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Protein

TRAF-interacting protein with FHA domain-containing protein B

Gene

TIFAB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.1 Publication

GO - Biological processi

  • auditory behavior Source: CAFA
  • cochlea development Source: CAFA
  • cochlea morphogenesis Source: CAFA
  • craniofacial suture morphogenesis Source: CAFA
  • genitalia development Source: CAFA
  • genitalia morphogenesis Source: CAFA
  • hard palate morphogenesis Source: CAFA
  • I-kappaB kinase/NF-kappaB signaling Source: InterPro
  • inner ear development Source: CAFA
  • inner ear morphogenesis Source: CAFA
  • learned vocalization behavior Source: CAFA
  • mastication Source: CAFA
  • negative regulation of relaxation of muscle Source: CAFA
  • negative regulation of saliva secretion Source: CAFA
  • neuromuscular process controlling balance Source: CAFA
  • palate development Source: CAFA
  • peristalsis Source: CAFA
  • regulation of muscle organ development Source: CAFA
  • thorax and anterior abdomen determination Source: CAFA
  • trigeminal nerve development Source: CAFA
  • vestibulocochlear nerve formation Source: CAFA

Names & Taxonomyi

Protein namesi
Recommended name:
TRAF-interacting protein with FHA domain-containing protein B
Alternative name(s):
TIFA-like protein
Gene namesi
Name:TIFAB1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:34024. TIFAB.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000255833.
PharmGKBiPA162405786.

Polymorphism and mutation databases

BioMutaiTIFAB.
DMDMi172046187.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206921 – 161TRAF-interacting protein with FHA domain-containing protein BAdd BLAST161

Proteomic databases

PaxDbiQ6ZNK6.
PeptideAtlasiQ6ZNK6.
PRIDEiQ6ZNK6.

Expressioni

Gene expression databases

BgeeiENSG00000255833.
CleanExiHS_TIFAB.
GenevisibleiQ6ZNK6. HS.

Organism-specific databases

HPAiHPA049372.

Interactioni

Subunit structurei

Interacts with TIFA.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000440509.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNK6.
SMRiQ6ZNK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 91FHASequence analysisAdd BLAST56

Phylogenomic databases

eggNOGiENOG410IYRT. Eukaryota.
ENOG410YZ4Y. LUCA.
GeneTreeiENSGT00510000049624.
HOGENOMiHOG000154576.
HOVERGENiHBG095665.
InParanoidiQ6ZNK6.
OMAiCVWVNGL.
OrthoDBiEOG091G0KR0.
PhylomeDBiQ6ZNK6.
TreeFamiTF333218.

Family and domain databases

InterProiView protein in InterPro
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR033621. TIFA.
PANTHERiPTHR31266. PTHR31266. 1 hit.
PfamiView protein in Pfam
PF00498. FHA. 1 hit.
SUPFAMiSSF49879. SSF49879. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZNK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPLTVLRV SLYHPTLGPS AFANVPPRLQ HDTSPLLLGR GQDAHLQLQL
60 70 80 90 100
PRLSRRHLSL EPYLEKGSAL LAFCLKALSR KGCVWVNGLT LRYLEQVPLS
110 120 130 140 150
TVNRVSFSGI QMLVRVEEGT SLEAFVCYFH VSPSPLIYRP EAEETDEWEG
160
ISQGQPPPGS G
Length:161
Mass (Da):17,888
Last modified:February 26, 2008 - v2
Checksum:iFE37A8C33F60BB42
GO

Sequence cautioni

The sequence BAC85138 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131088 mRNA. Translation: BAC85138.1. Different initiation.
AB161513 mRNA. Translation: BAD89018.1.
CCDSiCCDS43365.1.
RefSeqiNP_001092691.1. NM_001099221.1.
UniGeneiHs.552091.

Genome annotation databases

EnsembliENST00000537858; ENSP00000440509; ENSG00000255833.
GeneIDi497189.
KEGGihsa:497189.
UCSCiuc003law.5. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTIFAB_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNK6
Secondary accession number(s): Q5H8A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: May 10, 2017
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot