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Protein

Transmembrane protein 91

Gene

TMEM91

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 91
Alternative name(s):
Dispanin subfamily C member 3
Short name:
DSPC3
Gene namesi
Name:TMEM91
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32393. TMEM91.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9797ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Topological domaini161 – 17212ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670743.

Polymorphism and mutation databases

BioMutaiTMEM91.
DMDMi55976711.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Transmembrane protein 91PRO_0000135699Add
BLAST

Proteomic databases

PaxDbiQ6ZNR0.
PRIDEiQ6ZNR0.

PTM databases

iPTMnetiQ6ZNR0.

Expressioni

Gene expression databases

BgeeiQ6ZNR0.
CleanExiHS_TMEM91.
ExpressionAtlasiQ6ZNR0. baseline and differential.
GenevisibleiQ6ZNR0. HS.

Organism-specific databases

HPAiHPA053240.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375859.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWEQ. Eukaryota.
ENOG410XVDW. LUCA.
GeneTreeiENSGT00390000009914.
HOGENOMiHOG000143399.
HOVERGENiHBG062452.
InParanoidiQ6ZNR0.
OrthoDBiEOG7P5T2F.
PhylomeDBiQ6ZNR0.
TreeFamiTF331357.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZNR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSPSLRELQ QPLLEGTECE TPAQKPGRHE LGSPLREIAF AESLRGLQFL
60 70 80 90 100
SPPLPSVSAG LGEPRPPDVE DMSSSDSDSD WDGGSRLSPF LPHDHLGLAV
110 120 130 140 150
FSMLCCFWPV GIAAFCLAQK TNKAWAKGDI QGAGAASRRA FLLGVLAVGL
160 170
GVCTYAAALV TLAAYLASRD PP
Length:172
Mass (Da):18,162
Last modified:July 5, 2004 - v1
Checksum:i5F8CAAC51D662BD3
GO
Isoform 2 (identifier: Q6ZNR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-172: TNKAWAKGDIQGAGAASRRAFLLGVLAVGLGVCTYAAALVTLAAYLASRDPP → HPQCLTYSRCYVSAFGIHA

Note: No experimental confirmation available.
Show »
Length:139
Mass (Da):15,097
Checksum:i301F38376CF4916D
GO
Isoform 3 (identifier: Q6ZNR0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-172: TNKAWAKGDIQGAGAASRRAFLLGVLAVGLGVCTYAAALVTLAAYLASRDPP → LPLQPSL

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):13,711
Checksum:iF267E453D10D4C80
GO
Isoform 4 (identifier: Q6ZNR0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-172: TNKAWAKGDIQGAGAASRRAFLLGVLAVGLGVCTYAAALVTLAAYLASRDPP → PSL

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):13,259
Checksum:i810F8CC0F94AD91A
GO
Isoform 5 (identifier: Q6ZNR0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-171: NKAWAKGDIQGAGAASRRAFLLGVLAVGLGVCTYAAALVTLAAYLASRDP → RPSCPYSPHCE

Note: No experimental confirmation available.
Show »
Length:133
Mass (Da):14,417
Checksum:i4B43F165F4953E15
GO

Sequence cautioni

The sequence BM931402 differs from that shown. Reason: Frameshift at position 122. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → L in BX090160 (Ref. 2) Curated
Sequence conflicti114 – 1141A → G in BM931402 (PubMed:8889548).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei121 – 17252TNKAW…SRDPP → HPQCLTYSRCYVSAFGIHA in isoform 2. 1 PublicationVSP_042819Add
BLAST
Alternative sequencei121 – 17252TNKAW…SRDPP → LPLQPSL in isoform 3. 1 PublicationVSP_045717Add
BLAST
Alternative sequencei121 – 17252TNKAW…SRDPP → PSL in isoform 4. 1 PublicationVSP_047211Add
BLAST
Alternative sequencei122 – 17150NKAWA…ASRDP → RPSCPYSPHCE in isoform 5. 1 PublicationVSP_047212Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BM931402 mRNA. No translation available.
BX090160 mRNA. No translation available.
AK130820 mRNA. Translation: BAC85439.1.
AC011462 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57037.1.
BC063705 mRNA. Translation: AAH63705.1.
BF684543 mRNA. No translation available.
CCDSiCCDS42571.1. [Q6ZNR0-1]
CCDS42572.1. [Q6ZNR0-2]
CCDS46082.1. [Q6ZNR0-5]
CCDS46083.1. [Q6ZNR0-3]
CCDS46084.1. [Q6ZNR0-4]
RefSeqiNP_001036060.1. NM_001042595.2. [Q6ZNR0-2]
NP_001092291.1. NM_001098821.1. [Q6ZNR0-1]
NP_001092292.1. NM_001098822.1. [Q6ZNR0-5]
NP_001092293.1. NM_001098823.1. [Q6ZNR0-3]
NP_001092294.1. NM_001098824.1. [Q6ZNR0-4]
NP_001092295.1. NM_001098825.1. [Q6ZNR0-5]
UniGeneiHs.709417.

