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Q6ZPD9

- D19L3_HUMAN

UniProt

Q6ZPD9 - D19L3_HUMAN

Protein

Probable C-mannosyltransferase DPY19L3

Gene

DPY19L3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.By similarity

    GO - Molecular functioni

    1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable C-mannosyltransferase DPY19L3 (EC:2.4.1.-)
    Alternative name(s):
    Dpy-19-like protein 3
    Protein dpy-19 homolog 3
    Gene namesi
    Name:DPY19L3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:27120. DPY19L3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671954.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 716716Probable C-mannosyltransferase DPY19L3PRO_0000311901Add
    BLAST

    Proteomic databases

    MaxQBiQ6ZPD9.
    PaxDbiQ6ZPD9.
    PRIDEiQ6ZPD9.

    PTM databases

    PhosphoSiteiQ6ZPD9.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ6ZPD9.
    BgeeiQ6ZPD9.
    CleanExiHS_DPY19L3.
    GenevestigatoriQ6ZPD9.

    Organism-specific databases

    HPAiHPA008325.

    Interactioni

    Protein-protein interaction databases

    BioGridi127110. 1 interaction.
    IntActiQ6ZPD9. 2 interactions.
    STRINGi9606.ENSP00000344937.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZPD9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei156 – 17419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19517HelicalSequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei461 – 48121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei489 – 50921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei527 – 54721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dpy-19 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG236656.
    HOGENOMiHOG000007319.
    HOVERGENiHBG107792.
    InParanoidiQ6ZPD9.
    OMAiMMLMQAL.
    PhylomeDBiQ6ZPD9.
    TreeFamiTF313376.

    Family and domain databases

    InterProiIPR018732. Dpy-19.
    [Graphical view]
    PfamiPF10034. Dpy19. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZPD9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMSIRQRREI RATEVSEDFP AQEENVKLEN KLPSGCTSRR LWKILSLTIG    50
    GTIALCIGLL TSVYLATLHE NDLWFSNIKE VEREISFRTE CGLYYSYYKQ 100
    MLQAPTLVQG FHGLIYDNKT ESMKTINLLQ RMNIYQEVFL SILYRVLPIQ 150
    KYLEPVYFYI YTLFGLQAIY VTALYITSWL LSGTWLSGLL AAFWYVTNRI 200
    DTTRVEFTIP LRENWALPFF AIQIAAITYF LRPNLQPLSE RLTLLAIFIS 250
    TFLFSLTWQF NQFMMLMQAL VLFTLDSLDM LPAVKATWLY GIQITSLLLV 300
    CILQFFNSMI LGSLLISFNL SVFIARKLQK NLKTGSFLNR LGKLLLHLFM 350
    VLCLTLFLNN IIKKILNLKS DEHIFKFLKA KFGLGATRDF DANLYLCEEA 400
    FGLLPFNTFG RLSDTLLFYA YIFVLSITVI VAFVVAFHNL SDSTNQQSVG 450
    KMEKGTVDLK PETAYNLIHT ILFGFLALST MRMKYLWTSH MCVFASFGLC 500
    SPEIWELLLK SVHLYNPKRI CIMRYSVPIL ILLYLCYKFW PGMMDELSEL 550
    REFYDPDTVE LMNWINSNTP RKAVFAGSMQ LLAGVKLCTG RTLTNHPHYE 600
    DSSLRERTRA VYQIYAKRAP EEVHALLRSF GTDYVILEDS ICYERRHRRG 650
    CRLRDLLDIA NGHMMDGPGE NDPDLKPADH PRFCEEIKRN LPPYVAYFTR 700
    VFQNKTFHVY KLSRNK 716
    Length:716
    Mass (Da):83,197
    Last modified:July 5, 2004 - v1
    Checksum:iEE76B5A54024A8CC
    GO
    Isoform 2 (identifier: Q6ZPD9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         539-542: FWPG → NQKS
         543-716: Missing.

