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Protein

Potassium channel subfamily T member 1

Gene

Kcnt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calcium, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily T member 1
Gene namesi
Name:Kcnt1
Synonyms:Kiaa1422
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1924627. Kcnt1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 83CytoplasmicSequence analysisAdd BLAST83
Transmembranei84 – 104Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini105 – 141ExtracellularSequence analysisAdd BLAST37
Transmembranei142 – 162Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini163 – 173CytoplasmicSequence analysisAdd BLAST11
Transmembranei174 – 194Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini195 – 199ExtracellularSequence analysis5
Transmembranei200 – 212Helical; Name=Segment S4Sequence analysisAdd BLAST13
Topological domaini213 – 237CytoplasmicSequence analysisAdd BLAST25
Transmembranei238 – 258Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini259 – 267ExtracellularSequence analysis9
Intramembranei268 – 288Pore-formingSequence analysisAdd BLAST21
Topological domaini289 – 290ExtracellularSequence analysis2
Transmembranei291 – 311Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini312 – 1224CytoplasmicSequence analysisAdd BLAST913

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540911 – 1224Potassium channel subfamily T member 1Add BLAST1224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6ZPR4.
PRIDEiQ6ZPR4.

PTM databases

iPTMnetiQ6ZPR4.
PhosphoSitePlusiQ6ZPR4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000058740.
CleanExiMM_KCNT1.
ExpressionAtlasiQ6ZPR4. baseline and differential.
GenevisibleiQ6ZPR4. MM.

Interactioni

Subunit structurei

Interacts (via C-terminus) with FMR1; this interaction alters gating properties of KCNT1 (By similarity). Interacts with CRBN via its cytoplasmic C-terminus (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039058.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini461 – 582RCK N-terminalAdd BLAST122

Sequence similaritiesi

Contains 1 RCK N-terminal domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3193. Eukaryota.
ENOG410XSMA. LUCA.
GeneTreeiENSGT00530000063026.
HOGENOMiHOG000231460.
HOVERGENiHBG055190.
InParanoidiQ6ZPR4.
KOiK04946.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR003929. K_chnl_Ca-activ_BK_asu.
IPR013099. K_chnl_dom.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZPR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAKLPRSP SEGKAGPGDT PAGAAAPEEP HGLSPLLPAR GGGSVGSDVG
60 70 80 90 100
QRVQVEFYVN ENTFKERLKL FFIKNQRSSL RIRLFNFSLK LLTCLLYIVR
110 120 130 140 150
VLLDNPDQGI GCWGCTKYNY TFNGSSSEFH WAPILWVERK MALWVIQVIV
160 170 180 190 200
ATISFLETML IIYLSYKGNI WEQIFHVSFV LEMINTLPFI ITVFWPPLRN
210 220 230 240 250
LFIPVFLNCW LAKHALENMI NDFHRAILRT QSAMFNQVLI LFCTLLCLVF
260 270 280 290 300
TGTCGIQHLE RAGGNLNLLT SFYFCIVTFS TVGFGDVTPK IWPSQLLVVI
310 320 330 340 350
LICVTLVVLP LQFEELVYLW MERQKSGGNY SRHRARTEKH VVLCVSSLKI
360 370 380 390 400
DLLMDFLNEF YAHPRLQDYY VVILCPSEMD VQVRRVLQIP LWSQRVIYLQ
410 420 430 440 450
GSALKDQDLM RAKMDNGEAC FILSSRNEVD RTAADHQTIL RAWAVKDFAP
460 470 480 490 500
NCPLYVQILK PENKFHVKFA DHVVCEEECK YAMLALNCIC PATSTLITLL
510 520 530 540 550
VHTSRGQEGQ ESPEQWQRTY GRCSGNEVYH IRMGDSKFFR EYEGKSFTYA
560 570 580 590 600
AFHAHKKYGV CLIGLKREEN KSILLNPGPR HILAASDTCF YINITKEENS
610 620 630 640 650
AFIFKQEEKQ KRRGLAGQAL YEGPSRLPVH SIIASMGTVA MDLQNTDCRP
660 670 680 690 700
SQGGSGGDGT KLTLPTENGS GSRRPSIAPV LELADSSALL PCDLLSDQSE
710 720 730 740 750
DEVTPSDDEG LSVVEYVKGY PPNSPYIGSS PTLCHLLPVK APFCCLRLDK
760 770 780 790 800
GCKHNSYEDA KAYGFKNKLI IVSAETAGNG LYNFIVPLRA YYRSRRELNP
810 820 830 840 850
IVLLLDNKPD HHFLEAICCF PMVYYMEGSV DNLDSLLQCG IIYADNLVVV
860 870 880 890 900
DKESTMSAEE DYMADAKTIV NVQTMFRLFP SLSITTELTH PSNMRFMQFR
910 920 930 940 950
AKDSYSLALS KLEKQERENG SNLAFMFRLP FAAGRVFSIS MLDTLLYQSF
960 970 980 990 1000
VKDYMITITR LLLGLDTTPG SGYLCAMKVT EDDLWIRTYG RLFQKLCSSS
1010 1020 1030 1040 1050
AEIPIGIYRT ECHVFSEPHD VRAQSQISVN MEDCEDTREA KGPWGTRAAS
1060 1070 1080 1090 1100
GSGSTHGRHG GSADPVEHPL LRRKSLQWAR KLSRKSTKQA GKAPVATDWI
1110 1120 1130 1140 1150
TQQRLSLYRR SERQELSELV KNRMKHLGLP TTGYEDVANL TASDVMNRVN
1160 1170 1180 1190 1200
LGYLQDEMND HHQNTLSYVL INPPPDTRLE PNDIVYLIRS DPLAHVASSS
1210 1220
QSRKSSCSNK LSSCNPETRD ETQL
Length:1,224
Mass (Da):138,106
Last modified:August 30, 2005 - v2
Checksum:i7F343893D70E506B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141190 mRNA. Translation: AAI41191.1.
BC171963 mRNA. Translation: AAI71963.1.
AK086119 mRNA. Translation: BAC39614.1.
AK129355 mRNA. Translation: BAC98165.1.
CCDSiCCDS79757.1.
RefSeqiNP_001289280.1. NM_001302351.1.
NP_780671.2. NM_175462.4.
UniGeneiMm.119462.

