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Q6ZPU3

- Q6ZPU3_MOUSE

UniProt

Q6ZPU3 - Q6ZPU3_MOUSE

Protein
Submitted name:

MKIAA1303 protein

Gene

Rptor

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. RNA polymerase III type 1 promoter DNA binding Source: Ensembl
    2. RNA polymerase III type 2 promoter DNA binding Source: Ensembl
    3. RNA polymerase III type 3 promoter DNA binding Source: Ensembl

    GO - Biological processi

    1. cell growth Source: Ensembl
    2. cellular response to amino acid stimulus Source: Ensembl
    3. cellular response to nutrient levels Source: Ensembl
    4. positive regulation of endothelial cell proliferation Source: Ensembl
    5. positive regulation of protein serine/threonine kinase activity Source: Ensembl
    6. positive regulation of TOR signaling Source: Ensembl
    7. positive regulation of transcription from RNA polymerase III promoter Source: Ensembl
    8. regulation of cell size Source: Ensembl
    9. TOR signaling Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_213550. HSF1-dependent transactivation.
    REACT_220701. Regulation of AMPK activity via LKB1.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MKIAA1303 proteinImported
    Gene namesi
    Name:RptorImported
    Synonyms:mKIAA1303Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1921620. Rptor.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosomal membrane Source: Ensembl
    2. TORC1 complex Source: MGI

    Expressioni

    Gene expression databases

    BgeeiQ6ZPU3.
    GenevestigatoriQ6ZPU3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000026671.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZPU3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    RepeatUniRule annotation, WD repeatUniRule annotation

    Phylogenomic databases

    InParanoidiQ6ZPU3.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR004083. Raptor.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PANTHERiPTHR12848. PTHR12848. 1 hit.
    PfamiPF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q6ZPU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    SARYFAQPVM KIPEEHDLES QIRKEREWRF LRNTRVRKQA QQVIQKGITR    50
    LDDQIFLNRN PGVPSVVKFH PFTPCIAVAD KDSICFWDWE KGEKLDYFHN 100
    GNPRYTRVTA MEYLNGQDCS LLLTATDDGA IRVWKNFADL EKNPEMVTAW 150
    QGLSDMLPTT RGAGMVVDWE QETGLLMSSG DVRIVRIWDT DRETKVQDIP 200
    TGADSCVTSL SCDSHRSLIV AGLGDGSIRV YDRRMALSEC RVMTYREHTA 250
    WVVKAYLQKH PEGHIVSVSV NGDVRFFDPR MPESVNVMQI VKGLTALDIH 300
    PQANLIACGS MNQFTAIYNG NGELINNIKY YDGFMGQRVG AISCLAFHPH 350
    WPHLAVGSND YYISVYSVEK RVR 373
    Length:373
    Mass (Da):42,468
    Last modified:July 5, 2004 - v1
    Checksum:iEB0D62D2B0F091F5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129326 mRNA. Translation: BAC98136.1.
    UniGeneiMm.209933.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129326 mRNA. Translation: BAC98136.1 .
    UniGenei Mm.209933.

    3D structure databases

    ProteinModelPortali Q6ZPU3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000026671.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1921620. Rptor.

    Phylogenomic databases

    InParanoidi Q6ZPU3.

    Enzyme and pathway databases

    Reactomei REACT_213550. HSF1-dependent transactivation.
    REACT_220701. Regulation of AMPK activity via LKB1.

    Miscellaneous databases

    ChiTaRSi RPTOR. mouse.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZPU3.
    Genevestigatori Q6ZPU3.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR004083. Raptor.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    PANTHERi PTHR12848. PTHR12848. 1 hit.
    Pfami PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Embryonic tailImported.

    Entry informationi

    Entry nameiQ6ZPU3_MOUSE
    AccessioniPrimary (citable) accession number: Q6ZPU3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)