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Protein

Acid phosphatase type 7

Gene

ACP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141IronBy similarity1
Metal bindingi170IronBy similarity1
Metal bindingi170ZincBy similarity1
Metal bindingi173IronBy similarity1
Metal bindingi205ZincBy similarity1
Metal bindingi286ZincBy similarity1
Metal bindingi333ZincBy similarity1
Metal bindingi335IronBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33235-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase type 7Curated (EC:3.1.3.2)
Alternative name(s):
Purple acid phosphatase long form1 Publication
Gene namesi
Name:ACP7Imported
Synonyms:PAPL1 Publication, PAPL11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33781. ACP7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi390928.
OpenTargetsiENSG00000183760.

Polymorphism and mutation databases

BioMutaiPAPL.
DMDMi269849643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000031682427 – 438Acid phosphatase type 7Add BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1
Glycosylationi404N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZNF0.
PeptideAtlasiQ6ZNF0.
PRIDEiQ6ZNF0.

PTM databases

DEPODiQ6ZNF0.
iPTMnetiQ6ZNF0.
PhosphoSitePlusiQ6ZNF0.

Expressioni

Gene expression databases

BgeeiENSG00000183760.
ExpressionAtlasiQ6ZNF0. baseline and differential.

Organism-specific databases

HPAiHPA042005.
HPA042613.

Interactioni

Protein-protein interaction databases

BioGridi133739. 5 interactors.
STRINGi9606.ENSP00000327557.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1378. Eukaryota.
COG1409. LUCA.
GeneTreeiENSGT00390000015485.
HOGENOMiHOG000187275.
HOVERGENiHBG063988.
InParanoidiQ6ZNF0.
OMAiMHPLPGY.
OrthoDBiEOG091G0DVB.
PhylomeDBiQ6ZNF0.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
PF16656. Pur_ac_phosph_N. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZNF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPLPGYWSC YCLLLLFSLG VQGSLGAPSA APEQVHLSYP GEPGSMTVTW
60 70 80 90 100
TTWVPTRSEV QFGLQPSGPL PLRAQGTFVP FVDGGILRRK LYIHRVTLRK
110 120 130 140 150
LLPGVQYVYR CGSAQGWSRR FRFRALKNGA HWSPRLAVFG DLGADNPKAV
160 170 180 190 200
PRLRRDTQQG MYDAVLHVGD FAYNLDQDNA RVGDRFMRLI EPVAASLPYM
210 220 230 240 250
TCPGNHEERY NFSNYKARFS MPGDNEGLWY SWDLGPAHII SFSTEVYFFL
260 270 280 290 300
HYGRHLVQRQ FRWLESDLQK ANKNRAARPW IITMGHRPMY CSNADLDDCT
310 320 330 340 350
RHESKVRKGL QGKLYGLEDL FYKYGVDLQL WAHEHSYERL WPIYNYQVFN
360 370 380 390 400
GSREMPYTNP RGPVHIITGS AGCEERLTPF AVFPRPWSAV RVKEYGYTRL
410 420 430
HILNGTHIHI QQVSDDQDGK IVDDVWVVRP LFGRRMYL
Length:438
Mass (Da):50,480
Last modified:November 24, 2009 - v2
Checksum:i70C5109FAAB2DDC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti408I → T in BAD18425 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131245 mRNA. Translation: BAD18425.1.
AC011443 Genomic DNA. No translation available.
BC136721 mRNA. Translation: AAI36722.1.
BC136722 mRNA. Translation: AAI36723.1.
CCDSiCCDS33018.1.
RefSeqiNP_001004318.2. NM_001004318.2.
XP_011525268.1. XM_011526966.2.
XP_016882296.1. XM_017026807.1.
UniGeneiHs.448934.

Genome annotation databases

EnsembliENST00000331256; ENSP00000327557; ENSG00000183760.
GeneIDi390928.
KEGGihsa:390928.
UCSCiuc002oki.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131245 mRNA. Translation: BAD18425.1.
AC011443 Genomic DNA. No translation available.
BC136721 mRNA. Translation: AAI36722.1.
BC136722 mRNA. Translation: AAI36723.1.
CCDSiCCDS33018.1.
RefSeqiNP_001004318.2. NM_001004318.2.
XP_011525268.1. XM_011526966.2.
XP_016882296.1. XM_017026807.1.
UniGeneiHs.448934.

3D structure databases

ProteinModelPortaliQ6ZNF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133739. 5 interactors.
STRINGi9606.ENSP00000327557.

PTM databases

DEPODiQ6ZNF0.
iPTMnetiQ6ZNF0.
PhosphoSitePlusiQ6ZNF0.

Polymorphism and mutation databases

BioMutaiPAPL.
DMDMi269849643.

Proteomic databases

PaxDbiQ6ZNF0.
PeptideAtlasiQ6ZNF0.
PRIDEiQ6ZNF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331256; ENSP00000327557; ENSG00000183760.
GeneIDi390928.
KEGGihsa:390928.
UCSCiuc002oki.4. human.

Organism-specific databases

CTDi390928.
DisGeNETi390928.
GeneCardsiPAPL.
H-InvDBHIX0040034.
HGNCiHGNC:33781. ACP7.
HPAiHPA042005.
HPA042613.
MIMi610490. gene.
neXtProtiNX_Q6ZNF0.
OpenTargetsiENSG00000183760.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1378. Eukaryota.
COG1409. LUCA.
GeneTreeiENSGT00390000015485.
HOGENOMiHOG000187275.
HOVERGENiHBG063988.
InParanoidiQ6ZNF0.
OMAiMHPLPGY.
OrthoDBiEOG091G0DVB.
PhylomeDBiQ6ZNF0.

Enzyme and pathway databases

BioCyciZFISH:G66-33235-MONOMER.

Miscellaneous databases

GenomeRNAii390928.
PROiQ6ZNF0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183760.
ExpressionAtlasiQ6ZNF0. baseline and differential.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
PF16656. Pur_ac_phosph_N. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACP7_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNF0
Secondary accession number(s): B2RN68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.