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Q6ZNW5

- GDPP1_HUMAN

UniProt

Q6ZNW5 - GDPP1_HUMAN

Protein

GDP-D-glucose phosphorylase 1

Gene

GDPGP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.1 Publication

    Catalytic activityi

    GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.1 Publication

    Kineticsi

    kcat is 26 s(-1) at 31 degrees Celsius. The catalytic efficiency for GDP-D-glucose is 35-fold higher than for GDP-L-galactose.

    1. KM=2 µM for GDP-D-glucose (at 31 degrees Celsius)1 Publication
    2. KM=12 µM for GDP-L-galactose (at 31 degrees Celsius)1 Publication
    3. KM=42 µM for GDP-D-mannose (at 31 degrees Celsius)1 Publication
    4. KM=2.9 mM for inorganic phosphate (at 31 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei218 – 2181Tele-GMP-histidine intermediateBy similarity

    GO - Molecular functioni

    1. GDP-D-glucose phosphorylase activity Source: UniProtKB
    2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
    3. hydrolase activity Source: UniProtKB-KW
    4. nucleotide binding Source: UniProtKB-KW
    5. nucleotidyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. glucose metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor, Hydrolase, Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:G66-31756-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-D-glucose phosphorylase 1 (EC:2.7.7.78)
    Gene namesi
    Name:GDPGP1
    Synonyms:C15orf58
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:34360. GDPGP1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162378247.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385GDP-D-glucose phosphorylase 1PRO_0000336750Add
    BLAST

    Proteomic databases

    MaxQBiQ6ZNW5.
    PaxDbiQ6ZNW5.
    PRIDEiQ6ZNW5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZNW5.
    BgeeiQ6ZNW5.
    CleanExiHS_C15orf58.
    GenevestigatoriQ6ZNW5.

    Organism-specific databases

    HPAiHPA048189.

    Interactioni

    Protein-protein interaction databases

    BioGridi133642. 3 interactions.
    STRINGi9606.ENSP00000368405.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZNW5.
    SMRiQ6ZNW5. Positions 150-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GDPGP1 family.Curated

    Phylogenomic databases

    eggNOGiNOG307761.
    HOVERGENiHBG106673.
    InParanoidiQ6ZNW5.
    KOiK15630.
    OMAiGIQWPRN.
    OrthoDBiEOG7M98H0.
    PhylomeDBiQ6ZNW5.
    TreeFamiTF313615.

    Family and domain databases

    InterProiIPR026506. GDPGP.
    [Graphical view]
    PANTHERiPTHR20884. PTHR20884. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6ZNW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPHDSNET SYLLPPNNED WGRQTIPDFV YGQKDLMAEG IQWPRNAPGI    50
    PDALPQSPFD AALCSAWKQR VELGLFRYRL RELQTQILPG AVGFVAQLNV 100
    ERGVQRRPPQ TIKSVRQAFD PVQFNFNKIR PGEVLFRLHR EPDLPGTLLQ 150
    EDILVVINVS PLEWGHVLLV PEPARQLPQR LLPGALRAGI EAVLLSLHPG 200
    FRVGFNSLGG LASVNHLHLH GYYLAHRLPV EQAPSEPLDP GGHLHLLQDL 250
    PAPGFLFYTR GPGPDLESLI SRVCRATDYL TDHEIAHNLF VTRGAPPGKT 300
    SPSSALTGVR VILWARKSSF GIKDGEAFNV ALCELAGHLP VKTSQDFSSL 350
    TEAAAVALIQ DCRLPPSQAE DVQAALVALM SQEEQ 385
    Length:385
    Mass (Da):42,362
    Last modified:May 18, 2010 - v2
    Checksum:i921A656C721876EC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231R → G in BAC85370. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371M → T.1 Publication
    Corresponds to variant rs7171194 [ dbSNP | Ensembl ].
    VAR_043555
    Natural varianti264 – 2641P → T.1 Publication
    Corresponds to variant rs10152994 [ dbSNP | Ensembl ].
    VAR_043556
    Natural varianti307 – 3071T → I.1 Publication
    Corresponds to variant rs10153004 [ dbSNP | Ensembl ].
    VAR_043557

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK130527 mRNA. Translation: BAC85370.1.
    AC091167 Genomic DNA. No translation available.
    CCDSiCCDS32327.1.
    RefSeqiNP_001013679.2. NM_001013657.2.
    UniGeneiHs.304673.

    Genome annotation databases

    EnsembliENST00000329600; ENSP00000368405; ENSG00000183208.
    ENST00000558017; ENSP00000452793; ENSG00000183208.
    GeneIDi390637.
    KEGGihsa:390637.
    UCSCiuc002bpc.3. human.

    Polymorphism databases

    DMDMi296434456.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK130527 mRNA. Translation: BAC85370.1 .
    AC091167 Genomic DNA. No translation available.
    CCDSi CCDS32327.1.
    RefSeqi NP_001013679.2. NM_001013657.2.
    UniGenei Hs.304673.

    3D structure databases

    ProteinModelPortali Q6ZNW5.
    SMRi Q6ZNW5. Positions 150-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 133642. 3 interactions.
    STRINGi 9606.ENSP00000368405.

    Polymorphism databases

    DMDMi 296434456.

    Proteomic databases

    MaxQBi Q6ZNW5.
    PaxDbi Q6ZNW5.
    PRIDEi Q6ZNW5.

    Protocols and materials databases

    DNASUi 390637.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329600 ; ENSP00000368405 ; ENSG00000183208 .
    ENST00000558017 ; ENSP00000452793 ; ENSG00000183208 .
    GeneIDi 390637.
    KEGGi hsa:390637.
    UCSCi uc002bpc.3. human.

    Organism-specific databases

    CTDi 390637.
    GeneCardsi GC15P090778.
    HGNCi HGNC:34360. GDPGP1.
    HPAi HPA048189.
    neXtProti NX_Q6ZNW5.
    PharmGKBi PA162378247.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307761.
    HOVERGENi HBG106673.
    InParanoidi Q6ZNW5.
    KOi K15630.
    OMAi GIQWPRN.
    OrthoDBi EOG7M98H0.
    PhylomeDBi Q6ZNW5.
    TreeFami TF313615.

    Enzyme and pathway databases

    BioCyci MetaCyc:G66-31756-MONOMER.

    Miscellaneous databases

    GenomeRNAii 390637.
    NextBioi 103948.
    PROi Q6ZNW5.

    Gene expression databases

    ArrayExpressi Q6ZNW5.
    Bgeei Q6ZNW5.
    CleanExi HS_C15orf58.
    Genevestigatori Q6ZNW5.

    Family and domain databases

    InterProi IPR026506. GDPGP.
    [Graphical view ]
    PANTHERi PTHR20884. PTHR20884. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-37; THR-264 AND ILE-307.
      Tissue: Salivary gland.
    2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals."
      Adler L.N., Gomez T.A., Clarke S.G., Linster C.L.
      J. Biol. Chem. 286:21511-21523(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBSTRATE SPECIFICITY, KINETIC PARAMETERS.

    Entry informationi

    Entry nameiGDPP1_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZNW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The orthologs in A.thaliana are GDP-L-galactose phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families
    5. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3