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Protein

Zinc finger protein 704

Gene

ZNF704

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri193 – 218C2H2-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 704
Gene namesi
Name:ZNF704
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164684.13
HGNCiHGNC:32291 ZNF704
neXtProtiNX_Q6ZNC4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi619279
OpenTargetsiENSG00000164684
PharmGKBiPA142670501

Polymorphism and mutation databases

BioMutaiZNF704
DMDMi74758726

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888241 – 412Zinc finger protein 704Add BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei225PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZNC4
PeptideAtlasiQ6ZNC4
PRIDEiQ6ZNC4

PTM databases

iPTMnetiQ6ZNC4
PhosphoSitePlusiQ6ZNC4

Expressioni

Gene expression databases

BgeeiENSG00000164684
CleanExiHS_ZNF704
ExpressionAtlasiQ6ZNC4 baseline and differential
GenevisibleiQ6ZNC4 HS

Organism-specific databases

HPAiHPA024285
HPA024302

Interactioni

Protein-protein interaction databases

BioGridi534810, 17 interactors
STRINGi9606.ENSP00000331462

Structurei

3D structure databases

ProteinModelPortaliQ6ZNC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri193 – 218C2H2-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGPR Eukaryota
ENOG410XRGR LUCA
GeneTreeiENSGT00400000022069
HOGENOMiHOG000065745
HOVERGENiHBG061238
InParanoidiQ6ZNC4
OMAiEQRQHTH
OrthoDBiEOG091G0AXZ
PhylomeDBiQ6ZNC4
TreeFamiTF326610

Family and domain databases

InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZNC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFTFQSEDL KRDCGKKMSH QHVFSLAMEE DVKTADTKKA SRILDHEKEN
60 70 80 90 100
TRSICLLEQK RKVVSSNIDV PPARKSSEEL DMDKVTAAMV LTSLSTSPLV
110 120 130 140 150
RSPPVRPNES LSGSWKEGGC VPSSTSSSGY WSWSAPSDQS NPSTPSPPLS
160 170 180 190 200
ADSFKPFRSP AQPDDGIDEA EASNLLFDEP IPRKRKNSMK VMFKCLWKNC
210 220 230 240 250
GKVLSTAAGI QKHIRTIHLG RVGDSDYSDG EEDFYYTEIK LNTDSVADGL
260 270 280 290 300
SSLAPVSPSQ SLASPPTFPI PDSSRTETPC AKTETKLMTP LSRSAPTTLY
310 320 330 340 350
LVHTDHAYQA TPPVTIPGSA KFTPNGSSFS ISWQSPPVTF TGIPVSPTHH
360 370 380 390 400
PVGTGEQRQH AHTVLSSPPR GTVSLRKPRG EGKKCRKVYG MENRDMWCTA
410
CRWKKACQRF LD
Length:412
Mass (Da):45,276
Last modified:July 5, 2004 - v1
Checksum:i3093527F3415E748
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03250635A → S. Corresponds to variant dbSNP:rs3907424Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131274 mRNA Translation: BAD18451.1
BC136844 mRNA Translation: AAI36845.1
BC136845 mRNA Translation: AAI36846.1
CCDSiCCDS34913.1
RefSeqiNP_001028895.1, NM_001033723.2
UniGeneiHs.434957

Genome annotation databases

EnsembliENST00000327835; ENSP00000331462; ENSG00000164684
GeneIDi619279
KEGGihsa:619279
UCSCiuc003yby.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN704_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNC4
Secondary accession number(s): B2RNE6, B9EGW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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