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Q6ZPD9

- D19L3_HUMAN

UniProt

Q6ZPD9 - D19L3_HUMAN

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Protein

Probable C-mannosyltransferase DPY19L3

Gene

DPY19L3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.By similarity

GO - Molecular functioni

  1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-mannosyltransferase DPY19L3 (EC:2.4.1.-)
Alternative name(s):
Dpy-19-like protein 3
Protein dpy-19 homolog 3
Gene namesi
Name:DPY19L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:27120. DPY19L3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17419HelicalSequence AnalysisAdd
BLAST
Transmembranei179 – 19517HelicalSequence AnalysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence AnalysisAdd
BLAST
Transmembranei489 – 50921HelicalSequence AnalysisAdd
BLAST
Transmembranei527 – 54721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671954.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Probable C-mannosyltransferase DPY19L3PRO_0000311901Add
BLAST

Proteomic databases

MaxQBiQ6ZPD9.
PaxDbiQ6ZPD9.
PRIDEiQ6ZPD9.

PTM databases

PhosphoSiteiQ6ZPD9.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ6ZPD9.
CleanExiHS_DPY19L3.
ExpressionAtlasiQ6ZPD9. baseline and differential.
GenevestigatoriQ6ZPD9.

Organism-specific databases

HPAiHPA008325.

Interactioni

Protein-protein interaction databases

BioGridi127110. 3 interactions.
IntActiQ6ZPD9. 2 interactions.
STRINGi9606.ENSP00000344937.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG236656.
GeneTreeiENSGT00530000063023.
HOGENOMiHOG000007319.
HOVERGENiHBG107792.
InParanoidiQ6ZPD9.
OMAiMMLMQAL.
PhylomeDBiQ6ZPD9.
TreeFamiTF313376.

Family and domain databases

InterProiIPR018732. Dpy-19.
[Graphical view]
PfamiPF10034. Dpy19. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZPD9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSIRQRREI RATEVSEDFP AQEENVKLEN KLPSGCTSRR LWKILSLTIG
60 70 80 90 100
GTIALCIGLL TSVYLATLHE NDLWFSNIKE VEREISFRTE CGLYYSYYKQ
110 120 130 140 150
MLQAPTLVQG FHGLIYDNKT ESMKTINLLQ RMNIYQEVFL SILYRVLPIQ
160 170 180 190 200
KYLEPVYFYI YTLFGLQAIY VTALYITSWL LSGTWLSGLL AAFWYVTNRI
210 220 230 240 250
DTTRVEFTIP LRENWALPFF AIQIAAITYF LRPNLQPLSE RLTLLAIFIS
260 270 280 290 300
TFLFSLTWQF NQFMMLMQAL VLFTLDSLDM LPAVKATWLY GIQITSLLLV
310 320 330 340 350
CILQFFNSMI LGSLLISFNL SVFIARKLQK NLKTGSFLNR LGKLLLHLFM
360 370 380 390 400
VLCLTLFLNN IIKKILNLKS DEHIFKFLKA KFGLGATRDF DANLYLCEEA
410 420 430 440 450
FGLLPFNTFG RLSDTLLFYA YIFVLSITVI VAFVVAFHNL SDSTNQQSVG
460 470 480 490 500
KMEKGTVDLK PETAYNLIHT ILFGFLALST MRMKYLWTSH MCVFASFGLC
510 520 530 540 550
SPEIWELLLK SVHLYNPKRI CIMRYSVPIL ILLYLCYKFW PGMMDELSEL
560 570 580 590 600
REFYDPDTVE LMNWINSNTP RKAVFAGSMQ LLAGVKLCTG RTLTNHPHYE
610 620 630 640 650
DSSLRERTRA VYQIYAKRAP EEVHALLRSF GTDYVILEDS ICYERRHRRG
660 670 680 690 700
CRLRDLLDIA NGHMMDGPGE NDPDLKPADH PRFCEEIKRN LPPYVAYFTR
710
VFQNKTFHVY KLSRNK
Length:716
Mass (Da):83,197
Last modified:July 5, 2004 - v1
Checksum:iEE76B5A54024A8CC
GO
Isoform 2 (identifier: Q6ZPD9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-542: FWPG → NQKS
     543-716: Missing.

