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Protein

Diacylglycerol O-acyltransferase 2-like protein 6

Gene

DGAT2L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity). Has no wax synthase activity to produce wax esters.By similarity

GO - Molecular functioni

  1. transferase activity, transferring acyl groups other than amino-acyl groups Source: InterPro

GO - Biological processi

  1. lipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.20. 2681.
2.3.1.75. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol O-acyltransferase 2-like protein 6 (EC:2.3.1.-)
Alternative name(s):
Diacylglycerol O-acyltransferase candidate 3
Short name:
hDC3
Gene namesi
Name:DGAT2L6
Synonyms:DC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:23250. DGAT2L6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485448.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Diacylglycerol O-acyltransferase 2-like protein 6PRO_0000249054Add
BLAST

Proteomic databases

PRIDEiQ6ZPD8.

Expressioni

Tissue specificityi

Expressed in all tissues tested except pancreas.1 Publication

Gene expression databases

BgeeiQ6ZPD8.
CleanExiHS_DGAT2L6.
GenevestigatoriQ6ZPD8.

Organism-specific databases

HPAiHPA021530.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328036.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302620.
GeneTreeiENSGT00750000117391.
HOGENOMiHOG000179738.
HOVERGENiHBG065791.
InParanoidiQ6ZPD8.
KOiK11172.
OMAiWRTIMVI.
OrthoDBiEOG7KH9KB.
PhylomeDBiQ6ZPD8.
TreeFamiTF314707.

Family and domain databases

InterProiIPR007130. DAGAT.
[Graphical view]
PANTHERiPTHR12317. PTHR12317. 1 hit.
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZPD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFFSRLNLQ EGLQTFFVLQ WIPVYIFLGA IPILLIPYFL LFSKFWPLAV
60 70 80 90 100
LSLAWLTYDW NTHSQGGRRS AWVRNWTLWK YFRNYFPVKL VKTHDLSPKH
110 120 130 140 150
NYIIANHPHG ILSFGVFINF ATEATGIARI FPSITPFVGT LERIFWIPIV
160 170 180 190 200
REYVMSMGVC PVSSSALKYL LTQKGSGNAV VIVVGGAAEA LLCRPGASTL
210 220 230 240 250
FLKQRKGFVK MALQTGAYLV PSYSFGENEV FNQETFPEGT WLRLFQKTFQ
260 270 280 290 300
DTFKKILGLN FCTFHGRGFT RGSWGFLPFN RPITTVVGEP LPIPRIKRPN
310 320 330
QKTVDKYHAL YISALRKLFD QHKVEYGLPE TQELTIT
Length:337
Mass (Da):38,593
Last modified:July 4, 2004 - v1
Checksum:iE14B50FBD01981E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129500 mRNA. Translation: BAC85167.1.
AL139111, AL357752 Genomic DNA. Translation: CAI41588.1.
AL357752, AL139111 Genomic DNA. Translation: CAI41486.1.
BN000157 mRNA. Translation: CAD89268.1.
CCDSiCCDS14397.1.
RefSeqiNP_940914.1. NM_198512.2.
UniGeneiHs.454355.

Genome annotation databases

EnsembliENST00000333026; ENSP00000328036; ENSG00000184210.
GeneIDi347516.
KEGGihsa:347516.
UCSCiuc004dxx.1. human.

Polymorphism databases

DMDMi74749597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129500 mRNA. Translation: BAC85167.1.
AL139111, AL357752 Genomic DNA. Translation: CAI41588.1.
AL357752, AL139111 Genomic DNA. Translation: CAI41486.1.
BN000157 mRNA. Translation: CAD89268.1.
CCDSiCCDS14397.1.
RefSeqiNP_940914.1. NM_198512.2.
UniGeneiHs.454355.

3D structure databases

ProteinModelPortaliQ6ZPD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328036.

Polymorphism databases

DMDMi74749597.

Proteomic databases

PRIDEiQ6ZPD8.

Protocols and materials databases

DNASUi347516.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333026; ENSP00000328036; ENSG00000184210.
GeneIDi347516.
KEGGihsa:347516.
UCSCiuc004dxx.1. human.

Organism-specific databases

CTDi347516.
GeneCardsiGC0XP069397.
HGNCiHGNC:23250. DGAT2L6.
HPAiHPA021530.
MIMi300926. gene.
neXtProtiNX_Q6ZPD8.
PharmGKBiPA143485448.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG302620.
GeneTreeiENSGT00750000117391.
HOGENOMiHOG000179738.
HOVERGENiHBG065791.
InParanoidiQ6ZPD8.
KOiK11172.
OMAiWRTIMVI.
OrthoDBiEOG7KH9KB.
PhylomeDBiQ6ZPD8.
TreeFamiTF314707.

Enzyme and pathway databases

BRENDAi2.3.1.20. 2681.
2.3.1.75. 2681.

Miscellaneous databases

GenomeRNAii347516.
NextBioi99169.
PROiQ6ZPD8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZPD8.
CleanExiHS_DGAT2L6.
GenevestigatoriQ6ZPD8.

Family and domain databases

InterProiIPR007130. DAGAT.
[Graphical view]
PANTHERiPTHR12317. PTHR12317. 1 hit.
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Dermoid cancer.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals."
    Winter A., van Eckeveld M., Bininda-Emonds O.R.P., Habermann F.A., Fries R.
    Cytogenet. Genome Res. 102:42-47(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Identification of two novel human Acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily."
    Turkish A.R., Henneberry A.L., Cromley D., Padamsee M., Oelkers P., Bazzi H., Christiano A.M., Billheimer J.T., Sturley S.L.
    J. Biol. Chem. 280:14755-14764(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF WAX SYNTHASE ACTIVITY, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDG2L6_HUMAN
AccessioniPrimary (citable) accession number: Q6ZPD8
Secondary accession number(s): Q6IEE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 4, 2006
Last sequence update: July 4, 2004
Last modified: March 31, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.