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Protein

Probable C-mannosyltransferase DPY19L3

Gene

DPY19L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-mannosyltransferase DPY19L3 (EC:2.4.1.-)
Alternative name(s):
Dpy-19-like protein 3
Protein dpy-19 homolog 3
Gene namesi
Name:DPY19L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:27120. DPY19L3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17419HelicalSequence AnalysisAdd
BLAST
Transmembranei179 – 19517HelicalSequence AnalysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence AnalysisAdd
BLAST
Transmembranei489 – 50921HelicalSequence AnalysisAdd
BLAST
Transmembranei527 – 54721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671954.

Polymorphism and mutation databases

BioMutaiDPY19L3.
DMDMi74710923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Probable C-mannosyltransferase DPY19L3PRO_0000311901Add
BLAST

Proteomic databases

MaxQBiQ6ZPD9.
PaxDbiQ6ZPD9.
PRIDEiQ6ZPD9.

PTM databases

PhosphoSiteiQ6ZPD9.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ6ZPD9.
CleanExiHS_DPY19L3.
ExpressionAtlasiQ6ZPD9. baseline and differential.
GenevisibleiQ6ZPD9. HS.

Organism-specific databases

HPAiHPA008325.

Interactioni

Protein-protein interaction databases

BioGridi127110. 5 interactions.
IntActiQ6ZPD9. 2 interactions.
STRINGi9606.ENSP00000344937.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG236656.
GeneTreeiENSGT00530000063023.
HOGENOMiHOG000007319.
HOVERGENiHBG107792.
InParanoidiQ6ZPD9.
OMAiMMLMQAL.
PhylomeDBiQ6ZPD9.
TreeFamiTF313376.

Family and domain databases

InterProiIPR018732. Dpy-19/Dpy-19-like.
IPR030039. DPY19L3.
[Graphical view]
PANTHERiPTHR31488. PTHR31488. 1 hit.
PTHR31488:SF4. PTHR31488:SF4. 1 hit.
PfamiPF10034. Dpy19. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZPD9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSIRQRREI RATEVSEDFP AQEENVKLEN KLPSGCTSRR LWKILSLTIG
60 70 80 90 100
GTIALCIGLL TSVYLATLHE NDLWFSNIKE VEREISFRTE CGLYYSYYKQ
110 120 130 140 150
MLQAPTLVQG FHGLIYDNKT ESMKTINLLQ RMNIYQEVFL SILYRVLPIQ
160 170 180 190 200
KYLEPVYFYI YTLFGLQAIY VTALYITSWL LSGTWLSGLL AAFWYVTNRI
210 220 230 240 250
DTTRVEFTIP LRENWALPFF AIQIAAITYF LRPNLQPLSE RLTLLAIFIS
260 270 280 290 300
TFLFSLTWQF NQFMMLMQAL VLFTLDSLDM LPAVKATWLY GIQITSLLLV
310 320 330 340 350
CILQFFNSMI LGSLLISFNL SVFIARKLQK NLKTGSFLNR LGKLLLHLFM
360 370 380 390 400
VLCLTLFLNN IIKKILNLKS DEHIFKFLKA KFGLGATRDF DANLYLCEEA
410 420 430 440 450
FGLLPFNTFG RLSDTLLFYA YIFVLSITVI VAFVVAFHNL SDSTNQQSVG
460 470 480 490 500
KMEKGTVDLK PETAYNLIHT ILFGFLALST MRMKYLWTSH MCVFASFGLC
510 520 530 540 550
SPEIWELLLK SVHLYNPKRI CIMRYSVPIL ILLYLCYKFW PGMMDELSEL
560 570 580 590 600
REFYDPDTVE LMNWINSNTP RKAVFAGSMQ LLAGVKLCTG RTLTNHPHYE
610 620 630 640 650
DSSLRERTRA VYQIYAKRAP EEVHALLRSF GTDYVILEDS ICYERRHRRG
660 670 680 690 700
CRLRDLLDIA NGHMMDGPGE NDPDLKPADH PRFCEEIKRN LPPYVAYFTR
710
VFQNKTFHVY KLSRNK
Length:716
Mass (Da):83,197
Last modified:July 5, 2004 - v1
Checksum:iEE76B5A54024A8CC
GO
Isoform 2 (identifier: Q6ZPD9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-542: FWPG → NQKS
     543-716: Missing.

