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Q6ZNA5

- FRRS1_HUMAN

UniProt

Q6ZNA5 - FRRS1_HUMAN

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Protein
Ferric-chelate reductase 1
Gene
FRRS1, SDFR2, SDR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Ferric-chelate reductases reduce Fe3+ to Fe2+ before its transport from the endosome to the cytoplasm By similarity.

Cofactori

Binds 2 heme groups non-covalently By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi373 – 3731Iron (heme axial ligand) Reviewed prediction
Metal bindingi414 – 4141Iron (heme axial ligand) Reviewed prediction
Metal bindingi442 – 4421Iron (heme axial ligand) Reviewed prediction
Metal bindingi471 – 4711Iron (heme axial ligand) Reviewed prediction

GO - Molecular functioni

  1. ferric-chelate reductase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric-chelate reductase 1 (EC:1.-.-.-)
Alternative name(s):
Stromal cell-derived receptor 2
Short name:
SDR-2
Gene namesi
Name:FRRS1
Synonyms:SDFR2, SDR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:27622. FRRS1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei372 – 39221Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei415 – 43521Helical; Name=3; Reviewed prediction
Add
BLAST
Transmembranei446 – 46621Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei491 – 51121Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei515 – 53521Helical; Name=6; Reviewed prediction
Add
BLAST
Transmembranei569 – 58921Helical; Name=7; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670941.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592Ferric-chelate reductase 1
PRO_0000314843Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi138 – 1381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi308 – 3081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6ZNA5.
PaxDbiQ6ZNA5.
PRIDEiQ6ZNA5.

PTM databases

PhosphoSiteiQ6ZNA5.

Expressioni

Gene expression databases

BgeeiQ6ZNA5.
CleanExiHS_FRRS1.
GenevestigatoriQ6ZNA5.

Organism-specific databases

HPAiHPA017883.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000287474.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNA5.
SMRiQ6ZNA5. Positions 58-154, 368-466.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 179167Reelin
Add
BLAST
Domaini216 – 331116DOMON
Add
BLAST
Domaini335 – 534200Cytochrome b561
Add
BLAST

Sequence similaritiesi

Belongs to the FRRS1 family.
Contains 1 DOMON domain.
Contains 1 reelin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281275.
HOGENOMiHOG000112648.
HOVERGENiHBG107929.
OMAiIPGPIIS.
OrthoDBiEOG7K3TKQ.
PhylomeDBiQ6ZNA5.
TreeFamiTF316169.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR005018. DOMON_domain.
IPR002861. Reeler_dom.
[Graphical view]
PfamiPF03351. DOMON. 1 hit.
PF02014. Reeler. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
SM00664. DoH. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
PS50836. DOMON. 1 hit.
PS51019. REELIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZNA5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAVSGFTLGT CILLLHISYV ANYPNGKVTQ SCHGMIPEHG HSPQSVPVHD    50
IYVSQMTFRP GDQIEVTLSG HPFKGFLLEA RNAEDLNGPP IGSFTLIDSE 100
VSQLLTCEDI QGSAVSHRSA SKKTEIKVYW NAPSSAPNHT QFLVTVVEKY 150
KIYWVKIPGP IISQPNAFPF TTPKATVVPL PTLPPVSHLT KPFSASDCGN 200
KKFCIRSPLN CDPEKEASCV FLSFTRDDQS VMVEMSGPSK GYLSFALSHD 250
QWMGDDDAYL CIHEDQTVYI QPSHLTGRSH PVMDSRDTLE DMAWRLADGV 300
MQCSFRRNIT LPGVKNRFDL NTSYYIFLAD GAANDGRIYK HSQQPLITYE 350
KYDVTDSPKN IGGSHSVLLL KVHGALMFVA WMTTVSIGVL VARFFKPVWS 400
KAFLLGEAAW FQVHRMLMFT TTVLTCIAFV MPFIYRGGWS RHAGYHPYLG 450
CIVMTLAVLQ PLLAVFRPPL HDPRRQMFNW THWSMGTAAR IIAVAAMFLG 500
MDLPGLNLPD SWKTYAMTGF VAWHVGTEVV LEVHAYRLSR KVEILDDDRI 550
QILQSFTAVE TEGHAFKKAV LAIYVCGNVT FLIIFLSAIN HL 592
Length:592
Mass (Da):66,114
Last modified:January 15, 2008 - v2
Checksum:i21EC19981C4AA95D
GO
Isoform 2 (identifier: Q6ZNA5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-592: VHAYRLSRKV...IIFLSAINHL → LKYWMMTEFR...FSLGRLGSCL

Note: No experimental confirmation available.

Show »
Length:626
Mass (Da):70,465
Checksum:iA8F39D2DFA893E5B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei533 – 59260VHAYR…AINHL → LKYWMMTEFRSFSHLLQWKQ RVMLLKRQCWQFMSVGMLLF SSYFYLQSTIYEQAKTLAFA GQVIIIIKPKKLEACPDCLE HICEFSLGRLGSCL in isoform 2.
VSP_030400Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791P → L in BAD18470. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131302 mRNA. Translation: BAD18470.1.
AL451051 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW72988.1.
CCDSiCCDS30780.1. [Q6ZNA5-2]
RefSeqiNP_001013682.2. NM_001013660.2. [Q6ZNA5-2]
XP_005270918.1. XM_005270861.1. [Q6ZNA5-1]
UniGeneiHs.454779.

Genome annotation databases

EnsembliENST00000287474; ENSP00000287474; ENSG00000156869. [Q6ZNA5-2]
ENST00000414213; ENSP00000393884; ENSG00000156869. [Q6ZNA5-1]
GeneIDi391059.
KEGGihsa:391059.
UCSCiuc001dsh.1. human. [Q6ZNA5-2]

Polymorphism databases

DMDMi166198896.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131302 mRNA. Translation: BAD18470.1 .
AL451051 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW72988.1 .
CCDSi CCDS30780.1. [Q6ZNA5-2 ]
RefSeqi NP_001013682.2. NM_001013660.2. [Q6ZNA5-2 ]
XP_005270918.1. XM_005270861.1. [Q6ZNA5-1 ]
UniGenei Hs.454779.

3D structure databases

ProteinModelPortali Q6ZNA5.
SMRi Q6ZNA5. Positions 58-154, 368-466.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000287474.

PTM databases

PhosphoSitei Q6ZNA5.

Polymorphism databases

DMDMi 166198896.

Proteomic databases

MaxQBi Q6ZNA5.
PaxDbi Q6ZNA5.
PRIDEi Q6ZNA5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000287474 ; ENSP00000287474 ; ENSG00000156869 . [Q6ZNA5-2 ]
ENST00000414213 ; ENSP00000393884 ; ENSG00000156869 . [Q6ZNA5-1 ]
GeneIDi 391059.
KEGGi hsa:391059.
UCSCi uc001dsh.1. human. [Q6ZNA5-2 ]

Organism-specific databases

CTDi 391059.
GeneCardsi GC01M100174.
HGNCi HGNC:27622. FRRS1.
HPAi HPA017883.
MIMi 611578. gene.
neXtProti NX_Q6ZNA5.
PharmGKBi PA142670941.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281275.
HOGENOMi HOG000112648.
HOVERGENi HBG107929.
OMAi IPGPIIS.
OrthoDBi EOG7K3TKQ.
PhylomeDBi Q6ZNA5.
TreeFami TF316169.

Miscellaneous databases

GenomeRNAii 391059.
NextBioi 104295.
PROi Q6ZNA5.
SOURCEi Search...

Gene expression databases

Bgeei Q6ZNA5.
CleanExi HS_FRRS1.
Genevestigatori Q6ZNA5.

Family and domain databases

InterProi IPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR005018. DOMON_domain.
IPR002861. Reeler_dom.
[Graphical view ]
Pfami PF03351. DOMON. 1 hit.
PF02014. Reeler. 1 hit.
[Graphical view ]
SMARTi SM00665. B561. 1 hit.
SM00664. DoH. 1 hit.
[Graphical view ]
PROSITEi PS50939. CYTOCHROME_B561. 1 hit.
PS50836. DOMON. 1 hit.
PS51019. REELIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Cytochrome b561 protein family: expanding roles and versatile transmembrane electron transfer abilities as predicted by a new classification system and protein sequence motif analyses."
    Tsubaki M., Takeuchi F., Nakanishi N.
    Biochim. Biophys. Acta 1753:174-190(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiFRRS1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNA5
Secondary accession number(s): A6NLN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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