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Protein

Protein Jade-1

Gene

Jade1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 254PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri256 – 290C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri314 – 370PHD-type 2PROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Jade-1
Alternative name(s):
Jade family PHD finger protein 1
PHD finger protein 17
Gene namesi
Name:Jade1
Synonyms:Kiaa1807, Phf17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1925835. Jade1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication
  • Cytoplasmcytoskeletoncilium basal body By similarity

  • Note: Localizes to the ciliary transition zone.By similarity

GO - Cellular componenti

  • ciliary basal body Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • histone acetyltransferase complex Source: UniProtKB
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile, and show no visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535301 – 834Protein Jade-1Add BLAST834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineBy similarity1
Modified residuei93PhosphothreonineBy similarity1
Modified residuei603PhosphoserineBy similarity1
Modified residuei609N6-acetyllysineCombined sources1
Modified residuei704PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6ZPI0.
PeptideAtlasiQ6ZPI0.
PRIDEiQ6ZPI0.

PTM databases

iPTMnetiQ6ZPI0.
PhosphoSitePlusiQ6ZPI0.

Expressioni

Tissue specificityi

Highly expressed in kidney. Also present in liver (at protein level).1 Publication

Developmental stagei

Expressed from E6.5. From E12.5 to E15.5, expressed in the nervous system and developing muscles.1 Publication

Gene expression databases

BgeeiENSMUSG00000025764.
CleanExiMM_PHF17.
ExpressionAtlasiQ6ZPI0. baseline and differential.
GenevisibleiQ6ZPI0. MM.

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 2 interacts with VHL and KAT5. Interacts with NPHP4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi234652. 6 interactors.
IntActiQ6ZPI0. 1 interactor.
STRINGi10090.ENSMUSP00000026865.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPI0.
SMRiQ6ZPI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The 2 PHD-type zinc fingers are required for transcriptional activity.By similarity

Sequence similaritiesi

Belongs to the JADE family.Curated
Contains 1 C2HC pre-PHD-type zinc finger.PROSITE-ProRule annotation
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 254PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri256 – 290C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri314 – 370PHD-type 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0954. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000220882.
HOVERGENiHBG053585.
InParanoidiQ6ZPI0.
KOiK11347.
OMAiEAHEGAC.
OrthoDBiEOG091G0T5C.
PhylomeDBiQ6ZPI0.
TreeFamiTF316118.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51805. EPHD. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZPI0-1) [UniParc]FASTAAdd to basket
Also known as: Jade1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRGRLPSSS EDSDDNGSLS TTWSQHSRSQ HGRSSTCSRP EDRKPSEVFR
60 70 80 90 100
TDLITAMKLH DSYQLNPDDY YVLADPWRQE WEKGVQVPVS PGTIPQPVAR
110 120 130 140 150
VVSEEKSLMF IRPKKYIASS GSEPPALGYV DIRTLADSVC RYDLNDMDAA
160 170 180 190 200
WLEVTNEEFK EMGMPELDEY TMERVLEEFE QRCYDNMNHA IETEEGLGIE
210 220 230 240 250
YDEDVVCDVC QSPDGEDGNE MVFCDKCNIC VHQACYGILK VPEGSWLCRT
260 270 280 290 300
CALGVQPKCL LCPKKGGAMK PTRSGTKWVH VSCALWIPEV SIGSPEKMEP
310 320 330 340 350
ITKVSHIPSS RWALVCSLCN EKFGASIQCS VKNCRTAFHV TCAFDRGLEM
360 370 380 390 400
KTILAENDEV KFKSYCPKHS SHRKPEEGLG EGAAQENGAP ESSPQSPLEP
410 420 430 440 450
YGSLEPNREE AHRVSVRKQK LQQLEDEFYT FVNLLDVARA LRLPEEVVDF
460 470 480 490 500
LYQYWKLKRK INFNKPLITP KKDEEDNLAK REQDVLFRRL QLFTHLRQDL
510 520 530 540 550
ERVRNLTYMV TRREKIKRSV CKVQEQIFTQ YTKLLEQEKV SGVPSSCSSA
560 570 580 590 600
LENMLFFNSP SVGPNAPKIE DLKWHSAFFR KQMGTSLVHP LKKSHKRDAV
610 620 630 640 650
QNSSGTEGKT SHKQPGLCGR REGLEVSESL LSLEKTFAEA RLLSSAQQKN
660 670 680 690 700
GVVTPDHGKR RDNRFHCDLV KGDLKDKSFK QSHKPLRSTD TSQRHLDNTR
710 720 730 740 750
AATSPGVGQS APGTRKEIVP KCNGSLVKVP ITPASPVKSW GGFRIPKKGE
760 770 780 790 800
RQQQGEAHDG ACHQHSDCSH LGVSRAPAKE RAKSRLRADS ENDGYAPDGE
810 820 830
MSDSESEASE KKCIHASSTI SRRTDIIRRS ILAS
Length:834
Mass (Da):93,897
Last modified:October 17, 2006 - v2
Checksum:i43388FC7103D97D6
GO
Isoform 2 (identifier: Q6ZPI0-2) [UniParc]FASTAAdd to basket
Also known as: Jade1S

The sequence of this isoform differs from the canonical sequence as follows:
     504-510: RNLTYMV → MIDTDTL
     511-834: Missing.

