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Protein

FYVE, RhoGEF and PH domain-containing protein 5

Gene

FGD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1242 – 1301FYVE-typePROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 5
Alternative name(s):
Zinc finger FYVE domain-containing protein 23
Gene namesi
Name:FGD5
Synonyms:ZFYVE23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19117. FGD5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi152273.
OpenTargetsiENSG00000154783.
PharmGKBiPA134874843.

Polymorphism and mutation databases

BioMutaiFGD5.
DMDMi296439343.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809501 – 1462FYVE, RhoGEF and PH domain-containing protein 5Add BLAST1462

Proteomic databases

EPDiQ6ZNL6.
PaxDbiQ6ZNL6.
PeptideAtlasiQ6ZNL6.
PRIDEiQ6ZNL6.

PTM databases

iPTMnetiQ6ZNL6.
PhosphoSitePlusiQ6ZNL6.

Expressioni

Tissue specificityi

Expressed in endothelial cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000154783.
CleanExiHS_FGD5.
ExpressionAtlasiQ6ZNL6. baseline and differential.
GenevisibleiQ6ZNL6. HS.

Organism-specific databases

HPAiHPA014536.
HPA019191.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-7962481,EBI-349968

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127439. 3 interactors.
IntActiQ6ZNL6. 3 interactors.
STRINGi9606.ENSP00000285046.

Structurei

Secondary structure

11462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi891 – 917Combined sources27
Helixi919 – 929Combined sources11
Helixi936 – 968Combined sources33
Turni969 – 972Combined sources4
Helixi978 – 981Combined sources4
Turni982 – 986Combined sources5
Helixi987 – 1008Combined sources22
Helixi1012 – 1022Combined sources11
Helixi1032 – 1054Combined sources23
Helixi1062 – 1084Combined sources23
Helixi1088 – 1100Combined sources13
Beta strandi1114 – 1116Combined sources3
Beta strandi1119 – 1124Combined sources6
Beta strandi1127 – 1145Combined sources19
Beta strandi1151 – 1158Combined sources8
Beta strandi1174 – 1179Combined sources6
Beta strandi1184 – 1188Combined sources5
Helixi1192 – 1204Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MPXX-ray2.80A889-1304[»]
ProteinModelPortaliQ6ZNL6.
SMRiQ6ZNL6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6ZNL6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini892 – 1084DHPROSITE-ProRule annotationAdd BLAST193
Domaini1113 – 1207PH 1PROSITE-ProRule annotationAdd BLAST95
Domaini1363 – 1461PH 2PROSITE-ProRule annotationAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 323Glu-richAdd BLAST266
Compositional biasi645 – 650Poly-Lys6

