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Q6ZNL6

- FGD5_HUMAN

UniProt

Q6ZNL6 - FGD5_HUMAN

Protein

FYVE, RhoGEF and PH domain-containing protein 5

Gene

FGD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1242 – 130160FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. Rho guanyl-nucleotide exchange factor activity Source: InterPro
    5. small GTPase binding Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton organization Source: UniProtKB
    2. cytoskeleton organization Source: UniProtKB
    3. filopodium assembly Source: UniProtKB
    4. positive regulation of GTPase activity Source: GOC
    5. regulation of Cdc42 GTPase activity Source: UniProtKB
    6. regulation of cell shape Source: UniProtKB

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FYVE, RhoGEF and PH domain-containing protein 5
    Alternative name(s):
    Zinc finger FYVE domain-containing protein 23
    Gene namesi
    Name:FGD5
    Synonyms:ZFYVE23
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:19117. FGD5.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication. Cell projectionruffle membrane 1 Publication. Endoplasmic reticulum 1 Publication. Golgi apparatus 1 Publication. Early endosome 1 Publication
    Note: In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoskeleton Source: UniProtKB-SubCell
    3. early endosome Source: UniProtKB-SubCell
    4. endoplasmic reticulum Source: UniProtKB-SubCell
    5. Golgi apparatus Source: UniProtKB
    6. lamellipodium Source: UniProtKB
    7. ruffle Source: UniProtKB
    8. ruffle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134874843.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14621462FYVE, RhoGEF and PH domain-containing protein 5PRO_0000080950Add
    BLAST

    Proteomic databases

    PaxDbiQ6ZNL6.
    PRIDEiQ6ZNL6.

    PTM databases

    PhosphoSiteiQ6ZNL6.

    Expressioni

    Tissue specificityi

    Expressed in endothelial cells (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ6ZNL6.
    BgeeiQ6ZNL6.
    CleanExiHS_FGD5.
    GenevestigatoriQ6ZNL6.

    Organism-specific databases

    HPAiHPA014536.
    HPA019191.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SUV39H1O434632EBI-7962481,EBI-349968

    Protein-protein interaction databases

    BioGridi127439. 3 interactions.
    IntActiQ6ZNL6. 3 interactions.
    STRINGi9606.ENSP00000285046.

    Structurei

    Secondary structure

    1
    1462
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi891 – 91727
    Helixi919 – 92911
    Helixi936 – 96833
    Turni969 – 9724
    Helixi978 – 9814
    Turni982 – 9865
    Helixi987 – 100822
    Helixi1012 – 102211
    Helixi1032 – 105423
    Helixi1062 – 108423
    Helixi1088 – 110013
    Beta strandi1114 – 11163
    Beta strandi1119 – 11246
    Beta strandi1127 – 114519
    Beta strandi1151 – 11588
    Beta strandi1174 – 11796
    Beta strandi1184 – 11885
    Helixi1192 – 120413

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3MPXX-ray2.80A889-1304[»]
    ProteinModelPortaliQ6ZNL6.
    SMRiQ6ZNL6. Positions 890-1205, 1245-1301, 1369-1461.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6ZNL6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini892 – 1084193DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini1113 – 120795PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1363 – 146199PH 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi58 – 323266Glu-richAdd
    BLAST
    Compositional biasi645 – 6506Poly-Lys