Show »
Length:542
Mass (Da):62,774
Checksum:iCA1B8E2C37874908
GO

Sequence cautioni

The sequence BAC86508.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti482 – 4821R → G in BAC86676 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti350 – 3501M → V.
Corresponds to variant rs8105178 [ dbSNP | Ensembl ].
VAR_037336

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei539 – 5424FWPG → NQKS in isoform 2. 1 PublicationVSP_029634
Alternative sequencei543 – 716174Missing in isoform 2. 1 PublicationVSP_029635Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126264 mRNA. Translation: BAC86508.1. Different initiation.
AK126757 mRNA. Translation: BAC86676.1.
AK129497 mRNA. Translation: BAC85166.1.
BC131725 mRNA. Translation: AAI31726.1.
CR749459 mRNA. Translation: CAH18293.1.
CCDSiCCDS12422.1. [Q6ZPD9-1]
RefSeqiNP_001166245.1. NM_001172774.1. [Q6ZPD9-1]
NP_997208.2. NM_207325.2. [Q6ZPD9-1]
XP_011524828.1. XM_011526526.1. [Q6ZPD9-1]
UniGeneiHs.194392.

Genome annotation databases

EnsembliENST00000342179; ENSP00000344937; ENSG00000178904.
ENST00000392250; ENSP00000376081; ENSG00000178904.
GeneIDi147991.
KEGGihsa:147991.
UCSCiuc002ntg.3. human. [Q6ZPD9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126264 mRNA. Translation: BAC86508.1. Different initiation.
AK126757 mRNA. Translation: BAC86676.1.
AK129497 mRNA. Translation: BAC85166.1.
BC131725 mRNA. Translation: AAI31726.1.
CR749459 mRNA. Translation: CAH18293.1.
CCDSiCCDS12422.1. [Q6ZPD9-1]
RefSeqiNP_001166245.1. NM_001172774.1. [Q6ZPD9-1]
NP_997208.2. NM_207325.2. [Q6ZPD9-1]
XP_011524828.1. XM_011526526.1. [Q6ZPD9-1]
UniGeneiHs.194392.

3D structure databases

ProteinModelPortaliQ6ZPD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127110. 5 interactions.
IntActiQ6ZPD9. 2 interactions.
STRINGi9606.ENSP00000344937.

PTM databases

PhosphoSiteiQ6ZPD9.

Polymorphism and mutation databases

BioMutaiDPY19L3.
DMDMi74710923.

Proteomic databases

MaxQBiQ6ZPD9.
PaxDbiQ6ZPD9.
PRIDEiQ6ZPD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342179; ENSP00000344937; ENSG00000178904.
ENST00000392250; ENSP00000376081; ENSG00000178904.
GeneIDi147991.
KEGGihsa:147991.
UCSCiuc002ntg.3. human. [Q6ZPD9-1]

Organism-specific databases

CTDi147991.
GeneCardsiGC19P032897.
H-InvDBHIX0014990.
HGNCiHGNC:27120. DPY19L3.
HPAiHPA008325.
MIMi613894. gene.
neXtProtiNX_Q6ZPD9.
PharmGKBiPA142671954.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG236656.
GeneTreeiENSGT00530000063023.
HOGENOMiHOG000007319.
HOVERGENiHBG107792.
InParanoidiQ6ZPD9.
OMAiMMLMQAL.
PhylomeDBiQ6ZPD9.
TreeFamiTF313376.

Miscellaneous databases

GenomeRNAii147991.
NextBioi85804.
PROiQ6ZPD9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZPD9.
CleanExiHS_DPY19L3.
ExpressionAtlasiQ6ZPD9. baseline and differential.
GenevisibleiQ6ZPD9. HS.

Family and domain databases

InterProiIPR018732. Dpy-19/Dpy-19-like.
IPR030039. DPY19L3.
[Graphical view]
PANTHERiPTHR31488. PTHR31488. 1 hit.
PTHR31488:SF4. PTHR31488:SF4. 1 hit.
PfamiPF10034. Dpy19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 235-716 (ISOFORM 2).
    Tissue: Brain, Cerebellum and Trachea.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-716 (ISOFORM 1).
    Tissue: Prostate.
  4. "Duplication and relocation of the functional DPY19L2 gene within low copy repeats."
    Carson A.R., Cheung J., Scherer S.W.
    BMC Genomics 7:45-45(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiD19L3_HUMAN
AccessioniPrimary (citable) accession number: Q6ZPD9
Secondary accession number(s): Q68DC7, Q6ZTB7, Q6ZTS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.