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Protein

KIF1-binding protein

Gene

Kif1bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for neuronal development and differentiation. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
KIF1-binding proteinBy similarity
Gene namesi
Name:Kif1bpBy similarity
Synonyms:KbpBy similarity, Kiaa12791 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1919570 Kif1bp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507921 – 617KIF1-binding proteinAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZPU9
PaxDbiQ6ZPU9
PeptideAtlasiQ6ZPU9
PRIDEiQ6ZPU9

PTM databases

iPTMnetiQ6ZPU9
PhosphoSitePlusiQ6ZPU9

Expressioni

Tissue specificityi

In th embryo it is expressed in cortical neurons; expression increases during neuronal development.1 Publication

Gene expression databases

BgeeiENSMUSG00000036955
CleanExiMM_2510003E04RIK
ExpressionAtlasiQ6ZPU9 baseline and differential
GenevisibleiQ6ZPU9 MM

Interactioni

Subunit structurei

Interacts with KIF1B. Interacts with STMN2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215306, 22 interactors
IntActiQ6ZPU9, 22 interactors
STRINGi10090.ENSMUSP00000065160

Structurei

3D structure databases

ProteinModelPortaliQ6ZPU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KIF1-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410IE53 Eukaryota
ENOG410XSW1 LUCA
GeneTreeiENSGT00390000013819
HOVERGENiHBG108054
InParanoidiQ6ZPU9
OMAiICRECWY
OrthoDBiEOG091G063S
PhylomeDBiQ6ZPU9
TreeFamiTF324211

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR022083 KBP
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR20956:SF15 PTHR20956:SF15, 1 hit
PfamiView protein in Pfam
PF12309 KBP_C, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZPU9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANAPGPEIR EKFQAALALS RVELHKNPEK EPYKSKYGAR ALLEEVRALL
60 70 80 90 100
GPAPEDEDEP AADDGPGDQA LGAGEPREAE GPGAQRALRL AVVEFHLGVN
110 120 130 140 150
HIDTEELSAG EEHLVRCLSL LRPYRLSLGC VSLYIQAQNN LGILWSEREE
160 170 180 190 200
IETARTYLES SEALYSQYMK EIGSPPLDPT EHFLPEEEKL TEQERSKRFE
210 220 230 240 250
KVYTHNLYYL AQVYQHMEMF EKAAHYCHST LKRQLEHNAY HPMEWAINAA
260 270 280 290 300
TLSQFYINKL CFMEARHCLS AANVIFGQTG KIPATEDTPE VEGDVPELYH
310 320 330 340 350
QRKGEIARCW IKYCLTLMQN AQLSMQDNIG ELDLDKQSEL RALRKKELDE
360 370 380 390 400
EESVRKRAVQ FGTGELCDAI SAVEEKVRYL RPLDFEEARE LFLLGQHYVC
410 420 430 440 450
EAKEFFQIDG YVTDHIEVVQ DHSALFKVLS FFEADMERRC KMHKRRIAML
460 470 480 490 500
EPLTVDLNPQ YYLLVSRQIQ FEIAHAYYDM MDLKVAIADK LRDPDSHIVK
510 520 530 540 550
KINSLNKSAL KYYQLFLDSL RDPNKVFPEH IGEDVLRPAM LAKFRVARLY
560 570 580 590 600
GKIITADPKK ELENLATSLE HYKFIVDYCE THPEAAQEIE VELELSKEMV
610
SLLPTKMERF RAKMALT
Length:617
Mass (Da):71,052
Last modified:August 30, 2005 - v2
Checksum:i73FCED7C852DC51E
GO
Isoform 2 (identifier: Q6ZPU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-393: DNIGELDLDK...DFEEARELFL → VCTWKWPAAS...SLSLVLGLGD
     394-617: Missing.

Note: No experimental confirmation available.
Show »
Length:393
Mass (Da):44,340
Checksum:i2C041B075C741B80
GO
Isoform 3 (identifier: Q6ZPU9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-317: Missing.

Show »
Length:300
Mass (Da):35,055
Checksum:iED31EDBDE7062EA3
GO

Sequence cautioni

The sequence AAH90974 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC98130 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti321A → V in AAH38828 (PubMed:15489334).Curated1
Sequence conflicti512Y → H in AAH55307 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0152131 – 317Missing in isoform 3. 2 PublicationsAdd BLAST317
Alternative sequenceiVSP_015214327 – 393DNIGE…RELFL → VCTWKWPAASVRLIIRPTMC FVVLSFTLCVCVCVCVCICR FGGMYMSACGQPGFLRQSLS LVLGLGD in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_015215394 – 617Missing in isoform 2. 1 PublicationAdd BLAST224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129320 mRNA Translation: BAC98130.1 Different initiation.
AK035659 mRNA Translation: BAC29142.1
AK158730 mRNA Translation: BAE34633.1
BC038828 mRNA Translation: AAH38828.1
BC046485 mRNA Translation: AAH46485.1
BC055307 mRNA Translation: AAH55307.1
BC090974 mRNA Translation: AAH90974.1 Sequence problems.
CCDSiCCDS23890.1 [Q6ZPU9-1]
RefSeqiNP_082473.2, NM_028197.2 [Q6ZPU9-1]
UniGeneiMm.258955

Genome annotation databases

EnsembliENSMUST00000065887; ENSMUSP00000065160; ENSMUSG00000036955 [Q6ZPU9-1]
GeneIDi72320
KEGGimmu:72320
UCSCiuc007fhk.1 mouse [Q6ZPU9-1]
uc007fhl.1 mouse [Q6ZPU9-2]
uc011xfd.1 mouse [Q6ZPU9-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKBP_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPU9
Secondary accession number(s): Q3TYD0
, Q5BKR5, Q7TPE0, Q80VQ5, Q8BZE2, Q8CFS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: April 25, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health