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 2 PH domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1242 – 130160FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG291216.
    HOGENOMiHOG000168874.
    HOVERGENiHBG051609.
    InParanoidiQ6ZNL6.
    KOiK05724.
    OMAiEYDNTQG.
    PhylomeDBiQ6ZNL6.
    TreeFamiTF343077.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.30.29.30. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    PF00169. PH. 2 hits.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00064. FYVE. 1 hit.
    SM00233. PH. 2 hits.
    SM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    PROSITEiPS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZNL6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFRGPKPPIA PKPRLTAPNE WRASVYLNDS LNKCSNGRLP CVDRGLDEGP     50
    RSIPKCSESE TDEDYIVVPR VPLREDEPKD EGSVGNKALV SPESSAEEEE 100
    EREEGGEACG LEGTGAGEDS VAPAAPGAGA LSREGEEGTD LALEDEGEGC 150
    ADEPGTLEQV SRSEEEEKLV QPHRECSLED SGPWAGEGVF QSDLLLPHIH 200
    GEDQEPPDTP GEAEEDDEEG CASTDPAGAD EGSGPDRPTE DMGQDAEDTS 250
    EEPPEKEELA GVQEAETATD CPEVLEEGCE EATGVTGGEQ VDLSEPPDHE 300
    KKTNQEVAAA TLEDHAQDES AEESCQIVPF ENDCMEDFVT SLTGSPYEFF 350
    PTESTSFCSE SCSPLSESAK GLESEQAPKL GLRAEENPMV GALCGQCGSL 400
    QGGAAEGPAA PDVVVVLEEE ALDDALANPY VMGVGLPGQA APGEGGQAAS 450
    DALGGYGSKE ELNCEAEGGL VPADRKNTST RVRPHSGKVA GYVPETVPEE 500
    TGPEAGSSAP GIGGAAEEVG KTLLSLEGKP LEASRALPAK PRAFTLYPRS 550
    FSVEGREIPV SVYQEPEGSG LDDHRIKRKE DNLSLSCVIG SSGSFSQRNH 600
    LPSSGTSTPS SMVDIPPPFD LACITKKPIT KSSPSLLIES DSPDKYKKKK 650
    SSFKRFLALT FKKKTENKLH VDVNVSSSRS SSESSYHGPS RILEVDRRSL 700
    SNSPQLKSRT GKLRASESPS SLIFYRDGKR KGVPFSRTVS RVESFEDRSR 750
    PPFLPLPLTK PRSISFPSAD TSDYENIPAM NSDYENIQIP PRRPARAGAF 800
    TKLFEDQSRA LSTANENDGY VDMSSFNAFE SKQQSADQDA ESAYTEPYKV 850
    CPISSAAPKE DLTSDEEQRS SEEEDSASRD PSVTHKVEGQ SRALVIAQEL 900
    LSSEKAYVEM LQHLNLDFHG AVMRALDDMD HEGRDTLARE ELRQGLSELP 950
    AIHDLHQGIL EELEERLSNW ESQQKVADVF LAREQGFDHH ATHILQFDRY 1000
    LGLLSENCLH SPRLAAAVRE FEQSVQGGSQ TAKHRLLRVV QRLFQYQVLL 1050
    TDYLNNLCPD SAEYDNTQGA LSLISKVTDR ANDSMEQGEN LQKLVHIEHS 1100
    VRGQGDLLQP GREFLKEGTL MKVTGKNRRP RHLFLMNDVL LYTYPQKDGK 1150
    YRLKNTLAVA NMKVSRPVME KVPYALKIET SESCLMLSAS SCAERDEWYG 1200
    CLSRALPEDY KAQALAAFHH SVEIRERLGV SLGERPPTLV PVTHVMMCMN 1250
    CGCDFSLTLR RHHCHACGKI VCRNCSRNKY PLKYLKDRMA KVCDGCFGEL 1300
    KKRGRAVPGL MRERPVSMSF PLSSPRFSGS AFSSVFQSIN PSTFKKQKKV 1350
    PSALTEVAAS GEGSAISGYL SRCKRGKRHW KKLWFVIKGK VLYTYMASED 1400
    KVALESMPLL GFTIAPEKEE GSSEVGPIFH LYHKKTLFYS FKAEDTNSAQ 1450
    RWIEAMEDAS VL 1462
    Length:1,462
    Mass (Da):159,891
    Last modified:May 18, 2010 - v3
    Checksum:i3012049C00F7384B
    GO
    Isoform 2 (identifier: Q6ZNL6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-922: Missing.

    Show »
    Length:540
    Mass (Da):61,238
    Checksum:iA8ED7C2316625D0E
    GO

    Sequence cautioni

    The sequence BAC85128.1 differs from that shown. Reason: Frameshift at position 79.
    The sequence BAC04878.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC04989.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAD98090.1 differs from that shown. Reason: Erroneous termination at position 1279. Translated as Lys.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241A → T in BAC85128. (PubMed:14702039)Curated
    Sequence conflicti213 – 2131A → G in BAC85128. (PubMed:14702039)Curated
    Sequence conflicti354 – 3541S → G in CAE45896. (PubMed:17974005)Curated
    Sequence conflicti574 – 5741H → Y in BAC04989. (PubMed:14702039)Curated
    Sequence conflicti1112 – 11121R → M in CAE45896. (PubMed:17974005)Curated
    Sequence conflicti1196 – 11961D → N in CAE45896. (PubMed:17974005)Curated
    Sequence conflicti1289 – 12891M → T in CAE45896. (PubMed:17974005)Curated
    Sequence conflicti1382 – 13821K → E in BAC04989. (PubMed:14702039)Curated
    Sequence conflicti1400 – 14001D → G in CAD98090. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti403 – 4031G → R.
    Corresponds to variant rs7636593 [ dbSNP | Ensembl ].
    VAR_059799
    Natural varianti828 – 8281A → T.
    Corresponds to variant rs17038795 [ dbSNP | Ensembl ].
    VAR_059800
    Natural varianti941 – 9411E → K.
    Corresponds to variant rs2307092 [ dbSNP | Ensembl ].
    VAR_059801

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 922922Missing in isoform 2. 2 PublicationsVSP_013088Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096856 mRNA. Translation: BAC04878.1. Different initiation.
    AK097276 mRNA. Translation: BAC04989.1. Different initiation.
    AK131078 mRNA. Translation: BAC85128.1. Frameshift.
    AK123054 mRNA. Translation: BAG53865.1.
    AC087591 Genomic DNA. No translation available.
    AC090954 Genomic DNA. No translation available.
    BC035364 mRNA. Translation: AAH35364.1.
    BF989107 mRNA. No translation available.
    BX640820 Transcribed RNA. Translation: CAE45896.2.
    BX538312 mRNA. Translation: CAD98090.1. Sequence problems.
    CCDSiCCDS46767.1. [Q6ZNL6-1]
    RefSeqiNP_689749.3. NM_152536.3. [Q6ZNL6-1]
    UniGeneiHs.412406.

