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Q6ZNL6

- FGD5_HUMAN

UniProt

Q6ZNL6 - FGD5_HUMAN

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Protein
FYVE, RhoGEF and PH domain-containing protein 5
Gene
FGD5, ZFYVE23
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1242 – 130160FYVE-type
Add
BLAST

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
  2. guanyl-nucleotide exchange factor activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: IntAct
  5. small GTPase binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. actin cytoskeleton organization Source: UniProtKB
  2. cytoskeleton organization Source: UniProtKB
  3. filopodium assembly Source: UniProtKB
  4. regulation of Cdc42 GTPase activity Source: UniProtKB
  5. regulation of cell shape Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 5
Alternative name(s):
Zinc finger FYVE domain-containing protein 23
Gene namesi
Name:FGD5
Synonyms:ZFYVE23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:19117. FGD5.

Subcellular locationi

Cytoplasmcytoskeleton. Cell projectionruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome
Note: In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytoskeleton Source: UniProtKB-SubCell
  4. early endosome Source: UniProtKB-SubCell
  5. endoplasmic reticulum Source: UniProtKB-SubCell
  6. lamellipodium Source: UniProtKB
  7. ruffle Source: UniProtKB
  8. ruffle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134874843.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14621462FYVE, RhoGEF and PH domain-containing protein 5
PRO_0000080950Add
BLAST

Proteomic databases

PaxDbiQ6ZNL6.
PRIDEiQ6ZNL6.

PTM databases

PhosphoSiteiQ6ZNL6.

Expressioni

Tissue specificityi

Expressed in endothelial cells (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ6ZNL6.
BgeeiQ6ZNL6.
CleanExiHS_FGD5.
GenevestigatoriQ6ZNL6.

Organism-specific databases

HPAiHPA014536.
HPA019191.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-7962481,EBI-349968

Protein-protein interaction databases

BioGridi127439. 3 interactions.
IntActiQ6ZNL6. 3 interactions.
STRINGi9606.ENSP00000285046.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi891 – 91727
Helixi919 – 92911
Helixi936 – 96833
Turni969 – 9724
Helixi978 – 9814
Turni982 – 9865
Helixi987 – 100822
Helixi1012 – 102211
Helixi1032 – 105423
Helixi1062 – 108423
Helixi1088 – 110013
Beta strandi1114 – 11163
Beta strandi1119 – 11246
Beta strandi1127 – 114519
Beta strandi1151 – 11588
Beta strandi1174 – 11796
Beta strandi1184 – 11885
Helixi1192 – 120413

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MPXX-ray2.80A889-1304[»]
ProteinModelPortaliQ6ZNL6.
SMRiQ6ZNL6. Positions 890-1205, 1245-1301, 1369-1461.

Miscellaneous databases

EvolutionaryTraceiQ6ZNL6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini892 – 1084193DH
Add
BLAST
Domaini1113 – 120795PH 1
Add
BLAST
Domaini1363 – 146199PH 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 323266Glu-rich
Add
BLAST
Compositional biasi645 – 6506Poly-Lys

