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Protein

RNA-binding protein 44

Gene

RBM44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 44
Alternative name(s):
RNA-binding motif protein 44
Gene namesi
Name:RBM44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24756. RBM44.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Detected in the intercellular bridges.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400774.

Polymorphism and mutation databases

BioMutaiRBM44.
DMDMi152060496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10511051RNA-binding protein 44PRO_0000294174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei388 – 3881PhosphoserineBy similarity
Modified residuei391 – 3911PhosphoserineBy similarity
Modified residuei546 – 5461PhosphoserineBy similarity
Modified residuei726 – 7261PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZP01.
MaxQBiQ6ZP01.
PaxDbiQ6ZP01.
PeptideAtlasiQ6ZP01.
PRIDEiQ6ZP01.

PTM databases

iPTMnetiQ6ZP01.
PhosphoSiteiQ6ZP01.

Expressioni

Gene expression databases

BgeeiQ6ZP01.
ExpressionAtlasiQ6ZP01. baseline and differential.

Organism-specific databases

HPAiHPA003298.

Interactioni

Subunit structurei

Homodimer. Interacts with TEX14 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321179.

Structurei

3D structure databases

ProteinModelPortaliQ6ZP01.
SMRiQ6ZP01. Positions 828-902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini830 – 90374RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IG20. Eukaryota.
ENOG410YPIM. LUCA.
HOGENOMiHOG000154081.
HOVERGENiHBG108400.
InParanoidiQ6ZP01.
OMAiKYQVSEI.
OrthoDBiEOG76DTTN.
PhylomeDBiQ6ZP01.
TreeFamiTF337508.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZP01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQATAVVETA SGKGYHSNGG NLQKDKPSNP KKENLLLSSN GCDEVKLTFP
60 70 80 90 100
DDDWNSSTLE QRANNKEISN IDKMDLLEPF FSVSQDTNTE STQFQSSELE
110 120 130 140 150
DSTDYAFLNK TYSIPYSESK LKKESLTPLS SELDPEVQKK EEVFFNILEH
160 170 180 190 200
QDKTVGLERI YNISDANYRE SAEDTQKHDT DEDSQQEYHS AEEQEYISNH
210 220 230 240 250
LSFDQTKALD ISNPEVVELG NSGYEVKCAS NVEDNRVNSG SGSIISFDSL
260 270 280 290 300
DVYGQEESLH VSKFQNSVML REYHDLKHEK YKEQETNSMY HTVFDGSVLR
310 320 330 340 350
SNSPGNQESQ SKSGSLSPQK VLKMKIYTEN MKSQINEGKD FCGNKIVENK
360 370 380 390 400
ILLHLENPST LPQDKALETL LQPCKDCQTS WTSVFDDSII SACGYYESLQ
410 420 430 440 450
NTADSALDFS AMLPKIAVRD NQAIEDNTSL KVAHSSTTKK TCFHNIGEMC
460 470 480 490 500
TKSLTDAASC TVTINQTVDV STDFRACFTT SRATSARPSV VSTSSNTEIT
510 520 530 540 550
MMNKKRPDEW QNEKQKSVAC STDWSYSEDC IDTQMAITKG SGKSLSVDSL
560 570 580 590 600
KPNGNFLNKD FLELRKACGI TDLKKHPERE FQLFKDTEKD LPSMCCQKIM
610 620 630 640 650
QRAIKAELHL LNVHYQMCRR HCCDIYKLVM ENREGLNMNL SSNSAKKELG
660 670 680 690 700
SALLSLLGDL KVRYVTLKEK IHKGIPLEEL PPLSLESKLL STFSTFASRL
710 720 730 740 750
MKKETHVFSE ADAEQDNQRA HDVDVSSNLK KTLSQMSLSS DNSHATQNIS
760 770 780 790 800
PKKDDFKNGD INADFSQLKL GDKDCRHYQE TSEDWSDAKE SLTGVDVSGT
810 820 830 840 850
QGNQVEQDTW NLDLTGEMKN VEPSQRDKGY LIHVGGLCPS VSEADLRSHF
860 870 880 890 900
QKYQVSEISI YDSTNYRYAS LAFTKNSDAK IAVKEMNGIE INGKSVNVWP
910 920 930 940 950
VKILGEYTSP LSSKNGNRIS SNNLEKSTNK QIHSEFSISR LPRTRPRQLG
960 970 980 990 1000
SEQDSEVFPS DQGVKKNCKQ IESAKLLPDT PVQFIPPNTL NLRSFTKIIK
1010 1020 1030 1040 1050
RLAELHPEVS RDHIINALQE VRIRHKGFLN GLSITTIVEM TSSLLKNSAS

