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Q6ZPR4

- KCNT1_MOUSE

UniProt

Q6ZPR4 - KCNT1_MOUSE

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Protein

Potassium channel subfamily T member 1

Gene
Kcnt1, Kiaa1422
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) By similarity.

GO - Molecular functioni

  1. calcium-activated potassium channel activity Source: RefGenome
  2. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calcium, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily T member 1
Gene namesi
Name:Kcnt1
Synonyms:Kiaa1422
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1924627. Kcnt1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8383Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei84 – 10421Helical; Name=Segment S1; Reviewed predictionAdd
BLAST
Topological domaini105 – 14137Extracellular Reviewed predictionAdd
BLAST
Transmembranei142 – 16221Helical; Name=Segment S2; Reviewed predictionAdd
BLAST
Topological domaini163 – 17311Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei174 – 19421Helical; Name=Segment S3; Reviewed predictionAdd
BLAST
Topological domaini195 – 1995Extracellular Reviewed prediction
Transmembranei200 – 21213Helical; Name=Segment S4; Reviewed predictionAdd
BLAST
Topological domaini213 – 23725Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Name=Segment S5; Reviewed predictionAdd
BLAST
Topological domaini259 – 2679Extracellular Reviewed prediction
Intramembranei268 – 28821Pore-forming; Reviewed predictionAdd
BLAST
Topological domaini289 – 2902Extracellular Reviewed prediction
Transmembranei291 – 31121Helical; Name=Segment S6; Reviewed predictionAdd
BLAST
Topological domaini312 – 1224913Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12241224Potassium channel subfamily T member 1PRO_0000054091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi123 – 1231N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6ZPR4.
PRIDEiQ6ZPR4.

PTM databases

PhosphoSiteiQ6ZPR4.

Expressioni

Gene expression databases

BgeeiQ6ZPR4.
CleanExiMM_KCNT1.
GenevestigatoriQ6ZPR4.

Interactioni

Subunit structurei

Interacts with CRBN via its cytoplasmic C-terminus By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPR4.
SMRiQ6ZPR4. Positions 255-604, 762-1009.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini461 – 582122RCK N-terminalAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319129.
HOGENOMiHOG000231460.
HOVERGENiHBG055190.
KOiK04946.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013099. 2pore_dom_K_chnl_dom.
IPR003929. K_chnl_Ca-activ_BK_asu.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZPR4-1 [UniParc]FASTAAdd to Basket

« Hide

MARAKLPRSP SEGKAGPGDT PAGAAAPEEP HGLSPLLPAR GGGSVGSDVG     50
QRVQVEFYVN ENTFKERLKL FFIKNQRSSL RIRLFNFSLK LLTCLLYIVR 100
VLLDNPDQGI GCWGCTKYNY TFNGSSSEFH WAPILWVERK MALWVIQVIV 150
ATISFLETML IIYLSYKGNI WEQIFHVSFV LEMINTLPFI ITVFWPPLRN 200
LFIPVFLNCW LAKHALENMI NDFHRAILRT QSAMFNQVLI LFCTLLCLVF 250
TGTCGIQHLE RAGGNLNLLT SFYFCIVTFS TVGFGDVTPK IWPSQLLVVI 300
LICVTLVVLP LQFEELVYLW MERQKSGGNY SRHRARTEKH VVLCVSSLKI 350
DLLMDFLNEF YAHPRLQDYY VVILCPSEMD VQVRRVLQIP LWSQRVIYLQ 400
GSALKDQDLM RAKMDNGEAC FILSSRNEVD RTAADHQTIL RAWAVKDFAP 450
NCPLYVQILK PENKFHVKFA DHVVCEEECK YAMLALNCIC PATSTLITLL 500
VHTSRGQEGQ ESPEQWQRTY GRCSGNEVYH IRMGDSKFFR EYEGKSFTYA 550
AFHAHKKYGV CLIGLKREEN KSILLNPGPR HILAASDTCF YINITKEENS 600
AFIFKQEEKQ KRRGLAGQAL YEGPSRLPVH SIIASMGTVA MDLQNTDCRP 650
SQGGSGGDGT KLTLPTENGS GSRRPSIAPV LELADSSALL PCDLLSDQSE 700
DEVTPSDDEG LSVVEYVKGY PPNSPYIGSS PTLCHLLPVK APFCCLRLDK 750
GCKHNSYEDA KAYGFKNKLI IVSAETAGNG LYNFIVPLRA YYRSRRELNP 800
IVLLLDNKPD HHFLEAICCF PMVYYMEGSV DNLDSLLQCG IIYADNLVVV 850
DKESTMSAEE DYMADAKTIV NVQTMFRLFP SLSITTELTH PSNMRFMQFR 900
AKDSYSLALS KLEKQERENG SNLAFMFRLP FAAGRVFSIS MLDTLLYQSF 950
VKDYMITITR LLLGLDTTPG SGYLCAMKVT EDDLWIRTYG RLFQKLCSSS 1000
AEIPIGIYRT ECHVFSEPHD VRAQSQISVN MEDCEDTREA KGPWGTRAAS 1050
GSGSTHGRHG GSADPVEHPL LRRKSLQWAR KLSRKSTKQA GKAPVATDWI 1100
TQQRLSLYRR SERQELSELV KNRMKHLGLP TTGYEDVANL TASDVMNRVN 1150
LGYLQDEMND HHQNTLSYVL INPPPDTRLE PNDIVYLIRS DPLAHVASSS 1200
QSRKSSCSNK LSSCNPETRD ETQL 1224
Length:1,224
Mass (Da):138,106
Last modified:August 30, 2005 - v2
Checksum:i7F343893D70E506B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC141190 mRNA. Translation: AAI41191.1.
BC171963 mRNA. Translation: AAI71963.1.
AK086119 mRNA. Translation: BAC39614.1.
AK129355 mRNA. Translation: BAC98165.1.
RefSeqiNP_780671.2. NM_175462.3.
UniGeneiMm.119462.

Genome annotation databases

GeneIDi227632.
KEGGimmu:227632.
UCSCiuc008itq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC141190 mRNA. Translation: AAI41191.1 .
BC171963 mRNA. Translation: AAI71963.1 .
AK086119 mRNA. Translation: BAC39614.1 .
AK129355 mRNA. Translation: BAC98165.1 .
RefSeqi NP_780671.2. NM_175462.3.
UniGenei Mm.119462.

3D structure databases

ProteinModelPortali Q6ZPR4.
SMRi Q6ZPR4. Positions 255-604, 762-1009.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 385.

PTM databases

PhosphoSitei Q6ZPR4.

Proteomic databases

PaxDbi Q6ZPR4.
PRIDEi Q6ZPR4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 227632.
KEGGi mmu:227632.
UCSCi uc008itq.1. mouse.

Organism-specific databases

CTDi 57582.
MGIi MGI:1924627. Kcnt1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG319129.
HOGENOMi HOG000231460.
HOVERGENi HBG055190.
KOi K04946.

Miscellaneous databases

NextBioi 378702.
PROi Q6ZPR4.
SOURCEi Search...

Gene expression databases

Bgeei Q6ZPR4.
CleanExi MM_KCNT1.
Genevestigatori Q6ZPR4.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR013099. 2pore_dom_K_chnl_dom.
IPR003929. K_chnl_Ca-activ_BK_asu.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-297.
    Strain: C57BL/6J.
    Tissue: Head.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-1224.
    Tissue: Brain.

Entry informationi

Entry nameiKCNT1_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPR4
Secondary accession number(s): B2RUK3, Q8C3E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: June 11, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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