Sequence similaritiesi

Contains 2 PH domains.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG291216.
HOGENOMiHOG000168874.
HOVERGENiHBG051609.
InParanoidiQ6ZNL6.
KOiK05724.
OMAiEYDNTQG.
PhylomeDBiQ6ZNL6.
TreeFamiTF343077.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZNL6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFRGPKPPIA PKPRLTAPNE WRASVYLNDS LNKCSNGRLP CVDRGLDEGP     50
RSIPKCSESE TDEDYIVVPR VPLREDEPKD EGSVGNKALV SPESSAEEEE 100
EREEGGEACG LEGTGAGEDS VAPAAPGAGA LSREGEEGTD LALEDEGEGC 150
ADEPGTLEQV SRSEEEEKLV QPHRECSLED SGPWAGEGVF QSDLLLPHIH 200
GEDQEPPDTP GEAEEDDEEG CASTDPAGAD EGSGPDRPTE DMGQDAEDTS 250
EEPPEKEELA GVQEAETATD CPEVLEEGCE EATGVTGGEQ VDLSEPPDHE 300
KKTNQEVAAA TLEDHAQDES AEESCQIVPF ENDCMEDFVT SLTGSPYEFF 350
PTESTSFCSE SCSPLSESAK GLESEQAPKL GLRAEENPMV GALCGQCGSL 400
QGGAAEGPAA PDVVVVLEEE ALDDALANPY VMGVGLPGQA APGEGGQAAS 450
DALGGYGSKE ELNCEAEGGL VPADRKNTST RVRPHSGKVA GYVPETVPEE 500
TGPEAGSSAP GIGGAAEEVG KTLLSLEGKP LEASRALPAK PRAFTLYPRS 550
FSVEGREIPV SVYQEPEGSG LDDHRIKRKE DNLSLSCVIG SSGSFSQRNH 600
LPSSGTSTPS SMVDIPPPFD LACITKKPIT KSSPSLLIES DSPDKYKKKK 650
SSFKRFLALT FKKKTENKLH VDVNVSSSRS SSESSYHGPS RILEVDRRSL 700
SNSPQLKSRT GKLRASESPS SLIFYRDGKR KGVPFSRTVS RVESFEDRSR 750
PPFLPLPLTK PRSISFPSAD TSDYENIPAM NSDYENIQIP PRRPARAGAF 800
TKLFEDQSRA LSTANENDGY VDMSSFNAFE SKQQSADQDA ESAYTEPYKV 850
CPISSAAPKE DLTSDEEQRS SEEEDSASRD PSVTHKVEGQ SRALVIAQEL 900
LSSEKAYVEM LQHLNLDFHG AVMRALDDMD HEGRDTLARE ELRQGLSELP 950
AIHDLHQGIL EELEERLSNW ESQQKVADVF LAREQGFDHH ATHILQFDRY 1000
LGLLSENCLH SPRLAAAVRE FEQSVQGGSQ TAKHRLLRVV QRLFQYQVLL 1050
TDYLNNLCPD SAEYDNTQGA LSLISKVTDR ANDSMEQGEN LQKLVHIEHS 1100
VRGQGDLLQP GREFLKEGTL MKVTGKNRRP RHLFLMNDVL LYTYPQKDGK 1150
YRLKNTLAVA NMKVSRPVME KVPYALKIET SESCLMLSAS SCAERDEWYG 1200
CLSRALPEDY KAQALAAFHH SVEIRERLGV SLGERPPTLV PVTHVMMCMN 1250
CGCDFSLTLR RHHCHACGKI VCRNCSRNKY PLKYLKDRMA KVCDGCFGEL 1300
KKRGRAVPGL MRERPVSMSF PLSSPRFSGS AFSSVFQSIN PSTFKKQKKV 1350
PSALTEVAAS GEGSAISGYL SRCKRGKRHW KKLWFVIKGK VLYTYMASED 1400
KVALESMPLL GFTIAPEKEE GSSEVGPIFH LYHKKTLFYS FKAEDTNSAQ 1450
RWIEAMEDAS VL 1462
Length:1,462
Mass (Da):159,891
Last modified:May 18, 2010 - v3
Checksum:i3012049C00F7384B
GO
Isoform 2 (identifier: Q6ZNL6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-922: Missing.

Show »
Length:540
Mass (Da):61,238
Checksum:iA8ED7C2316625D0E
GO

Sequence cautioni

The sequence BAC85128.1 differs from that shown. Reason: Frameshift at position 79.
The sequence BAC04878.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC04989.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAD98090.1 differs from that shown. Reason: Erroneous termination at position 1279. Translated as Lys.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti403 – 4031G → R.
Corresponds to variant rs7636593 [ dbSNP | Ensembl ].
VAR_059799
Natural varianti828 – 8281A → T.
Corresponds to variant rs17038795 [ dbSNP | Ensembl ].
VAR_059800
Natural varianti941 – 9411E → K.
Corresponds to variant rs2307092 [ dbSNP | Ensembl ].
VAR_059801

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 922922Missing in isoform 2.
VSP_013088Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241A → T in BAC85128. 1 Publication
Sequence conflicti213 – 2131A → G in BAC85128. 1 Publication
Sequence conflicti354 – 3541S → G in CAE45896. 1 Publication
Sequence conflicti574 – 5741H → Y in BAC04989. 1 Publication
Sequence conflicti1112 – 11121R → M in CAE45896. 1 Publication
Sequence conflicti1196 – 11961D → N in CAE45896. 1 Publication
Sequence conflicti1289 – 12891M → T in CAE45896. 1 Publication
Sequence conflicti1382 – 13821K → E in BAC04989. 1 Publication
Sequence conflicti1400 – 14001D → G in CAD98090. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096856 mRNA. Translation: BAC04878.1. Different initiation.
AK097276 mRNA. Translation: BAC04989.1. Different initiation.
AK131078 mRNA. Translation: BAC85128.1. Frameshift.
AK123054 mRNA. Translation: BAG53865.1.
AC087591 Genomic DNA. No translation available.
AC090954 Genomic DNA. No translation available.
BC035364 mRNA. Translation: AAH35364.1.
BF989107 mRNA. No translation available.
BX640820 Transcribed RNA. Translation: CAE45896.2.
BX538312 mRNA. Translation: CAD98090.1. Sequence problems.
CCDSiCCDS46767.1. [Q6ZNL6-1]
RefSeqiNP_689749.3. NM_152536.3. [Q6ZNL6-1]
UniGeneiHs.412406.