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1242 – 1301FYVE-typePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1729. Eukaryota.
KOG3531. Eukaryota.
ENOG410XRXV. LUCA.
GeneTreeiENSGT00750000117280.
HOGENOMiHOG000168874.
HOVERGENiHBG051609.
InParanoidiQ6ZNL6.
KOiK05724.
OMAiAMSSDYE.
OrthoDBiEOG091G00IK.
PhylomeDBiQ6ZNL6.
TreeFamiTF343077.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZNL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRGPKPPIA PKPRLTAPNE WRASVYLNDS LNKCSNGRLP CVDRGLDEGP
60 70 80 90 100
RSIPKCSESE TDEDYIVVPR VPLREDEPKD EGSVGNKALV SPESSAEEEE
110 120 130 140 150
EREEGGEACG LEGTGAGEDS VAPAAPGAGA LSREGEEGTD LALEDEGEGC
160 170 180 190 200
ADEPGTLEQV SRSEEEEKLV QPHRECSLED SGPWAGEGVF QSDLLLPHIH
210 220 230 240 250
GEDQEPPDTP GEAEEDDEEG CASTDPAGAD EGSGPDRPTE DMGQDAEDTS
260 270 280 290 300
EEPPEKEELA GVQEAETATD CPEVLEEGCE EATGVTGGEQ VDLSEPPDHE
310 320 330 340 350
KKTNQEVAAA TLEDHAQDES AEESCQIVPF ENDCMEDFVT SLTGSPYEFF
360 370 380 390 400
PTESTSFCSE SCSPLSESAK GLESEQAPKL GLRAEENPMV GALCGQCGSL
410 420 430 440 450
QGGAAEGPAA PDVVVVLEEE ALDDALANPY VMGVGLPGQA APGEGGQAAS
460 470 480 490 500
DALGGYGSKE ELNCEAEGGL VPADRKNTST RVRPHSGKVA GYVPETVPEE
510 520 530 540 550
TGPEAGSSAP GIGGAAEEVG KTLLSLEGKP LEASRALPAK PRAFTLYPRS
560 570 580 590 600
FSVEGREIPV SVYQEPEGSG LDDHRIKRKE DNLSLSCVIG SSGSFSQRNH
610 620 630 640 650
LPSSGTSTPS SMVDIPPPFD LACITKKPIT KSSPSLLIES DSPDKYKKKK
660 670 680 690 700
SSFKRFLALT FKKKTENKLH VDVNVSSSRS SSESSYHGPS RILEVDRRSL
710 720 730 740 750
SNSPQLKSRT GKLRASESPS SLIFYRDGKR KGVPFSRTVS RVESFEDRSR
760 770 780 790 800
PPFLPLPLTK PRSISFPSAD TSDYENIPAM NSDYENIQIP PRRPARAGAF
810 820 830 840 850
TKLFEDQSRA LSTANENDGY VDMSSFNAFE SKQQSADQDA ESAYTEPYKV
860 870 880 890 900
CPISSAAPKE DLTSDEEQRS SEEEDSASRD PSVTHKVEGQ SRALVIAQEL
910 920 930 940 950
LSSEKAYVEM LQHLNLDFHG AVMRALDDMD HEGRDTLARE ELRQGLSELP
960 970 980 990 1000
AIHDLHQGIL EELEERLSNW ESQQKVADVF LAREQGFDHH ATHILQFDRY
1010 1020 1030 1040 1050
LGLLSENCLH SPRLAAAVRE FEQSVQGGSQ TAKHRLLRVV QRLFQYQVLL
1060 1070 1080 1090 1100
TDYLNNLCPD SAEYDNTQGA LSLISKVTDR ANDSMEQGEN LQKLVHIEHS
1110 1120 1130 1140 1150
VRGQGDLLQP GREFLKEGTL MKVTGKNRRP RHLFLMNDVL LYTYPQKDGK
1160 1170 1180 1190 1200
YRLKNTLAVA NMKVSRPVME KVPYALKIET SESCLMLSAS SCAERDEWYG
1210 1220 1230 1240 1250
CLSRALPEDY KAQALAAFHH SVEIRERLGV SLGERPPTLV PVTHVMMCMN
1260 1270 1280 1290 1300
CGCDFSLTLR RHHCHACGKI VCRNCSRNKY PLKYLKDRMA KVCDGCFGEL
1310 1320 1330 1340 1350
KKRGRAVPGL MRERPVSMSF PLSSPRFSGS AFSSVFQSIN PSTFKKQKKV
1360 1370 1380 1390 1400
PSALTEVAAS GEGSAISGYL SRCKRGKRHW KKLWFVIKGK VLYTYMASED
1410 1420 1430 1440 1450
KVALESMPLL GFTIAPEKEE GSSEVGPIFH LYHKKTLFYS FKAEDTNSAQ
1460
RWIEAMEDAS VL
Length:1,462
Mass (Da):159,891
Last modified:May 18, 2010 - v3
Checksum:i3012049C00F7384B
GO
Isoform 2 (identifier: Q6ZNL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-922: Missing.

Show »
Length:540
Mass (Da):61,238
Checksum:iA8ED7C2316625D0E
GO

Sequence cautioni

The sequence BAC04878 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04989 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC85128 differs from that shown. Reason: Frameshift at position 79.Curated
The sequence CAD98090 differs from that shown. Reason: Erroneous termination at position 1279. Translated as Lys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124A → T in BAC85128 (PubMed:14702039).Curated1
Sequence conflicti213A → G in BAC85128 (PubMed:14702039).Curated1
Sequence conflicti354S → G in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti574H → Y in BAC04989 (PubMed:14702039).Curated1
Sequence conflicti1112R → M in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti1196D → N in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti1289M → T in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti1382K → E in BAC04989 (PubMed:14702039).Curated1
Sequence conflicti1400D → G in CAD98090 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059799403G → R.Corresponds to variant rs7636593dbSNPEnsembl.1
Natural variantiVAR_059800828A → T.Corresponds to variant rs17038795dbSNPEnsembl.1
Natural variantiVAR_059801941E → K.Corresponds to variant rs2307092dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0130881 – 922Missing in isoform 2. 2 PublicationsAdd BLAST922

