Reviewed, UniProtKB/Swiss-Prot Q6ZNF1 (AKD1_HUMAN)

Names and origin

Protein names

Recommended name:
    Adenylate kinase domain-containing protein 1

Gene names

Name:

AKD1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the adenylate kinase family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro nucleobase, nucleoside, nucleotide kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZNF1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZNF1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     291-336: VSSFVFFFKT...GSSHLSLSKC → PNKEKRKRGI...LSKQNIHNQK

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Adenylate kinase domain-containing protein 1		PRO_0000342683
Regions
	Compositional bias	102 – 193	92	Glu-rich
Natural variations
	Alternative sequence	291 – 336	46	VSSFV…SLSKC → PNKEKRKRGISENTTCYKCN HMSPWCEYAGLPYRGLLILY SATATATAGTKHCRSGAKVI VALSKQNIHNQK in isoform 2.		VSP_034531

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 5FB4ED6C265E1CFE	FASTA	336	39,019
	10 20 30 40 50 60 MKERKRHLGD TKHFCPVVLK ENFILQPGNT EEAAKYREKI YYFSSAEAKE KFLEHPEDYV 70 80 90 100 110 120 AHEEPLKAPP LRICLVGPQG SGKTMCGRQL AEKLNIFHIQ FEEVLQEKLL LKTEKKVGPE 130 140 150 160 170 180 FEEDSENEQA AKQELEELAI QANVKVEEEN TKKQLPEVQL TEEEEVIKSS LMENEPLPPE 190 200 210 220 230 240 ILEVILSEWW LKEPIRSTGF ILDGFPRYPE EAQFLGDRGF FPDAAVFIQV DDQDIFDRLL 250 260 270 280 290 300 PAQIEKWKLK QKKKLERKKL IKDMKAKIRV DTIAKRRAEL ILERDKKRRE VSSFVFFFKT 310 320 330 GSHSVAQGRV QWHNHSSLQP RTPGLKGSSH LSLSKC
	Isoform 2. Checksum: 21719BB10456B2AD	FASTA	362	41,972
	10 20 30 40 50 60 MKERKRHLGD TKHFCPVVLK ENFILQPGNT EEAAKYREKI YYFSSAEAKE KFLEHPEDYV 70 80 90 100 110 120 AHEEPLKAPP LRICLVGPQG SGKTMCGRQL AEKLNIFHIQ FEEVLQEKLL LKTEKKVGPE 130 140 150 160 170 180 FEEDSENEQA AKQELEELAI QANVKVEEEN TKKQLPEVQL TEEEEVIKSS LMENEPLPPE 190 200 210 220 230 240 ILEVILSEWW LKEPIRSTGF ILDGFPRYPE EAQFLGDRGF FPDAAVFIQV DDQDIFDRLL 250 260 270 280 290 300 PAQIEKWKLK QKKKLERKKL IKDMKAKIRV DTIAKRRAEL ILERDKKRRE PNKEKRKRGI 310 320 330 340 350 360 SENTTCYKCN HMSPWCEYAG LPYRGLLILY SATATATAGT KHCRSGAKVI VALSKQNIHN QK

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Caudate nucleus.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 146-336 (ISOFORM 2). Tissue: Pituitary.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK131244 mRNA. Translation: BAD18424.1. BC087860 mRNA. Translation: AAH87860.1.
IPI	IPI00418605. IPI00552962.
UniGene	Hs.205144
3D structure databases
HSSP	HSSP built from PDB template 1KAG based on UniProtKB P0A6D7.
ModBase	Search...
Proteomic databases
PRIDE	Q6ZNF1.
Genome annotation databases
Ensembl	ENST00000355283; ENSP00000347431; ENSG00000155085; Homo sapiens. [Genome view]
UCSC	uc003pto.1. human. uc003ptp.1. human.
Organism-specific databases
GeneCards	GC06M109977.
HGNC	HGNC:33814. AKD1.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q6ZNF1.
OMA	LGIFHIQ
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000017320-MON.
Gene expression databases
ArrayExpress	Q6ZNF1.
Bgee	Q6ZNF1.
Genevestigator	Q6ZNF1.
Family and domain databases
InterPro	IPR000850. Adenylate_kin. IPR007029. YHS. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF04945. YHS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	106685.

Entry information

Entry name

AKD1_HUMAN

Accession

Primary (citable) accession number: Q6ZNF1
Secondary accession number(s): Q5I0W8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 5, 2004
Last modified:	November 24, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.