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Protein

RUN and FYVE domain-containing protein 4

Gene

RUFY4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri474 – 567FYVE-typePROSITE-ProRule annotationAdd BLAST94

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32042-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RUN and FYVE domain-containing protein 4
Gene namesi
Name:RUFY4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24804. RUFY4.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188282.
PharmGKBiPA147357421.

Polymorphism and mutation databases

BioMutaiRUFY4.
DMDMi215273875.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846711 – 571RUN and FYVE domain-containing protein 4Add BLAST571

Proteomic databases

EPDiQ6ZNE9.
PaxDbiQ6ZNE9.
PRIDEiQ6ZNE9.

Expressioni

Gene expression databases

BgeeiENSG00000188282.
CleanExiHS_RUFY4.
ExpressionAtlasiQ6ZNE9. baseline and differential.

Organism-specific databases

HPAiHPA037980.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB15EBI-10181525,EBI-739832
NDC80O147775EBI-10181525,EBI-715849

Protein-protein interaction databases

BioGridi130035. 3 interactors.
IntActiQ6ZNE9. 4 interactors.
STRINGi9606.ENSP00000363270.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNE9.
SMRiQ6ZNE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 166RUNPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 RUN domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri474 – 567FYVE-typePROSITE-ProRule annotationAdd BLAST94

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1729. Eukaryota.
ENOG410XPJK. LUCA.
GeneTreeiENSGT00730000110715.
HOGENOMiHOG000154226.
HOVERGENiHBG108427.
InParanoidiQ6ZNE9.
PhylomeDBiQ6ZNE9.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004012. Run_dom.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZNE9-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEEGAILKV TKDLRAAVSA ILQGYGDGQG PVTDTSAELH RLCGCLELLL
60 70 80 90 100
QFDQKEQKSF LGPRKDYWDF LCTALRRQRG NMEPIHFVRS QDKLKTPLGK
110 120 130 140 150
GRAFIRFCLA RGQLAEALQL CLLNSELTRE WYGPRSPLLC PERQEDILDS
160 170 180 190 200
LYALNGVAFE LDLQQPDLDG AWPMFSESRC SSSTQTQGRR PRKNKDAPKK
210 220 230 240 250
IPAAYGGPEN VQIEDSHTSQ AICLQDAPSG QQLAGLPRSQ QQRHLPFFLE
260 270 280 290 300
KKGESSRKHR YPQSMWEPEG KELQLDQEER APWIEIFLGN STPSTQGQGK
310 320 330 340 350
GAMGTQKEVI GMEAEVTGVL LVAEGQRTTE GTHKKEAEWS HVQRLLMPSP
360 370 380 390 400
RGAVEGAVSG SRQGSGGSSI LGEPWVLQGH ATKEDSTVEN PQVQTEVTLV
410 420 430 440 450
ARREEQAEVS LQDEIKSLRL GLRKAEEQAQ RQEQLLREQE GELQALREQL
460 470 480 490 500
SRCQEERAEL QAQLEQKQQE AERRDAMYQE ELGGQRDLVQ AMKRRVLELI
510 520 530 540 550
QEKDRLWQRL QHLSSMAPEC CVACSKIFGR FSRRYPCRLC GGLLCHACSM
560 570
DYKKRDRCCP PCAQGREAQV T
Note: No experimental confirmation available.
Length:571
Mass (Da):64,350
Last modified:November 25, 2008 - v2
Checksum:i7B45C3BB8685F515
GO
Isoform 2 (identifier: Q6ZNE9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-172: LKTPLGKGRA...LQQPDLDGAW → GMVWTPEPSA...KEDPSRIWRA
     173-571: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:172
Mass (Da):19,374
Checksum:i995B33DF3170E970
GO

Sequence cautioni

The sequence AAI13713 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC87417 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03581594 – 172LKTPL…LDGAW → GMVWTPEPSALPRTPRRHPG LSLCSQWGGLRVGPPAARPG WSLAHVLRVTLLQFHPNPGK ETQKKQRCPKEDPSRIWRA in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_035816173 – 571Missing in isoform 2. 1 PublicationAdd BLAST399

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128393 mRNA. Translation: BAC87417.1. Sequence problems.
AC124768 Genomic DNA. No translation available.
BC113712 mRNA. Translation: AAI13713.1. Different initiation.
RefSeqiNP_940885.2. NM_198483.3. [Q6ZNE9-2]
XP_011509316.1. XM_011511014.2. [Q6ZNE9-2]
XP_016859385.1. XM_017003896.1. [Q6ZNE9-2]
UniGeneiHs.570069.

Genome annotation databases

EnsembliENST00000344321; ENSP00000345900; ENSG00000188282. [Q6ZNE9-2]
ENST00000457754; ENSP00000410091; ENSG00000188282. [Q6ZNE9-3]
GeneIDi285180.
KEGGihsa:285180.
UCSCiuc061shp.1. human. [Q6ZNE9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128393 mRNA. Translation: BAC87417.1. Sequence problems.
AC124768 Genomic DNA. No translation available.
BC113712 mRNA. Translation: AAI13713.1. Different initiation.
RefSeqiNP_940885.2. NM_198483.3. [Q6ZNE9-2]
XP_011509316.1. XM_011511014.2. [Q6ZNE9-2]
XP_016859385.1. XM_017003896.1. [Q6ZNE9-2]
UniGeneiHs.570069.

3D structure databases

ProteinModelPortaliQ6ZNE9.
SMRiQ6ZNE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130035. 3 interactors.
IntActiQ6ZNE9. 4 interactors.
STRINGi9606.ENSP00000363270.

Polymorphism and mutation databases

BioMutaiRUFY4.
DMDMi215273875.

Proteomic databases

EPDiQ6ZNE9.
PaxDbiQ6ZNE9.
PRIDEiQ6ZNE9.

Protocols and materials databases

DNASUi285180.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344321; ENSP00000345900; ENSG00000188282. [Q6ZNE9-2]
ENST00000457754; ENSP00000410091; ENSG00000188282. [Q6ZNE9-3]
GeneIDi285180.
KEGGihsa:285180.
UCSCiuc061shp.1. human. [Q6ZNE9-2]

Organism-specific databases

CTDi285180.
GeneCardsiRUFY4.
HGNCiHGNC:24804. RUFY4.
HPAiHPA037980.
neXtProtiNX_Q6ZNE9.
OpenTargetsiENSG00000188282.
PharmGKBiPA147357421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1729. Eukaryota.
ENOG410XPJK. LUCA.
GeneTreeiENSGT00730000110715.
HOGENOMiHOG000154226.
HOVERGENiHBG108427.
InParanoidiQ6ZNE9.
PhylomeDBiQ6ZNE9.

Enzyme and pathway databases

BioCyciZFISH:G66-32042-MONOMER.

Miscellaneous databases

GenomeRNAii285180.
PROiQ6ZNE9.

Gene expression databases

BgeeiENSG00000188282.
CleanExiHS_RUFY4.
ExpressionAtlasiQ6ZNE9. baseline and differential.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004012. Run_dom.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRUFY4_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNE9
Secondary accession number(s): Q6ZR96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.