Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6ZPI0 (JADE1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Jade-1
Alternative name(s):
Jade family PHD finger protein 1
PHD finger protein 17
Gene names
Name:Jade1
Synonyms:Kiaa1807, Phf17
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length834 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor By similarity.

Subunit structure

Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 By similarity. Isoform 2 interacts with VHL and KAT5.

Subcellular location

Cytoplasm. Nucleus Ref.4.

Tissue specificity

Highly expressed in kidney. Also present in liver (at protein level). Ref.5

Developmental stage

Expressed from E6.5. From E12.5 to E15.5, expressed in the nervous system and developing muscles. Ref.4

Domain

The 2 PHD-type zinc fingers are required for transcriptional activity By similarity.

Disruption phenotype

Mice are viable and fertile, and show no visible phenotype. Ref.4

Sequence similarities

Belongs to the JADE family.

Contains 2 PHD-type zinc fingers.

Sequence caution

The sequence AAH26471.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC98255.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZPI0-1)

Also known as: Jade1L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZPI0-2)

Also known as: Jade1S;

The sequence of this isoform differs from the canonical sequence as follows:
     504-510: RNLTYMV → MIDTDTL
     511-834: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 834834Protein Jade-1
PRO_0000253530

Regions

Zinc finger204 – 25451PHD-type 1
Zinc finger313 – 37260PHD-type 2; atypical

Amino acid modifications

Modified residue901Phosphoserine By similarity
Modified residue931Phosphothreonine By similarity
Modified residue6031Phosphoserine By similarity
Modified residue6091N6-acetyllysine Ref.6
Modified residue7351Phosphoserine By similarity

Natural variations

Alternative sequence504 – 5107RNLTYMV → MIDTDTL in isoform 2.
VSP_021048
Alternative sequence511 – 834324Missing in isoform 2.
VSP_021049

Experimental info

Sequence conflict1901A → D in BAC33688. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Jade1L) [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 43388FC7103D97D6

FASTA83493,897
        10         20         30         40         50         60 
MKRGRLPSSS EDSDDNGSLS TTWSQHSRSQ HGRSSTCSRP EDRKPSEVFR TDLITAMKLH 

        70         80         90        100        110        120 
DSYQLNPDDY YVLADPWRQE WEKGVQVPVS PGTIPQPVAR VVSEEKSLMF IRPKKYIASS 

       130        140        150        160        170        180 
GSEPPALGYV DIRTLADSVC RYDLNDMDAA WLEVTNEEFK EMGMPELDEY TMERVLEEFE 

       190        200        210        220        230        240 
QRCYDNMNHA IETEEGLGIE YDEDVVCDVC QSPDGEDGNE MVFCDKCNIC VHQACYGILK 

       250        260        270        280        290        300 
VPEGSWLCRT CALGVQPKCL LCPKKGGAMK PTRSGTKWVH VSCALWIPEV SIGSPEKMEP 

       310        320        330        340        350        360 
ITKVSHIPSS RWALVCSLCN EKFGASIQCS VKNCRTAFHV TCAFDRGLEM KTILAENDEV 

       370        380        390        400        410        420 
KFKSYCPKHS SHRKPEEGLG EGAAQENGAP ESSPQSPLEP YGSLEPNREE AHRVSVRKQK 

       430        440        450        460        470        480 
LQQLEDEFYT FVNLLDVARA LRLPEEVVDF LYQYWKLKRK INFNKPLITP KKDEEDNLAK 

       490        500        510        520        530        540 
REQDVLFRRL QLFTHLRQDL ERVRNLTYMV TRREKIKRSV CKVQEQIFTQ YTKLLEQEKV 

       550        560        570        580        590        600 
SGVPSSCSSA LENMLFFNSP SVGPNAPKIE DLKWHSAFFR KQMGTSLVHP LKKSHKRDAV 

