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Protein

Kelch-like protein 9

Gene

Klhl9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 9
Gene namesi
Name:Klhl9
Synonyms:Kiaa1354
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2180122. Klhl9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Kelch-like protein 9PRO_0000119111Add
BLAST

Proteomic databases

EPDiQ6ZPT1.
MaxQBiQ6ZPT1.
PaxDbiQ6ZPT1.
PeptideAtlasiQ6ZPT1.
PRIDEiQ6ZPT1.

PTM databases

iPTMnetiQ6ZPT1.
PhosphoSiteiQ6ZPT1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000070923.
CleanExiMM_KLHL9.
GenevisibleiQ6ZPT1. MM.

Interactioni

Subunit structurei

Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092602.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPT1.
SMRiQ6ZPT1. Positions 27-273, 300-592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 11970BTBPROSITE-ProRule annotationAdd
BLAST
Domaini154 – 255102BACKAdd
BLAST
Repeati299 – 34749Kelch 1Add
BLAST
Repeati348 – 39952Kelch 2Add
BLAST
Repeati400 – 44647Kelch 3Add
BLAST
Repeati448 – 49346Kelch 4Add
BLAST
Repeati495 – 54551Kelch 5Add
BLAST
Repeati546 – 59449Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ6ZPT1.
KOiK10447.
OMAiCRWLRYE.
OrthoDBiEOG091G039V.
PhylomeDBiQ6ZPT1.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 5 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZPT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSLGNGDM GVSAHLQPCK SGTTRFFTSN THSSVVLQGF DQLRIEGLLC
60 70 80 90 100
DVTLVPGDGE EIFPVHRAMM ASASDYFKAM FTGGMKEKDL MCIKLHGVNK
110 120 130 140 150
VGLKKIIDFI YTAKLSLNMD NLQDTLEAAS FLQILPVLDF CKVFLISGVS
160 170 180 190 200
LDNCVEVGRI ANTYNLIEVD KYVNNFILKN FPALLNTGEF LKLPFERLAF
210 220 230 240 250
VLSSNSLKHC SELELFKAAC RWLRLEDPRM DYAAKLMKNI RFPLMTPQDL
260 270 280 290 300
INYVQTVDFM RTDNTCVNLL LEASNYQMMP YMQPVMQSDR TAIRSDSTHL
310 320 330 340 350
VTLGGVLRQQ LVVSKELRMY DERAQEWKSL APMDAPRYQH GIAVIGNFLY
360 370 380 390 400
VVGGQSNYDT KGKTAVDTVF RFDPRYNKWM QVASLNEKRT FFHLSALKGH
410 420 430 440 450
LYAVGGRSAA GELATVECYN PRMNEWSYVA KMSEPHYGHA GTVYGGLMYI
460 470 480 490 500
SGGITHDTFQ NELMCFDPDT DKWTQKAPMT TVRGLHCMCT VGDKLYVIGG
510 520 530 540 550
NHFRGTSDYD DVLSCEYYSP TLDQWTPIAA MLRGQSDVGV AVFENKIYVV
560 570 580 590 600
GGYSWNNRCM VEIVQKYDPE KDEWHKVFDL PESLGGIRAC TLTVFPPEEN
610
PGSPSRESPL SAPSDHS
Length:617
Mass (Da):69,400
Last modified:August 16, 2004 - v2
Checksum:iE4670F700065ABFE
GO

Sequence cautioni

The sequence BAC98148 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129338 mRNA. Translation: BAC98148.1. Different initiation.
BC094556 mRNA. Translation: AAH94556.1.
AL928605 Genomic DNA. Translation: CAM14922.1.
CCDSiCCDS38800.1.
RefSeqiNP_766459.2. NM_172871.2.
UniGeneiMm.260601.

Genome annotation databases

EnsembliENSMUST00000094993; ENSMUSP00000092602; ENSMUSG00000070923.
GeneIDi242521.
KEGGimmu:242521.
UCSCiuc008tnk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129338 mRNA. Translation: BAC98148.1. Different initiation.
BC094556 mRNA. Translation: AAH94556.1.
AL928605 Genomic DNA. Translation: CAM14922.1.
CCDSiCCDS38800.1.
RefSeqiNP_766459.2. NM_172871.2.
UniGeneiMm.260601.

3D structure databases

ProteinModelPortaliQ6ZPT1.
SMRiQ6ZPT1. Positions 27-273, 300-592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092602.

PTM databases

iPTMnetiQ6ZPT1.
PhosphoSiteiQ6ZPT1.

Proteomic databases

EPDiQ6ZPT1.
MaxQBiQ6ZPT1.
PaxDbiQ6ZPT1.
PeptideAtlasiQ6ZPT1.
PRIDEiQ6ZPT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094993; ENSMUSP00000092602; ENSMUSG00000070923.
GeneIDi242521.
KEGGimmu:242521.
UCSCiuc008tnk.1. mouse.

Organism-specific databases

CTDi55958.
MGIiMGI:2180122. Klhl9.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ6ZPT1.
KOiK10447.
OMAiCRWLRYE.
OrthoDBiEOG091G039V.
PhylomeDBiQ6ZPT1.
TreeFamiTF328485.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiKlhl9. mouse.
PROiQ6ZPT1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070923.
CleanExiMM_KLHL9.
GenevisibleiQ6ZPT1. MM.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 5 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLHL9_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPT1
Secondary accession number(s): Q505G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.