    Genome annotation databases

    EnsembliENST00000285046; ENSP00000285046; ENSG00000154783. [Q6ZNL6-1]
    GeneIDi152273.
    KEGGihsa:152273.
    UCSCiuc003bzc.3. human. [Q6ZNL6-1]
    uc003bzd.3. human. [Q6ZNL6-2]

    Polymorphism databases

    DMDMi296439343.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096856 mRNA. Translation: BAC04878.1 . Different initiation.
    AK097276 mRNA. Translation: BAC04989.1 . Different initiation.
    AK131078 mRNA. Translation: BAC85128.1 . Frameshift.
    AK123054 mRNA. Translation: BAG53865.1 .
    AC087591 Genomic DNA. No translation available.
    AC090954 Genomic DNA. No translation available.
    BC035364 mRNA. Translation: AAH35364.1 .
    BF989107 mRNA. No translation available.
    BX640820 Transcribed RNA. Translation: CAE45896.2 .
    BX538312 mRNA. Translation: CAD98090.1 . Sequence problems.
    CCDSi CCDS46767.1. [Q6ZNL6-1 ]
    RefSeqi NP_689749.3. NM_152536.3. [Q6ZNL6-1 ]
    UniGenei Hs.412406.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3MPX X-ray 2.80 A 889-1304 [» ]
    ProteinModelPortali Q6ZNL6.
    SMRi Q6ZNL6. Positions 890-1205, 1245-1301, 1369-1461.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127439. 3 interactions.
    IntActi Q6ZNL6. 3 interactions.
    STRINGi 9606.ENSP00000285046.

    PTM databases

    PhosphoSitei Q6ZNL6.

    Polymorphism databases

    DMDMi 296439343.

    Proteomic databases

    PaxDbi Q6ZNL6.
    PRIDEi Q6ZNL6.

    Protocols and materials databases

    DNASUi 152273.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000285046 ; ENSP00000285046 ; ENSG00000154783 . [Q6ZNL6-1 ]
    GeneIDi 152273.
    KEGGi hsa:152273.
    UCSCi uc003bzc.3. human. [Q6ZNL6-1 ]
    uc003bzd.3. human. [Q6ZNL6-2 ]

    Organism-specific databases

    CTDi 152273.
    GeneCardsi GC03P014860.
    H-InvDB HIX0003091.
    HIX0003092.
    HGNCi HGNC:19117. FGD5.
    HPAi HPA014536.
    HPA019191.
    MIMi 614788. gene.
    neXtProti NX_Q6ZNL6.
    PharmGKBi PA134874843.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291216.
    HOGENOMi HOG000168874.
    HOVERGENi HBG051609.
    InParanoidi Q6ZNL6.
    KOi K05724.
    OMAi EYDNTQG.
    PhylomeDBi Q6ZNL6.
    TreeFami TF343077.

    Miscellaneous databases

    EvolutionaryTracei Q6ZNL6.
    GenomeRNAii 152273.
    NextBioi 86934.
    PROi Q6ZNL6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZNL6.
    Bgeei Q6ZNL6.
    CleanExi HS_FGD5.
    Genevestigatori Q6ZNL6.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.30.29.30. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    PF00169. PH. 2 hits.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00064. FYVE. 1 hit.
    SM00233. PH. 2 hits.
    SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    PROSITEi PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 77-1462 (ISOFORM 1).
      Tissue: Spleen and Testis.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-215 (ISOFORM 1).
      Tissue: Placenta.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-1462 (ISOFORM 1).
      Tissue: Esophageal carcinoma and Uterus.
    6. "FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells."
      Kurogane Y., Miyata M., Kubo Y., Nagamatsu Y., Kundu R.K., Uemura A., Ishida T., Quertermous T., Hirata K., Rikitake Y.
      Arterioscler. Thromb. Vasc. Biol. 32:988-996(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. "Crystal structure of the DH and PH-1 domains of human FGD5."
      Structural genomics consortium (SGC)
      Submitted (JUN-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 889-1304.

    Entry informationi

    Entry nameiFGD5_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZNL6
    Secondary accession number(s): B3KVQ3
    , Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 108 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3