Show »
Length:510
Mass (Da):58,126
Checksum:i6AB26BB5C624EE82
GO

Sequence cautioni

The sequence AAH26471 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98255 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190A → D in BAC33688 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021048504 – 510RNLTYMV → MIDTDTL in isoform 2. Curated7
Alternative sequenceiVSP_021049511 – 834Missing in isoform 2. CuratedAdd BLAST324

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129445 mRNA. Translation: BAC98255.1. Different initiation.
AK049332 mRNA. Translation: BAC33688.1.
AK147466 mRNA. Translation: BAE27932.1.
BC020316 mRNA. Translation: AAH20316.1.
BC026471 mRNA. Translation: AAH26471.1. Different initiation.
BN000282 mRNA. Translation: CAE30497.1.
BN000281 mRNA. Translation: CAE30496.1.
CCDSiCCDS17331.1. [Q6ZPI0-1]
RefSeqiNP_001123656.1. NM_001130184.1. [Q6ZPI0-1]
NP_001123657.1. NM_001130185.1. [Q6ZPI0-1]
NP_001123658.1. NM_001130186.1. [Q6ZPI0-1]
NP_758507.3. NM_172303.4. [Q6ZPI0-1]
UniGeneiMm.286285.

Genome annotation databases

EnsembliENSMUST00000026865; ENSMUSP00000026865; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000163764; ENSMUSP00000128152; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000168086; ENSMUSP00000131441; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000170711; ENSMUSP00000127113; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000191952; ENSMUSP00000141499; ENSMUSG00000025764. [Q6ZPI0-2]
GeneIDi269424.
KEGGimmu:269424.
UCSCiuc008pcj.2. mouse. [Q6ZPI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129445 mRNA. Translation: BAC98255.1. Different initiation.
AK049332 mRNA. Translation: BAC33688.1.
AK147466 mRNA. Translation: BAE27932.1.
BC020316 mRNA. Translation: AAH20316.1.
BC026471 mRNA. Translation: AAH26471.1. Different initiation.
BN000282 mRNA. Translation: CAE30497.1.
BN000281 mRNA. Translation: CAE30496.1.
CCDSiCCDS17331.1. [Q6ZPI0-1]
RefSeqiNP_001123656.1. NM_001130184.1. [Q6ZPI0-1]
NP_001123657.1. NM_001130185.1. [Q6ZPI0-1]
NP_001123658.1. NM_001130186.1. [Q6ZPI0-1]
NP_758507.3. NM_172303.4. [Q6ZPI0-1]
UniGeneiMm.286285.

3D structure databases

ProteinModelPortaliQ6ZPI0.
SMRiQ6ZPI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234652. 6 interactors.
IntActiQ6ZPI0. 1 interactor.
STRINGi10090.ENSMUSP00000026865.

PTM databases

iPTMnetiQ6ZPI0.
PhosphoSitePlusiQ6ZPI0.

Proteomic databases

PaxDbiQ6ZPI0.
PeptideAtlasiQ6ZPI0.
PRIDEiQ6ZPI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026865; ENSMUSP00000026865; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000163764; ENSMUSP00000128152; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000168086; ENSMUSP00000131441; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000170711; ENSMUSP00000127113; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000191952; ENSMUSP00000141499; ENSMUSG00000025764. [Q6ZPI0-2]
GeneIDi269424.
KEGGimmu:269424.
UCSCiuc008pcj.2. mouse. [Q6ZPI0-1]

Organism-specific databases

CTDi79960.
MGIiMGI:1925835. Jade1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0954. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000220882.
HOVERGENiHBG053585.
InParanoidiQ6ZPI0.
KOiK11347.
OMAiEAHEGAC.
OrthoDBiEOG091G0T5C.
PhylomeDBiQ6ZPI0.
TreeFamiTF316118.

Enzyme and pathway databases

ReactomeiR-MMU-3214847. HATs acetylate histones.

Miscellaneous databases

PROiQ6ZPI0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025764.
CleanExiMM_PHF17.
ExpressionAtlasiQ6ZPI0. baseline and differential.
GenevisibleiQ6ZPI0. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51805. EPHD. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJADE1_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPI0
Secondary accession number(s): Q6IE84
, Q8C7S6, Q8CFM2, Q8R362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.