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Q6ZPI3 (LCOR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ligand-dependent corepressor

Short name=LCoR
Alternative name(s):
Mblk1-related protein 2
Gene names
Name:Lcor
Synonyms:Kiaa1795, Mlr2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR By similarity. May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. Ref.1

Subunit structure

Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2 By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Detected in heart and kidney. Ref.1

Sequence similarities

Contains 1 HTH psq-type DNA-binding domain.

Sequence caution

The sequence BAC98252.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAE32988.1 differs from that shown. Reason: Frameshift at position 421.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Ligand-dependent corepressor
PRO_0000236808

Regions

Domain340 – 39253HTH psq-type
DNA binding368 – 38821H-T-H motif By similarity
Motif53 – 575Interaction with nuclear receptors By similarity
Motif339 – 3457Nuclear localization signal Potential

Amino acid modifications

Modified residue631Phosphoserine By similarity
Modified residue2491Phosphoserine By similarity

Experimental info

Sequence conflict3111S → F in BAE32988. Ref.3
Sequence conflict3821L → P in AAH90652. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q6ZPI3 [UniParc].

Last modified May 30, 2006. Version 2.
Checksum: 736656D1F7E9A041

FASTA43347,125
        10         20         30         40         50         60 
MQRMIQQFAA EYTSKTSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN PVLSKLLMAD 

        70         80         90        100        110        120 
QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCASSTSLSH SPGCSSTQGN GRPGRPSQYR 

       130        140        150        160        170        180 
PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK VPLARSLQIS EELLSRNQLS TAASLGPSGL 

       190        200        210        220        230        240 
QNHGQHLILS REASWAKPHY EFSLSRMKFR GNGALSNISD LPFLAENSAF PKMAHQTKQD 

       250        260        270        280        290        300 
GKRDMSHSSP VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQN 

       310        320        330        340        350        360 
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN SEILEEAISV 

       370        380        390        400        410        420 
VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK MKLMRSEGPD VSVKIELDPQ 

       430 
GEAAQSANES KTE 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain."
Kunieda T., Park J.-M., Takeuchi H., Kubo T.
FEBS Lett. 535:61-65(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryonic tail.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Aorta, Dendritic cell, Thymus and Vein.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Head and Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB076079 mRNA. Translation: BAC20955.1.
AK129442 mRNA. Translation: BAC98252.1. Different initiation.
AK041090 mRNA. Translation: BAC30816.1.
AK041621 mRNA. Translation: BAC31007.2.
AK155007 mRNA. Translation: BAE32988.1. Frameshift.
BC050068 mRNA. Translation: AAH50068.1.
BC090652 mRNA. Translation: AAH90652.1.
RefSeqNP_742166.1. NM_172154.4.
XP_006526912.1. XM_006526849.1.
XP_006526913.1. XM_006526850.1.
UniGeneMm.422910.
Mm.459119.

3D structure databases

ProteinModelPortalQ6ZPI3.
SMRQ6ZPI3. Positions 346-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60279N.

PTM databases

PhosphoSiteQ6ZPI3.

Proteomic databases

PRIDEQ6ZPI3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000067795; ENSMUSP00000067603; ENSMUSG00000025019.
ENSMUST00000163929; ENSMUSP00000126441; ENSMUSG00000025019.
GeneID212391.
KEGGmmu:212391.
UCSCuc008hly.1. mouse.

Organism-specific databases

CTD84458.
MGIMGI:2443930. Lcor.
RougeSearch...

Phylogenomic databases

eggNOGNOG309364.
GeneTreeENSGT00520000055615.
HOGENOMHOG000253915.
HOVERGENHBG079596.
InParanoidQ6ZPI3.
OMAFQDCEPE.
OrthoDBEOG73RBBB.
PhylomeDBQ6ZPI3.
TreeFamTF319589.

Gene expression databases

ArrayExpressQ6ZPI3.
BgeeQ6ZPI3.
CleanExMM_LCOR.
GenevestigatorQ6ZPI3.

Family and domain databases

InterProIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamPF05225. HTH_psq. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio373549.
PROQ6ZPI3.
SOURCESearch...

Entry information

Entry nameLCOR_MOUSE
AccessionPrimary (citable) accession number: Q6ZPI3
Secondary accession number(s): Q3U302 expand/collapse secondary AC list , Q5CZW7, Q80VA8, Q8BGT2, Q8C9Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot