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Protein

KIF1-binding protein

Gene

Kif1bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for neuronal development and differentiation. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
KIF1-binding proteinBy similarity
Gene namesi
Name:Kif1bpBy similarity
Synonyms:KbpBy similarity, Kiaa12791 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1919570. Kif1bp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507921 – 617KIF1-binding proteinAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZPU9.
PaxDbiQ6ZPU9.
PeptideAtlasiQ6ZPU9.
PRIDEiQ6ZPU9.

PTM databases

iPTMnetiQ6ZPU9.
PhosphoSitePlusiQ6ZPU9.

Expressioni

Tissue specificityi

In th embryo it is expressed in cortical neurons; expression increases during neuronal development.1 Publication

Gene expression databases

BgeeiENSMUSG00000036955.
CleanExiMM_2510003E04RIK.
ExpressionAtlasiQ6ZPU9. baseline and differential.
GenevisibleiQ6ZPU9. MM.

Interactioni

Subunit structurei

Interacts with KIF1B. Interacts with STMN2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215306. 21 interactors.
IntActiQ6ZPU9. 21 interactors.
STRINGi10090.ENSMUSP00000065160.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KIF1-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410IE53. Eukaryota.
ENOG410XSW1. LUCA.
GeneTreeiENSGT00390000013819.
HOVERGENiHBG108054.
InParanoidiQ6ZPU9.
OMAiYEMMDLK.
OrthoDBiEOG091G063S.
PhylomeDBiQ6ZPU9.
TreeFamiTF324211.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR022083. KBP.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR20956:SF0. PTHR20956:SF0. 2 hits.
PfamiPF12309. KBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZPU9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANAPGPEIR EKFQAALALS RVELHKNPEK EPYKSKYGAR ALLEEVRALL
60 70 80 90 100
GPAPEDEDEP AADDGPGDQA LGAGEPREAE GPGAQRALRL AVVEFHLGVN
110 120 130 140 150
HIDTEELSAG EEHLVRCLSL LRPYRLSLGC VSLYIQAQNN LGILWSEREE
160 170 180 190 200
IETARTYLES SEALYSQYMK EIGSPPLDPT EHFLPEEEKL TEQERSKRFE
210 220 230 240 250
KVYTHNLYYL AQVYQHMEMF EKAAHYCHST LKRQLEHNAY HPMEWAINAA
260 270 280 290 300
TLSQFYINKL CFMEARHCLS AANVIFGQTG KIPATEDTPE VEGDVPELYH
310 320 330 340 350
QRKGEIARCW IKYCLTLMQN AQLSMQDNIG ELDLDKQSEL RALRKKELDE
360 370 380 390 400
EESVRKRAVQ FGTGELCDAI SAVEEKVRYL RPLDFEEARE LFLLGQHYVC
410 420 430 440 450
EAKEFFQIDG YVTDHIEVVQ DHSALFKVLS FFEADMERRC KMHKRRIAML
460 470 480 490 500
EPLTVDLNPQ YYLLVSRQIQ FEIAHAYYDM MDLKVAIADK LRDPDSHIVK
510 520 530 540 550
KINSLNKSAL KYYQLFLDSL RDPNKVFPEH IGEDVLRPAM LAKFRVARLY
560 570 580 590 600
GKIITADPKK ELENLATSLE HYKFIVDYCE THPEAAQEIE VELELSKEMV
610
SLLPTKMERF RAKMALT
Length:617
Mass (Da):71,052
Last modified:August 30, 2005 - v2
Checksum:i73FCED7C852DC51E
GO
Isoform 2 (identifier: Q6ZPU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-393: DNIGELDLDK...DFEEARELFL → VCTWKWPAAS...SLSLVLGLGD
     394-617: Missing.

Note: No experimental confirmation available.
Show »
Length:393
Mass (Da):44,340
Checksum:i2C041B075C741B80
GO
Isoform 3 (identifier: Q6ZPU9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-317: Missing.