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096856 mRNA. Translation: BAC04878.1. Different initiation.
AK097276 mRNA. Translation: BAC04989.1. Different initiation.
AK131078 mRNA. Translation: BAC85128.1. Frameshift.
AK123054 mRNA. Translation: BAG53865.1.
AC087591 Genomic DNA. No translation available.
AC090954 Genomic DNA. No translation available.
BC035364 mRNA. Translation: AAH35364.1.
BF989107 mRNA. No translation available.
BX640820 Transcribed RNA. Translation: CAE45896.2.
BX538312 mRNA. Translation: CAD98090.1. Sequence problems.
CCDSiCCDS46767.1. [Q6ZNL6-1]
RefSeqiNP_689749.3. NM_152536.3. [Q6ZNL6-1]
UniGeneiHs.412406.

Genome annotation databases

EnsembliENST00000285046; ENSP00000285046; ENSG00000154783. [Q6ZNL6-1]
GeneIDi152273.
KEGGihsa:152273.
UCSCiuc003bzc.4. human. [Q6ZNL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096856 mRNA. Translation: BAC04878.1. Different initiation.
AK097276 mRNA. Translation: BAC04989.1. Different initiation.
AK131078 mRNA. Translation: BAC85128.1. Frameshift.
AK123054 mRNA. Translation: BAG53865.1.
AC087591 Genomic DNA. No translation available.
AC090954 Genomic DNA. No translation available.
BC035364 mRNA. Translation: AAH35364.1.
BF989107 mRNA. No translation available.
BX640820 Transcribed RNA. Translation: CAE45896.2.
BX538312 mRNA. Translation: CAD98090.1. Sequence problems.
CCDSiCCDS46767.1. [Q6ZNL6-1]
RefSeqiNP_689749.3. NM_152536.3. [Q6ZNL6-1]
UniGeneiHs.412406.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MPXX-ray2.80A889-1304[»]
ProteinModelPortaliQ6ZNL6.
SMRiQ6ZNL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127439. 3 interactors.
IntActiQ6ZNL6. 3 interactors.
STRINGi9606.ENSP00000285046.

PTM databases

iPTMnetiQ6ZNL6.
PhosphoSitePlusiQ6ZNL6.

Polymorphism and mutation databases

BioMutaiFGD5.
DMDMi296439343.

Proteomic databases

EPDiQ6ZNL6.
PaxDbiQ6ZNL6.
PeptideAtlasiQ6ZNL6.
PRIDEiQ6ZNL6.

Protocols and materials databases

DNASUi152273.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285046; ENSP00000285046; ENSG00000154783. [Q6ZNL6-1]
GeneIDi152273.
KEGGihsa:152273.
UCSCiuc003bzc.4. human. [Q6ZNL6-1]

Organism-specific databases

CTDi152273.
DisGeNETi152273.
GeneCardsiFGD5.
H-InvDBHIX0003091.
HIX0003092.
HGNCiHGNC:19117. FGD5.
HPAiHPA014536.
HPA019191.
MIMi614788. gene.
neXtProtiNX_Q6ZNL6.
OpenTargetsiENSG00000154783.
PharmGKBiPA134874843.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1729. Eukaryota.
KOG3531. Eukaryota.
ENOG410XRXV. LUCA.
GeneTreeiENSGT00750000117280.
HOGENOMiHOG000168874.
HOVERGENiHBG051609.
InParanoidiQ6ZNL6.
KOiK05724.
OMAiAMSSDYE.
OrthoDBiEOG091G00IK.
PhylomeDBiQ6ZNL6.
TreeFamiTF343077.

Miscellaneous databases

ChiTaRSiFGD5. human.
EvolutionaryTraceiQ6ZNL6.
GenomeRNAii152273.
PROiQ6ZNL6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154783.
CleanExiHS_FGD5.
ExpressionAtlasiQ6ZNL6. baseline and differential.
GenevisibleiQ6ZNL6. HS.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGD5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNL6
Secondary accession number(s): B3KVQ3
, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.