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Protein

Zinc finger protein 600

Gene

ZNF600

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri162 – 184C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri582 – 604C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri610 – 632C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri638 – 660C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri666 – 688C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri694 – 716C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33168-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 600
Gene namesi
Name:ZNF600
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30951. ZNF600.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189190.
PharmGKBiPA134977938.

Polymorphism and mutation databases

BioMutaiZNF600.
DMDMi296453048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345931 – 722Zinc finger protein 600Add BLAST722

Proteomic databases

EPDiQ6ZNG1.
MaxQBiQ6ZNG1.
PaxDbiQ6ZNG1.
PeptideAtlasiQ6ZNG1.
PRIDEiQ6ZNG1.

PTM databases

iPTMnetiQ6ZNG1.
PhosphoSitePlusiQ6ZNG1.

Expressioni

Gene expression databases

BgeeiENSG00000189190.
CleanExiHS_ZNF600.
GenevisibleiQ6ZNG1. HS.

Interactioni

Protein-protein interaction databases

BioGridi127833. 1 interactor.
IntActiQ6ZNG1. 1 interactor.
STRINGi9606.ENSP00000344791.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNG1.
SMRiQ6ZNG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 20 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri162 – 184C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri582 – 604C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri610 – 632C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri638 – 660C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri666 – 688C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri694 – 716C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZNG1.
KOiK09228.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ZNG1.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 20 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 19 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZNG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKEVLSTGQ GNTEVIHTGT LQRYQSYHIG DFCFQEIEKE IHDIEFQCQE
60 70 80 90 100
DERNGHEAPM TKIKKLTGST DQHDHRHAGN KPIKDQLGSS FYSHLPELHI
110 120 130 140 150
IQIKGKIGNQ FEKSTSDAPS VSTSQRISPR PQIHISNNYG NNSPNSSLLP
160 170 180 190 200
QKQEVYMREK SFQCNESGKA FNCSSLLRKH QIPHLGDKQY KCDVCGKLFN
210 220 230 240 250
HKQYLTCHCR CHTGEKPYKC NECGKSFSQV SSLTCHRRLH TAVKSHKCNE
260 270 280 290 300
CGKIFGQNSA LVIHKAIHTG EKPYKCNECD KAFNQQSNLA RHRRIHTGEK
310 320 330 340 350
PYKCEECDKV FSRKSTLESH KRIHTGEKPY KCKVCDTAFT WNSQLARHKR
360 370 380 390 400
IHTGEKTYKC NECGKTFSHK SSLVCHHRLH GGEKSYKCKV CDKAFAWNSH
410 420 430 440 450
LVRHTRIHSG GKPYKCNECG KTFGQNSDLL IHKSIHTGEQ PYKYEECEKV
460 470 480 490 500
FSCGSTLETH KIIHTGEKPY KCKVCDKAFA CHSYLAKHTR IHSGEKPYKC
510 520 530 540 550
NECSKTFRLR SYLASHRRVH SGEKPYKCNE CSKTFSQRSY LHCHRRLHSG
560 570 580 590 600
EKPYKCNECG KTFSHKPSLV HHRRLHTGEK SYKCTVCDKA FVRNSYLARH
610 620 630 640 650
TRIHTAEKPY KCNECGKAFN QQSQLSLHHR IHAGEKLYKC ETCDKVFSRK
660 670 680 690 700
SHLKRHRRIH PGKKPYKCKV CDKTFGSDSH LKQHTGLHTG EKPYKCNECG
710 720
KAFSKQSTLI HHQAVHGVGK LD
Length:722
Mass (Da):83,124
Last modified:May 18, 2010 - v2
Checksum:iE316D2E12AFB59F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti508R → H in BAD18414 (PubMed:14702039).Curated1
Sequence conflicti631I → V in CAE45968 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0574272M → V.Corresponds to variant rs7252818dbSNPEnsembl.1
Natural variantiVAR_05992513T → R.Corresponds to variant rs7252128dbSNPEnsembl.1
Natural variantiVAR_059926209C → R.2 PublicationsCorresponds to variant rs1820128dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131231 mRNA. Translation: BAD18414.1.
BX640933 mRNA. Translation: CAE45968.1.
AC008813 Genomic DNA. No translation available.
CCDSiCCDS12856.1.
RefSeqiNP_001308795.1. NM_001321866.1.
NP_001308796.1. NM_001321867.1.
NP_940859.3. NM_198457.3.
UniGeneiHs.696848.

Genome annotation databases

EnsembliENST00000338230; ENSP00000344791; ENSG00000189190.
GeneIDi162966.
KEGGihsa:162966.
UCSCiuc002qab.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131231 mRNA. Translation: BAD18414.1.
BX640933 mRNA. Translation: CAE45968.1.
AC008813 Genomic DNA. No translation available.
CCDSiCCDS12856.1.
RefSeqiNP_001308795.1. NM_001321866.1.
NP_001308796.1. NM_001321867.1.
NP_940859.3. NM_198457.3.
UniGeneiHs.696848.

3D structure databases

ProteinModelPortaliQ6ZNG1.
SMRiQ6ZNG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127833. 1 interactor.
IntActiQ6ZNG1. 1 interactor.
STRINGi9606.ENSP00000344791.

PTM databases

iPTMnetiQ6ZNG1.
PhosphoSitePlusiQ6ZNG1.

Polymorphism and mutation databases

BioMutaiZNF600.
DMDMi296453048.

Proteomic databases

EPDiQ6ZNG1.
MaxQBiQ6ZNG1.
PaxDbiQ6ZNG1.
PeptideAtlasiQ6ZNG1.
PRIDEiQ6ZNG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338230; ENSP00000344791; ENSG00000189190.
GeneIDi162966.
KEGGihsa:162966.
UCSCiuc002qab.5. human.

Organism-specific databases

CTDi162966.
GeneCardsiZNF600.
HGNCiHGNC:30951. ZNF600.
neXtProtiNX_Q6ZNG1.
OpenTargetsiENSG00000189190.
PharmGKBiPA134977938.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZNG1.
KOiK09228.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ZNG1.
TreeFamiTF341892.

Enzyme and pathway databases

BioCyciZFISH:G66-33168-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii162966.
PROiQ6ZNG1.

Gene expression databases

BgeeiENSG00000189190.
CleanExiHS_ZNF600.
GenevisibleiQ6ZNG1. HS.

Family and domain databases

Gene3Di3.30.160.60. 20 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 19 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN600_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNG1
Secondary accession number(s): Q6MZR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.