Show »
Length:300
Mass (Da):35,055
Checksum:iED31EDBDE7062EA3
GO

Sequence cautioni

The sequence AAH90974 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC98130 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti321A → V in AAH38828 (PubMed:15489334).Curated1
Sequence conflicti512Y → H in AAH55307 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0152131 – 317Missing in isoform 3. 2 PublicationsAdd BLAST317
Alternative sequenceiVSP_015214327 – 393DNIGE…RELFL → VCTWKWPAASVRLIIRPTMC FVVLSFTLCVCVCVCVCICR FGGMYMSACGQPGFLRQSLS LVLGLGD in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_015215394 – 617Missing in isoform 2. 1 PublicationAdd BLAST224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129320 mRNA. Translation: BAC98130.1. Different initiation.
AK035659 mRNA. Translation: BAC29142.1.
AK158730 mRNA. Translation: BAE34633.1.
BC038828 mRNA. Translation: AAH38828.1.
BC046485 mRNA. Translation: AAH46485.1.
BC055307 mRNA. Translation: AAH55307.1.
BC090974 mRNA. Translation: AAH90974.1. Sequence problems.
CCDSiCCDS23890.1. [Q6ZPU9-1]
RefSeqiNP_082473.2. NM_028197.2. [Q6ZPU9-1]
UniGeneiMm.258955.

Genome annotation databases

EnsembliENSMUST00000065887; ENSMUSP00000065160; ENSMUSG00000036955. [Q6ZPU9-1]
GeneIDi72320.
KEGGimmu:72320.
UCSCiuc007fhk.1. mouse. [Q6ZPU9-1]
uc007fhl.1. mouse. [Q6ZPU9-2]
uc011xfd.1. mouse. [Q6ZPU9-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129320 mRNA. Translation: BAC98130.1. Different initiation.
AK035659 mRNA. Translation: BAC29142.1.
AK158730 mRNA. Translation: BAE34633.1.
BC038828 mRNA. Translation: AAH38828.1.
BC046485 mRNA. Translation: AAH46485.1.
BC055307 mRNA. Translation: AAH55307.1.
BC090974 mRNA. Translation: AAH90974.1. Sequence problems.
CCDSiCCDS23890.1. [Q6ZPU9-1]
RefSeqiNP_082473.2. NM_028197.2. [Q6ZPU9-1]
UniGeneiMm.258955.

3D structure databases

ProteinModelPortaliQ6ZPU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215306. 21 interactors.
IntActiQ6ZPU9. 21 interactors.
STRINGi10090.ENSMUSP00000065160.

PTM databases

iPTMnetiQ6ZPU9.
PhosphoSitePlusiQ6ZPU9.

Proteomic databases

EPDiQ6ZPU9.
PaxDbiQ6ZPU9.
PeptideAtlasiQ6ZPU9.
PRIDEiQ6ZPU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065887; ENSMUSP00000065160; ENSMUSG00000036955. [Q6ZPU9-1]
GeneIDi72320.
KEGGimmu:72320.
UCSCiuc007fhk.1. mouse. [Q6ZPU9-1]
uc007fhl.1. mouse. [Q6ZPU9-2]
uc011xfd.1. mouse. [Q6ZPU9-3]

Organism-specific databases

CTDi26128.
MGIiMGI:1919570. Kif1bp.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IE53. Eukaryota.
ENOG410XSW1. LUCA.
GeneTreeiENSGT00390000013819.
HOVERGENiHBG108054.
InParanoidiQ6ZPU9.
OMAiYEMMDLK.
OrthoDBiEOG091G063S.
PhylomeDBiQ6ZPU9.
TreeFamiTF324211.

Miscellaneous databases

PROiQ6ZPU9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036955.
CleanExiMM_2510003E04RIK.
ExpressionAtlasiQ6ZPU9. baseline and differential.
GenevisibleiQ6ZPU9. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR022083. KBP.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR20956:SF0. PTHR20956:SF0. 2 hits.
PfamiPF12309. KBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKBP_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPU9
Secondary accession number(s): Q3TYD0
, Q5BKR5, Q7TPE0, Q80VQ5, Q8BZE2, Q8CFS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.