Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-dependent RNA helicase DDX55

Gene

Ddx55

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable ATP-binding RNA helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 608ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX55 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 55
Gene namesi
Name:Ddx55
Synonyms:Kiaa1595
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915098. Ddx55.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600ATP-dependent RNA helicase DDX55PRO_0000252211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei544 – 5441PhosphoserineCombined sources
Modified residuei594 – 5941PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZPL9.
MaxQBiQ6ZPL9.
PaxDbiQ6ZPL9.
PRIDEiQ6ZPL9.

PTM databases

iPTMnetiQ6ZPL9.

Expressioni

Gene expression databases

BgeeiQ6ZPL9.
CleanExiMM_DDX55.
ExpressionAtlasiQ6ZPL9. baseline and differential.
GenevisibleiQ6ZPL9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ6ZPL9. 2 interactions.
STRINGi10090.ENSMUSP00000070279.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPL9.
SMRiQ6ZPL9. Positions 9-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 223184Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini254 – 402149Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi9 – 3729Q motifAdd
BLAST
Motifi171 – 1744DEAD box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi487 – 56882Lys-richAdd
BLAST

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0345. Eukaryota.
ENOG410XNT7. LUCA.
GeneTreeiENSGT00550000074969.
HOGENOMiHOG000268803.
HOVERGENiHBG107796.
InParanoidiQ6ZPL9.
KOiK14809.
OMAiRANVVEK.
OrthoDBiEOG7QVM2B.
PhylomeDBiQ6ZPL9.
TreeFamiTF314573.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZPL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHVTEGAWE SLQVPLHPRV LGALRELGFP HMTPVQSATI PLFMKNKDVA
60 70 80 90 100
AEAVTGSGKT LAFVIPILEI LLRREEKLKK NQVGAIVITP TRELAIQIDE
110 120 130 140 150
VLSHFTKHFP QFSQILWIGG RNPGEDVERF KQHGGNIIVA TPGRLEDMFR
160 170 180 190 200
RKAEGLDLAS CVKSLDVLVL DEADRLLDMG FEASINTILE FLPKQRRTGL
210 220 230 240 250
FSATQTQEVE NLVRAGLRNP VRISVKEKGV AASSTQKTPS RLENHYMICK
260 270 280 290 300
ADEKFNQLVH FLRSRQQEKH LVFFSTCACV EYYGKALEAL LKKVKILCIH
310 320 330 340 350
GKMKYKRNKI FMEFRKLQSG ILVCTDVMAR GIDIPEVNWV LQYDPPSNAS
360 370 380 390 400
AFVHRCGRTA RIGHGGSALV FLLPMEEAYI NFLAINQKCP LQEMSLQRNT
410 420 430 440 450
IDLLPKLRAM ALADRAVFEK GMKAFVSFVQ AYAKHECSLI FRLKDLDFAG
460 470 480 490 500
LARGFALLRM PRMPELRGKQ FPDFVPVDID TDTIPFKDKI REKQRQKLLE
510 520 530 540 550
QKRKERSENE GRKKFIKNKA WSKQKAKKER KKKMNAKRKK DEGSDIDDED
560 570 580 590 600
MEELLNDTRL LKKFKKGKIT EEEFEKGLLT SAKRTVQLTD LGVSDLEEDS
Length:600
Mass (Da):68,465
Last modified:October 3, 2006 - v2
Checksum:i7CEBB0F4C33A1469
GO

Sequence cautioni

The sequence BAC98212.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE32574.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti482 – 4821D → H in AAI17787 (PubMed:15489334).Curated
Sequence conflicti482 – 4821D → H in AAI17788 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129402 mRNA. Translation: BAC98212.1. Different initiation.
AK033741 mRNA. Translation: BAC28459.1.
AK154422 mRNA. Translation: BAE32574.1. Different initiation.
BC117786 mRNA. Translation: AAI17787.1.
BC117787 mRNA. Translation: AAI17788.1.
CCDSiCCDS39281.1.
RefSeqiNP_080685.2. NM_026409.4.
UniGeneiMm.281601.

Genome annotation databases

EnsembliENSMUST00000071057; ENSMUSP00000070279; ENSMUSG00000029389.
GeneIDi67848.
KEGGimmu:67848.
UCSCiuc008zqc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129402 mRNA. Translation: BAC98212.1. Different initiation.
AK033741 mRNA. Translation: BAC28459.1.
AK154422 mRNA. Translation: BAE32574.1. Different initiation.
BC117786 mRNA. Translation: AAI17787.1.
BC117787 mRNA. Translation: AAI17788.1.
CCDSiCCDS39281.1.
RefSeqiNP_080685.2. NM_026409.4.
UniGeneiMm.281601.

3D structure databases

ProteinModelPortaliQ6ZPL9.
SMRiQ6ZPL9. Positions 9-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6ZPL9. 2 interactions.
STRINGi10090.ENSMUSP00000070279.

PTM databases

iPTMnetiQ6ZPL9.

Proteomic databases

EPDiQ6ZPL9.
MaxQBiQ6ZPL9.
PaxDbiQ6ZPL9.
PRIDEiQ6ZPL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071057; ENSMUSP00000070279; ENSMUSG00000029389.
GeneIDi67848.
KEGGimmu:67848.
UCSCiuc008zqc.2. mouse.

Organism-specific databases

CTDi57696.
MGIiMGI:1915098. Ddx55.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0345. Eukaryota.
ENOG410XNT7. LUCA.
GeneTreeiENSGT00550000074969.
HOGENOMiHOG000268803.
HOVERGENiHBG107796.
InParanoidiQ6ZPL9.
KOiK14809.
OMAiRANVVEK.
OrthoDBiEOG7QVM2B.
PhylomeDBiQ6ZPL9.
TreeFamiTF314573.

Miscellaneous databases

ChiTaRSiDdx55. mouse.
PROiQ6ZPL9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZPL9.
CleanExiMM_DDX55.
ExpressionAtlasiQ6ZPL9. baseline and differential.
GenevisibleiQ6ZPL9. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Cecum.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544 AND SER-594, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544 AND SER-594, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Liver, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiDDX55_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPL9
Secondary accession number(s): Q149H5, Q3U460, Q8BZR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 8, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.