    Show »
    Length:542
    Mass (Da):62,774
    Checksum:iCA1B8E2C37874908
    GO

    Sequence cautioni

    The sequence BAC86508.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti482 – 4821R → G in BAC86676. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti350 – 3501M → V.
    Corresponds to variant rs8105178 [ dbSNP | Ensembl ].
    VAR_037336

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei539 – 5424FWPG → NQKS in isoform 2. 1 PublicationVSP_029634
    Alternative sequencei543 – 716174Missing in isoform 2. 1 PublicationVSP_029635Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK126264 mRNA. Translation: BAC86508.1. Different initiation.
    AK126757 mRNA. Translation: BAC86676.1.
    AK129497 mRNA. Translation: BAC85166.1.
    BC131725 mRNA. Translation: AAI31726.1.
    CR749459 mRNA. Translation: CAH18293.1.
    CCDSiCCDS12422.1. [Q6ZPD9-1]
    RefSeqiNP_001166245.1. NM_001172774.1. [Q6ZPD9-1]
    NP_997208.2. NM_207325.2. [Q6ZPD9-1]
    UniGeneiHs.194392.

    Genome annotation databases

    EnsembliENST00000342179; ENSP00000344937; ENSG00000178904. [Q6ZPD9-1]
    ENST00000392250; ENSP00000376081; ENSG00000178904. [Q6ZPD9-1]
    GeneIDi147991.
    KEGGihsa:147991.
    UCSCiuc002ntg.3. human. [Q6ZPD9-1]

    Polymorphism databases

    DMDMi74710923.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK126264 mRNA. Translation: BAC86508.1 . Different initiation.
    AK126757 mRNA. Translation: BAC86676.1 .
    AK129497 mRNA. Translation: BAC85166.1 .
    BC131725 mRNA. Translation: AAI31726.1 .
    CR749459 mRNA. Translation: CAH18293.1 .
    CCDSi CCDS12422.1. [Q6ZPD9-1 ]
    RefSeqi NP_001166245.1. NM_001172774.1. [Q6ZPD9-1 ]
    NP_997208.2. NM_207325.2. [Q6ZPD9-1 ]
    UniGenei Hs.194392.

    3D structure databases

    ProteinModelPortali Q6ZPD9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127110. 1 interaction.
    IntActi Q6ZPD9. 2 interactions.
    STRINGi 9606.ENSP00000344937.

    PTM databases

    PhosphoSitei Q6ZPD9.

    Polymorphism databases

    DMDMi 74710923.

    Proteomic databases

    MaxQBi Q6ZPD9.
    PaxDbi Q6ZPD9.
    PRIDEi Q6ZPD9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342179 ; ENSP00000344937 ; ENSG00000178904 . [Q6ZPD9-1 ]
    ENST00000392250 ; ENSP00000376081 ; ENSG00000178904 . [Q6ZPD9-1 ]
    GeneIDi 147991.
    KEGGi hsa:147991.
    UCSCi uc002ntg.3. human. [Q6ZPD9-1 ]

    Organism-specific databases

    CTDi 147991.
    GeneCardsi GC19P032897.
    H-InvDB HIX0014990.
    HGNCi HGNC:27120. DPY19L3.
    HPAi HPA008325.
    MIMi 613894. gene.
    neXtProti NX_Q6ZPD9.
    PharmGKBi PA142671954.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG236656.
    HOGENOMi HOG000007319.
    HOVERGENi HBG107792.
    InParanoidi Q6ZPD9.
    OMAi MMLMQAL.
    PhylomeDBi Q6ZPD9.
    TreeFami TF313376.

    Miscellaneous databases

    GenomeRNAii 147991.
    NextBioi 85804.
    PROi Q6ZPD9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZPD9.
    Bgeei Q6ZPD9.
    CleanExi HS_DPY19L3.
    Genevestigatori Q6ZPD9.

    Family and domain databases

    InterProi IPR018732. Dpy-19.
    [Graphical view ]
    Pfami PF10034. Dpy19. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 235-716 (ISOFORM 2).
      Tissue: Brain, Cerebellum and Trachea.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-716 (ISOFORM 1).
      Tissue: Prostate.
    4. "Duplication and relocation of the functional DPY19L2 gene within low copy repeats."
      Carson A.R., Cheung J., Scherer S.W.
      BMC Genomics 7:45-45(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiD19L3_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZPD9
    Secondary accession number(s): Q68DC7, Q6ZTB7, Q6ZTS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3