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Q6ZPI0

- JADE1_MOUSE

UniProt

Q6ZPI0 - JADE1_MOUSE

Protein

Protein Jade-1

Gene

Jade1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri204 – 25451PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri313 – 37260PHD-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II transcription coactivator activity Source: Ensembl
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. histone H3 acetylation Source: UniProtKB
    3. histone H4-K12 acetylation Source: UniProtKB
    4. histone H4-K5 acetylation Source: UniProtKB
    5. histone H4-K8 acetylation Source: UniProtKB
    6. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_226917. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Jade-1
    Alternative name(s):
    Jade family PHD finger protein 1
    PHD finger protein 17
    Gene namesi
    Name:Jade1
    Synonyms:Kiaa1807, Phf17
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1925835. Jade1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. histone acetyltransferase complex Source: UniProtKB
    2. mitochondrion Source: Ensembl
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice are viable and fertile, and show no visible phenotype.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 834834Protein Jade-1PRO_0000253530Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei90 – 901PhosphoserineBy similarity
    Modified residuei93 – 931PhosphothreonineBy similarity
    Modified residuei603 – 6031PhosphoserineBy similarity
    Modified residuei609 – 6091N6-acetyllysine1 Publication
    Modified residuei735 – 7351PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ6ZPI0.
    PRIDEiQ6ZPI0.

    PTM databases

    PhosphoSiteiQ6ZPI0.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney. Also present in liver (at protein level).1 Publication

    Developmental stagei

    Expressed from E6.5. From E12.5 to E15.5, expressed in the nervous system and developing muscles.1 Publication

    Gene expression databases

    ArrayExpressiQ6ZPI0.
    BgeeiQ6ZPI0.
    CleanExiMM_PHF17.
    GenevestigatoriQ6ZPI0.

    Interactioni

    Subunit structurei

    Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 By similarity. Isoform 2 interacts with VHL and KAT5.By similarity

    Protein-protein interaction databases

    BioGridi234652. 6 interactions.
    IntActiQ6ZPI0. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZPI0.
    SMRiQ6ZPI0. Positions 202-251, 256-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The 2 PHD-type zinc fingers are required for transcriptional activity.By similarity

    Sequence similaritiesi

    Belongs to the JADE family.Curated
    Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri204 – 25451PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri313 – 37260PHD-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5141.
    GeneTreeiENSGT00740000115415.
    HOGENOMiHOG000220882.
    HOVERGENiHBG053585.
    InParanoidiQ6ZPI0.
    KOiK11347.
    OMAiEAHEGAC.
    OrthoDBiEOG738044.
    PhylomeDBiQ6ZPI0.
    TreeFamiTF316118.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR019542. Enhancer_polycomb-like_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF10513. EPL1. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 2 hits.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZPI0-1) [UniParc]FASTAAdd to Basket

    Also known as: Jade1L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKRGRLPSSS EDSDDNGSLS TTWSQHSRSQ HGRSSTCSRP EDRKPSEVFR    50
    TDLITAMKLH DSYQLNPDDY YVLADPWRQE WEKGVQVPVS PGTIPQPVAR 100
    VVSEEKSLMF IRPKKYIASS GSEPPALGYV DIRTLADSVC RYDLNDMDAA 150
    WLEVTNEEFK EMGMPELDEY TMERVLEEFE QRCYDNMNHA IETEEGLGIE 200
    YDEDVVCDVC QSPDGEDGNE MVFCDKCNIC VHQACYGILK VPEGSWLCRT 250
    CALGVQPKCL LCPKKGGAMK PTRSGTKWVH VSCALWIPEV SIGSPEKMEP 300
    ITKVSHIPSS RWALVCSLCN EKFGASIQCS VKNCRTAFHV TCAFDRGLEM 350
    KTILAENDEV KFKSYCPKHS SHRKPEEGLG EGAAQENGAP ESSPQSPLEP 400
    YGSLEPNREE AHRVSVRKQK LQQLEDEFYT FVNLLDVARA LRLPEEVVDF 450
    LYQYWKLKRK INFNKPLITP KKDEEDNLAK REQDVLFRRL QLFTHLRQDL 500
    ERVRNLTYMV TRREKIKRSV CKVQEQIFTQ YTKLLEQEKV SGVPSSCSSA 550
    LENMLFFNSP SVGPNAPKIE DLKWHSAFFR KQMGTSLVHP LKKSHKRDAV 600
    QNSSGTEGKT SHKQPGLCGR REGLEVSESL LSLEKTFAEA RLLSSAQQKN 650
    GVVTPDHGKR RDNRFHCDLV KGDLKDKSFK QSHKPLRSTD TSQRHLDNTR 700
    AATSPGVGQS APGTRKEIVP KCNGSLVKVP ITPASPVKSW GGFRIPKKGE 750
    RQQQGEAHDG ACHQHSDCSH LGVSRAPAKE RAKSRLRADS ENDGYAPDGE 800
    MSDSESEASE KKCIHASSTI SRRTDIIRRS ILAS 834
    Length:834
    Mass (Da):93,897
    Last modified:October 17, 2006 - v2
    Checksum:i43388FC7103D97D6
    GO
    Isoform 2 (identifier: Q6ZPI0-2) [UniParc]FASTAAdd to Basket

    Also known as: Jade1S

    The sequence of this isoform differs from the canonical sequence as follows:
         504-510: RNLTYMV → MIDTDTL
         511-834: Missing.