Genome annotation databases

EnsembliENSMUST00000114172; ENSMUSP00000109809; ENSMUSG00000058740.
GeneIDi227632.
KEGGimmu:227632.
UCSCiuc008itq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141190 mRNA. Translation: AAI41191.1.
BC171963 mRNA. Translation: AAI71963.1.
AK086119 mRNA. Translation: BAC39614.1.
AK129355 mRNA. Translation: BAC98165.1.
CCDSiCCDS79757.1.
RefSeqiNP_001289280.1. NM_001302351.1.
NP_780671.2. NM_175462.4.
UniGeneiMm.119462.

3D structure databases

ProteinModelPortaliQ6ZPR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039058.

Chemistry databases

GuidetoPHARMACOLOGYi385.

PTM databases

iPTMnetiQ6ZPR4.
PhosphoSitePlusiQ6ZPR4.

Proteomic databases

PaxDbiQ6ZPR4.
PRIDEiQ6ZPR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114172; ENSMUSP00000109809; ENSMUSG00000058740.
GeneIDi227632.
KEGGimmu:227632.
UCSCiuc008itq.2. mouse.

Organism-specific databases

CTDi57582.
MGIiMGI:1924627. Kcnt1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3193. Eukaryota.
ENOG410XSMA. LUCA.
GeneTreeiENSGT00530000063026.
HOGENOMiHOG000231460.
HOVERGENiHBG055190.
InParanoidiQ6ZPR4.
KOiK04946.

Miscellaneous databases

PROiQ6ZPR4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058740.
CleanExiMM_KCNT1.
ExpressionAtlasiQ6ZPR4. baseline and differential.
GenevisibleiQ6ZPR4. MM.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR003929. K_chnl_Ca-activ_BK_asu.
IPR013099. K_chnl_dom.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCNT1_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPR4
Secondary accession number(s): B2RUK3, Q8C3E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.