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Q6ZNF0

- PAPL_HUMAN

UniProt

Q6ZNF0 - PAPL_HUMAN

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Protein

Iron/zinc purple acid phosphatase-like protein

Gene
PAPL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Binds 1 iron ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi141 – 1411Iron By similarity
Metal bindingi170 – 1701Iron By similarity
Metal bindingi170 – 1701Zinc By similarity
Metal bindingi173 – 1731Iron By similarity
Metal bindingi205 – 2051Zinc By similarity
Metal bindingi286 – 2861Zinc By similarity
Metal bindingi333 – 3331Zinc By similarity
Metal bindingi335 – 3351Iron By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Iron/zinc purple acid phosphatase-like protein (EC:3.1.3.2)
Gene namesi
Name:PAPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 438412Iron/zinc purple acid phosphatase-like proteinPRO_0000316824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi211 – 2111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi350 – 3501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi404 – 4041N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZNF0.
PRIDEiQ6ZNF0.

PTM databases

PhosphoSiteiQ6ZNF0.

Expressioni

Gene expression databases

BgeeiQ6ZNF0.
GenevestigatoriQ6ZNF0.

Organism-specific databases

HPAiHPA042005.
HPA042613.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNF0.
SMRiQ6ZNF0. Positions 2-437.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000187275.
HOVERGENiHBG063988.
InParanoidiQ6ZNF0.
OMAiMHPLPGY.
PhylomeDBiQ6ZNF0.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZNF0-1 [UniParc]FASTAAdd to Basket

« Hide

MHPLPGYWSC YCLLLLFSLG VQGSLGAPSA APEQVHLSYP GEPGSMTVTW    50
TTWVPTRSEV QFGLQPSGPL PLRAQGTFVP FVDGGILRRK LYIHRVTLRK 100
LLPGVQYVYR CGSAQGWSRR FRFRALKNGA HWSPRLAVFG DLGADNPKAV 150
PRLRRDTQQG MYDAVLHVGD FAYNLDQDNA RVGDRFMRLI EPVAASLPYM 200
TCPGNHEERY NFSNYKARFS MPGDNEGLWY SWDLGPAHII SFSTEVYFFL 250
HYGRHLVQRQ FRWLESDLQK ANKNRAARPW IITMGHRPMY CSNADLDDCT 300
RHESKVRKGL QGKLYGLEDL FYKYGVDLQL WAHEHSYERL WPIYNYQVFN 350
GSREMPYTNP RGPVHIITGS AGCEERLTPF AVFPRPWSAV RVKEYGYTRL 400
HILNGTHIHI QQVSDDQDGK IVDDVWVVRP LFGRRMYL 438
Length:438
Mass (Da):50,480
Last modified:November 24, 2009 - v2
Checksum:i70C5109FAAB2DDC5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti408 – 4081I → T in BAD18425. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131245 mRNA. Translation: BAD18425.1.
AC011443 Genomic DNA. No translation available.
BC136721 mRNA. Translation: AAI36722.1.
BC136722 mRNA. Translation: AAI36723.1.
CCDSiCCDS33018.1.
RefSeqiNP_001004318.2. NM_001004318.2.
UniGeneiHs.448934.

Genome annotation databases

GeneIDi390928.
KEGGihsa:390928.
UCSCiuc002oki.3. human.

Polymorphism databases

DMDMi269849643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131245 mRNA. Translation: BAD18425.1 .
AC011443 Genomic DNA. No translation available.
BC136721 mRNA. Translation: AAI36722.1 .
BC136722 mRNA. Translation: AAI36723.1 .
CCDSi CCDS33018.1.
RefSeqi NP_001004318.2. NM_001004318.2.
UniGenei Hs.448934.

3D structure databases

ProteinModelPortali Q6ZNF0.
SMRi Q6ZNF0. Positions 2-437.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6ZNF0.

Polymorphism databases

DMDMi 269849643.

Proteomic databases

PaxDbi Q6ZNF0.
PRIDEi Q6ZNF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 390928.
KEGGi hsa:390928.
UCSCi uc002oki.3. human.

Organism-specific databases

CTDi 390928.
GeneCardsi GC19P039574.
H-InvDB HIX0040034.
HPAi HPA042005.
HPA042613.
MIMi 610490. gene.
neXtProti NX_Q6ZNF0.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000187275.
HOVERGENi HBG063988.
InParanoidi Q6ZNF0.
OMAi MHPLPGY.
PhylomeDBi Q6ZNF0.

Miscellaneous databases

GenomeRNAii 390928.
NextBioi 104165.
PROi Q6ZNF0.
SOURCEi Search...

Gene expression databases

Bgeei Q6ZNF0.
Genevestigatori Q6ZNF0.

Family and domain databases

Gene3Di 2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view ]
SUPFAMi SSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Corpus callosum.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase."
    Flanagan J.U., Cassady A.I., Schenk G., Guddat L.W., Hume D.A.
    Gene 377:12-20(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiPAPL_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNF0
Secondary accession number(s): B2RN68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 24, 2009
Last modified: July 9, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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