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Q6ZPD9 (D19L3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable C-mannosyltransferase DPY19L3

EC=2.4.1.-
Alternative name(s):
Dpy-19-like protein 3
Protein dpy-19 homolog 3
Gene names
Name:DPY19L3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length716 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Widely expressed. Ref.4

Sequence similarities

Belongs to the dpy-19 family.

Sequence caution

The sequence BAC86508.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransferase activity, transferring glycosyl groups

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZPD9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZPD9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     539-542: FWPG → NQKS
     543-716: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 716716Probable C-mannosyltransferase DPY19L3
PRO_0000311901

Regions

Transmembrane44 – 6421Helical; Potential
Transmembrane156 – 17419Helical; Potential
Transmembrane179 – 19517Helical; Potential
Transmembrane215 – 23521Helical; Potential
Transmembrane244 – 26421Helical; Potential
Transmembrane269 – 28921Helical; Potential
Transmembrane298 – 31821Helical; Potential
Transmembrane342 – 36221Helical; Potential
Transmembrane417 – 43721Helical; Potential
Transmembrane461 – 48121Helical; Potential
Transmembrane489 – 50921Helical; Potential
Transmembrane527 – 54721Helical; Potential

Natural variations

Alternative sequence539 – 5424FWPG → NQKS in isoform 2.
VSP_029634
Alternative sequence543 – 716174Missing in isoform 2.
VSP_029635
Natural variant3501M → V.
Corresponds to variant rs8105178 [ dbSNP | Ensembl ].
VAR_037336

Experimental info

Sequence conflict4821R → G in BAC86676. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: EE76B5A54024A8CC

FASTA71683,197
        10         20         30         40         50         60 
MMSIRQRREI RATEVSEDFP AQEENVKLEN KLPSGCTSRR LWKILSLTIG GTIALCIGLL 

        70         80         90        100        110        120 
TSVYLATLHE NDLWFSNIKE VEREISFRTE CGLYYSYYKQ MLQAPTLVQG FHGLIYDNKT 

       130        140        150        160        170        180 
ESMKTINLLQ RMNIYQEVFL SILYRVLPIQ KYLEPVYFYI YTLFGLQAIY VTALYITSWL 

       190        200        210        220        230        240 
LSGTWLSGLL AAFWYVTNRI DTTRVEFTIP LRENWALPFF AIQIAAITYF LRPNLQPLSE 

       250        260        270        280        290        300 
RLTLLAIFIS TFLFSLTWQF NQFMMLMQAL VLFTLDSLDM LPAVKATWLY GIQITSLLLV 

       310        320        330        340        350        360 
CILQFFNSMI LGSLLISFNL SVFIARKLQK NLKTGSFLNR LGKLLLHLFM VLCLTLFLNN 

       370        380        390        400        410        420 
IIKKILNLKS DEHIFKFLKA KFGLGATRDF DANLYLCEEA FGLLPFNTFG RLSDTLLFYA 

       430        440        450        460        470        480 
YIFVLSITVI VAFVVAFHNL SDSTNQQSVG KMEKGTVDLK PETAYNLIHT ILFGFLALST 

       490        500        510        520        530        540 
MRMKYLWTSH MCVFASFGLC SPEIWELLLK SVHLYNPKRI CIMRYSVPIL ILLYLCYKFW 

       550        560        570        580        590        600 
PGMMDELSEL REFYDPDTVE LMNWINSNTP RKAVFAGSMQ LLAGVKLCTG RTLTNHPHYE 

       610        620        630        640        650        660 
DSSLRERTRA VYQIYAKRAP EEVHALLRSF GTDYVILEDS ICYERRHRRG CRLRDLLDIA 

       670        680        690        700        710 
NGHMMDGPGE NDPDLKPADH PRFCEEIKRN LPPYVAYFTR VFQNKTFHVY KLSRNK 

« Hide

Isoform 2 [UniParc].

Checksum: CA1B8E2C37874908
Show »

FASTA54262,774

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 235-716 (ISOFORM 2).
Tissue: Brain, Cerebellum and Trachea.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-716 (ISOFORM 1).
Tissue: Prostate.
[4]"Duplication and relocation of the functional DPY19L2 gene within low copy repeats."
Carson A.R., Cheung J., Scherer S.W.
BMC Genomics 7:45-45(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK126264 mRNA. Translation: BAC86508.1. Different initiation.
AK126757 mRNA. Translation: BAC86676.1.
AK129497 mRNA. Translation: BAC85166.1.
BC131725 mRNA. Translation: AAI31726.1.
CR749459 mRNA. Translation: CAH18293.1.
RefSeqNP_001166245.1. NM_001172774.1.
NP_997208.2. NM_207325.2.
UniGeneHs.194392.

3D structure databases

ProteinModelPortalQ6ZPD9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127110. 1 interaction.
IntActQ6ZPD9. 2 interactions.
STRING9606.ENSP00000344937.

PTM databases

PhosphoSiteQ6ZPD9.

Polymorphism databases

DMDM74710923.

Proteomic databases

PaxDbQ6ZPD9.
PRIDEQ6ZPD9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342179; ENSP00000344937; ENSG00000178904. [Q6ZPD9-1]
ENST00000392250; ENSP00000376081; ENSG00000178904. [Q6ZPD9-1]
GeneID147991.
KEGGhsa:147991.
UCSCuc002ntg.3. human. [Q6ZPD9-1]

Organism-specific databases

CTD147991.
GeneCardsGC19P032897.
H-InvDBHIX0014990.
HGNCHGNC:27120. DPY19L3.
HPAHPA008325.
MIM613894. gene.
neXtProtNX_Q6ZPD9.
PharmGKBPA142671954.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG236656.
HOGENOMHOG000007319.
HOVERGENHBG107792.
InParanoidQ6ZPD9.
OMAMMLMQAL.
PhylomeDBQ6ZPD9.
TreeFamTF313376.

Gene expression databases

ArrayExpressQ6ZPD9.
BgeeQ6ZPD9.
CleanExHS_DPY19L3.
GenevestigatorQ6ZPD9.

Family and domain databases

InterProIPR018732. Dpy-19.
[Graphical view]
PfamPF10034. Dpy19. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi147991.
NextBio85804.
PROQ6ZPD9.
SOURCESearch...

Entry information

Entry nameD19L3_HUMAN
AccessionPrimary (citable) accession number: Q6ZPD9
Secondary accession number(s): Q68DC7, Q6ZTB7, Q6ZTS2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM