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Protein

Iron/zinc purple acid phosphatase-like protein

Gene

PAPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi141 – 1411IronBy similarity
Metal bindingi170 – 1701IronBy similarity
Metal bindingi170 – 1701ZincBy similarity
Metal bindingi173 – 1731IronBy similarity
Metal bindingi205 – 2051ZincBy similarity
Metal bindingi286 – 2861ZincBy similarity
Metal bindingi333 – 3331ZincBy similarity
Metal bindingi335 – 3351IronBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Iron/zinc purple acid phosphatase-like protein (EC:3.1.3.2)
Gene namesi
Name:PAPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 438412Iron/zinc purple acid phosphatase-like proteinPRO_0000316824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZNF0.
PRIDEiQ6ZNF0.

PTM databases

DEPODiQ6ZNF0.
PhosphoSiteiQ6ZNF0.

Expressioni

Gene expression databases

BgeeiQ6ZNF0.
ExpressionAtlasiQ6ZNF0. baseline and differential.
GenevestigatoriQ6ZNF0.

Organism-specific databases

HPAiHPA042005.
HPA042613.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNF0.
SMRiQ6ZNF0. Positions 31-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1409.
GeneTreeiENSGT00390000015485.
HOGENOMiHOG000187275.
HOVERGENiHBG063988.
InParanoidiQ6ZNF0.
OMAiMHPLPGY.
PhylomeDBiQ6ZNF0.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZNF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHPLPGYWSC YCLLLLFSLG VQGSLGAPSA APEQVHLSYP GEPGSMTVTW
60 70 80 90 100
TTWVPTRSEV QFGLQPSGPL PLRAQGTFVP FVDGGILRRK LYIHRVTLRK
110 120 130 140 150
LLPGVQYVYR CGSAQGWSRR FRFRALKNGA HWSPRLAVFG DLGADNPKAV
160 170 180 190 200
PRLRRDTQQG MYDAVLHVGD FAYNLDQDNA RVGDRFMRLI EPVAASLPYM
210 220 230 240 250
TCPGNHEERY NFSNYKARFS MPGDNEGLWY SWDLGPAHII SFSTEVYFFL
260 270 280 290 300
HYGRHLVQRQ FRWLESDLQK ANKNRAARPW IITMGHRPMY CSNADLDDCT
310 320 330 340 350
RHESKVRKGL QGKLYGLEDL FYKYGVDLQL WAHEHSYERL WPIYNYQVFN
360 370 380 390 400
GSREMPYTNP RGPVHIITGS AGCEERLTPF AVFPRPWSAV RVKEYGYTRL
410 420 430
HILNGTHIHI QQVSDDQDGK IVDDVWVVRP LFGRRMYL
Length:438
Mass (Da):50,480
Last modified:November 24, 2009 - v2
Checksum:i70C5109FAAB2DDC5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti408 – 4081I → T in BAD18425. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131245 mRNA. Translation: BAD18425.1.
AC011443 Genomic DNA. No translation available.
BC136721 mRNA. Translation: AAI36722.1.
BC136722 mRNA. Translation: AAI36723.1.
CCDSiCCDS33018.1.
RefSeqiNP_001004318.2. NM_001004318.2.
UniGeneiHs.448934.

Genome annotation databases

GeneIDi390928.
KEGGihsa:390928.
UCSCiuc002oki.3. human.

Polymorphism databases

DMDMi269849643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131245 mRNA. Translation: BAD18425.1.
AC011443 Genomic DNA. No translation available.
BC136721 mRNA. Translation: AAI36722.1.
BC136722 mRNA. Translation: AAI36723.1.
CCDSiCCDS33018.1.
RefSeqiNP_001004318.2. NM_001004318.2.
UniGeneiHs.448934.

3D structure databases

ProteinModelPortaliQ6ZNF0.
SMRiQ6ZNF0. Positions 31-437.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

DEPODiQ6ZNF0.
PhosphoSiteiQ6ZNF0.

Polymorphism databases

DMDMi269849643.

Proteomic databases

PaxDbiQ6ZNF0.
PRIDEiQ6ZNF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi390928.
KEGGihsa:390928.
UCSCiuc002oki.3. human.

Organism-specific databases

CTDi390928.
GeneCardsiGC19P039574.
H-InvDBHIX0040034.
HPAiHPA042005.
HPA042613.
MIMi610490. gene.
neXtProtiNX_Q6ZNF0.

Phylogenomic databases

eggNOGiCOG1409.
GeneTreeiENSGT00390000015485.
HOGENOMiHOG000187275.
HOVERGENiHBG063988.
InParanoidiQ6ZNF0.
OMAiMHPLPGY.
PhylomeDBiQ6ZNF0.

Miscellaneous databases

GenomeRNAii390928.
NextBioi104165.
PROiQ6ZNF0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZNF0.
ExpressionAtlasiQ6ZNF0. baseline and differential.
GenevestigatoriQ6ZNF0.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Corpus callosum.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase."
    Flanagan J.U., Cassady A.I., Schenk G., Guddat L.W., Hume D.A.
    Gene 377:12-20(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiPAPL_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNF0
Secondary accession number(s): B2RN68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 24, 2009
Last modified: January 7, 2015
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.