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Q6ZNA5

- FRRS1_HUMAN

UniProt

Q6ZNA5 - FRRS1_HUMAN

Protein

Ferric-chelate reductase 1

Gene

FRRS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Ferric-chelate reductases reduce Fe3+ to Fe2+ before its transport from the endosome to the cytoplasm.By similarity

    Cofactori

    Binds 2 heme groups non-covalently.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi373 – 3731Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi414 – 4141Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi442 – 4421Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi471 – 4711Iron (heme axial ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric-chelate reductase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferric-chelate reductase 1 (EC:1.-.-.-)
    Alternative name(s):
    Stromal cell-derived receptor 2
    Short name:
    SDR-2
    Gene namesi
    Name:FRRS1
    Synonyms:SDFR2, SDR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:27622. FRRS1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670941.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 592592Ferric-chelate reductase 1PRO_0000314843Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ6ZNA5.
    PaxDbiQ6ZNA5.
    PRIDEiQ6ZNA5.

    PTM databases

    PhosphoSiteiQ6ZNA5.

    Expressioni

    Gene expression databases

    BgeeiQ6ZNA5.
    CleanExiHS_FRRS1.
    GenevestigatoriQ6ZNA5.

    Organism-specific databases

    HPAiHPA017883.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000287474.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZNA5.
    SMRiQ6ZNA5. Positions 58-154, 368-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei415 – 43521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei446 – 46621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei491 – 51121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei515 – 53521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei569 – 58921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 179167ReelinPROSITE-ProRule annotationAdd
    BLAST
    Domaini216 – 331116DOMONPROSITE-ProRule annotationAdd
    BLAST
    Domaini335 – 534200Cytochrome b561PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FRRS1 family.Curated
    Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation
    Contains 1 DOMON domain.PROSITE-ProRule annotation
    Contains 1 reelin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281275.
    HOGENOMiHOG000112648.
    HOVERGENiHBG107929.
    OMAiIPGPIIS.
    OrthoDBiEOG7K3TKQ.
    PhylomeDBiQ6ZNA5.
    TreeFamiTF316169.

    Family and domain databases

    InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
    IPR005018. DOMON_domain.
    IPR002861. Reeler_dom.
    [Graphical view]
    PfamiPF03351. DOMON. 1 hit.
    PF02014. Reeler. 1 hit.
    [Graphical view]
    SMARTiSM00665. B561. 1 hit.
    SM00664. DoH. 1 hit.
    [Graphical view]
    PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
    PS50836. DOMON. 1 hit.
    PS51019. REELIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZNA5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVSGFTLGT CILLLHISYV ANYPNGKVTQ SCHGMIPEHG HSPQSVPVHD    50
    IYVSQMTFRP GDQIEVTLSG HPFKGFLLEA RNAEDLNGPP IGSFTLIDSE 100
    VSQLLTCEDI QGSAVSHRSA SKKTEIKVYW NAPSSAPNHT QFLVTVVEKY 150
    KIYWVKIPGP IISQPNAFPF TTPKATVVPL PTLPPVSHLT KPFSASDCGN 200
    KKFCIRSPLN CDPEKEASCV FLSFTRDDQS VMVEMSGPSK GYLSFALSHD 250
    QWMGDDDAYL CIHEDQTVYI QPSHLTGRSH PVMDSRDTLE DMAWRLADGV 300
    MQCSFRRNIT LPGVKNRFDL NTSYYIFLAD GAANDGRIYK HSQQPLITYE 350
    KYDVTDSPKN IGGSHSVLLL KVHGALMFVA WMTTVSIGVL VARFFKPVWS 400
    KAFLLGEAAW FQVHRMLMFT TTVLTCIAFV MPFIYRGGWS RHAGYHPYLG 450
    CIVMTLAVLQ PLLAVFRPPL HDPRRQMFNW THWSMGTAAR IIAVAAMFLG 500
    MDLPGLNLPD SWKTYAMTGF VAWHVGTEVV LEVHAYRLSR KVEILDDDRI 550
    QILQSFTAVE TEGHAFKKAV LAIYVCGNVT FLIIFLSAIN HL 592
    Length:592
    Mass (Da):66,114
    Last modified:January 15, 2008 - v2
    Checksum:i21EC19981C4AA95D
    GO
    Isoform 2 (identifier: Q6ZNA5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         533-592: VHAYRLSRKV...IIFLSAINHL → LKYWMMTEFR...FSLGRLGSCL

    Note: No experimental confirmation available.

