Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein Jade-1

Gene

Jade1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 254PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri256 – 290C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri314 – 370PHD-type 2PROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processApoptosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Jade-1
Alternative name(s):
Jade family PHD finger protein 1
PHD finger protein 17
Gene namesi
Name:Jade1
Synonyms:Kiaa1807, Phf17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1925835 Jade1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile, and show no visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535301 – 834Protein Jade-1Add BLAST834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineBy similarity1
Modified residuei93PhosphothreonineBy similarity1
Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei603PhosphoserineBy similarity1
Modified residuei609N6-acetyllysineCombined sources1
Modified residuei704PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6ZPI0
PeptideAtlasiQ6ZPI0
PRIDEiQ6ZPI0

PTM databases

iPTMnetiQ6ZPI0
PhosphoSitePlusiQ6ZPI0

Expressioni

Tissue specificityi

Highly expressed in kidney. Also present in liver (at protein level).1 Publication

Developmental stagei

Expressed from E6.5. From E12.5 to E15.5, expressed in the nervous system and developing muscles.1 Publication

Gene expression databases

BgeeiENSMUSG00000025764
CleanExiMM_PHF17
ExpressionAtlasiQ6ZPI0 baseline and differential
GenevisibleiQ6ZPI0 MM

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 2 interacts with VHL and KAT5. Interacts with NPHP4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi234652, 6 interactors
IntActiQ6ZPI0, 1 interactor
STRINGi10090.ENSMUSP00000026865

Structurei

3D structure databases

ProteinModelPortaliQ6ZPI0
SMRiQ6ZPI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The 2 PHD-type zinc fingers are required for transcriptional activity.By similarity

Sequence similaritiesi

Belongs to the JADE family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 254PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri256 – 290C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri314 – 370PHD-type 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0954 Eukaryota
COG5141 LUCA
GeneTreeiENSGT00740000114866
HOGENOMiHOG000220882
HOVERGENiHBG053585
InParanoidiQ6ZPI0
KOiK11347
OMAiEAHEGAC
OrthoDBiEOG091G0T5C
PhylomeDBiQ6ZPI0
TreeFamiTF316118

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF10513 EPL1, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZPI0-1) [UniParc]FASTAAdd to basket
Also known as: Jade1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRGRLPSSS EDSDDNGSLS TTWSQHSRSQ HGRSSTCSRP EDRKPSEVFR
60 70 80 90 100
TDLITAMKLH DSYQLNPDDY YVLADPWRQE WEKGVQVPVS PGTIPQPVAR
110 120 130 140 150
VVSEEKSLMF IRPKKYIASS GSEPPALGYV DIRTLADSVC RYDLNDMDAA
160 170 180 190 200
WLEVTNEEFK EMGMPELDEY TMERVLEEFE QRCYDNMNHA IETEEGLGIE
210 220 230 240 250
YDEDVVCDVC QSPDGEDGNE MVFCDKCNIC VHQACYGILK VPEGSWLCRT
260 270 280 290 300
CALGVQPKCL LCPKKGGAMK PTRSGTKWVH VSCALWIPEV SIGSPEKMEP
310 320 330 340 350
ITKVSHIPSS RWALVCSLCN EKFGASIQCS VKNCRTAFHV TCAFDRGLEM
360 370 380 390 400
KTILAENDEV KFKSYCPKHS SHRKPEEGLG EGAAQENGAP ESSPQSPLEP
410 420 430 440 450
YGSLEPNREE AHRVSVRKQK LQQLEDEFYT FVNLLDVARA LRLPEEVVDF
460 470 480 490 500
LYQYWKLKRK INFNKPLITP KKDEEDNLAK REQDVLFRRL QLFTHLRQDL
510 520 530 540 550
ERVRNLTYMV TRREKIKRSV CKVQEQIFTQ YTKLLEQEKV SGVPSSCSSA
560 570 580 590 600
LENMLFFNSP SVGPNAPKIE DLKWHSAFFR KQMGTSLVHP LKKSHKRDAV
610 620 630 640 650
QNSSGTEGKT SHKQPGLCGR REGLEVSESL LSLEKTFAEA RLLSSAQQKN
660 670 680 690 700
GVVTPDHGKR RDNRFHCDLV KGDLKDKSFK QSHKPLRSTD TSQRHLDNTR
710 720 730 740 750
AATSPGVGQS APGTRKEIVP KCNGSLVKVP ITPASPVKSW GGFRIPKKGE
760 770 780 790 800
RQQQGEAHDG ACHQHSDCSH LGVSRAPAKE RAKSRLRADS ENDGYAPDGE
810 820 830
MSDSESEASE KKCIHASSTI SRRTDIIRRS ILAS
Length:834
Mass (Da):93,897
Last modified:October 17, 2006 - v2
Checksum:i43388FC7103D97D6
GO
Isoform 2 (identifier: Q6ZPI0-2) [UniParc]FASTAAdd to basket
Also known as: Jade1S

The sequence of this isoform differs from the canonical sequence as follows:
     504-510: RNLTYMV → MIDTDTL
     511-834: Missing.

Show »
Length:510
Mass (Da):58,126
Checksum:i6AB26BB5C624EE82
GO

Sequence cautioni

The sequence AAH26471 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98255 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190A → D in BAC33688 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021048504 – 510RNLTYMV → MIDTDTL in isoform 2. Curated7
Alternative sequenceiVSP_021049511 – 834Missing in isoform 2. CuratedAdd BLAST324

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129445 mRNA Translation: BAC98255.1 Different initiation.
AK049332 mRNA Translation: BAC33688.1
AK147466 mRNA Translation: BAE27932.1
BC020316 mRNA Translation: AAH20316.1
BC026471 mRNA Translation: AAH26471.1 Different initiation.
BN000282 mRNA Translation: CAE30497.1
BN000281 mRNA Translation: CAE30496.1
CCDSiCCDS17331.1 [Q6ZPI0-1]
RefSeqiNP_001123656.1, NM_001130184.1 [Q6ZPI0-1]
NP_001123657.1, NM_001130185.1 [Q6ZPI0-1]
NP_001123658.1, NM_001130186.1 [Q6ZPI0-1]
NP_758507.3, NM_172303.4 [Q6ZPI0-1]
UniGeneiMm.286285

Genome annotation databases

EnsembliENSMUST00000026865; ENSMUSP00000026865; ENSMUSG00000025764 [Q6ZPI0-1]
ENSMUST00000163764; ENSMUSP00000128152; ENSMUSG00000025764 [Q6ZPI0-1]
ENSMUST00000168086; ENSMUSP00000131441; ENSMUSG00000025764 [Q6ZPI0-1]
ENSMUST00000170711; ENSMUSP00000127113; ENSMUSG00000025764 [Q6ZPI0-1]
ENSMUST00000191952; ENSMUSP00000141499; ENSMUSG00000025764 [Q6ZPI0-2]
GeneIDi269424
KEGGimmu:269424
UCSCiuc008pcj.2 mouse [Q6ZPI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiJADE1_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPI0
Secondary accession number(s): Q6IE84
, Q8C7S6, Q8CFM2, Q8R362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health