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Protein

Membrane-associated phosphatidylinositol transfer protein 2

Gene

Pitpnm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Lipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated phosphatidylinositol transfer protein 2
Alternative name(s):
Drosophila retinal degeneration B homolog 2
Short name:
RdgB2
Phosphatidylinositol transfer protein, membrane-associated 2
Short name:
PITPnm 2
Pyk2 N-terminal domain-interacting receptor 3
Short name:
NIR-3
Gene namesi
Name:Pitpnm2
Synonyms:Kiaa1457, Nir3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1336192. Pitpnm2.

Subcellular locationi

  • Endomembrane system By similarity; Peripheral membrane protein By similarity
  • Cytoplasmcytoskeleton 1 Publication

  • Note: May associate with the cytoskeleton.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13351335Membrane-associated phosphatidylinositol transfer protein 2PRO_0000232742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei334 – 3341PhosphoserineCombined sources
Modified residuei338 – 3381PhosphoserineCombined sources
Modified residuei365 – 3651PhosphoserineCombined sources
Modified residuei586 – 5861PhosphoserineCombined sources
Modified residuei630 – 6301PhosphoserineBy similarity
Modified residuei686 – 6861PhosphoserineCombined sources
Modified residuei687 – 6871PhosphoserineCombined sources
Modified residuei688 – 6881PhosphoserineCombined sources
Modified residuei1263 – 12631PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZPQ6.
MaxQBiQ6ZPQ6.
PRIDEiQ6ZPQ6.

PTM databases

iPTMnetiQ6ZPQ6.
PhosphoSiteiQ6ZPQ6.

Expressioni

Tissue specificityi

Detected in retina and in the dentate gyrus of the cerebellum.1 Publication

Gene expression databases

BgeeiQ6ZPQ6.
ExpressionAtlasiQ6ZPQ6. baseline and differential.
GenevisibleiQ6ZPQ6. MM.

