Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ligand-dependent corepressor

Gene

Lcor

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (By similarity). May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi368 – 38821H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: MGI
  3. transcription factor binding Source: MGI

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  2. regulation of transcription from RNA polymerase II promoter Source: MGI
  3. transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ligand-dependent corepressor
Short name:
LCoR
Alternative name(s):
Mblk1-related protein 2
Gene namesi
Name:Lcor
Synonyms:Kiaa1795, Mlr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:2443930. Lcor.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Ligand-dependent corepressorPRO_0000236808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631PhosphoserineBy similarity
Modified residuei249 – 2491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6ZPI3.

PTM databases

PhosphoSiteiQ6ZPI3.

Expressioni

Tissue specificityi

Detected in heart and kidney.1 Publication

Gene expression databases

BgeeiQ6ZPI3.
CleanExiMM_LCOR.
ExpressionAtlasiQ6ZPI3. baseline and differential.
GenevestigatoriQ6ZPI3.

Interactioni

Subunit structurei

Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-60279N.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPI3.
SMRiQ6ZPI3. Positions 346-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini340 – 39253HTH psq-typePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 575Interaction with nuclear receptorsBy similarity
Motifi339 – 3457Nuclear localization signalSequence Analysis

Sequence similaritiesi

Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG309364.
GeneTreeiENSGT00520000055615.
HOGENOMiHOG000253915.
HOVERGENiHBG079596.
InParanoidiQ6ZPI3.
OMAiHYEFNFS.
OrthoDBiEOG73RBBB.
PhylomeDBiQ6ZPI3.
TreeFamiTF319589.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF05225. HTH_psq. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZPI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRMIQQFAA EYTSKTSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN
60 70 80 90 100
PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCASSTSLSH
110 120 130 140 150
SPGCSSTQGN GRPGRPSQYR PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK
160 170 180 190 200
VPLARSLQIS EELLSRNQLS TAASLGPSGL QNHGQHLILS REASWAKPHY
210 220 230 240 250
EFSLSRMKFR GNGALSNISD LPFLAENSAF PKMAHQTKQD GKRDMSHSSP
260 270 280 290 300
VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQN
310 320 330 340 350
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN
360 370 380 390 400
SEILEEAISV VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK
410 420 430
MKLMRSEGPD VSVKIELDPQ GEAAQSANES KTE
Length:433
Mass (Da):47,125
Last modified:May 30, 2006 - v2
Checksum:i736656D1F7E9A041
GO

Sequence cautioni

The sequence BAC98252.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE32988.1 differs from that shown. Reason: Frameshift at position 421. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti311 – 3111S → F in BAE32988 (PubMed:16141072).Curated
Sequence conflicti382 – 3821L → P in AAH90652 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076079 mRNA. Translation: BAC20955.1.
AK129442 mRNA. Translation: BAC98252.1. Different initiation.
AK041090 mRNA. Translation: BAC30816.1.
AK041621 mRNA. Translation: BAC31007.2.
AK155007 mRNA. Translation: BAE32988.1. Frameshift.
BC050068 mRNA. Translation: AAH50068.1.
BC090652 mRNA. Translation: AAH90652.1.
CCDSiCCDS29810.1.
RefSeqiNP_742166.1. NM_172154.4.
XP_006526912.1. XM_006526849.1.
XP_006526913.1. XM_006526850.1.
UniGeneiMm.422910.
Mm.459119.

Genome annotation databases

EnsembliENSMUST00000067795; ENSMUSP00000067603; ENSMUSG00000025019.
ENSMUST00000163929; ENSMUSP00000126441; ENSMUSG00000025019.
GeneIDi212391.
KEGGimmu:212391.
UCSCiuc008hly.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076079 mRNA. Translation: BAC20955.1.
AK129442 mRNA. Translation: BAC98252.1. Different initiation.
AK041090 mRNA. Translation: BAC30816.1.
AK041621 mRNA. Translation: BAC31007.2.
AK155007 mRNA. Translation: BAE32988.1. Frameshift.
BC050068 mRNA. Translation: AAH50068.1.
BC090652 mRNA. Translation: AAH90652.1.
CCDSiCCDS29810.1.
RefSeqiNP_742166.1. NM_172154.4.
XP_006526912.1. XM_006526849.1.
XP_006526913.1. XM_006526850.1.
UniGeneiMm.422910.
Mm.459119.

3D structure databases

ProteinModelPortaliQ6ZPI3.
SMRiQ6ZPI3. Positions 346-405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60279N.

PTM databases

PhosphoSiteiQ6ZPI3.

Proteomic databases

PRIDEiQ6ZPI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067795; ENSMUSP00000067603; ENSMUSG00000025019.
ENSMUST00000163929; ENSMUSP00000126441; ENSMUSG00000025019.
GeneIDi212391.
KEGGimmu:212391.
UCSCiuc008hly.1. mouse.

Organism-specific databases

CTDi84458.
MGIiMGI:2443930. Lcor.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG309364.
GeneTreeiENSGT00520000055615.
HOGENOMiHOG000253915.
HOVERGENiHBG079596.
InParanoidiQ6ZPI3.
OMAiHYEFNFS.
OrthoDBiEOG73RBBB.
PhylomeDBiQ6ZPI3.
TreeFamiTF319589.

Miscellaneous databases

NextBioi373549.
PROiQ6ZPI3.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZPI3.
CleanExiMM_LCOR.
ExpressionAtlasiQ6ZPI3. baseline and differential.
GenevestigatoriQ6ZPI3.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF05225. HTH_psq. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain."
    Kunieda T., Park J.-M., Takeuchi H., Kubo T.
    FEBS Lett. 535:61-65(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta, Dendritic cell, Thymus and Vein.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Head and Mammary gland.

Entry informationi

Entry nameiLCOR_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPI3
Secondary accession number(s): Q3U302
, Q5CZW7, Q80VA8, Q8BGT2, Q8C9Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: March 4, 2015
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.