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Q6ZPR4 (KCNT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel subfamily T member 1
Gene names
Name:Kcnt1
Synonyms:Kiaa1422
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1224 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) By similarity.

Subunit structure

Interacts with CRBN via its cytoplasmic C-terminus By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Post-translational modification

Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity By similarity.

Sequence similarities

Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. [View classification]

Contains 1 RCK N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12241224Potassium channel subfamily T member 1
PRO_0000054091

Regions

Topological domain1 – 8383Cytoplasmic Potential
Transmembrane84 – 10421Helical; Name=Segment S1; Potential
Topological domain105 – 14137Extracellular Potential
Transmembrane142 – 16221Helical; Name=Segment S2; Potential
Topological domain163 – 17311Cytoplasmic Potential
Transmembrane174 – 19421Helical; Name=Segment S3; Potential
Topological domain195 – 1995Extracellular Potential
Transmembrane200 – 21213Helical; Name=Segment S4; Potential
Topological domain213 – 23725Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=Segment S5; Potential
Topological domain259 – 2679Extracellular Potential
Intramembrane268 – 28821Pore-forming; Potential
Topological domain289 – 2902Extracellular Potential
Transmembrane291 – 31121Helical; Name=Segment S6; Potential
Topological domain312 – 1224913Cytoplasmic Potential
Domain461 – 582122RCK N-terminal

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation1231N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6ZPR4 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: 7F343893D70E506B

FASTA1,224138,106
        10         20         30         40         50         60 
MARAKLPRSP SEGKAGPGDT PAGAAAPEEP HGLSPLLPAR GGGSVGSDVG QRVQVEFYVN 

        70         80         90        100        110        120 
ENTFKERLKL FFIKNQRSSL RIRLFNFSLK LLTCLLYIVR VLLDNPDQGI GCWGCTKYNY 

       130        140        150        160        170        180 
TFNGSSSEFH WAPILWVERK MALWVIQVIV ATISFLETML IIYLSYKGNI WEQIFHVSFV 

       190        200        210        220        230        240 
LEMINTLPFI ITVFWPPLRN LFIPVFLNCW LAKHALENMI NDFHRAILRT QSAMFNQVLI 

       250        260        270        280        290        300 
LFCTLLCLVF TGTCGIQHLE RAGGNLNLLT SFYFCIVTFS TVGFGDVTPK IWPSQLLVVI 

       310        320        330        340        350        360 
LICVTLVVLP LQFEELVYLW MERQKSGGNY SRHRARTEKH VVLCVSSLKI DLLMDFLNEF 

       370        380        390        400        410        420 
YAHPRLQDYY VVILCPSEMD VQVRRVLQIP LWSQRVIYLQ GSALKDQDLM RAKMDNGEAC 

       430        440        450        460        470        480 
FILSSRNEVD RTAADHQTIL RAWAVKDFAP NCPLYVQILK PENKFHVKFA DHVVCEEECK 

       490        500        510        520        530        540 
YAMLALNCIC PATSTLITLL VHTSRGQEGQ ESPEQWQRTY GRCSGNEVYH IRMGDSKFFR 

       550        560        570        580        590        600 
EYEGKSFTYA AFHAHKKYGV CLIGLKREEN KSILLNPGPR HILAASDTCF YINITKEENS 

       610        620        630        640        650        660 
AFIFKQEEKQ KRRGLAGQAL YEGPSRLPVH SIIASMGTVA MDLQNTDCRP SQGGSGGDGT 

       670        680        690        700        710        720 
KLTLPTENGS GSRRPSIAPV LELADSSALL PCDLLSDQSE DEVTPSDDEG LSVVEYVKGY 

       730        740        750        760        770        780 
PPNSPYIGSS PTLCHLLPVK APFCCLRLDK GCKHNSYEDA KAYGFKNKLI IVSAETAGNG 

       790        800        810        820        830        840 
LYNFIVPLRA YYRSRRELNP IVLLLDNKPD HHFLEAICCF PMVYYMEGSV DNLDSLLQCG 

       850        860        870        880        890        900 
IIYADNLVVV DKESTMSAEE DYMADAKTIV NVQTMFRLFP SLSITTELTH PSNMRFMQFR 

       910        920        930        940        950        960 
AKDSYSLALS KLEKQERENG SNLAFMFRLP FAAGRVFSIS MLDTLLYQSF VKDYMITITR 

       970        980        990       1000       1010       1020 
LLLGLDTTPG SGYLCAMKVT EDDLWIRTYG RLFQKLCSSS AEIPIGIYRT ECHVFSEPHD 

      1030       1040       1050       1060       1070       1080 
VRAQSQISVN MEDCEDTREA KGPWGTRAAS GSGSTHGRHG GSADPVEHPL LRRKSLQWAR 

      1090       1100       1110       1120       1130       1140 
KLSRKSTKQA GKAPVATDWI TQQRLSLYRR SERQELSELV KNRMKHLGLP TTGYEDVANL 

      1150       1160       1170       1180       1190       1200 
TASDVMNRVN LGYLQDEMND HHQNTLSYVL INPPPDTRLE PNDIVYLIRS DPLAHVASSS 

      1210       1220 
QSRKSSCSNK LSSCNPETRD ETQL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-297.
Strain: C57BL/6J.
Tissue: Head.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-1224.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC141190 mRNA. Translation: AAI41191.1.
BC171963 mRNA. Translation: AAI71963.1.
AK086119 mRNA. Translation: BAC39614.1.
AK129355 mRNA. Translation: BAC98165.1.
RefSeqNP_780671.2. NM_175462.3.
UniGeneMm.119462.

3D structure databases

ProteinModelPortalQ6ZPR4.
SMRQ6ZPR4. Positions 255-604, 762-1009.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY385.

PTM databases

PhosphoSiteQ6ZPR4.

Proteomic databases

PaxDbQ6ZPR4.
PRIDEQ6ZPR4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID227632.
KEGGmmu:227632.
UCSCuc008itq.1. mouse.

Organism-specific databases

CTD57582.
MGIMGI:1924627. Kcnt1.
RougeSearch...

Phylogenomic databases

eggNOGNOG319129.
HOGENOMHOG000231460.
HOVERGENHBG055190.
KOK04946.

Gene expression databases

BgeeQ6ZPR4.
CleanExMM_KCNT1.
GenevestigatorQ6ZPR4.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR013099. 2pore_dom_K_chnl_dom.
IPR003929. K_chnl_Ca-activ_BK_asu.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio378702.
PROQ6ZPR4.
SOURCESearch...

Entry information

Entry nameKCNT1_MOUSE
AccessionPrimary (citable) accession number: Q6ZPR4
Secondary accession number(s): B2RUK3, Q8C3E7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: June 11, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot