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Q6ZPI0

- JADE1_MOUSE

UniProt

Q6ZPI0 - JADE1_MOUSE

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Protein
Protein Jade-1
Gene
Jade1, Kiaa1807, Phf17
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 25451PHD-type 1
Add
BLAST
Zinc fingeri313 – 37260PHD-type 2; atypical
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II transcription coactivator activity Source: Ensembl
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. histone H3 acetylation Source: UniProtKB
  3. histone H4-K12 acetylation Source: UniProtKB
  4. histone H4-K5 acetylation Source: UniProtKB
  5. histone H4-K8 acetylation Source: UniProtKB
  6. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_226917. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Jade-1
Alternative name(s):
Jade family PHD finger protein 1
PHD finger protein 17
Gene namesi
Name:Jade1
Synonyms:Kiaa1807, Phf17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1925835. Jade1.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. histone acetyltransferase complex Source: UniProtKB
  2. mitochondrion Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile, and show no visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Protein Jade-1
PRO_0000253530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901Phosphoserine By similarity
Modified residuei93 – 931Phosphothreonine By similarity
Modified residuei603 – 6031Phosphoserine By similarity
Modified residuei609 – 6091N6-acetyllysine1 Publication
Modified residuei735 – 7351Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6ZPI0.
PRIDEiQ6ZPI0.

PTM databases

PhosphoSiteiQ6ZPI0.

Expressioni

Tissue specificityi

Highly expressed in kidney. Also present in liver (at protein level).1 Publication

Developmental stagei

Expressed from E6.5. From E12.5 to E15.5, expressed in the nervous system and developing muscles.1 Publication

Gene expression databases

ArrayExpressiQ6ZPI0.
BgeeiQ6ZPI0.
CleanExiMM_PHF17.
GenevestigatoriQ6ZPI0.

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 By similarity. Isoform 2 interacts with VHL and KAT5.

Protein-protein interaction databases

BioGridi234652. 6 interactions.
IntActiQ6ZPI0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPI0.
SMRiQ6ZPI0. Positions 202-251, 256-370.

Family & Domainsi

Domaini

The 2 PHD-type zinc fingers are required for transcriptional activity By similarity.

Sequence similaritiesi

Belongs to the JADE family.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5141.
GeneTreeiENSGT00740000115415.
HOGENOMiHOG000220882.
HOVERGENiHBG053585.
InParanoidiQ6ZPI0.
KOiK11347.
OMAiEAHEGAC.
OrthoDBiEOG738044.
PhylomeDBiQ6ZPI0.
TreeFamiTF316118.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZPI0-1) [UniParc]FASTAAdd to Basket

Also known as: Jade1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKRGRLPSSS EDSDDNGSLS TTWSQHSRSQ HGRSSTCSRP EDRKPSEVFR    50
TDLITAMKLH DSYQLNPDDY YVLADPWRQE WEKGVQVPVS PGTIPQPVAR 100
VVSEEKSLMF IRPKKYIASS GSEPPALGYV DIRTLADSVC RYDLNDMDAA 150
WLEVTNEEFK EMGMPELDEY TMERVLEEFE QRCYDNMNHA IETEEGLGIE 200
YDEDVVCDVC QSPDGEDGNE MVFCDKCNIC VHQACYGILK VPEGSWLCRT 250
CALGVQPKCL LCPKKGGAMK PTRSGTKWVH VSCALWIPEV SIGSPEKMEP 300
ITKVSHIPSS RWALVCSLCN EKFGASIQCS VKNCRTAFHV TCAFDRGLEM 350
KTILAENDEV KFKSYCPKHS SHRKPEEGLG EGAAQENGAP ESSPQSPLEP 400
YGSLEPNREE AHRVSVRKQK LQQLEDEFYT FVNLLDVARA LRLPEEVVDF 450
LYQYWKLKRK INFNKPLITP KKDEEDNLAK REQDVLFRRL QLFTHLRQDL 500
ERVRNLTYMV TRREKIKRSV CKVQEQIFTQ YTKLLEQEKV SGVPSSCSSA 550
LENMLFFNSP SVGPNAPKIE DLKWHSAFFR KQMGTSLVHP LKKSHKRDAV 600
QNSSGTEGKT SHKQPGLCGR REGLEVSESL LSLEKTFAEA RLLSSAQQKN 650
GVVTPDHGKR RDNRFHCDLV KGDLKDKSFK QSHKPLRSTD TSQRHLDNTR 700
AATSPGVGQS APGTRKEIVP KCNGSLVKVP ITPASPVKSW GGFRIPKKGE 750
RQQQGEAHDG ACHQHSDCSH LGVSRAPAKE RAKSRLRADS ENDGYAPDGE 800
MSDSESEASE KKCIHASSTI SRRTDIIRRS ILAS 834
Length:834
Mass (Da):93,897
Last modified:October 17, 2006 - v2
Checksum:i43388FC7103D97D6
GO
Isoform 2 (identifier: Q6ZPI0-2) [UniParc]FASTAAdd to Basket

Also known as: Jade1S

The sequence of this isoform differs from the canonical sequence as follows:
     504-510: RNLTYMV → MIDTDTL
     511-834: Missing.

Show »
Length:510
Mass (Da):58,126
Checksum:i6AB26BB5C624EE82
GO

Sequence cautioni

The sequence AAH26471.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC98255.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei504 – 5107RNLTYMV → MIDTDTL in isoform 2.
VSP_021048
Alternative sequencei511 – 834324Missing in isoform 2.
VSP_021049Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901A → D in BAC33688. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129445 mRNA. Translation: BAC98255.1. Different initiation.
AK049332 mRNA. Translation: BAC33688.1.
AK147466 mRNA. Translation: BAE27932.1.
BC020316 mRNA. Translation: AAH20316.1.
BC026471 mRNA. Translation: AAH26471.1. Different initiation.
BN000282 mRNA. Translation: CAE30497.1.
BN000281 mRNA. Translation: CAE30496.1.
CCDSiCCDS17331.1. [Q6ZPI0-1]
RefSeqiNP_001123656.1. NM_001130184.1. [Q6ZPI0-1]
NP_001123657.1. NM_001130185.1. [Q6ZPI0-1]
NP_001123658.1. NM_001130186.1. [Q6ZPI0-1]
NP_758507.3. NM_172303.4. [Q6ZPI0-1]
XP_006500848.1. XM_006500785.1. [Q6ZPI0-1]
UniGeneiMm.286285.

Genome annotation databases

EnsembliENSMUST00000026865; ENSMUSP00000026865; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000163764; ENSMUSP00000128152; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000168086; ENSMUSP00000131441; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000170711; ENSMUSP00000127113; ENSMUSG00000025764. [Q6ZPI0-1]
GeneIDi269424.
KEGGimmu:269424.
UCSCiuc008pcj.2. mouse. [Q6ZPI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129445 mRNA. Translation: BAC98255.1 . Different initiation.
AK049332 mRNA. Translation: BAC33688.1 .
AK147466 mRNA. Translation: BAE27932.1 .
BC020316 mRNA. Translation: AAH20316.1 .
BC026471 mRNA. Translation: AAH26471.1 . Different initiation.
BN000282 mRNA. Translation: CAE30497.1 .
BN000281 mRNA. Translation: CAE30496.1 .
CCDSi CCDS17331.1. [Q6ZPI0-1 ]
RefSeqi NP_001123656.1. NM_001130184.1. [Q6ZPI0-1 ]
NP_001123657.1. NM_001130185.1. [Q6ZPI0-1 ]
NP_001123658.1. NM_001130186.1. [Q6ZPI0-1 ]
NP_758507.3. NM_172303.4. [Q6ZPI0-1 ]
XP_006500848.1. XM_006500785.1. [Q6ZPI0-1 ]
UniGenei Mm.286285.

3D structure databases

ProteinModelPortali Q6ZPI0.
SMRi Q6ZPI0. Positions 202-251, 256-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 234652. 6 interactions.
IntActi Q6ZPI0. 1 interaction.

PTM databases

PhosphoSitei Q6ZPI0.

Proteomic databases

PaxDbi Q6ZPI0.
PRIDEi Q6ZPI0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026865 ; ENSMUSP00000026865 ; ENSMUSG00000025764 . [Q6ZPI0-1 ]
ENSMUST00000163764 ; ENSMUSP00000128152 ; ENSMUSG00000025764 . [Q6ZPI0-1 ]
ENSMUST00000168086 ; ENSMUSP00000131441 ; ENSMUSG00000025764 . [Q6ZPI0-1 ]
ENSMUST00000170711 ; ENSMUSP00000127113 ; ENSMUSG00000025764 . [Q6ZPI0-1 ]
GeneIDi 269424.
KEGGi mmu:269424.
UCSCi uc008pcj.2. mouse. [Q6ZPI0-1 ]

Organism-specific databases

CTDi 79960.
MGIi MGI:1925835. Jade1.
Rougei Search...

Phylogenomic databases

eggNOGi COG5141.
GeneTreei ENSGT00740000115415.
HOGENOMi HOG000220882.
HOVERGENi HBG053585.
InParanoidi Q6ZPI0.
KOi K11347.
OMAi EAHEGAC.
OrthoDBi EOG738044.
PhylomeDBi Q6ZPI0.
TreeFami TF316118.

Enzyme and pathway databases

Reactomei REACT_226917. HATs acetylate histones.

Miscellaneous databases

NextBioi 392846.
PROi Q6ZPI0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6ZPI0.
Bgeei Q6ZPI0.
CleanExi MM_PHF17.
Genevestigatori Q6ZPI0.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF10513. EPL1. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
    Tzouanacou E., Tweedie S., Wilson V.
    Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, ALTERNATIVE SPLICING, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    Strain: C57BL/6.
  5. "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."
    Zhou M.I., Wang H., Ross J.J., Kuzmin I., Xu C., Cohen H.T.
    J. Biol. Chem. 277:39887-39898(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiJADE1_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPI0
Secondary accession number(s): Q6IE84
, Q8C7S6, Q8CFM2, Q8R362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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