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Protein

Kelch-like protein 9

Gene

Klhl9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 9
Gene namesi
Name:Klhl9
Synonyms:Kiaa1354
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2180122 Klhl9

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191111 – 617Kelch-like protein 9Add BLAST617

Proteomic databases

EPDiQ6ZPT1
MaxQBiQ6ZPT1
PaxDbiQ6ZPT1
PeptideAtlasiQ6ZPT1
PRIDEiQ6ZPT1

PTM databases

iPTMnetiQ6ZPT1
PhosphoSitePlusiQ6ZPT1

Expressioni

Gene expression databases

BgeeiENSMUSG00000070923
CleanExiMM_KLHL9
GenevisibleiQ6ZPT1 MM

Interactioni

Subunit structurei

Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092602

Structurei

3D structure databases

ProteinModelPortaliQ6ZPT1
SMRiQ6ZPT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 119BTBPROSITE-ProRule annotationAdd BLAST70
Domaini154 – 255BACKAdd BLAST102
Repeati299 – 347Kelch 1Add BLAST49
Repeati348 – 399Kelch 2Add BLAST52
Repeati400 – 446Kelch 3Add BLAST47
Repeati448 – 493Kelch 4Add BLAST46
Repeati495 – 545Kelch 5Add BLAST51
Repeati546 – 594Kelch 6Add BLAST49

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118825
HOGENOMiHOG000231583
HOVERGENiHBG106526
InParanoidiQ6ZPT1
KOiK10447
OMAiDDAHMKV
OrthoDBiEOG091G039V
PhylomeDBiQ6ZPT1
TreeFamiTF328485

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 5 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZPT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSLGNGDM GVSAHLQPCK SGTTRFFTSN THSSVVLQGF DQLRIEGLLC
60 70 80 90 100
DVTLVPGDGE EIFPVHRAMM ASASDYFKAM FTGGMKEKDL MCIKLHGVNK
110 120 130 140 150
VGLKKIIDFI YTAKLSLNMD NLQDTLEAAS FLQILPVLDF CKVFLISGVS
160 170 180 190 200
LDNCVEVGRI ANTYNLIEVD KYVNNFILKN FPALLNTGEF LKLPFERLAF
210 220 230 240 250
VLSSNSLKHC SELELFKAAC RWLRLEDPRM DYAAKLMKNI RFPLMTPQDL
260 270 280 290 300
INYVQTVDFM RTDNTCVNLL LEASNYQMMP YMQPVMQSDR TAIRSDSTHL
310 320 330 340 350
VTLGGVLRQQ LVVSKELRMY DERAQEWKSL APMDAPRYQH GIAVIGNFLY
360 370 380 390 400
VVGGQSNYDT KGKTAVDTVF RFDPRYNKWM QVASLNEKRT FFHLSALKGH
410 420 430 440 450
LYAVGGRSAA GELATVECYN PRMNEWSYVA KMSEPHYGHA GTVYGGLMYI
460 470 480 490 500
SGGITHDTFQ NELMCFDPDT DKWTQKAPMT TVRGLHCMCT VGDKLYVIGG
510 520 530 540 550
NHFRGTSDYD DVLSCEYYSP TLDQWTPIAA MLRGQSDVGV AVFENKIYVV
560 570 580 590 600
GGYSWNNRCM VEIVQKYDPE KDEWHKVFDL PESLGGIRAC TLTVFPPEEN
610
PGSPSRESPL SAPSDHS
Length:617
Mass (Da):69,400
Last modified:August 16, 2004 - v2
Checksum:iE4670F700065ABFE
GO

Sequence cautioni

The sequence BAC98148 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129338 mRNA Translation: BAC98148.1 Different initiation.
BC094556 mRNA Translation: AAH94556.1
AL928605 Genomic DNA No translation available.
CCDSiCCDS38800.1
RefSeqiNP_766459.2, NM_172871.2
UniGeneiMm.260601

Genome annotation databases

EnsembliENSMUST00000094993; ENSMUSP00000092602; ENSMUSG00000070923
GeneIDi242521
KEGGimmu:242521
UCSCiuc008tnk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKLHL9_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPT1
Secondary accession number(s): Q505G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health