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Protein

Ferric-chelate reductase 1

Gene

FRRS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ferric-chelate reductases reduce Fe3+ to Fe2+ before its transport from the endosome to the cytoplasm.By similarity

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi373Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi414Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi442Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi471Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • ferric-chelate reductase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS14639-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric-chelate reductase 1 (EC:1.-.-.-)
Alternative name(s):
Stromal cell-derived receptor 2
Short name:
SDR-2
Gene namesi
Name:FRRS1
Synonyms:SDFR2, SDR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27622. FRRS1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei372 – 392Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei415 – 435Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei446 – 466Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei491 – 511Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei515 – 535Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei569 – 589Helical; Name=7Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi391059.
OpenTargetsiENSG00000156869.
PharmGKBiPA142670941.

Polymorphism and mutation databases

BioMutaiFRRS1.
DMDMi166198896.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148431 – 592Ferric-chelate reductase 1Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Glycosylationi308N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6ZNA5.
PaxDbiQ6ZNA5.
PeptideAtlasiQ6ZNA5.
PRIDEiQ6ZNA5.

Expressioni

Gene expression databases

BgeeiENSG00000156869.
CleanExiHS_FRRS1.

Organism-specific databases

HPAiHPA017883.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000287474.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNA5.
SMRiQ6ZNA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 179ReelinPROSITE-ProRule annotationAdd BLAST167
Domaini216 – 331DOMONPROSITE-ProRule annotationAdd BLAST116
Domaini335 – 534Cytochrome b561PROSITE-ProRule annotationAdd BLAST200

Sequence similaritiesi

Belongs to the FRRS1 family.Curated
Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation
Contains 1 DOMON domain.PROSITE-ProRule annotation
Contains 1 reelin domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4293. Eukaryota.
ENOG410XR70. LUCA.
GeneTreeiENSGT00760000119309.
HOGENOMiHOG000112648.
HOVERGENiHBG107929.
InParanoidiQ6ZNA5.
OMAiLMFVAWI.
OrthoDBiEOG091G05GA.
PhylomeDBiQ6ZNA5.
TreeFamiTF316169.

Family and domain databases

CDDicd08544. Reeler. 1 hit.
InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR005018. DOMON_domain.
IPR002861. Reeler_dom.
[Graphical view]
PfamiPF03351. DOMON. 1 hit.
PF02014. Reeler. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
SM00664. DoH. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
PS50836. DOMON. 1 hit.
PS51019. REELIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZNA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVSGFTLGT CILLLHISYV ANYPNGKVTQ SCHGMIPEHG HSPQSVPVHD
60 70 80 90 100
IYVSQMTFRP GDQIEVTLSG HPFKGFLLEA RNAEDLNGPP IGSFTLIDSE
110 120 130 140 150
VSQLLTCEDI QGSAVSHRSA SKKTEIKVYW NAPSSAPNHT QFLVTVVEKY
160 170 180 190 200
KIYWVKIPGP IISQPNAFPF TTPKATVVPL PTLPPVSHLT KPFSASDCGN
210 220 230 240 250
KKFCIRSPLN CDPEKEASCV FLSFTRDDQS VMVEMSGPSK GYLSFALSHD
260 270 280 290 300
QWMGDDDAYL CIHEDQTVYI QPSHLTGRSH PVMDSRDTLE DMAWRLADGV
310 320 330 340 350
MQCSFRRNIT LPGVKNRFDL NTSYYIFLAD GAANDGRIYK HSQQPLITYE
360 370 380 390 400
KYDVTDSPKN IGGSHSVLLL KVHGALMFVA WMTTVSIGVL VARFFKPVWS
410 420 430 440 450
KAFLLGEAAW FQVHRMLMFT TTVLTCIAFV MPFIYRGGWS RHAGYHPYLG
460 470 480 490 500
CIVMTLAVLQ PLLAVFRPPL HDPRRQMFNW THWSMGTAAR IIAVAAMFLG
510 520 530 540 550
MDLPGLNLPD SWKTYAMTGF VAWHVGTEVV LEVHAYRLSR KVEILDDDRI
560 570 580 590
QILQSFTAVE TEGHAFKKAV LAIYVCGNVT FLIIFLSAIN HL
Length:592
Mass (Da):66,114
Last modified:January 15, 2008 - v2
Checksum:i21EC19981C4AA95D
GO
Isoform 2 (identifier: Q6ZNA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-592: VHAYRLSRKV...IIFLSAINHL → LKYWMMTEFR...FSLGRLGSCL

