Reviewed, UniProtKB/Swiss-Prot Q6ZNF0 (PAPL_HUMAN)

Names and origin

Protein names

Recommended name:
    Iron/zinc purple acid phosphatase-like protein
    EC=3.1.3.2

Gene names

Name:

PAPL

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 438	412	Iron/zinc purple acid phosphatase-like protein		PRO_0000316824
Sites
	Metal binding	141	1	Iron By similarity
	Metal binding	170	1	Iron By similarity
	Metal binding	170	1	Zinc By similarity
	Metal binding	173	1	Iron By similarity
	Metal binding	205	1	Zinc By similarity
	Metal binding	286	1	Zinc By similarity
	Metal binding	333	1	Zinc By similarity
	Metal binding	335	1	Iron By similarity
Amino acid modifications
	Glycosylation	211	1	N-linked (GlcNAc...) Potential
	Glycosylation	350	1	N-linked (GlcNAc...) Potential
	Glycosylation	404	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	408	1	I → T in BAD18425. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6ZNF0-1 [UniParc]. Last modified November 24, 2009. Version 2. Checksum: 70C5109FAAB2DDC5	FASTA	438	50,480
	10 20 30 40 50 60 MHPLPGYWSC YCLLLLFSLG VQGSLGAPSA APEQVHLSYP GEPGSMTVTW TTWVPTRSEV 70 80 90 100 110 120 QFGLQPSGPL PLRAQGTFVP FVDGGILRRK LYIHRVTLRK LLPGVQYVYR CGSAQGWSRR 130 140 150 160 170 180 FRFRALKNGA HWSPRLAVFG DLGADNPKAV PRLRRDTQQG MYDAVLHVGD FAYNLDQDNA 190 200 210 220 230 240 RVGDRFMRLI EPVAASLPYM TCPGNHEERY NFSNYKARFS MPGDNEGLWY SWDLGPAHII 250 260 270 280 290 300 SFSTEVYFFL HYGRHLVQRQ FRWLESDLQK ANKNRAARPW IITMGHRPMY CSNADLDDCT 310 320 330 340 350 360 RHESKVRKGL QGKLYGLEDL FYKYGVDLQL WAHEHSYERL WPIYNYQVFN GSREMPYTNP 370 380 390 400 410 420 RGPVHIITGS AGCEERLTPF AVFPRPWSAV RVKEYGYTRL HILNGTHIHI QQVSDDQDGK 430 IVDDVWVVRP LFGRRMYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Corpus callosum.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase." Flanagan J.U., Cassady A.I., Schenk G., Guddat L.W., Hume D.A. Gene 377:12-20(2006) [PubMed: 16793224] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK131245 mRNA. Translation: BAD18425.1. AC011443 Genomic DNA. No translation available. BC136721 mRNA. Translation: AAI36722.1. BC136722 mRNA. Translation: AAI36723.1.
IPI	IPI00793512.
RefSeq	NP_001004318.2.
UniGene	Hs.448934
3D structure databases
SMR	Q6ZNF0. Positions 30-430.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6ZNF0.
Proteomic databases
PRIDE	Q6ZNF0.
Genome annotation databases
Ensembl	ENST00000331256; ENSP00000327557; ENSG00000183760; Homo sapiens. [Genome view]
GeneID	390928.
KEGG	hsa:390928.
UCSC	uc002oki.1. human.
Organism-specific databases
CTD	390928.
GeneCards	GC19P044267.
MIM	610490. gene.
Phylogenomic databases
eggNOG	prNOG05614.
HOGENOM	HBG314435.
HOVERGEN	Q6ZNF0.
InParanoid	Q6ZNF0.
Enzyme and pathway databases
BRENDA	3.1.3.2. 247.
Gene expression databases
ArrayExpress	Q6ZNF0.
Genevestigator	Q6ZNF0.
Family and domain databases
InterPro	IPR004843. M-pesterase. IPR008963. Purple_acid_Pase-like_N. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	104165.
SOURCE	Search...

Entry information

Entry name

PAPL_HUMAN

Accession

Primary (citable) accession number: Q6ZNF0
Secondary accession number(s): B2RN68

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 24, 2009
Last modified:	February 9, 2010
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.