Genome annotation databases

EnsembliENST00000285046; ENSP00000285046; ENSG00000154783. [Q6ZNL6-1]
GeneIDi152273.
KEGGihsa:152273.
UCSCiuc003bzc.3. human. [Q6ZNL6-1]
uc003bzd.3. human. [Q6ZNL6-2]

Polymorphism databases

DMDMi296439343.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096856 mRNA. Translation: BAC04878.1 . Different initiation.
AK097276 mRNA. Translation: BAC04989.1 . Different initiation.
AK131078 mRNA. Translation: BAC85128.1 . Frameshift.
AK123054 mRNA. Translation: BAG53865.1 .
AC087591 Genomic DNA. No translation available.
AC090954 Genomic DNA. No translation available.
BC035364 mRNA. Translation: AAH35364.1 .
BF989107 mRNA. No translation available.
BX640820 Transcribed RNA. Translation: CAE45896.2 .
BX538312 mRNA. Translation: CAD98090.1 . Sequence problems.
CCDSi CCDS46767.1. [Q6ZNL6-1 ]
RefSeqi NP_689749.3. NM_152536.3. [Q6ZNL6-1 ]
UniGenei Hs.412406.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3MPX X-ray 2.80 A 889-1304 [» ]
ProteinModelPortali Q6ZNL6.
SMRi Q6ZNL6. Positions 890-1205, 1245-1301, 1369-1461.
ModBasei Search...

Protein-protein interaction databases

BioGridi 127439. 3 interactions.
IntActi Q6ZNL6. 3 interactions.
STRINGi 9606.ENSP00000285046.

PTM databases

PhosphoSitei Q6ZNL6.

Polymorphism databases

DMDMi 296439343.

Proteomic databases

PaxDbi Q6ZNL6.
PRIDEi Q6ZNL6.

Protocols and materials databases

DNASUi 152273.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285046 ; ENSP00000285046 ; ENSG00000154783 . [Q6ZNL6-1 ]
GeneIDi 152273.
KEGGi hsa:152273.
UCSCi uc003bzc.3. human. [Q6ZNL6-1 ]
uc003bzd.3. human. [Q6ZNL6-2 ]

Organism-specific databases

CTDi 152273.
GeneCardsi GC03P014860.
H-InvDBi HIX0003091.
HIX0003092.
HGNCi HGNC:19117. FGD5.
HPAi HPA014536.
HPA019191.
MIMi 614788. gene.
neXtProti NX_Q6ZNL6.
PharmGKBi PA134874843.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291216.
HOGENOMi HOG000168874.
HOVERGENi HBG051609.
InParanoidi Q6ZNL6.
KOi K05724.
OMAi EYDNTQG.
PhylomeDBi Q6ZNL6.
TreeFami TF343077.

Miscellaneous databases

EvolutionaryTracei Q6ZNL6.
GenomeRNAii 152273.
NextBioi 86934.
PROi Q6ZNL6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6ZNL6.
Bgeei Q6ZNL6.
CleanExi HS_FGD5.
Genevestigatori Q6ZNL6.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 77-1462 (ISOFORM 1).
    Tissue: Spleen and Testis.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-215 (ISOFORM 1).
    Tissue: Placenta.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-1462 (ISOFORM 1).
    Tissue: Esophageal carcinoma and Uterus.
  6. "FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells."
    Kurogane Y., Miyata M., Kubo Y., Nagamatsu Y., Kundu R.K., Uemura A., Ishida T., Quertermous T., Hirata K., Rikitake Y.
    Arterioscler. Thromb. Vasc. Biol. 32:988-996(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "Crystal structure of the DH and PH-1 domains of human FGD5."
    Structural genomics consortium (SGC)
    Submitted (JUN-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 889-1304.

Entry informationi

Entry nameiFGD5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNL6
Secondary accession number(s): B3KVQ3
, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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