Note: No experimental confirmation available.
Show »
Length:626
Mass (Da):70,465
Checksum:iA8F39D2DFA893E5B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179P → L in BAD18470 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030400533 – 592VHAYR…AINHL → LKYWMMTEFRSFSHLLQWKQ RVMLLKRQCWQFMSVGMLLF SSYFYLQSTIYEQAKTLAFA GQVIIIIKPKKLEACPDCLE HICEFSLGRLGSCL in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131302 mRNA. Translation: BAD18470.1.
AL451051 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW72988.1.
CCDSiCCDS30780.1. [Q6ZNA5-2]
RefSeqiNP_001013682.2. NM_001013660.2. [Q6ZNA5-2]
XP_005270918.1. XM_005270861.3. [Q6ZNA5-1]
XP_011539753.1. XM_011541451.2. [Q6ZNA5-1]
XP_016856760.1. XM_017001271.1. [Q6ZNA5-1]
UniGeneiHs.454779.

Genome annotation databases

EnsembliENST00000287474; ENSP00000287474; ENSG00000156869. [Q6ZNA5-2]
GeneIDi391059.
KEGGihsa:391059.
UCSCiuc001dsh.1. human. [Q6ZNA5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131302 mRNA. Translation: BAD18470.1.
AL451051 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW72988.1.
CCDSiCCDS30780.1. [Q6ZNA5-2]
RefSeqiNP_001013682.2. NM_001013660.2. [Q6ZNA5-2]
XP_005270918.1. XM_005270861.3. [Q6ZNA5-1]
XP_011539753.1. XM_011541451.2. [Q6ZNA5-1]
XP_016856760.1. XM_017001271.1. [Q6ZNA5-1]
UniGeneiHs.454779.

3D structure databases

ProteinModelPortaliQ6ZNA5.
SMRiQ6ZNA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000287474.

Polymorphism and mutation databases

BioMutaiFRRS1.
DMDMi166198896.

Proteomic databases

MaxQBiQ6ZNA5.
PaxDbiQ6ZNA5.
PeptideAtlasiQ6ZNA5.
PRIDEiQ6ZNA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287474; ENSP00000287474; ENSG00000156869. [Q6ZNA5-2]
GeneIDi391059.
KEGGihsa:391059.
UCSCiuc001dsh.1. human. [Q6ZNA5-1]

Organism-specific databases

CTDi391059.
DisGeNETi391059.
GeneCardsiFRRS1.
HGNCiHGNC:27622. FRRS1.
HPAiHPA017883.
MIMi611578. gene.
neXtProtiNX_Q6ZNA5.
OpenTargetsiENSG00000156869.
PharmGKBiPA142670941.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4293. Eukaryota.
ENOG410XR70. LUCA.
GeneTreeiENSGT00760000119309.
HOGENOMiHOG000112648.
HOVERGENiHBG107929.
InParanoidiQ6ZNA5.
OMAiLMFVAWI.
OrthoDBiEOG091G05GA.
PhylomeDBiQ6ZNA5.
TreeFamiTF316169.

Enzyme and pathway databases

BioCyciZFISH:HS14639-MONOMER.

Miscellaneous databases

GenomeRNAii391059.
PROiQ6ZNA5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156869.
CleanExiHS_FRRS1.

Family and domain databases

CDDicd08544. Reeler. 1 hit.
InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR005018. DOMON_domain.
IPR002861. Reeler_dom.
[Graphical view]
PfamiPF03351. DOMON. 1 hit.
PF02014. Reeler. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
SM00664. DoH. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
PS50836. DOMON. 1 hit.
PS51019. REELIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRRS1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNA5
Secondary accession number(s): A6NLN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.