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Q6ZPR4

- KCNT1_MOUSE

UniProt

Q6ZPR4 - KCNT1_MOUSE

Protein

Potassium channel subfamily T member 1

Gene

Kcnt1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) By similarity.By similarity

    GO - Molecular functioni

    1. calcium-activated potassium channel activity Source: RefGenome
    2. voltage-gated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Potassium channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Calcium, Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily T member 1
    Gene namesi
    Name:Kcnt1
    Synonyms:Kiaa1422
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1924627. Kcnt1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12241224Potassium channel subfamily T member 1PRO_0000054091Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity By similarity.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ6ZPR4.
    PRIDEiQ6ZPR4.

    PTM databases

    PhosphoSiteiQ6ZPR4.

    Expressioni

    Gene expression databases

    BgeeiQ6ZPR4.
    CleanExiMM_KCNT1.
    GenevestigatoriQ6ZPR4.

    Interactioni

    Subunit structurei

    Interacts with CRBN via its cytoplasmic C-terminus.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZPR4.
    SMRiQ6ZPR4. Positions 255-604, 762-1009.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8383CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini105 – 14137ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini163 – 17311CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini195 – 1995ExtracellularSequence Analysis
    Topological domaini213 – 23725CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 2679ExtracellularSequence Analysis
    Topological domaini289 – 2902ExtracellularSequence Analysis
    Topological domaini312 – 1224913CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei268 – 28821Pore-formingSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei84 – 10421Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 21213Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei291 – 31121Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini461 – 582122RCK N-terminalAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RCK N-terminal domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG319129.
    HOGENOMiHOG000231460.
    HOVERGENiHBG055190.
    KOiK04946.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR013099. 2pore_dom_K_chnl_dom.
    IPR003929. K_chnl_Ca-activ_BK_asu.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF03493. BK_channel_a. 1 hit.
    PF07885. Ion_trans_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZPR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARAKLPRSP SEGKAGPGDT PAGAAAPEEP HGLSPLLPAR GGGSVGSDVG     50
    QRVQVEFYVN ENTFKERLKL FFIKNQRSSL RIRLFNFSLK LLTCLLYIVR 100
    VLLDNPDQGI GCWGCTKYNY TFNGSSSEFH WAPILWVERK MALWVIQVIV 150
    ATISFLETML IIYLSYKGNI WEQIFHVSFV LEMINTLPFI ITVFWPPLRN 200
    LFIPVFLNCW LAKHALENMI NDFHRAILRT QSAMFNQVLI LFCTLLCLVF 250
    TGTCGIQHLE RAGGNLNLLT SFYFCIVTFS TVGFGDVTPK IWPSQLLVVI 300
    LICVTLVVLP LQFEELVYLW MERQKSGGNY SRHRARTEKH VVLCVSSLKI 350
    DLLMDFLNEF YAHPRLQDYY VVILCPSEMD VQVRRVLQIP LWSQRVIYLQ 400
    GSALKDQDLM RAKMDNGEAC FILSSRNEVD RTAADHQTIL RAWAVKDFAP 450
    NCPLYVQILK PENKFHVKFA DHVVCEEECK YAMLALNCIC PATSTLITLL 500
    VHTSRGQEGQ ESPEQWQRTY GRCSGNEVYH IRMGDSKFFR EYEGKSFTYA 550
    AFHAHKKYGV CLIGLKREEN KSILLNPGPR HILAASDTCF YINITKEENS 600
    AFIFKQEEKQ KRRGLAGQAL YEGPSRLPVH SIIASMGTVA MDLQNTDCRP 650
    SQGGSGGDGT KLTLPTENGS GSRRPSIAPV LELADSSALL PCDLLSDQSE 700
    DEVTPSDDEG LSVVEYVKGY PPNSPYIGSS PTLCHLLPVK APFCCLRLDK 750
    GCKHNSYEDA KAYGFKNKLI IVSAETAGNG LYNFIVPLRA YYRSRRELNP 800
    IVLLLDNKPD HHFLEAICCF PMVYYMEGSV DNLDSLLQCG IIYADNLVVV 850
    DKESTMSAEE DYMADAKTIV NVQTMFRLFP SLSITTELTH PSNMRFMQFR 900
    AKDSYSLALS KLEKQERENG SNLAFMFRLP FAAGRVFSIS MLDTLLYQSF 950
    VKDYMITITR LLLGLDTTPG SGYLCAMKVT EDDLWIRTYG RLFQKLCSSS 1000
    AEIPIGIYRT ECHVFSEPHD VRAQSQISVN MEDCEDTREA KGPWGTRAAS 1050
    GSGSTHGRHG GSADPVEHPL LRRKSLQWAR KLSRKSTKQA GKAPVATDWI 1100
    TQQRLSLYRR SERQELSELV KNRMKHLGLP TTGYEDVANL TASDVMNRVN 1150
    LGYLQDEMND HHQNTLSYVL INPPPDTRLE PNDIVYLIRS DPLAHVASSS 1200
    QSRKSSCSNK LSSCNPETRD ETQL 1224
    Length:1,224
    Mass (Da):138,106
    Last modified:August 30, 2005 - v2
    Checksum:i7F343893D70E506B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC141190 mRNA. Translation: AAI41191.1.
    BC171963 mRNA. Translation: AAI71963.1.
    AK086119 mRNA. Translation: BAC39614.1.
    AK129355 mRNA. Translation: BAC98165.1.
    RefSeqiNP_780671.2. NM_175462.3.
    UniGeneiMm.119462.

    Genome annotation databases

    GeneIDi227632.
    KEGGimmu:227632.
    UCSCiuc008itq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC141190 mRNA. Translation: AAI41191.1 .
    BC171963 mRNA. Translation: AAI71963.1 .
    AK086119 mRNA. Translation: BAC39614.1 .
    AK129355 mRNA. Translation: BAC98165.1 .
    RefSeqi NP_780671.2. NM_175462.3.
    UniGenei Mm.119462.

    3D structure databases

    ProteinModelPortali Q6ZPR4.
    SMRi Q6ZPR4. Positions 255-604, 762-1009.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 385.

    PTM databases

    PhosphoSitei Q6ZPR4.

    Proteomic databases

    PaxDbi Q6ZPR4.
    PRIDEi Q6ZPR4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 227632.
    KEGGi mmu:227632.
    UCSCi uc008itq.1. mouse.

    Organism-specific databases

    CTDi 57582.
    MGIi MGI:1924627. Kcnt1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG319129.
    HOGENOMi HOG000231460.
    HOVERGENi HBG055190.
    KOi K04946.

    Miscellaneous databases

    NextBioi 378702.
    PROi Q6ZPR4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZPR4.
    CleanExi MM_KCNT1.
    Genevestigatori Q6ZPR4.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR013099. 2pore_dom_K_chnl_dom.
    IPR003929. K_chnl_Ca-activ_BK_asu.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF03493. BK_channel_a. 1 hit.
    PF07885. Ion_trans_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-297.
      Strain: C57BL/6J.
      Tissue: Head.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-1224.
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNT1_MOUSE
    AccessioniPrimary (citable) accession number: Q6ZPR4
    Secondary accession number(s): B2RUK3, Q8C3E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3