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Protein

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7

Gene

GCNT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Glycosyltransferase.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-913709. O-linked glycosylation of mucins.
SignaLinkiQ6ZNI0.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT14. Glycosyltransferase Family 14.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 (EC:2.4.1.-)
Gene namesi
Name:GCNT7
Synonyms:C20orf105
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16099. GCNT7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 2517Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini26 – 430405ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389279.

Polymorphism and mutation databases

BioMutaiGCNT7.
DMDMi156630799.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7PRO_0000299038Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 205By similarity
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Disulfide bondi139 ↔ 354By similarity
Disulfide bondi160 ↔ 187By similarity
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi363 ↔ 395By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6ZNI0.
PRIDEiQ6ZNI0.

PTM databases

iPTMnetiQ6ZNI0.
PhosphoSiteiQ6ZNI0.

Expressioni

Gene expression databases

BgeeiQ6ZNI0.
CleanExiHS_GCNT7.
ExpressionAtlasiQ6ZNI0. baseline and differential.
GenevisibleiQ6ZNI0. HS.

Organism-specific databases

HPAiHPA052617.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000243913.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNI0.
SMRiQ6ZNI0. Positions 68-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 14 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0799. Eukaryota.
ENOG410XQ7M. LUCA.
HOGENOMiHOG000293251.
HOVERGENiHBG051711.
InParanoidiQ6ZNI0.
OrthoDBiEOG74N5HW.
PhylomeDBiQ6ZNI0.
TreeFamiTF315534.

Family and domain databases

InterProiIPR003406. Glyco_trans_14.
[Graphical view]
PfamiPF02485. Branch. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZNI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLRATKSG LVVRAVICIF IFLYLRNPTP AESEEEPAQP EVVECGFYPD
60 70 80 90 100
ELCSALFEGK GAAPQIAKFC KTPHKSEIHA HLHTPGNCSR ISRGLHFITR
110 120 130 140 150
PLSAEEGDFS LAYIITIHKE LAMFVQLLRA IYVPQNVYCI HVDEKAPMKY
160 170 180 190 200
KTAVQTLVNC FENVFISSKT EKVAYAGFTR LQADINCMKV LVHSKFQWNY
210 220 230 240 250
VINLCGQDFP IKTNREIIHY IRSKWSDKNI TPGVIQPLHI KSKTSQSHLE
260 270 280 290 300
FVPKGSIYAP PNNRFKDKPP HNLTIYFGSA YYVLTRKFVE FILTDIHAKD
310 320 330 340 350
MLQWSKDIRS PEQHYWVTLN RLKDAPGATP NAGWEGNVRA IKRKSEEGNV
360 370 380 390 400
HDGCKGRYVE DICVYGPGDL PWLIQSPSLF ANKFEPSTDP LVVTCLERRH
410 420 430
RLQVLRQAEV PIEPHWHFQQ QSHFNMRLNR
Length:430
Mass (Da):49,319
Last modified:August 21, 2007 - v2
Checksum:iA134E24C3F4D8499
GO

Sequence cautioni

The sequence CAC03741.2 differs from that shown. Reason: Erroneous termination at position 65. Translated as Gln.Curated
The sequence CAC03741.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti352 – 3521D → E.1 Publication
Corresponds to variant rs34552628 [ dbSNP | Ensembl ].
VAR_061211
Natural varianti425 – 4251N → H.
Corresponds to variant rs3746627 [ dbSNP | Ensembl ].
VAR_059315

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131203 mRNA. Translation: BAD18395.1.
AL109806 Genomic DNA. Translation: CAC03741.2. Sequence problems.
RefSeqiNP_542182.1. NM_080615.1.
UniGeneiHs.655916.

Genome annotation databases

EnsembliENST00000243913; ENSP00000243913; ENSG00000124091.
GeneIDi140687.
KEGGihsa:140687.
UCSCiuc061xwx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131203 mRNA. Translation: BAD18395.1.
AL109806 Genomic DNA. Translation: CAC03741.2. Sequence problems.
RefSeqiNP_542182.1. NM_080615.1.
UniGeneiHs.655916.

3D structure databases

ProteinModelPortaliQ6ZNI0.
SMRiQ6ZNI0. Positions 68-405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000243913.

Protein family/group databases

CAZyiGT14. Glycosyltransferase Family 14.

PTM databases

iPTMnetiQ6ZNI0.
PhosphoSiteiQ6ZNI0.

Polymorphism and mutation databases

BioMutaiGCNT7.
DMDMi156630799.

Proteomic databases

PaxDbiQ6ZNI0.
PRIDEiQ6ZNI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243913; ENSP00000243913; ENSG00000124091.
GeneIDi140687.
KEGGihsa:140687.
UCSCiuc061xwx.1. human.

Organism-specific databases

CTDi140687.
GeneCardsiGCNT7.
HGNCiHGNC:16099. GCNT7.
HPAiHPA052617.
neXtProtiNX_Q6ZNI0.
PharmGKBiPA162389279.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0799. Eukaryota.
ENOG410XQ7M. LUCA.
HOGENOMiHOG000293251.
HOVERGENiHBG051711.
InParanoidiQ6ZNI0.
OrthoDBiEOG74N5HW.
PhylomeDBiQ6ZNI0.
TreeFamiTF315534.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-HSA-913709. O-linked glycosylation of mucins.
SignaLinkiQ6ZNI0.

Miscellaneous databases

ChiTaRSiGCNT7. human.
GenomeRNAii140687.
PROiQ6ZNI0.

Gene expression databases

BgeeiQ6ZNI0.
CleanExiHS_GCNT7.
ExpressionAtlasiQ6ZNI0. baseline and differential.
GenevisibleiQ6ZNI0. HS.

Family and domain databases

InterProiIPR003406. Glyco_trans_14.
[Graphical view]
PfamiPF02485. Branch. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-352.
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGCNT7_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNI0
Secondary accession number(s): Q9HCV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 8, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.