S
Length:1,051
Mass (Da):117,985
Last modified:July 10, 2007 - v2
Checksum:i45400796EEAF1415
GO

Sequence cautioni

The sequence AAI26112.1 differs from that shown.Unlikely splicing event.Curated
The sequence BAC85324.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511D → H.
Corresponds to variant rs13393001 [ dbSNP | Ensembl ].
VAR_057247
Natural varianti52 – 521D → H.
Corresponds to variant rs13393001 [ dbSNP | Ensembl ].
VAR_033147
Natural varianti892 – 8921N → H.
Corresponds to variant rs10186505 [ dbSNP | Ensembl ].
VAR_033148

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012076 Genomic DNA. No translation available.
BC126111 mRNA. Translation: AAI26112.1. Sequence problems.
AK130316 mRNA. Translation: BAC85324.1. Different initiation.
RefSeqiNP_001073973.2. NM_001080504.2.
XP_011509457.1. XM_011511155.1.
UniGeneiHs.607265.
Hs.720233.

Genome annotation databases

EnsembliENST00000611254; ENSP00000483448; ENSG00000177483.
GeneIDi375316.
KEGGihsa:375316.
UCSCiuc061ubp.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012076 Genomic DNA. No translation available.
BC126111 mRNA. Translation: AAI26112.1. Sequence problems.
AK130316 mRNA. Translation: BAC85324.1. Different initiation.
RefSeqiNP_001073973.2. NM_001080504.2.
XP_011509457.1. XM_011511155.1.
UniGeneiHs.607265.
Hs.720233.

3D structure databases

ProteinModelPortaliQ6ZP01.
SMRiQ6ZP01. Positions 828-902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321179.

PTM databases

iPTMnetiQ6ZP01.
PhosphoSiteiQ6ZP01.

Polymorphism and mutation databases

BioMutaiRBM44.
DMDMi152060496.

Proteomic databases

EPDiQ6ZP01.
MaxQBiQ6ZP01.
PaxDbiQ6ZP01.
PeptideAtlasiQ6ZP01.
PRIDEiQ6ZP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611254; ENSP00000483448; ENSG00000177483.
GeneIDi375316.
KEGGihsa:375316.
UCSCiuc061ubp.1. human.

Organism-specific databases

CTDi375316.
GeneCardsiRBM44.
HGNCiHGNC:24756. RBM44.
HPAiHPA003298.
neXtProtiNX_Q6ZP01.
PharmGKBiPA162400774.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG20. Eukaryota.
ENOG410YPIM. LUCA.
HOGENOMiHOG000154081.
HOVERGENiHBG108400.
InParanoidiQ6ZP01.
OMAiKYQVSEI.
OrthoDBiEOG76DTTN.
PhylomeDBiQ6ZP01.
TreeFamiTF337508.

Miscellaneous databases

GenomeRNAii375316.
PROiQ6ZP01.

Gene expression databases

BgeeiQ6ZP01.
ExpressionAtlasiQ6ZP01. baseline and differential.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-1051.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 810-1051.
    Tissue: Prostate.

Entry informationi

Entry nameiRBM44_HUMAN
AccessioniPrimary (citable) accession number: Q6ZP01
Secondary accession number(s): A0AUW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.