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Protein

Zinc finger protein 704

Gene

ZNF704

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri193 – 218C2H2-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 704
Gene namesi
Name:ZNF704
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:32291. ZNF704.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi619279.
OpenTargetsiENSG00000164684.
PharmGKBiPA142670501.

Polymorphism and mutation databases

BioMutaiZNF704.
DMDMi74758726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888241 – 412Zinc finger protein 704Add BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei225PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZNC4.
PeptideAtlasiQ6ZNC4.
PRIDEiQ6ZNC4.

PTM databases

iPTMnetiQ6ZNC4.
PhosphoSitePlusiQ6ZNC4.

Expressioni

Gene expression databases

BgeeiENSG00000164684.
CleanExiHS_ZNF704.
ExpressionAtlasiQ6ZNC4. baseline and differential.
GenevisibleiQ6ZNC4. HS.

Organism-specific databases

HPAiHPA024285.
HPA024302.

Interactioni

Protein-protein interaction databases

BioGridi534810. 17 interactors.
STRINGi9606.ENSP00000331462.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri193 – 218C2H2-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGPR. Eukaryota.
ENOG410XRGR. LUCA.
GeneTreeiENSGT00400000022069.
HOGENOMiHOG000065745.
HOVERGENiHBG061238.
InParanoidiQ6ZNC4.
OMAiYTEIRLN.
OrthoDBiEOG091G0AXZ.
PhylomeDBiQ6ZNC4.
TreeFamiTF326610.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZNC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFTFQSEDL KRDCGKKMSH QHVFSLAMEE DVKTADTKKA SRILDHEKEN
60 70 80 90 100
TRSICLLEQK RKVVSSNIDV PPARKSSEEL DMDKVTAAMV LTSLSTSPLV
110 120 130 140 150
RSPPVRPNES LSGSWKEGGC VPSSTSSSGY WSWSAPSDQS NPSTPSPPLS
160 170 180 190 200
ADSFKPFRSP AQPDDGIDEA EASNLLFDEP IPRKRKNSMK VMFKCLWKNC
210 220 230 240 250
GKVLSTAAGI QKHIRTIHLG RVGDSDYSDG EEDFYYTEIK LNTDSVADGL
260 270 280 290 300
SSLAPVSPSQ SLASPPTFPI PDSSRTETPC AKTETKLMTP LSRSAPTTLY
310 320 330 340 350
LVHTDHAYQA TPPVTIPGSA KFTPNGSSFS ISWQSPPVTF TGIPVSPTHH
360 370 380 390 400
PVGTGEQRQH AHTVLSSPPR GTVSLRKPRG EGKKCRKVYG MENRDMWCTA
410
CRWKKACQRF LD
Length:412
Mass (Da):45,276
Last modified:July 5, 2004 - v1
Checksum:i3093527F3415E748
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03250635A → S.Corresponds to variant rs3907424dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131274 mRNA. Translation: BAD18451.1.
BC136844 mRNA. Translation: AAI36845.1.
BC136845 mRNA. Translation: AAI36846.1.
CCDSiCCDS34913.1.
RefSeqiNP_001028895.1. NM_001033723.2.
UniGeneiHs.434957.

Genome annotation databases

EnsembliENST00000327835; ENSP00000331462; ENSG00000164684.
GeneIDi619279.
KEGGihsa:619279.
UCSCiuc003yby.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131274 mRNA. Translation: BAD18451.1.
BC136844 mRNA. Translation: AAI36845.1.
BC136845 mRNA. Translation: AAI36846.1.
CCDSiCCDS34913.1.
RefSeqiNP_001028895.1. NM_001033723.2.
UniGeneiHs.434957.

3D structure databases

ProteinModelPortaliQ6ZNC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi534810. 17 interactors.
STRINGi9606.ENSP00000331462.

PTM databases

iPTMnetiQ6ZNC4.
PhosphoSitePlusiQ6ZNC4.

Polymorphism and mutation databases

BioMutaiZNF704.
DMDMi74758726.

Proteomic databases

PaxDbiQ6ZNC4.
PeptideAtlasiQ6ZNC4.
PRIDEiQ6ZNC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327835; ENSP00000331462; ENSG00000164684.
GeneIDi619279.
KEGGihsa:619279.
UCSCiuc003yby.2. human.

Organism-specific databases

CTDi619279.
DisGeNETi619279.
GeneCardsiZNF704.
HGNCiHGNC:32291. ZNF704.
HPAiHPA024285.
HPA024302.
neXtProtiNX_Q6ZNC4.
OpenTargetsiENSG00000164684.
PharmGKBiPA142670501.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGPR. Eukaryota.
ENOG410XRGR. LUCA.
GeneTreeiENSGT00400000022069.
HOGENOMiHOG000065745.
HOVERGENiHBG061238.
InParanoidiQ6ZNC4.
OMAiYTEIRLN.
OrthoDBiEOG091G0AXZ.
PhylomeDBiQ6ZNC4.
TreeFamiTF326610.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF704. human.
GenomeRNAii619279.
PROiQ6ZNC4.

Gene expression databases

BgeeiENSG00000164684.
CleanExiHS_ZNF704.
ExpressionAtlasiQ6ZNC4. baseline and differential.
GenevisibleiQ6ZNC4. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN704_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNC4
Secondary accession number(s): B2RNE6, B9EGW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.