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Q6ZPD8

- DG2L6_HUMAN

UniProt

Q6ZPD8 - DG2L6_HUMAN

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Protein

Diacylglycerol O-acyltransferase 2-like protein 6

Gene
DGAT2L6, DC3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable acyltransferase uses fatty acyl-CoA as substrate By similarity. Has no wax synthase activity to produce wax esters.

GO - Molecular functioni

  1. transferase activity, transferring acyl groups other than amino-acyl groups Source: InterPro

GO - Biological processi

  1. lipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.20. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol O-acyltransferase 2-like protein 6 (EC:2.3.1.-)
Alternative name(s):
Diacylglycerol O-acyltransferase candidate 3
Short name:
hDC3
Gene namesi
Name:DGAT2L6
Synonyms:DC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:23250. DGAT2L6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221Helical; Reviewed predictionAdd
BLAST
Transmembranei102 – 12221Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485448.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Diacylglycerol O-acyltransferase 2-like protein 6PRO_0000249054Add
BLAST

Proteomic databases

PRIDEiQ6ZPD8.

Expressioni

Tissue specificityi

Expressed in all tissues tested except pancreas.1 Publication

Gene expression databases

BgeeiQ6ZPD8.
CleanExiHS_DGAT2L6.
GenevestigatoriQ6ZPD8.

Organism-specific databases

HPAiHPA021530.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328036.

Structurei

3D structure databases

ProteinModelPortaliQ6ZPD8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302620.
HOGENOMiHOG000179738.
HOVERGENiHBG065791.
InParanoidiQ6ZPD8.
KOiK11172.
OMAiREYVMSM.
OrthoDBiEOG7KH9KB.
PhylomeDBiQ6ZPD8.
TreeFamiTF314707.

Family and domain databases

InterProiIPR007130. DAGAT.
[Graphical view]
PANTHERiPTHR12317. PTHR12317. 1 hit.
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZPD8-1 [UniParc]FASTAAdd to Basket

« Hide

MAFFSRLNLQ EGLQTFFVLQ WIPVYIFLGA IPILLIPYFL LFSKFWPLAV    50
LSLAWLTYDW NTHSQGGRRS AWVRNWTLWK YFRNYFPVKL VKTHDLSPKH 100
NYIIANHPHG ILSFGVFINF ATEATGIARI FPSITPFVGT LERIFWIPIV 150
REYVMSMGVC PVSSSALKYL LTQKGSGNAV VIVVGGAAEA LLCRPGASTL 200
FLKQRKGFVK MALQTGAYLV PSYSFGENEV FNQETFPEGT WLRLFQKTFQ 250
DTFKKILGLN FCTFHGRGFT RGSWGFLPFN RPITTVVGEP LPIPRIKRPN 300
QKTVDKYHAL YISALRKLFD QHKVEYGLPE TQELTIT 337
Length:337
Mass (Da):38,593
Last modified:July 5, 2004 - v1
Checksum:iE14B50FBD01981E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129500 mRNA. Translation: BAC85167.1.
AL139111, AL357752 Genomic DNA. Translation: CAI41588.1.
AL357752, AL139111 Genomic DNA. Translation: CAI41486.1.
BN000157 mRNA. Translation: CAD89268.1.
CCDSiCCDS14397.1.
RefSeqiNP_940914.1. NM_198512.1.
UniGeneiHs.454355.

Genome annotation databases

EnsembliENST00000333026; ENSP00000328036; ENSG00000184210.
GeneIDi347516.
KEGGihsa:347516.
UCSCiuc004dxx.1. human.

Polymorphism databases

DMDMi74749597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129500 mRNA. Translation: BAC85167.1 .
AL139111 , AL357752 Genomic DNA. Translation: CAI41588.1 .
AL357752 , AL139111 Genomic DNA. Translation: CAI41486.1 .
BN000157 mRNA. Translation: CAD89268.1 .
CCDSi CCDS14397.1.
RefSeqi NP_940914.1. NM_198512.1.
UniGenei Hs.454355.

3D structure databases

ProteinModelPortali Q6ZPD8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000328036.

Polymorphism databases

DMDMi 74749597.

Proteomic databases

PRIDEi Q6ZPD8.

Protocols and materials databases

DNASUi 347516.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333026 ; ENSP00000328036 ; ENSG00000184210 .
GeneIDi 347516.
KEGGi hsa:347516.
UCSCi uc004dxx.1. human.

Organism-specific databases

CTDi 347516.
GeneCardsi GC0XP069397.
HGNCi HGNC:23250. DGAT2L6.
HPAi HPA021530.
neXtProti NX_Q6ZPD8.
PharmGKBi PA143485448.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302620.
HOGENOMi HOG000179738.
HOVERGENi HBG065791.
InParanoidi Q6ZPD8.
KOi K11172.
OMAi REYVMSM.
OrthoDBi EOG7KH9KB.
PhylomeDBi Q6ZPD8.
TreeFami TF314707.

Enzyme and pathway databases

BRENDAi 2.3.1.20. 2681.

Miscellaneous databases

GenomeRNAii 347516.
NextBioi 99169.
PROi Q6ZPD8.

Gene expression databases

Bgeei Q6ZPD8.
CleanExi HS_DGAT2L6.
Genevestigatori Q6ZPD8.

Family and domain databases

InterProi IPR007130. DAGAT.
[Graphical view ]
PANTHERi PTHR12317. PTHR12317. 1 hit.
Pfami PF03982. DAGAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Dermoid cancer.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals."
    Winter A., van Eckeveld M., Bininda-Emonds O.R.P., Habermann F.A., Fries R.
    Cytogenet. Genome Res. 102:42-47(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Identification of two novel human Acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily."
    Turkish A.R., Henneberry A.L., Cromley D., Padamsee M., Oelkers P., Bazzi H., Christiano A.M., Billheimer J.T., Sturley S.L.
    J. Biol. Chem. 280:14755-14764(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF WAX SYNTHASE ACTIVITY, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDG2L6_HUMAN
AccessioniPrimary (citable) accession number: Q6ZPD8
Secondary accession number(s): Q6IEE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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