Interactioni

Subunit structurei

Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with PTK2B via its C-terminus (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi202842. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPQ6.
SMRiQ6ZPQ6. Positions 1-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini701 – 949249DDHDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi576 – 689114Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 DDHD domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119216.
HOGENOMiHOG000294231.
HOVERGENiHBG052733.
InParanoidiQ6ZPQ6.
OMAiQVMRHDS.
OrthoDBiEOG7NW69J.
PhylomeDBiQ6ZPQ6.
TreeFamiTF312967.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR004177. DDHD_dom.
IPR023214. HAD-like_dom.
IPR031315. LNS2/PITP.
IPR001666. PI_transfer.
IPR023393. START-like_dom.
[Graphical view]
PANTHERiPTHR10658. PTHR10658. 2 hits.
PfamiPF02862. DDHD. 1 hit.
PF02121. IP_trans. 1 hit.
[Graphical view]
PRINTSiPR00391. PITRANSFER.
SMARTiSM01127. DDHD. 1 hit.
SM00775. LNS2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
PROSITEiPS51043. DDHD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZPQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIIKEYRIPL PMTVDEYRIA QLYMIQKKSR NETHGQGSGV EILENRPYTD
60 70 80 90 100
GPGGSGQYTH KVYHVGMHIP GWFRSILPKA ALRVVEESWN AYPYTRTRFT
110 120 130 140 150
CPFVEKFSID IETFYKTDTG ENNNVFNLSP VEKSQLITDI IDIVKDPVPP
160 170 180 190 200
SEYKTEEDPK LFQSVKTCRG PLSENWIQEY KKRLLPIMCA YKLCKVEFRY
210 220 230 240 250
WGMQSKIERF IHDTGLRRVM VRAHRQAWCW QDEWYGLTME KIRELEREVQ
260 270 280 290 300
LMLSRKMAQF SEEGPSELSK DSATKDQASG TTSDPGSKNG EPLGRGLKKQ
310 320 330 340 350
WSTSSKSSRS SKRGASPSRH SISEWRMQSI ARDSDEGSEE EFFDAHENLY
360 370 380 390 400
CTEEKQAKDM TKWNSNDLMD KMESPEPEES QDEIYQQSGS EFRVASSVEQ
410 420 430 440 450
LNIIEDEVSQ PLAAPPSKIH VLLLVLHGGT ILDTGAGDPS SKQGDTNTIT
460 470 480 490 500
NVFDTVMRVH YPSALGHLAI RLVPCPPICA DAFALVSNLS PYGHDEGCLS
510 520 530 540 550
SSQDHIPLAA LPLLATSSPQ YQEAVATVIQ RANLAYGDFI KSQEGVTFNG
560 570 580 590 600
QVCLIGDCVG GILAFDALCY SGQPVSESQS SSRRGSVVSM QDADLLSPGT
610 620 630 640 650
LANAAHCSGG SGGGGSGGSS LESSRHLSRS NIDIPRSNGT EDSRRQLPRK
660 670 680 690 700
RSDSSTYELD TIQQHQAFLS SLHASVLRNE PSSRRSSSST MLDGAGALGK
710 720 730 740 750
FDFEIADLFL FGCPLGLVLA LRKTVIPSLD VFQLRPACQQ VYNLFHPADP
760 770 780 790 800
SASRLEPLLE RRFHSLPPFS IPRYQRYPLG DGCSTLLADV LQTHNTVFQE
810 820 830 840 850
HAAPSSPGTA PAGRGFRRAS EISIASQVSG MAESYTASSI AQKGPSSLNH
860 870 880 890 900
TPSIRRLSLL ALPPPSPTTQ GPRARARQVS PNLERAPCLP DLDIGEVAAK
910 920 930 940 950
WWGQKRIDYA LYCPDALTAF PTVALPHLFH ASYWESTDVV SFLLRQVMRH
960 970 980 990 1000
DSSSILELDG KEVSVFTPSQ PRERWQRKRT HVKLRNVAAN HRINDAVANE
1010 1020 1030 1040 1050
DGPQVVTGRF MYGPLDMVTL TGEKVDVHIM TQPPSGEWLH LDTLVTNSSG
1060 1070 1080 1090 1100
RVSYTIPETH RLGVGVYPIK MVVRGDHTFA DSYITVLPRG TEFVVFSIDG
1110 1120 1130 1140 1150
SFAASVSIMG SDPKVRAGAV DVVRHWQDLG YLIIYVTGRP DMQKQRVVAW
1160 1170 1180 1190 1200
LAQHNFPHGV VSFCDGLVHD PLRHKANFLK LLISELHLRA HAAYGSTKDV
1210 1220 1230 1240 1250
AVYNSISLSP MHIYIVGRPT KKLQQQCQFI TDGYAAHLAQ LKYNHRARPA
1260 1270 1280 1290 1300
RNTATRMALR KGSFGLPGQS DFLRSRNHLL RTISAQPSGP SHRHDRTQTQ
1310 1320 1330
MDSEQRGQRS MSVAASCWGR AMAGRLEPGA ATGPK
Length:1,335
Mass (Da):148,035
Last modified:April 18, 2006 - v2
Checksum:i6119814AF6D15CBC
GO
Isoform 2 (identifier: Q6ZPQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     843-897: KGPSSLNHTPSIRRLSLLALPPPSPTTQGPRARARQVSPNLERAPCLPDLDIGEV → I

Show »
Length:1,281
Mass (Da):142,288
Checksum:i307411DF5AE52084
GO

Sequence cautioni

The sequence BAC98174.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei843 – 89755KGPSS…DIGEV → I in isoform 2. 1 PublicationVSP_017964Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058693 mRNA. Translation: AAD51375.1.
AK129364 mRNA. Translation: BAC98174.1. Different initiation.
CCDSiCCDS19674.1. [Q6ZPQ6-2]
CCDS71669.1. [Q6ZPQ6-1]
RefSeqiNP_001276401.1. NM_001289472.1. [Q6ZPQ6-1]
NP_035386.1. NM_011256.3. [Q6ZPQ6-2]
XP_006530282.1. XM_006530219.1. [Q6ZPQ6-1]
UniGeneiMm.44261.

