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Q6ZPD8

- DG2L6_HUMAN

UniProt

Q6ZPD8 - DG2L6_HUMAN

Protein

Diacylglycerol O-acyltransferase 2-like protein 6

Gene

DGAT2L6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Probable acyltransferase uses fatty acyl-CoA as substrate By similarity. Has no wax synthase activity to produce wax esters.By similarity

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups other than amino-acyl groups Source: InterPro

    GO - Biological processi

    1. lipid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BRENDAi2.3.1.20. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol O-acyltransferase 2-like protein 6 (EC:2.3.1.-)
    Alternative name(s):
    Diacylglycerol O-acyltransferase candidate 3
    Short name:
    hDC3
    Gene namesi
    Name:DGAT2L6
    Synonyms:DC3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:23250. DGAT2L6.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485448.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Diacylglycerol O-acyltransferase 2-like protein 6PRO_0000249054Add
    BLAST

    Proteomic databases

    PRIDEiQ6ZPD8.

    Expressioni

    Tissue specificityi

    Expressed in all tissues tested except pancreas.1 Publication

    Gene expression databases

    BgeeiQ6ZPD8.
    CleanExiHS_DGAT2L6.
    GenevestigatoriQ6ZPD8.

    Organism-specific databases

    HPAiHPA021530.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000328036.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZPD8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG302620.
    HOGENOMiHOG000179738.
    HOVERGENiHBG065791.
    InParanoidiQ6ZPD8.
    KOiK11172.
    OMAiREYVMSM.
    OrthoDBiEOG7KH9KB.
    PhylomeDBiQ6ZPD8.
    TreeFamiTF314707.

    Family and domain databases

    InterProiIPR007130. DAGAT.
    [Graphical view]
    PANTHERiPTHR12317. PTHR12317. 1 hit.
    PfamiPF03982. DAGAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZPD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFFSRLNLQ EGLQTFFVLQ WIPVYIFLGA IPILLIPYFL LFSKFWPLAV    50
    LSLAWLTYDW NTHSQGGRRS AWVRNWTLWK YFRNYFPVKL VKTHDLSPKH 100
    NYIIANHPHG ILSFGVFINF ATEATGIARI FPSITPFVGT LERIFWIPIV 150
    REYVMSMGVC PVSSSALKYL LTQKGSGNAV VIVVGGAAEA LLCRPGASTL 200
    FLKQRKGFVK MALQTGAYLV PSYSFGENEV FNQETFPEGT WLRLFQKTFQ 250
    DTFKKILGLN FCTFHGRGFT RGSWGFLPFN RPITTVVGEP LPIPRIKRPN 300
    QKTVDKYHAL YISALRKLFD QHKVEYGLPE TQELTIT 337
    Length:337
    Mass (Da):38,593
    Last modified:July 5, 2004 - v1
    Checksum:iE14B50FBD01981E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129500 mRNA. Translation: BAC85167.1.
    AL139111, AL357752 Genomic DNA. Translation: CAI41588.1.
    AL357752, AL139111 Genomic DNA. Translation: CAI41486.1.
    BN000157 mRNA. Translation: CAD89268.1.
    CCDSiCCDS14397.1.
    RefSeqiNP_940914.1. NM_198512.1.
    UniGeneiHs.454355.

    Genome annotation databases

    EnsembliENST00000333026; ENSP00000328036; ENSG00000184210.
    GeneIDi347516.
    KEGGihsa:347516.
    UCSCiuc004dxx.1. human.

    Polymorphism databases

    DMDMi74749597.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129500 mRNA. Translation: BAC85167.1 .
    AL139111 , AL357752 Genomic DNA. Translation: CAI41588.1 .
    AL357752 , AL139111 Genomic DNA. Translation: CAI41486.1 .
    BN000157 mRNA. Translation: CAD89268.1 .
    CCDSi CCDS14397.1.
    RefSeqi NP_940914.1. NM_198512.1.
    UniGenei Hs.454355.

    3D structure databases

    ProteinModelPortali Q6ZPD8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000328036.

    Polymorphism databases

    DMDMi 74749597.

    Proteomic databases

    PRIDEi Q6ZPD8.

    Protocols and materials databases

    DNASUi 347516.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333026 ; ENSP00000328036 ; ENSG00000184210 .
    GeneIDi 347516.
    KEGGi hsa:347516.
    UCSCi uc004dxx.1. human.

    Organism-specific databases

    CTDi 347516.
    GeneCardsi GC0XP069397.
    HGNCi HGNC:23250. DGAT2L6.
    HPAi HPA021530.
    MIMi 300926. gene.
    neXtProti NX_Q6ZPD8.
    PharmGKBi PA143485448.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302620.
    HOGENOMi HOG000179738.
    HOVERGENi HBG065791.
    InParanoidi Q6ZPD8.
    KOi K11172.
    OMAi REYVMSM.
    OrthoDBi EOG7KH9KB.
    PhylomeDBi Q6ZPD8.
    TreeFami TF314707.

    Enzyme and pathway databases

    BRENDAi 2.3.1.20. 2681.

    Miscellaneous databases

    GenomeRNAii 347516.
    NextBioi 99169.
    PROi Q6ZPD8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZPD8.
    CleanExi HS_DGAT2L6.
    Genevestigatori Q6ZPD8.

    Family and domain databases

    InterProi IPR007130. DAGAT.
    [Graphical view ]
    PANTHERi PTHR12317. PTHR12317. 1 hit.
    Pfami PF03982. DAGAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Dermoid cancer.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals."
      Winter A., van Eckeveld M., Bininda-Emonds O.R.P., Habermann F.A., Fries R.
      Cytogenet. Genome Res. 102:42-47(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. "Identification of two novel human Acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily."
      Turkish A.R., Henneberry A.L., Cromley D., Padamsee M., Oelkers P., Bazzi H., Christiano A.M., Billheimer J.T., Sturley S.L.
      J. Biol. Chem. 280:14755-14764(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF WAX SYNTHASE ACTIVITY, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiDG2L6_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZPD8
    Secondary accession number(s): Q6IEE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3