    Show »
    Length:626
    Mass (Da):70,465
    Checksum:iA8F39D2DFA893E5B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791P → L in BAD18470. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei533 – 59260VHAYR…AINHL → LKYWMMTEFRSFSHLLQWKQ RVMLLKRQCWQFMSVGMLLF SSYFYLQSTIYEQAKTLAFA GQVIIIIKPKKLEACPDCLE HICEFSLGRLGSCL in isoform 2. 1 PublicationVSP_030400Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131302 mRNA. Translation: BAD18470.1.
    AL451051 Genomic DNA. No translation available.
    CH471097 Genomic DNA. Translation: EAW72988.1.
    CCDSiCCDS30780.1. [Q6ZNA5-2]
    RefSeqiNP_001013682.2. NM_001013660.2. [Q6ZNA5-2]
    XP_005270918.1. XM_005270861.1. [Q6ZNA5-1]
    UniGeneiHs.454779.

    Genome annotation databases

    EnsembliENST00000287474; ENSP00000287474; ENSG00000156869. [Q6ZNA5-2]
    GeneIDi391059.
    KEGGihsa:391059.
    UCSCiuc001dsh.1. human. [Q6ZNA5-2]

    Polymorphism databases

    DMDMi166198896.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131302 mRNA. Translation: BAD18470.1 .
    AL451051 Genomic DNA. No translation available.
    CH471097 Genomic DNA. Translation: EAW72988.1 .
    CCDSi CCDS30780.1. [Q6ZNA5-2 ]
    RefSeqi NP_001013682.2. NM_001013660.2. [Q6ZNA5-2 ]
    XP_005270918.1. XM_005270861.1. [Q6ZNA5-1 ]
    UniGenei Hs.454779.

    3D structure databases

    ProteinModelPortali Q6ZNA5.
    SMRi Q6ZNA5. Positions 58-154, 368-466.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000287474.

    PTM databases

    PhosphoSitei Q6ZNA5.

    Polymorphism databases

    DMDMi 166198896.

    Proteomic databases

    MaxQBi Q6ZNA5.
    PaxDbi Q6ZNA5.
    PRIDEi Q6ZNA5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000287474 ; ENSP00000287474 ; ENSG00000156869 . [Q6ZNA5-2 ]
    GeneIDi 391059.
    KEGGi hsa:391059.
    UCSCi uc001dsh.1. human. [Q6ZNA5-2 ]

    Organism-specific databases

    CTDi 391059.
    GeneCardsi GC01M100174.
    HGNCi HGNC:27622. FRRS1.
    HPAi HPA017883.
    MIMi 611578. gene.
    neXtProti NX_Q6ZNA5.
    PharmGKBi PA142670941.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281275.
    HOGENOMi HOG000112648.
    HOVERGENi HBG107929.
    OMAi IPGPIIS.
    OrthoDBi EOG7K3TKQ.
    PhylomeDBi Q6ZNA5.
    TreeFami TF316169.

    Miscellaneous databases

    GenomeRNAii 391059.
    NextBioi 104295.
    PROi Q6ZNA5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZNA5.
    CleanExi HS_FRRS1.
    Genevestigatori Q6ZNA5.

    Family and domain databases

    InterProi IPR006593. Cyt_b561/ferric_Rdtase_TM.
    IPR005018. DOMON_domain.
    IPR002861. Reeler_dom.
    [Graphical view ]
    Pfami PF03351. DOMON. 1 hit.
    PF02014. Reeler. 1 hit.
    [Graphical view ]
    SMARTi SM00665. B561. 1 hit.
    SM00664. DoH. 1 hit.
    [Graphical view ]
    PROSITEi PS50939. CYTOCHROME_B561. 1 hit.
    PS50836. DOMON. 1 hit.
    PS51019. REELIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Teratocarcinoma.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Cytochrome b561 protein family: expanding roles and versatile transmembrane electron transfer abilities as predicted by a new classification system and protein sequence motif analyses."
      Tsubaki M., Takeuchi F., Nakanishi N.
      Biochim. Biophys. Acta 1753:174-190(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiFRRS1_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZNA5
    Secondary accession number(s): A6NLN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3