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Protein

Membrane-associated phosphatidylinositol transfer protein 2

Gene

Pitpnm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Lipid-binding, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1483226 Synthesis of PI

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated phosphatidylinositol transfer protein 2
Alternative name(s):
Drosophila retinal degeneration B homolog 2
Short name:
RdgB2
Phosphatidylinositol transfer protein, membrane-associated 2
Short name:
PITPnm 2
Pyk2 N-terminal domain-interacting receptor 3
Short name:
NIR-3
Gene namesi
Name:Pitpnm2
Synonyms:Kiaa1457, Nir3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1336192 Pitpnm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002327421 – 1335Membrane-associated phosphatidylinositol transfer protein 2Add BLAST1335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei334PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei586PhosphoserineCombined sources1
Modified residuei630PhosphoserineBy similarity1
Modified residuei686PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei814Omega-N-methylarginineCombined sources1
Modified residuei1263PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PRIDEiQ6ZPQ6

PTM databases

iPTMnetiQ6ZPQ6
PhosphoSitePlusiQ6ZPQ6

Expressioni

Tissue specificityi

Detected in retina and in the dentate gyrus of the cerebellum.1 Publication

Gene expression databases

BgeeiENSMUSG00000029406
ExpressionAtlasiQ6ZPQ6 baseline and differential
GenevisibleiQ6ZPQ6 MM

Interactioni

Subunit structurei

Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with PTK2B via its C-terminus (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202842, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6ZPQ6
SMRiQ6ZPQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini701 – 949DDHDPROSITE-ProRule annotationAdd BLAST249

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi576 – 689Ser-richAdd BLAST114

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000119216
HOGENOMiHOG000294231
HOVERGENiHBG052733
InParanoidiQ6ZPQ6
OMAiLARPNCH
OrthoDBiEOG091G0BMT
PhylomeDBiQ6ZPQ6
TreeFamiTF312967

