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Protein

Zinc finger protein 497

Gene

ZNF497

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri106 – 12823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 15623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri162 – 18423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri190 – 21223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri218 – 24023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 497
Gene namesi
Name:ZNF497
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23714. ZNF497.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134994387.

Polymorphism and mutation databases

BioMutaiZNF497.
DMDMi229462815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Zinc finger protein 497PRO_0000047618Add
BLAST

Proteomic databases

PaxDbiQ6ZNH5.
PeptideAtlasiQ6ZNH5.
PRIDEiQ6ZNH5.

PTM databases

iPTMnetiQ6ZNH5.
PhosphoSiteiQ6ZNH5.

Expressioni

Gene expression databases

BgeeiENSG00000174586.
CleanExiHS_ZNF497.
ExpressionAtlasiQ6ZNH5. baseline and differential.
GenevisibleiQ6ZNH5. HS.

Organism-specific databases

HPAiHPA047872.

Interactioni

Protein-protein interaction databases

BioGridi127835. 2 interactions.
STRINGi9606.ENSP00000311183.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNH5.
SMRiQ6ZNH5. Positions 107-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri106 – 12823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 15623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri162 – 18423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri190 – 21223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri218 – 24023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129960.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZNH5.
OMAiAFSWNSN.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ZNH5.
TreeFamiTF337005.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZNH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPRGWTLQ VAPEEGQVLC NVKTATRGLS EGAVSGGWGA WENSTEVPRE
60 70 80 90 100
AGDGQRQQAT LGAADEQGGP GRELGPADGG RDGAGPRSEP ADRALRPSPL
110 120 130 140 150
PEEPGCRCGE CGKAFSQGSY LLQHRRVHTG EKPYTCPECG KAFAWSSNLS
160 170 180 190 200
QHQRIHSGEK PYACRECGKA FRAHSQLIHH QETHSGLKPF RCPDCGKSFG
210 220 230 240 250
RSTTLVQHRR THTGEKPYEC PECGKAFSWN SNFLEHRRVH TGARPHACRD
260 270 280 290 300
CGKAFSQSSN LAEHLKIHAG ARPHACPDCG KAFVRVAGLR QHRRTHSSEK
310 320 330 340 350
PFPCAECGKA FRESSQLLQH QRTHTGERPF ECAECGQAFV MGSYLAEHRR
360 370 380 390 400
VHTGEKPHAC AQCGKAFSQR SNLLSHRRTH SGAKPFACAD CGKAFRGSSG
410 420 430 440 450
LAHHRLSHTG ERPFACAECG KAFRGSSELR QHQRLHSGER PFVCAHCSKA
460 470 480 490
FVRKSELLSH RRTHTGERPY ACGECGKPFS HRCNLNEHQK RHGGRAAP
Length:498
Mass (Da):54,721
Last modified:May 5, 2009 - v2
Checksum:iAAC4DD81A06CECFA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti212 – 2143HTG → RA in AAF16412 (Ref. 4) Curated
Sequence conflicti241 – 2411T → A in AAF16412 (Ref. 4) Curated
Sequence conflicti320 – 3201H → Y in AAF16412 (Ref. 4) Curated
Sequence conflicti367 – 3671F → S in BAC86660 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti174 – 1741H → Q.2 Publications
Corresponds to variant rs12609654 [ dbSNP | Ensembl ].
VAR_055270

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126727 mRNA. Translation: BAC86660.1.
AK131209 mRNA. Translation: BAD18400.1.
CH471135 Genomic DNA. Translation: EAW72578.1.
BC118983 mRNA. Translation: AAI18984.1.
BC125273 mRNA. Translation: AAI25274.1.
AF064790 Genomic DNA. Translation: AAF16412.1.
CCDSiCCDS12977.1.
RefSeqiNP_001193938.1. NM_001207009.1.
NP_940860.2. NM_198458.2.
UniGeneiHs.447840.

Genome annotation databases

EnsembliENST00000311044; ENSP00000311183; ENSG00000174586.
ENST00000425453; ENSP00000402815; ENSG00000174586.
GeneIDi162968.
KEGGihsa:162968.
UCSCiuc002qsh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126727 mRNA. Translation: BAC86660.1.
AK131209 mRNA. Translation: BAD18400.1.
CH471135 Genomic DNA. Translation: EAW72578.1.
BC118983 mRNA. Translation: AAI18984.1.
BC125273 mRNA. Translation: AAI25274.1.
AF064790 Genomic DNA. Translation: AAF16412.1.
CCDSiCCDS12977.1.
RefSeqiNP_001193938.1. NM_001207009.1.
NP_940860.2. NM_198458.2.
UniGeneiHs.447840.

3D structure databases

ProteinModelPortaliQ6ZNH5.
SMRiQ6ZNH5. Positions 107-492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127835. 2 interactions.
STRINGi9606.ENSP00000311183.

PTM databases

iPTMnetiQ6ZNH5.
PhosphoSiteiQ6ZNH5.

Polymorphism and mutation databases

BioMutaiZNF497.
DMDMi229462815.

Proteomic databases

PaxDbiQ6ZNH5.
PeptideAtlasiQ6ZNH5.
PRIDEiQ6ZNH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311044; ENSP00000311183; ENSG00000174586.
ENST00000425453; ENSP00000402815; ENSG00000174586.
GeneIDi162968.
KEGGihsa:162968.
UCSCiuc002qsh.3. human.

Organism-specific databases

CTDi162968.
GeneCardsiZNF497.
HGNCiHGNC:23714. ZNF497.
HPAiHPA047872.
neXtProtiNX_Q6ZNH5.
PharmGKBiPA134994387.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129960.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZNH5.
OMAiAFSWNSN.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ZNH5.
TreeFamiTF337005.

Miscellaneous databases

GenomeRNAii162968.
PROiQ6ZNH5.

Gene expression databases

BgeeiENSG00000174586.
CleanExiHS_ZNF497.
ExpressionAtlasiQ6ZNH5. baseline and differential.
GenevisibleiQ6ZNH5. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN497_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNH5
Secondary accession number(s): Q05AG8
, Q0VF48, Q6ZTD2, Q9UIA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 5, 2009
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.