    Show »
    Length:510
    Mass (Da):58,126
    Checksum:i6AB26BB5C624EE82
    GO

    Sequence cautioni

    The sequence AAH26471.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC98255.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti190 – 1901A → D in BAC33688. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei504 – 5107RNLTYMV → MIDTDTL in isoform 2. CuratedVSP_021048
    Alternative sequencei511 – 834324Missing in isoform 2. CuratedVSP_021049Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129445 mRNA. Translation: BAC98255.1. Different initiation.
    AK049332 mRNA. Translation: BAC33688.1.
    AK147466 mRNA. Translation: BAE27932.1.
    BC020316 mRNA. Translation: AAH20316.1.
    BC026471 mRNA. Translation: AAH26471.1. Different initiation.
    BN000282 mRNA. Translation: CAE30497.1.
    BN000281 mRNA. Translation: CAE30496.1.
    CCDSiCCDS17331.1. [Q6ZPI0-1]
    RefSeqiNP_001123656.1. NM_001130184.1. [Q6ZPI0-1]
    NP_001123657.1. NM_001130185.1. [Q6ZPI0-1]
    NP_001123658.1. NM_001130186.1. [Q6ZPI0-1]
    NP_758507.3. NM_172303.4. [Q6ZPI0-1]
    XP_006500848.1. XM_006500785.1. [Q6ZPI0-1]
    UniGeneiMm.286285.

    Genome annotation databases

    EnsembliENSMUST00000026865; ENSMUSP00000026865; ENSMUSG00000025764. [Q6ZPI0-1]
    ENSMUST00000163764; ENSMUSP00000128152; ENSMUSG00000025764. [Q6ZPI0-1]
    ENSMUST00000168086; ENSMUSP00000131441; ENSMUSG00000025764. [Q6ZPI0-1]
    ENSMUST00000170711; ENSMUSP00000127113; ENSMUSG00000025764. [Q6ZPI0-1]
    GeneIDi269424.
    KEGGimmu:269424.
    UCSCiuc008pcj.2. mouse. [Q6ZPI0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129445 mRNA. Translation: BAC98255.1 . Different initiation.
    AK049332 mRNA. Translation: BAC33688.1 .
    AK147466 mRNA. Translation: BAE27932.1 .
    BC020316 mRNA. Translation: AAH20316.1 .
    BC026471 mRNA. Translation: AAH26471.1 . Different initiation.
    BN000282 mRNA. Translation: CAE30497.1 .
    BN000281 mRNA. Translation: CAE30496.1 .
    CCDSi CCDS17331.1. [Q6ZPI0-1 ]
    RefSeqi NP_001123656.1. NM_001130184.1. [Q6ZPI0-1 ]
    NP_001123657.1. NM_001130185.1. [Q6ZPI0-1 ]
    NP_001123658.1. NM_001130186.1. [Q6ZPI0-1 ]
    NP_758507.3. NM_172303.4. [Q6ZPI0-1 ]
    XP_006500848.1. XM_006500785.1. [Q6ZPI0-1 ]
    UniGenei Mm.286285.

    3D structure databases

    ProteinModelPortali Q6ZPI0.
    SMRi Q6ZPI0. Positions 202-251, 256-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 234652. 6 interactions.
    IntActi Q6ZPI0. 1 interaction.

    PTM databases

    PhosphoSitei Q6ZPI0.

    Proteomic databases

    PaxDbi Q6ZPI0.
    PRIDEi Q6ZPI0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026865 ; ENSMUSP00000026865 ; ENSMUSG00000025764 . [Q6ZPI0-1 ]
    ENSMUST00000163764 ; ENSMUSP00000128152 ; ENSMUSG00000025764 . [Q6ZPI0-1 ]
    ENSMUST00000168086 ; ENSMUSP00000131441 ; ENSMUSG00000025764 . [Q6ZPI0-1 ]
    ENSMUST00000170711 ; ENSMUSP00000127113 ; ENSMUSG00000025764 . [Q6ZPI0-1 ]
    GeneIDi 269424.
    KEGGi mmu:269424.
    UCSCi uc008pcj.2. mouse. [Q6ZPI0-1 ]

    Organism-specific databases

    CTDi 79960.
    MGIi MGI:1925835. Jade1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5141.
    GeneTreei ENSGT00740000115415.
    HOGENOMi HOG000220882.
    HOVERGENi HBG053585.
    InParanoidi Q6ZPI0.
    KOi K11347.
    OMAi EAHEGAC.
    OrthoDBi EOG738044.
    PhylomeDBi Q6ZPI0.
    TreeFami TF316118.

    Enzyme and pathway databases

    Reactomei REACT_226917. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 392846.
    PROi Q6ZPI0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZPI0.
    Bgeei Q6ZPI0.
    CleanExi MM_PHF17.
    Genevestigatori Q6ZPI0.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR019542. Enhancer_polycomb-like_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF10513. EPL1. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Mammary gland.
    4. "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
      Tzouanacou E., Tweedie S., Wilson V.
      Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, ALTERNATIVE SPLICING, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
      Strain: C57BL/6.
    5. "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."
      Zhou M.I., Wang H., Ross J.J., Kuzmin I., Xu C., Cohen H.T.
      J. Biol. Chem. 277:39887-39898(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiJADE1_MOUSE
    AccessioniPrimary (citable) accession number: Q6ZPI0
    Secondary accession number(s): Q6IE84
    , Q8C7S6, Q8CFM2, Q8R362
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3