Show »
Length:542
Mass (Da):62,774
Checksum:iCA1B8E2C37874908
GO

Sequence cautioni

The sequence BAC86508.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti482 – 4821R → G in BAC86676. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti350 – 3501M → V.
Corresponds to variant rs8105178 [ dbSNP | Ensembl ].
VAR_037336

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei539 – 5424FWPG → NQKS in isoform 2. 1 PublicationVSP_029634
Alternative sequencei543 – 716174Missing in isoform 2. 1 PublicationVSP_029635Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126264 mRNA. Translation: BAC86508.1. Different initiation.
AK126757 mRNA. Translation: BAC86676.1.
AK129497 mRNA. Translation: BAC85166.1.
BC131725 mRNA. Translation: AAI31726.1.
CR749459 mRNA. Translation: CAH18293.1.
CCDSiCCDS12422.1. [Q6ZPD9-1]
RefSeqiNP_001166245.1. NM_001172774.1. [Q6ZPD9-1]
NP_997208.2. NM_207325.2. [Q6ZPD9-1]
UniGeneiHs.194392.

Genome annotation databases

EnsembliENST00000342179; ENSP00000344937; ENSG00000178904. [Q6ZPD9-1]
ENST00000392250; ENSP00000376081; ENSG00000178904. [Q6ZPD9-1]
GeneIDi147991.
KEGGihsa:147991.
UCSCiuc002ntg.3. human. [Q6ZPD9-1]

Polymorphism databases

DMDMi74710923.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126264 mRNA. Translation: BAC86508.1 . Different initiation.
AK126757 mRNA. Translation: BAC86676.1 .
AK129497 mRNA. Translation: BAC85166.1 .
BC131725 mRNA. Translation: AAI31726.1 .
CR749459 mRNA. Translation: CAH18293.1 .
CCDSi CCDS12422.1. [Q6ZPD9-1 ]
RefSeqi NP_001166245.1. NM_001172774.1. [Q6ZPD9-1 ]
NP_997208.2. NM_207325.2. [Q6ZPD9-1 ]
UniGenei Hs.194392.

3D structure databases

ProteinModelPortali Q6ZPD9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127110. 3 interactions.
IntActi Q6ZPD9. 2 interactions.
STRINGi 9606.ENSP00000344937.

PTM databases

PhosphoSitei Q6ZPD9.

Polymorphism databases

DMDMi 74710923.

Proteomic databases

MaxQBi Q6ZPD9.
PaxDbi Q6ZPD9.
PRIDEi Q6ZPD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342179 ; ENSP00000344937 ; ENSG00000178904 . [Q6ZPD9-1 ]
ENST00000392250 ; ENSP00000376081 ; ENSG00000178904 . [Q6ZPD9-1 ]
GeneIDi 147991.
KEGGi hsa:147991.
UCSCi uc002ntg.3. human. [Q6ZPD9-1 ]

Organism-specific databases

CTDi 147991.
GeneCardsi GC19P032897.
H-InvDB HIX0014990.
HGNCi HGNC:27120. DPY19L3.
HPAi HPA008325.
MIMi 613894. gene.
neXtProti NX_Q6ZPD9.
PharmGKBi PA142671954.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236656.
GeneTreei ENSGT00530000063023.
HOGENOMi HOG000007319.
HOVERGENi HBG107792.
InParanoidi Q6ZPD9.
OMAi MMLMQAL.
PhylomeDBi Q6ZPD9.
TreeFami TF313376.

Miscellaneous databases

GenomeRNAii 147991.
NextBioi 85804.
PROi Q6ZPD9.
SOURCEi Search...

Gene expression databases

Bgeei Q6ZPD9.
CleanExi HS_DPY19L3.
ExpressionAtlasi Q6ZPD9. baseline and differential.
Genevestigatori Q6ZPD9.

Family and domain databases

InterProi IPR018732. Dpy-19.
[Graphical view ]
Pfami PF10034. Dpy19. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 235-716 (ISOFORM 2).
    Tissue: Brain, Cerebellum and Trachea.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-716 (ISOFORM 1).
    Tissue: Prostate.
  4. "Duplication and relocation of the functional DPY19L2 gene within low copy repeats."
    Carson A.R., Cheung J., Scherer S.W.
    BMC Genomics 7:45-45(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiD19L3_HUMAN
AccessioniPrimary (citable) accession number: Q6ZPD9
Secondary accession number(s): Q68DC7, Q6ZTB7, Q6ZTS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3