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Protein

Potassium channel subfamily T member 1

Gene

Kcnt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calcium, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily T member 1
Gene namesi
Name:Kcnt1
Synonyms:Kiaa1422
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924627. Kcnt1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8383CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei84 – 10421Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Topological domaini105 – 14137ExtracellularSequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini163 – 17311CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei174 – 19421Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Topological domaini195 – 1995ExtracellularSequence Analysis
Transmembranei200 – 21213Helical; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini213 – 23725CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Topological domaini259 – 2679ExtracellularSequence Analysis
Intramembranei268 – 28821Pore-formingSequence AnalysisAdd
BLAST
Topological domaini289 – 2902ExtracellularSequence Analysis
Transmembranei291 – 31121Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini312 – 1224913CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12241224Potassium channel subfamily T member 1PRO_0000054091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6ZPR4.
PRIDEiQ6ZPR4.

PTM databases

PhosphoSiteiQ6ZPR4.

Expressioni

Gene expression databases

BgeeiQ6ZPR4.
CleanExiMM_KCNT1.
ExpressionAtlasiQ6ZPR4. baseline and differential.
GenevisibleiQ6ZPR4. MM.

Interactioni

Subunit structurei

Interacts with CRBN via its cytoplasmic C-terminus.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039058.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPR4.
SMRiQ6ZPR4. Positions 255-604, 762-1009.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini461 – 582122RCK N-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 RCK N-terminal domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319129.
HOGENOMiHOG000231460.
HOVERGENiHBG055190.
InParanoidiQ6ZPR4.
KOiK04946.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013099. 2pore_dom_K_chnl_dom.
IPR003929. K_chnl_Ca-activ_BK_asu.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZPR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAKLPRSP SEGKAGPGDT PAGAAAPEEP HGLSPLLPAR GGGSVGSDVG
60 70 80 90 100
QRVQVEFYVN ENTFKERLKL FFIKNQRSSL RIRLFNFSLK LLTCLLYIVR
110 120 130 140 150
VLLDNPDQGI GCWGCTKYNY TFNGSSSEFH WAPILWVERK MALWVIQVIV
160 170 180 190 200
ATISFLETML IIYLSYKGNI WEQIFHVSFV LEMINTLPFI ITVFWPPLRN
210 220 230 240 250
LFIPVFLNCW LAKHALENMI NDFHRAILRT QSAMFNQVLI LFCTLLCLVF
260 270 280 290 300
TGTCGIQHLE RAGGNLNLLT SFYFCIVTFS TVGFGDVTPK IWPSQLLVVI
310 320 330 340 350
LICVTLVVLP LQFEELVYLW MERQKSGGNY SRHRARTEKH VVLCVSSLKI
360 370 380 390 400
DLLMDFLNEF YAHPRLQDYY VVILCPSEMD VQVRRVLQIP LWSQRVIYLQ
410 420 430 440 450
GSALKDQDLM RAKMDNGEAC FILSSRNEVD RTAADHQTIL RAWAVKDFAP
460 470 480 490 500
NCPLYVQILK PENKFHVKFA DHVVCEEECK YAMLALNCIC PATSTLITLL
510 520 530 540 550
VHTSRGQEGQ ESPEQWQRTY GRCSGNEVYH IRMGDSKFFR EYEGKSFTYA
560 570 580 590 600
AFHAHKKYGV CLIGLKREEN KSILLNPGPR HILAASDTCF YINITKEENS
610 620 630 640 650
AFIFKQEEKQ KRRGLAGQAL YEGPSRLPVH SIIASMGTVA MDLQNTDCRP
660 670 680 690 700
SQGGSGGDGT KLTLPTENGS GSRRPSIAPV LELADSSALL PCDLLSDQSE
710 720 730 740 750
DEVTPSDDEG LSVVEYVKGY PPNSPYIGSS PTLCHLLPVK APFCCLRLDK
760 770 780 790 800
GCKHNSYEDA KAYGFKNKLI IVSAETAGNG LYNFIVPLRA YYRSRRELNP
810 820 830 840 850
IVLLLDNKPD HHFLEAICCF PMVYYMEGSV DNLDSLLQCG IIYADNLVVV
860 870 880 890 900
DKESTMSAEE DYMADAKTIV NVQTMFRLFP SLSITTELTH PSNMRFMQFR
910 920 930 940 950
AKDSYSLALS KLEKQERENG SNLAFMFRLP FAAGRVFSIS MLDTLLYQSF
960 970 980 990 1000
VKDYMITITR LLLGLDTTPG SGYLCAMKVT EDDLWIRTYG RLFQKLCSSS
1010 1020 1030 1040 1050
AEIPIGIYRT ECHVFSEPHD VRAQSQISVN MEDCEDTREA KGPWGTRAAS
1060 1070 1080 1090 1100
GSGSTHGRHG GSADPVEHPL LRRKSLQWAR KLSRKSTKQA GKAPVATDWI
1110 1120 1130 1140 1150
TQQRLSLYRR SERQELSELV KNRMKHLGLP TTGYEDVANL TASDVMNRVN
1160 1170 1180 1190 1200
LGYLQDEMND HHQNTLSYVL INPPPDTRLE PNDIVYLIRS DPLAHVASSS
1210 1220
QSRKSSCSNK LSSCNPETRD ETQL
Length:1,224
Mass (Da):138,106
Last modified:August 30, 2005 - v2
Checksum:i7F343893D70E506B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141190 mRNA. Translation: AAI41191.1.
BC171963 mRNA. Translation: AAI71963.1.
AK086119 mRNA. Translation: BAC39614.1.
AK129355 mRNA. Translation: BAC98165.1.
RefSeqiNP_001289280.1. NM_001302351.1.
NP_780671.2. NM_175462.4.
UniGeneiMm.119462.

Genome annotation databases

GeneIDi227632.
KEGGimmu:227632.
UCSCiuc008itq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141190 mRNA. Translation: AAI41191.1.
BC171963 mRNA. Translation: AAI71963.1.
AK086119 mRNA. Translation: BAC39614.1.
AK129355 mRNA. Translation: BAC98165.1.
RefSeqiNP_001289280.1. NM_001302351.1.
NP_780671.2. NM_175462.4.
UniGeneiMm.119462.

3D structure databases

ProteinModelPortaliQ6ZPR4.
SMRiQ6ZPR4. Positions 255-604, 762-1009.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039058.

Chemistry

GuidetoPHARMACOLOGYi385.

PTM databases

PhosphoSiteiQ6ZPR4.

Proteomic databases

PaxDbiQ6ZPR4.
PRIDEiQ6ZPR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi227632.
KEGGimmu:227632.
UCSCiuc008itq.1. mouse.

Organism-specific databases

CTDi57582.
MGIiMGI:1924627. Kcnt1.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG319129.
HOGENOMiHOG000231460.
HOVERGENiHBG055190.
InParanoidiQ6ZPR4.
KOiK04946.

Miscellaneous databases

NextBioi378702.
PROiQ6ZPR4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZPR4.
CleanExiMM_KCNT1.
ExpressionAtlasiQ6ZPR4. baseline and differential.
GenevisibleiQ6ZPR4. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013099. 2pore_dom_K_chnl_dom.
IPR003929. K_chnl_Ca-activ_BK_asu.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-297.
    Strain: C57BL/6J.
    Tissue: Head.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-1224.
    Tissue: Brain.

Entry informationi

Entry nameiKCNT1_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPR4
Secondary accession number(s): B2RUK3, Q8C3E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: June 24, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.