Q6ZNF0 (PAPL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Iron/zinc purple acid phosphatase-like protein
EC=3.1.3.2

Gene names

Name:

PAPL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 438	412	Iron/zinc purple acid phosphatase-like protein		PRO_0000316824
Sites
	Metal binding	141	1	Iron By similarity
	Metal binding	170	1	Iron By similarity
	Metal binding	170	1	Zinc By similarity
	Metal binding	173	1	Iron By similarity
	Metal binding	205	1	Zinc By similarity
	Metal binding	286	1	Zinc By similarity
	Metal binding	333	1	Zinc By similarity
	Metal binding	335	1	Iron By similarity
Amino acid modifications
	Glycosylation	211	1	N-linked (GlcNAc...) Potential
	Glycosylation	350	1	N-linked (GlcNAc...) Potential
	Glycosylation	404	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	408	1	I → T in BAD18425. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6ZNF0 [UniParc]. Last modified November 24, 2009. Version 2. Checksum: 70C5109FAAB2DDC5	FASTA	438	50,480
	10 20 30 40 50 60 MHPLPGYWSC YCLLLLFSLG VQGSLGAPSA APEQVHLSYP GEPGSMTVTW TTWVPTRSEV 70 80 90 100 110 120 QFGLQPSGPL PLRAQGTFVP FVDGGILRRK LYIHRVTLRK LLPGVQYVYR CGSAQGWSRR 130 140 150 160 170 180 FRFRALKNGA HWSPRLAVFG DLGADNPKAV PRLRRDTQQG MYDAVLHVGD FAYNLDQDNA 190 200 210 220 230 240 RVGDRFMRLI EPVAASLPYM TCPGNHEERY NFSNYKARFS MPGDNEGLWY SWDLGPAHII 250 260 270 280 290 300 SFSTEVYFFL HYGRHLVQRQ FRWLESDLQK ANKNRAARPW IITMGHRPMY CSNADLDDCT 310 320 330 340 350 360 RHESKVRKGL QGKLYGLEDL FYKYGVDLQL WAHEHSYERL WPIYNYQVFN GSREMPYTNP 370 380 390 400 410 420 RGPVHIITGS AGCEERLTPF AVFPRPWSAV RVKEYGYTRL HILNGTHIHI QQVSDDQDGK 430 IVDDVWVVRP LFGRRMYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Corpus callosum.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase." Flanagan J.U., Cassady A.I., Schenk G., Guddat L.W., Hume D.A. Gene 377:12-20(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK131245 mRNA. Translation: BAD18425.1. AC011443 Genomic DNA. No translation available. BC136721 mRNA. Translation: AAI36722.1. BC136722 mRNA. Translation: AAI36723.1.
IPI	IPI00793512.
RefSeq	NP_001004318.2. NM_001004318.2.
UniGene	Hs.448934.
3D structure databases
ProteinModelPortal	Q6ZNF0.
SMR	Q6ZNF0. Positions 31-437.
ModBase	Search...
PTM databases
PhosphoSite	Q6ZNF0.
Polymorphism databases
DMDM	269849643.
Proteomic databases
PaxDb	Q6ZNF0.
PRIDE	Q6ZNF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	390928.
KEGG	hsa:390928.
UCSC	uc002oki.3. human.
Organism-specific databases
CTD	390928.
GeneCards	GC19P039574.
H-InvDB	HIX0040034.
HPA	HPA042005. HPA042613.
MIM	610490. gene.
neXtProt	NX_Q6ZNF0.
Phylogenomic databases
eggNOG	COG1409.
HOGENOM	HOG000187275.
HOVERGEN	HBG063988.
InParanoid	Q6ZNF0.
OMA	HPLPGYW.
OrthoDB	EOG4NS3BK.
PhylomeDB	Q6ZNF0.
Gene expression databases
Bgee	Q6ZNF0.
Genevestigator	Q6ZNF0.
Family and domain databases
Gene3D	2.60.40.380. 1 hit.
InterPro	IPR004843. Metallo_PEstase_dom. IPR008963. Purple_acid_Pase-like_N. IPR015914. Purple_acid_Pase_N. IPR025733. Purple_acid_PPase_C_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. PF14008. Metallophos_C. 1 hit. [Graphical view]
SUPFAM	SSF49363. Purple_Pase_N. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	390928.
NextBio	104165.
SOURCE	Search...

Entry information

Entry name

PAPL_HUMAN

Accession

Primary (citable) accession number: Q6ZNF0
Secondary accession number(s): B2RN68

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 24, 2009
Last modified:	May 1, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.