       610        620        630        640        650        660 
QNSSGTEGKT SHKQPGLCGR REGLEVSESL LSLEKTFAEA RLLSSAQQKN GVVTPDHGKR 

       670        680        690        700        710        720 
RDNRFHCDLV KGDLKDKSFK QSHKPLRSTD TSQRHLDNTR AATSPGVGQS APGTRKEIVP 

       730        740        750        760        770        780 
KCNGSLVKVP ITPASPVKSW GGFRIPKKGE RQQQGEAHDG ACHQHSDCSH LGVSRAPAKE 

       790        800        810        820        830 
RAKSRLRADS ENDGYAPDGE MSDSESEASE KKCIHASSTI SRRTDIIRRS ILAS 

« Hide

Isoform 2 (Jade1S) [UniParc].

Checksum: 6AB26BB5C624EE82
Show »

FASTA51058,126

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Mammary gland.
[4]"Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
Tzouanacou E., Tweedie S., Wilson V.
Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, ALTERNATIVE SPLICING, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
Strain: C57BL/6.
[5]"The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."
Zhou M.I., Wang H., Ross J.J., Kuzmin I., Xu C., Cohen H.T.
J. Biol. Chem. 277:39887-39898(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK129445 mRNA. Translation: BAC98255.1. Different initiation.
AK049332 mRNA. Translation: BAC33688.1.
AK147466 mRNA. Translation: BAE27932.1.
BC020316 mRNA. Translation: AAH20316.1.
BC026471 mRNA. Translation: AAH26471.1. Different initiation.
BN000282 mRNA. Translation: CAE30497.1.
BN000281 mRNA. Translation: CAE30496.1.
CCDSCCDS17331.1. [Q6ZPI0-1]
RefSeqNP_001123656.1. NM_001130184.1. [Q6ZPI0-1]
NP_001123657.1. NM_001130185.1. [Q6ZPI0-1]
NP_001123658.1. NM_001130186.1. [Q6ZPI0-1]
NP_758507.3. NM_172303.4. [Q6ZPI0-1]
XP_006500848.1. XM_006500785.1. [Q6ZPI0-1]
UniGeneMm.286285.

3D structure databases

ProteinModelPortalQ6ZPI0.
SMRQ6ZPI0. Positions 202-251, 256-370.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid234652. 6 interactions.
IntActQ6ZPI0. 1 interaction.

PTM databases

PhosphoSiteQ6ZPI0.

Proteomic databases

PaxDbQ6ZPI0.
PRIDEQ6ZPI0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026865; ENSMUSP00000026865; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000163764; ENSMUSP00000128152; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000168086; ENSMUSP00000131441; ENSMUSG00000025764. [Q6ZPI0-1]
ENSMUST00000170711; ENSMUSP00000127113; ENSMUSG00000025764. [Q6ZPI0-1]
GeneID269424.
KEGGmmu:269424.
UCSCuc008pcj.2. mouse. [Q6ZPI0-1]

Organism-specific databases

CTD79960.
MGIMGI:1925835. Jade1.
RougeSearch...

Phylogenomic databases

eggNOGCOG5141.
GeneTreeENSGT00740000115415.
HOGENOMHOG000220882.
HOVERGENHBG053585.
InParanoidQ6ZPI0.
KOK11347.
OMAEAHEGAC.
OrthoDBEOG738044.
PhylomeDBQ6ZPI0.
TreeFamTF316118.

Gene expression databases

ArrayExpressQ6ZPI0.
BgeeQ6ZPI0.
CleanExMM_PHF17.
GenevestigatorQ6ZPI0.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF10513. EPL1. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio392846.
PROQ6ZPI0.
SOURCESearch...

Entry information

Entry nameJADE1_MOUSE
AccessionPrimary (citable) accession number: Q6ZPI0
Secondary accession number(s): Q6IE84 expand/collapse secondary AC list , Q8C7S6, Q8CFM2, Q8R362
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot