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Protein

Zinc finger protein 620

Gene

ZNF620

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri196 – 21823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 620
Gene namesi
Name:ZNF620
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28742. ZNF620.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134942360.

Polymorphism and mutation databases

BioMutaiZNF620.
DMDMi74762397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Zinc finger protein 620PRO_0000047691Add
BLAST

Proteomic databases

PaxDbiQ6ZNG0.
PRIDEiQ6ZNG0.

PTM databases

PhosphoSiteiQ6ZNG0.

Expressioni

Gene expression databases

BgeeiQ6ZNG0.
CleanExiHS_ZNF620.
ExpressionAtlasiQ6ZNG0. baseline and differential.

Organism-specific databases

HPAiHPA031452.

Interactioni

Protein-protein interaction databases

BioGridi128978. 3 interactions.
IntActiQ6ZNG0. 1 interaction.
STRINGi9606.ENSP00000322265.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNG0.
SMRiQ6ZNG0. Positions 11-52, 152-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 8272KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri196 – 21823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123072.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZNG0.
KOiK09228.
OMAiSSLEQPQ.
PhylomeDBiQ6ZNG0.
TreeFamiTF350844.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZNG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQTAWRQEP VTFEDVAVYF TQNEWASLDS VQRALYREVM LENYANVASL
60 70 80 90 100
AFPFTTPVLV SQLEQGELPW GLDPWEPMGR EALRGICPGD EARTEKEGLT
110 120 130 140 150
PKDHVSKETE SFRLMVGGLP GNVSQHLDFG SSLEQPQGHW IIKTKSKRRH
160 170 180 190 200
FTDTSARHHE AYEVKNGEKF EKLGKNISVS TQLTTNQTNP SGQISYECGQ
210 220 230 240 250
CGRYFIQMAD FHRHEKCHTG EKSFECKECG KYFRYNSLLI RHQIIHTGKK
260 270 280 290 300
PFKCKECGKG LSSDTALIQH QRIHTGEKPY ECKECGKAFS SSSVFLQHQR
310 320 330 340 350
FHTGEKLYEC NECWKTFSCS SSFTVHQRMH TGEKPYECKE CGKRLSSNTA
360 370 380 390 400
LTQHQRIHTG EKPFECKECG KAFNQKITLI QHQRVHTGEK PYECKVCGKT
410 420
FSWCGRFILH QKLHTQKTPV QA
Length:422
Mass (Da):48,503
Last modified:July 5, 2004 - v1
Checksum:i25F673810C3A1923
GO
Isoform 2 (identifier: Q6ZNG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.

Note: No experimental confirmation available.
Show »
Length:308
Mass (Da):35,439
Checksum:i6ED0278EE86AAFB4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 114114Missing in isoform 2. 1 PublicationVSP_016040Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093599 mRNA. Translation: BAC04203.1.
AK131232 mRNA. Translation: BAD18415.1.
CCDSiCCDS33740.1. [Q6ZNG0-1]
CCDS58825.1. [Q6ZNG0-2]
RefSeqiNP_001243096.1. NM_001256167.1. [Q6ZNG0-2]
NP_001243097.1. NM_001256168.1. [Q6ZNG0-2]
NP_787084.1. NM_175888.3. [Q6ZNG0-1]
XP_005265068.1. XM_005265011.2. [Q6ZNG0-1]
XP_005265069.1. XM_005265012.2. [Q6ZNG0-1]
UniGeneiHs.581541.

Genome annotation databases

EnsembliENST00000314529; ENSP00000322265; ENSG00000177842. [Q6ZNG0-1]
ENST00000418905; ENSP00000391472; ENSG00000177842. [Q6ZNG0-2]
GeneIDi253639.
KEGGihsa:253639.
UCSCiuc003ckk.5. human. [Q6ZNG0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093599 mRNA. Translation: BAC04203.1.
AK131232 mRNA. Translation: BAD18415.1.
CCDSiCCDS33740.1. [Q6ZNG0-1]
CCDS58825.1. [Q6ZNG0-2]
RefSeqiNP_001243096.1. NM_001256167.1. [Q6ZNG0-2]
NP_001243097.1. NM_001256168.1. [Q6ZNG0-2]
NP_787084.1. NM_175888.3. [Q6ZNG0-1]
XP_005265068.1. XM_005265011.2. [Q6ZNG0-1]
XP_005265069.1. XM_005265012.2. [Q6ZNG0-1]
UniGeneiHs.581541.

3D structure databases

ProteinModelPortaliQ6ZNG0.
SMRiQ6ZNG0. Positions 11-52, 152-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128978. 3 interactions.
IntActiQ6ZNG0. 1 interaction.
STRINGi9606.ENSP00000322265.

PTM databases

PhosphoSiteiQ6ZNG0.

Polymorphism and mutation databases

BioMutaiZNF620.
DMDMi74762397.

Proteomic databases

PaxDbiQ6ZNG0.
PRIDEiQ6ZNG0.

Protocols and materials databases

DNASUi253639.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314529; ENSP00000322265; ENSG00000177842. [Q6ZNG0-1]
ENST00000418905; ENSP00000391472; ENSG00000177842. [Q6ZNG0-2]
GeneIDi253639.
KEGGihsa:253639.
UCSCiuc003ckk.5. human. [Q6ZNG0-1]

Organism-specific databases

CTDi253639.
GeneCardsiZNF620.
HGNCiHGNC:28742. ZNF620.
HPAiHPA031452.
neXtProtiNX_Q6ZNG0.
PharmGKBiPA134942360.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123072.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZNG0.
KOiK09228.
OMAiSSLEQPQ.
PhylomeDBiQ6ZNG0.
TreeFamiTF350844.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii253639.
NextBioi92139.
PROiQ6ZNG0.

Gene expression databases

BgeeiQ6ZNG0.
CleanExiHS_ZNF620.
ExpressionAtlasiQ6ZNG0. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Thymus.

Entry informationi

Entry nameiZN620_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNG0
Secondary accession number(s): Q8N223
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.