
MGIiMGI:2682314. Zc3h4.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1040. Eukaryota.
ENOG410Y9BS. LUCA.
HOGENOMiHOG000231733.
HOVERGENiHBG108366.
InParanoidiQ6ZPZ3.
PhylomeDBiQ6ZPZ3.

Miscellaneous databases

PROiQ6ZPZ3.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ZC3H4.

Family and domain databases

Gene3Di4.10.1000.10. 3 hits.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 3 hits.
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZC3H4_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.