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR004177 DDHD_dom
IPR036412 HAD-like_sf
IPR031315 LNS2/PITP
IPR001666 PI_transfer
IPR023393 START-like_dom_sf
PANTHERiPTHR10658 PTHR10658, 1 hit
PfamiView protein in Pfam
PF02862 DDHD, 1 hit
PF02121 IP_trans, 1 hit
PRINTSiPR00391 PITRANSFER
SMARTiView protein in SMART
SM01127 DDHD, 1 hit
SM00775 LNS2, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
PROSITEiView protein in PROSITE
PS51043 DDHD, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZPQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIIKEYRIPL PMTVDEYRIA QLYMIQKKSR NETHGQGSGV EILENRPYTD
60 70 80 90 100
GPGGSGQYTH KVYHVGMHIP GWFRSILPKA ALRVVEESWN AYPYTRTRFT
110 120 130 140 150
CPFVEKFSID IETFYKTDTG ENNNVFNLSP VEKSQLITDI IDIVKDPVPP
160 170 180 190 200
SEYKTEEDPK LFQSVKTCRG PLSENWIQEY KKRLLPIMCA YKLCKVEFRY
210 220 230 240 250
WGMQSKIERF IHDTGLRRVM VRAHRQAWCW QDEWYGLTME KIRELEREVQ
260 270 280 290 300
LMLSRKMAQF SEEGPSELSK DSATKDQASG TTSDPGSKNG EPLGRGLKKQ
310 320 330 340 350
WSTSSKSSRS SKRGASPSRH SISEWRMQSI ARDSDEGSEE EFFDAHENLY
360 370 380 390 400
CTEEKQAKDM TKWNSNDLMD KMESPEPEES QDEIYQQSGS EFRVASSVEQ
410 420 430 440 450
LNIIEDEVSQ PLAAPPSKIH VLLLVLHGGT ILDTGAGDPS SKQGDTNTIT
460 470 480 490 500
NVFDTVMRVH YPSALGHLAI RLVPCPPICA DAFALVSNLS PYGHDEGCLS
510 520 530 540 550
SSQDHIPLAA LPLLATSSPQ YQEAVATVIQ RANLAYGDFI KSQEGVTFNG
560 570 580 590 600
QVCLIGDCVG GILAFDALCY SGQPVSESQS SSRRGSVVSM QDADLLSPGT
610 620 630 640 650
LANAAHCSGG SGGGGSGGSS LESSRHLSRS NIDIPRSNGT EDSRRQLPRK
660 670 680 690 700
RSDSSTYELD TIQQHQAFLS SLHASVLRNE PSSRRSSSST MLDGAGALGK
710 720 730 740 750
FDFEIADLFL FGCPLGLVLA LRKTVIPSLD VFQLRPACQQ VYNLFHPADP
760 770 780 790 800
SASRLEPLLE RRFHSLPPFS IPRYQRYPLG DGCSTLLADV LQTHNTVFQE
810 820 830 840 850
HAAPSSPGTA PAGRGFRRAS EISIASQVSG MAESYTASSI AQKGPSSLNH
860 870 880 890 900
TPSIRRLSLL ALPPPSPTTQ GPRARARQVS PNLERAPCLP DLDIGEVAAK
910 920 930 940 950
WWGQKRIDYA LYCPDALTAF PTVALPHLFH ASYWESTDVV SFLLRQVMRH
960 970 980 990 1000
DSSSILELDG KEVSVFTPSQ PRERWQRKRT HVKLRNVAAN HRINDAVANE
1010 1020 1030 1040 1050
DGPQVVTGRF MYGPLDMVTL TGEKVDVHIM TQPPSGEWLH LDTLVTNSSG
1060 1070 1080 1090 1100
RVSYTIPETH RLGVGVYPIK MVVRGDHTFA DSYITVLPRG TEFVVFSIDG
1110 1120 1130 1140 1150
SFAASVSIMG SDPKVRAGAV DVVRHWQDLG YLIIYVTGRP DMQKQRVVAW
1160 1170 1180 1190 1200
LAQHNFPHGV VSFCDGLVHD PLRHKANFLK LLISELHLRA HAAYGSTKDV
1210 1220 1230 1240 1250
AVYNSISLSP MHIYIVGRPT KKLQQQCQFI TDGYAAHLAQ LKYNHRARPA
1260 1270 1280 1290 1300
RNTATRMALR KGSFGLPGQS DFLRSRNHLL RTISAQPSGP SHRHDRTQTQ
1310 1320 1330
MDSEQRGQRS MSVAASCWGR AMAGRLEPGA ATGPK
Length:1,335
Mass (Da):148,035
Last modified:April 18, 2006 - v2
Checksum:i6119814AF6D15CBC
GO
Isoform 2 (identifier: Q6ZPQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     843-897: KGPSSLNHTPSIRRLSLLALPPPSPTTQGPRARARQVSPNLERAPCLPDLDIGEV → I

Show »
Length:1,281
Mass (Da):142,288
Checksum:i307411DF5AE52084
GO

Sequence cautioni

The sequence BAC98174 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017964843 – 897KGPSS…DIGEV → I in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058693 mRNA Translation: AAD51375.1
AK129364 mRNA Translation: BAC98174.1 Different initiation.
CCDSiCCDS19674.1 [Q6ZPQ6-2]
CCDS71669.1 [Q6ZPQ6-1]
RefSeqiNP_001276401.1, NM_001289472.1 [Q6ZPQ6-1]
NP_035386.1, NM_011256.3 [Q6ZPQ6-2]
XP_017176233.1, XM_017320744.1 [Q6ZPQ6-1]
UniGeneiMm.44261

Genome annotation databases

EnsembliENSMUST00000086123; ENSMUSP00000083292; ENSMUSG00000029406 [Q6ZPQ6-2]
ENSMUST00000161938; ENSMUSP00000124111; ENSMUSG00000029406 [Q6ZPQ6-1]
ENSMUST00000162812; ENSMUSP00000124740; ENSMUSG00000029406 [Q6ZPQ6-2]
GeneIDi19679
KEGGimmu:19679
UCSCiuc008zpb.3 mouse [Q6ZPQ6-1]
uc008zpc.3 mouse [Q6ZPQ6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPITM2_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPQ6
Secondary accession number(s): Q9R1P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: March 28, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health