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Q6ZNG2

- DBX2_HUMAN

UniProt

Q6ZNG2 - DBX2_HUMAN

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Protein

Homeobox protein DBX2

Gene
DBX2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi186 – 24560HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
  2. transcription regulatory region sequence-specific DNA binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DBX2
Alternative name(s):
Developing brain homeobox protein 2
Gene namesi
Name:DBX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:33186. DBX2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383249.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Homeobox protein DBX2PRO_0000302849Add
BLAST

Proteomic databases

PaxDbiQ6ZNG2.
PRIDEiQ6ZNG2.

PTM databases

PhosphoSiteiQ6ZNG2.

Expressioni

Gene expression databases

BgeeiQ6ZNG2.
CleanExiHS_DBX2.
GenevestigatoriQ6ZNG2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331470.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNG2.
SMRiQ6ZNG2. Positions 157-244.

Family & Domainsi

Sequence similaritiesi

Belongs to the H2.0 homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG270330.
HOGENOMiHOG000112172.
HOVERGENiHBG104467.
InParanoidiQ6ZNG2.
OMAiGTRWAFQ.
OrthoDBiEOG7SXW4H.
PhylomeDBiQ6ZNG2.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZNG2-1 [UniParc]FASTAAdd to Basket

« Hide

MLPSAVAAHA GAYWDVVASS ALLNLPAAPG FGNLGKSFLI ENLLRVGGAP    50
TPRLQPPAPH DPATALATAG AQLRPLPASP VPLKLCPAAE QVSPAGAPYG 100
TRWAFQVLSP SADSARLPGR APGDRDCTFQ PSAPAPSKPF LLSTPPFYSA 150
CCGGSCRRPA SSTAFPREES MLPLLTQDSN SKARRGILRR AVFSEDQRKA 200
LEKMFQKQKY ISKTDRKKLA INLGLKESQV KIWFQNRRMK WRNSKEKEVL 250
SNRCIQEVGL QEDPLSRSAL GFPSPCPSIW DVPQQHSSPR WRENSPEPSE 300
RLIQESSGAP PPEANSLQGA LYLCSEEEAG SKGVLTGAV 339
Length:339
Mass (Da):36,555
Last modified:May 18, 2010 - v2
Checksum:i7E9CAD61C3DAEBEB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti171 – 1711M → V.1 Publication
Corresponds to variant rs2731038 [ dbSNP | Ensembl ].
VAR_034969

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131230 mRNA. Translation: BAD18413.1.
AC008127 Genomic DNA. No translation available.
AC079033 Genomic DNA. No translation available.
AC089986 Genomic DNA. No translation available.
CCDSiCCDS31781.1.
RefSeqiNP_001004329.2. NM_001004329.2.
UniGeneiHs.302764.

Genome annotation databases

EnsembliENST00000332700; ENSP00000331470; ENSG00000185610.
GeneIDi440097.
KEGGihsa:440097.
UCSCiuc001rok.1. human.

Polymorphism databases

DMDMi296434473.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131230 mRNA. Translation: BAD18413.1 .
AC008127 Genomic DNA. No translation available.
AC079033 Genomic DNA. No translation available.
AC089986 Genomic DNA. No translation available.
CCDSi CCDS31781.1.
RefSeqi NP_001004329.2. NM_001004329.2.
UniGenei Hs.302764.

3D structure databases

ProteinModelPortali Q6ZNG2.
SMRi Q6ZNG2. Positions 157-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000331470.

PTM databases

PhosphoSitei Q6ZNG2.

Polymorphism databases

DMDMi 296434473.

Proteomic databases

PaxDbi Q6ZNG2.
PRIDEi Q6ZNG2.

Protocols and materials databases

DNASUi 440097.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332700 ; ENSP00000331470 ; ENSG00000185610 .
GeneIDi 440097.
KEGGi hsa:440097.
UCSCi uc001rok.1. human.

Organism-specific databases

CTDi 440097.
GeneCardsi GC12M045408.
HGNCi HGNC:33186. DBX2.
neXtProti NX_Q6ZNG2.
PharmGKBi PA162383249.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG270330.
HOGENOMi HOG000112172.
HOVERGENi HBG104467.
InParanoidi Q6ZNG2.
OMAi GTRWAFQ.
OrthoDBi EOG7SXW4H.
PhylomeDBi Q6ZNG2.
TreeFami TF350735.

Miscellaneous databases

GeneWikii DBX2.
GenomeRNAii 440097.
NextBioi 108942.
PROi Q6ZNG2.

Gene expression databases

Bgeei Q6ZNG2.
CleanExi HS_DBX2.
Genevestigatori Q6ZNG2.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-171.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDBX2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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