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Protein

KRAB-A domain-containing protein 2

Gene

KRBA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
KRAB-A domain-containing protein 2
Gene namesi
Name:KRBA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26989. KRBA2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393680.

Polymorphism and mutation databases

BioMutaiKRBA2.
DMDMi74710682.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492KRAB-A domain-containing protein 2PRO_0000300113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151PhosphoserineCombined sources
Modified residuei117 – 1171PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZNG9.
PeptideAtlasiQ6ZNG9.
PRIDEiQ6ZNG9.

PTM databases

iPTMnetiQ6ZNG9.
PhosphoSiteiQ6ZNG9.

Expressioni

Gene expression databases

BgeeiENSG00000184619.
CleanExiHS_KRBA2.
ExpressionAtlasiQ6ZNG9. baseline and differential.
GenevisibleiQ6ZNG9. HS.

Organism-specific databases

HPAiHPA022849.

Interactioni

Protein-protein interaction databases

BioGridi125885. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNG9.
SMRiQ6ZNG9. Positions 203-444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 11782KRABAdd
BLAST
Domaini247 – 415169Integrase catalyticPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili427 – 45731Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 integrase catalytic domain.PROSITE-ProRule annotation
Contains 1 KRAB domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0017. Eukaryota.
COG2801. LUCA.
GeneTreeiENSGT00760000119070.
HOGENOMiHOG000015353.
HOVERGENiHBG100065.
InParanoidiQ6ZNG9.
OMAiKYFQTIK.
OrthoDBiEOG091G09O3.
PhylomeDBiQ6ZNG9.
TreeFamiTF323092.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.420.10. 1 hit.
InterProiIPR001584. Integrase_cat-core.
IPR001909. KRAB.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50994. INTEGRASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZNG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSFLVPSLV SSPVLLKLLF SPGPKTIWSL WQQPMLFQEA TAFENMTKDW
60 70 80 90 100
NYLEGSQKDC YRDTMLDSYE NTVPQGSFLQ LSMMPQRAGN DPPGVSNASE
110 120 130 140 150
MEMEISNMRE KFLMSVTKLV ESKSYNSKVF SKEKYFQTIK EVKEAKEKGK
160 170 180 190 200
KSSRDYRRAA KYDVISVQGT EKLIEATHGE RDRIRYYVHK EELFDILHDT
210 220 230 240 250
HLSIGHGGRT RMLKELQGKY GNVTKEVIVL YLTLCKQCHQ KNPVPKRGLA
260 270 280 290 300
PKPMTFKDID STCQVEILDM QSSADGEFKF ILYYQDHSTK FIILRPLRTK
310 320 330 340 350
QAHEVVSVLL DIFTILGTPS VLDSDSGVEF TNQVVHELNE LWPDLKIVSG
360 370 380 390 400
KYHPGQSQGS LEGASRDVKN MISTWMQSNH SCHWAKGLRF MQMVRNQAFD
410 420 430 440 450
VSLQQSPFEA MFGYKAKFGL YSSNLPRETV ATLQTEEELE IAEEQLENSL
460 470 480 490
WIRQEERAEI GADRSDMDDD MDPTPEASEP STSQGTSGLL CW
Length:492
Mass (Da):56,205
Last modified:July 5, 2004 - v1
Checksum:iD84C1502A38DCCAF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti435 – 4351T → M.
Corresponds to variant rs370752 [ dbSNP | Ensembl ].
VAR_051087

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131219 mRNA. Translation: BAD18406.1.
BC033390 mRNA. Translation: AAH33390.1.
CCDSiCCDS11141.1.
RefSeqiNP_001291876.1. NM_001304947.1.
NP_998762.1. NM_213597.3.
UniGeneiHs.304604.

Genome annotation databases

EnsembliENST00000331336; ENSP00000328017; ENSG00000184619.
GeneIDi124751.
KEGGihsa:124751.
UCSCiuc002glf.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131219 mRNA. Translation: BAD18406.1.
BC033390 mRNA. Translation: AAH33390.1.
CCDSiCCDS11141.1.
RefSeqiNP_001291876.1. NM_001304947.1.
NP_998762.1. NM_213597.3.
UniGeneiHs.304604.

3D structure databases

ProteinModelPortaliQ6ZNG9.
SMRiQ6ZNG9. Positions 203-444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125885. 5 interactions.

PTM databases

iPTMnetiQ6ZNG9.
PhosphoSiteiQ6ZNG9.

Polymorphism and mutation databases

BioMutaiKRBA2.
DMDMi74710682.

Proteomic databases

PaxDbiQ6ZNG9.
PeptideAtlasiQ6ZNG9.
PRIDEiQ6ZNG9.

Protocols and materials databases

DNASUi124751.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331336; ENSP00000328017; ENSG00000184619.
GeneIDi124751.
KEGGihsa:124751.
UCSCiuc002glf.1. human.

Organism-specific databases

CTDi124751.
GeneCardsiKRBA2.
H-InvDBHIX0039124.
HGNCiHGNC:26989. KRBA2.
HPAiHPA022849.
neXtProtiNX_Q6ZNG9.
PharmGKBiPA162393680.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0017. Eukaryota.
COG2801. LUCA.
GeneTreeiENSGT00760000119070.
HOGENOMiHOG000015353.
HOVERGENiHBG100065.
InParanoidiQ6ZNG9.
OMAiKYFQTIK.
OrthoDBiEOG091G09O3.
PhylomeDBiQ6ZNG9.
TreeFamiTF323092.

Miscellaneous databases

GenomeRNAii124751.
PROiQ6ZNG9.

Gene expression databases

BgeeiENSG00000184619.
CleanExiHS_KRBA2.
ExpressionAtlasiQ6ZNG9. baseline and differential.
GenevisibleiQ6ZNG9. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.420.10. 1 hit.
InterProiIPR001584. Integrase_cat-core.
IPR001909. KRAB.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50994. INTEGRASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRBA2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNG9
Secondary accession number(s): Q8IYY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-46 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.