Genome annotation databases

EnsembliENST00000356385; ENSP00000348750; ENSG00000142046. [Q6ZNR0-2]
ENST00000392002; ENSP00000375859; ENSG00000142046. [Q6ZNR0-1]
ENST00000413014; ENSP00000413192; ENSG00000142046. [Q6ZNR0-5]
ENST00000436170; ENSP00000407003; ENSG00000142046. [Q6ZNR0-4]
ENST00000447302; ENSP00000405647; ENSG00000142046. [Q6ZNR0-3]
ENST00000544232; ENSP00000437779; ENSG00000142046. [Q6ZNR0-5]
GeneIDi641649.
KEGGihsa:641649.
UCSCiuc002oqk.5. human. [Q6ZNR0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BM931402 mRNA. No translation available.
BX090160 mRNA. No translation available.
AK130820 mRNA. Translation: BAC85439.1.
AC011462 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57037.1.
BC063705 mRNA. Translation: AAH63705.1.
BF684543 mRNA. No translation available.
CCDSiCCDS42571.1. [Q6ZNR0-1]
CCDS42572.1. [Q6ZNR0-2]
CCDS46082.1. [Q6ZNR0-5]
CCDS46083.1. [Q6ZNR0-3]
CCDS46084.1. [Q6ZNR0-4]
RefSeqiNP_001036060.1. NM_001042595.2. [Q6ZNR0-2]
NP_001092291.1. NM_001098821.1. [Q6ZNR0-1]
NP_001092292.1. NM_001098822.1. [Q6ZNR0-5]
NP_001092293.1. NM_001098823.1. [Q6ZNR0-3]
NP_001092294.1. NM_001098824.1. [Q6ZNR0-4]
NP_001092295.1. NM_001098825.1. [Q6ZNR0-5]
UniGeneiHs.709417.

3D structure databases

ProteinModelPortaliQ6ZNR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000375859.

PTM databases

iPTMnetiQ6ZNR0.

Polymorphism and mutation databases

BioMutaiTMEM91.
DMDMi55976711.

Proteomic databases

PaxDbiQ6ZNR0.
PRIDEiQ6ZNR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356385; ENSP00000348750; ENSG00000142046. [Q6ZNR0-2]
ENST00000392002; ENSP00000375859; ENSG00000142046. [Q6ZNR0-1]
ENST00000413014; ENSP00000413192; ENSG00000142046. [Q6ZNR0-5]
ENST00000436170; ENSP00000407003; ENSG00000142046. [Q6ZNR0-4]
ENST00000447302; ENSP00000405647; ENSG00000142046. [Q6ZNR0-3]
ENST00000544232; ENSP00000437779; ENSG00000142046. [Q6ZNR0-5]
GeneIDi641649.
KEGGihsa:641649.
UCSCiuc002oqk.5. human. [Q6ZNR0-1]

Organism-specific databases

CTDi641649.
GeneCardsiTMEM91.
HGNCiHGNC:32393. TMEM91.
HPAiHPA053240.
neXtProtiNX_Q6ZNR0.
PharmGKBiPA142670743.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWEQ. Eukaryota.
ENOG410XVDW. LUCA.
GeneTreeiENSGT00390000009914.
HOGENOMiHOG000143399.
HOVERGENiHBG062452.
InParanoidiQ6ZNR0.
OrthoDBiEOG7P5T2F.
PhylomeDBiQ6ZNR0.
TreeFamiTF331357.

Miscellaneous databases

ChiTaRSiTMEM91. human.
GenomeRNAii641649.
PROiQ6ZNR0.

Gene expression databases

BgeeiQ6ZNR0.
CleanExiHS_TMEM91.
ExpressionAtlasiQ6ZNR0. baseline and differential.
GenevisibleiQ6ZNR0. HS.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Normalization and subtraction: two approaches to facilitate gene discovery."
    Bonaldo M.F., Lennon G., Soares M.B.
    Genome Res. 6:791-806(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  2. Ebert L., Heil O., Hennig S., Neubert P., Partsch E., Peters M., Radelof U., Schneider D., Korn B.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thymus.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Leiomyosarcoma and Skin.
  7. "The dispanins: a novel gene family of ancient origin that contains 14 human members."
    Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
    PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiTMM91_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNR0
Secondary accession number(s): C9J9D1
, C9JZ62, C9K046, Q6P434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.