ID   Q6ZPE7_MOUSE            Unreviewed;       858 AA.
AC   Q6ZPE7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   03-MAY-2023, entry version 94.
DE   SubName: Full=MKIAA3015 protein {ECO:0000313|EMBL:BAC98290.1};
DE   Flags: Fragment;
GN   Name=Nav2 {ECO:0000313|MGI:MGI:2183691};
GN   Synonyms=mKIAA3015 {ECO:0000313|EMBL:BAC98290.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC98290.1};
RN   [1] {ECO:0000313|EMBL:BAC98290.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAC98290.1};
RX   PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:167-180(2003).
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DR   EMBL; AK129480; BAC98290.1; -; mRNA.
DR   RefSeq; NP_001104486.1; NM_001111016.1.
DR   RefSeq; NP_780481.2; NM_175272.3.
DR   AlphaFoldDB; Q6ZPE7; -.
DR   PeptideAtlas; Q6ZPE7; -.
DR   DNASU; 78286; -.
DR   GeneID; 78286; -.
DR   KEGG; mmu:78286; -.
DR   UCSC; uc009hbh.2; mouse.
DR   AGR; MGI:2183691; -.
DR   CTD; 89797; -.
DR   MGI; MGI:2183691; Nav2.
DR   OrthoDB; 4233432at2759; -.
DR   BioGRID-ORCS; 78286; 8 hits in 73 CRISPR screens.
DR   ChiTaRS; Nav2; mouse.
DR   GO; GO:0031012; C:extracellular matrix; IDA:MGI.
DR   GO; GO:0005614; C:interstitial matrix; IDA:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0043138; F:3'-5' DNA helicase activity; ISO:MGI.
DR   GO; GO:0008201; F:heparin binding; IDA:MGI.
DR   GO; GO:0021563; P:glossopharyngeal nerve development; IMP:MGI.
DR   GO; GO:0007626; P:locomotory behavior; IMP:MGI.
DR   GO; GO:0007399; P:nervous system development; ISO:MGI.
DR   GO; GO:0022008; P:neurogenesis; IEA:InterPro.
DR   GO; GO:0021554; P:optic nerve development; IMP:MGI.
DR   GO; GO:0003025; P:regulation of systemic arterial blood pressure by baroreceptor feedback; IMP:MGI.
DR   GO; GO:0007608; P:sensory perception of smell; IMP:MGI.
DR   GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
DR   GO; GO:0021564; P:vagus nerve development; IMP:MGI.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR039041; Nav/unc-53.
DR   PANTHER; PTHR12784:SF6; NEURON NAVIGATOR 2; 1.
DR   PANTHER; PTHR12784; STEERIN; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   PROSITE; PS50021; CH; 1.
DR   Genevisible; Q6ZPE7; MM.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054}.
FT   DOMAIN          1..96
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   REGION          96..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          619..647
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..303
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..376
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..461
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..588
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        619..640
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAC98290.1"
SQ   SEQUENCE   858 AA;  90986 MW;  D7997FDDB543CAE1 CRC64;
     PNPPEIAGAA GADGGGAPVA EEQLSGERVR YPANDKIEDI NGCPKNRSQM IENIDACLNF
     LAAKGINTQG LSAEEIRNGN LKAILGLFFS LSRYKQQQQQ QQQQPEKQPL SSSPLPPAGS
     QVAGAPSQCQ AGTPQHQGLA TPQAPCQLLQ PVSHQQGKTQ VEMQSSASSK DSSQSKIIRF
     TLGQKKISRL PGPTARVAAA GSEAKTRGGS AAANNRRSQS FNNYDKSKPV TSPPPPAPPS
     NHEKEPLASS ASSHPGMSEN VPAPLENSPS VPVNCSSSAI PQPSMTSKPW RSKSLSVKHT
     ATSAMLSVKP AGPEAPRPTP EAMKPAPNNQ KSMLEKLKLF NSKGGSKAGE GSASRDTSCE
     RLEILPSFEE TEELEATANR ALSTVGPASS SPKIALKGIA QRTFSRALTN KKSSPKGNEK
     EKEKQQREKE KEKEKEKGKD LTKRVSVTDR PDLKEETKAD LSGVAVTEMP KKSSKIASFI
     PKGGKLNSTK KEATAPSHSG IPKPGMKNVS AKSPSAPIPP KEGERSRGKL SSGLPPQKAQ
     LDSRHSSSSS SLASSEGKGP GGTSLNPSIS SQTVSGSVGT TQTTGSNTVS VQLPQPQQQY
     NHPNTATVAP FLYRSQTDTE GNVTAESSSA GVSMEPSHYT KSGQPALEEL TEDPEARRLR
     TVKNIADLRQ NLEETMSSLR GTQVTHSTLE TTFDTNVTTE ISGRSILSLT GRPTPLSWRL
     GQSSPRLQAG DAPSMGNGYP PRANASRFIS AEAGRYVYSA PLRRQLASRG SSICHVDVSD
     KADDDVDLEG ISMDAPGYMS DGDVLSKNIR SDDITSGYMT DGGLGLYTRR LNRLPDGMAV
     VRETLQRNTS LGLGDADR
//