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Protein
Submitted name:

MKIAA1303 protein

Gene

Rptor

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 14-3-3 protein binding Source: MGI
  2. protein complex binding Source: MGI
  3. protein kinase binding Source: MGI
  4. RNA polymerase III type 1 promoter DNA binding Source: MGI
  5. RNA polymerase III type 2 promoter DNA binding Source: MGI
  6. RNA polymerase III type 3 promoter DNA binding Source: MGI
  7. TFIIIC-class transcription factor binding Source: MGI

GO - Biological processi

  1. cell growth Source: MGI
  2. cellular response to amino acid stimulus Source: MGI
  3. cellular response to nutrient levels Source: MGI
  4. positive regulation of endothelial cell proliferation Source: Ensembl
  5. positive regulation of protein serine/threonine kinase activity Source: MGI
  6. positive regulation of TOR signaling Source: MGI
  7. positive regulation of transcription from RNA polymerase III promoter Source: MGI
  8. regulation of cell size Source: MGI
  9. TOR signaling Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.
REACT_241655. Release of eIF4E.
REACT_255725. mTOR signalling.
REACT_260675. S6K1-mediated signalling.

Names & Taxonomyi

Protein namesi
Submitted name:
MKIAA1303 proteinImported
Gene namesi
Name:RptorImported
Synonyms:mKIAA1303Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1921620. Rptor.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. dendrite Source: Ensembl
  3. intracellular membrane-bounded organelle Source: MGI
  4. lysosomal membrane Source: MGI
  5. lysosome Source: MGI
  6. neuronal cell body Source: Ensembl
  7. nucleoplasm Source: MGI
  8. TORC1 complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ6ZPU3.
ExpressionAtlasiQ6ZPU3. baseline and differential.
GenevestigatoriQ6ZPU3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026671.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatUniRule annotation, WD repeatUniRule annotation

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR004083. Raptor.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6ZPU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SARYFAQPVM KIPEEHDLES QIRKEREWRF LRNTRVRKQA QQVIQKGITR
60 70 80 90 100
LDDQIFLNRN PGVPSVVKFH PFTPCIAVAD KDSICFWDWE KGEKLDYFHN
110 120 130 140 150
GNPRYTRVTA MEYLNGQDCS LLLTATDDGA IRVWKNFADL EKNPEMVTAW
160 170 180 190 200
QGLSDMLPTT RGAGMVVDWE QETGLLMSSG DVRIVRIWDT DRETKVQDIP
210 220 230 240 250
TGADSCVTSL SCDSHRSLIV AGLGDGSIRV YDRRMALSEC RVMTYREHTA
260 270 280 290 300
WVVKAYLQKH PEGHIVSVSV NGDVRFFDPR MPESVNVMQI VKGLTALDIH
310 320 330 340 350
PQANLIACGS MNQFTAIYNG NGELINNIKY YDGFMGQRVG AISCLAFHPH
360 370
WPHLAVGSND YYISVYSVEK RVR
Length:373
Mass (Da):42,468
Last modified:July 5, 2004 - v1
Checksum:iEB0D62D2B0F091F5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129326 mRNA. Translation: BAC98136.1.
UniGeneiMm.209933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129326 mRNA. Translation: BAC98136.1.
UniGeneiMm.209933.

3D structure databases

ProteinModelPortaliQ6ZPU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026671.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1921620. Rptor.

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.
REACT_241655. Release of eIF4E.
REACT_255725. mTOR signalling.
REACT_260675. S6K1-mediated signalling.

Miscellaneous databases

ChiTaRSiRptor. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZPU3.
ExpressionAtlasiQ6ZPU3. baseline and differential.
GenevestigatoriQ6ZPU3.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR004083. Raptor.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Embryonic tailImported.

Entry informationi

Entry nameiQ6ZPU3_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPU3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.