Genome annotation databases

EnsembliENSMUST00000086123; ENSMUSP00000083292; ENSMUSG00000029406. [Q6ZPQ6-2]
ENSMUST00000161938; ENSMUSP00000124111; ENSMUSG00000029406. [Q6ZPQ6-1]
ENSMUST00000162812; ENSMUSP00000124740; ENSMUSG00000029406. [Q6ZPQ6-2]
GeneIDi19679.
KEGGimmu:19679.
UCSCiuc008zpb.3. mouse. [Q6ZPQ6-1]
uc008zpc.3. mouse. [Q6ZPQ6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058693 mRNA. Translation: AAD51375.1.
AK129364 mRNA. Translation: BAC98174.1. Different initiation.
CCDSiCCDS19674.1. [Q6ZPQ6-2]
CCDS71669.1. [Q6ZPQ6-1]
RefSeqiNP_001276401.1. NM_001289472.1. [Q6ZPQ6-1]
NP_035386.1. NM_011256.3. [Q6ZPQ6-2]
XP_006530282.1. XM_006530219.1. [Q6ZPQ6-1]
UniGeneiMm.44261.

3D structure databases

ProteinModelPortaliQ6ZPQ6.
SMRiQ6ZPQ6. Positions 1-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202842. 2 interactions.

PTM databases

iPTMnetiQ6ZPQ6.
PhosphoSiteiQ6ZPQ6.

Proteomic databases

EPDiQ6ZPQ6.
MaxQBiQ6ZPQ6.
PRIDEiQ6ZPQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086123; ENSMUSP00000083292; ENSMUSG00000029406. [Q6ZPQ6-2]
ENSMUST00000161938; ENSMUSP00000124111; ENSMUSG00000029406. [Q6ZPQ6-1]
ENSMUST00000162812; ENSMUSP00000124740; ENSMUSG00000029406. [Q6ZPQ6-2]
GeneIDi19679.
KEGGimmu:19679.
UCSCiuc008zpb.3. mouse. [Q6ZPQ6-1]
uc008zpc.3. mouse. [Q6ZPQ6-2]

Organism-specific databases

CTDi57605.
MGIiMGI:1336192. Pitpnm2.
RougeiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119216.
HOGENOMiHOG000294231.
HOVERGENiHBG052733.
InParanoidiQ6ZPQ6.
OMAiQVMRHDS.
OrthoDBiEOG7NW69J.
PhylomeDBiQ6ZPQ6.
TreeFamiTF312967.

Miscellaneous databases

ChiTaRSiPitpnm2. mouse.
PROiQ6ZPQ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZPQ6.
ExpressionAtlasiQ6ZPQ6. baseline and differential.
GenevisibleiQ6ZPQ6. MM.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR004177. DDHD_dom.
IPR023214. HAD-like_dom.
IPR031315. LNS2/PITP.
IPR001666. PI_transfer.
IPR023393. START-like_dom.
[Graphical view]
PANTHERiPTHR10658. PTHR10658. 2 hits.
PfamiPF02862. DDHD. 1 hit.
PF02121. IP_trans. 1 hit.
[Graphical view]
PRINTSiPR00391. PITRANSFER.
SMARTiSM01127. DDHD. 1 hit.
SM00775. LNS2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
PROSITEiPS51043. DDHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus."
    Lu C., Vihtelic T.S., Hyde D.R., Li T.
    J. Neurosci. 19:7317-7325(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Retina.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif."
    Tomsig J.L., Snyder S.L., Creutz C.E.
    J. Biol. Chem. 278:10048-10054(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CPNE4.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334; SER-338; SER-365; SER-586; SER-686; SER-687; SER-688 AND SER-1263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiPITM2_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPQ6
Secondary accession number(s): Q9R1P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.