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Protein

Zinc finger protein 836

Gene

ZNF836

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri582 – 604C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri610 – 632C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri638 – 660C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri666 – 688C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri694 – 716C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri722 – 744C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri750 – 772C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri778 – 800C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri806 – 828C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri834 – 856C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri862 – 884C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri890 – 912C2H2-type 25PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 836
Gene namesi
Name:ZNF836
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196267.12
HGNCiHGNC:34333 ZNF836
neXtProtiNX_Q6ZNA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196267
PharmGKBiPA162410788

Polymorphism and mutation databases

BioMutaiZNF836
DMDMi172046146

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003194341 – 936Zinc finger protein 836Add BLAST936

Proteomic databases

EPDiQ6ZNA1
MaxQBiQ6ZNA1
PaxDbiQ6ZNA1
PeptideAtlasiQ6ZNA1
PRIDEiQ6ZNA1

PTM databases

iPTMnetiQ6ZNA1
PhosphoSitePlusiQ6ZNA1

Expressioni

Gene expression databases

BgeeiENSG00000196267
CleanExiHS_ZNF836
ExpressionAtlasiQ6ZNA1 baseline and differential
GenevisibleiQ6ZNA1 HS

Interactioni

Protein-protein interaction databases

BioGridi127831, 2 interactors
STRINGi9606.ENSP00000325038

Structurei

3D structure databases

ProteinModelPortaliQ6ZNA1
SMRiQ6ZNA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 83KRABPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri582 – 604C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri610 – 632C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri638 – 660C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri666 – 688C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri694 – 716C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri722 – 744C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri750 – 772C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri778 – 800C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri806 – 828C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri834 – 856C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri862 – 884C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri890 – 912C2H2-type 25PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144059
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6ZNA1
KOiK09228
PhylomeDBiQ6ZNA1
TreeFamiTF343410

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 24 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 13 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 24 hits
PS50157 ZINC_FINGER_C2H2_2, 25 hits

Sequencei

Sequence statusi: Complete.

Q6ZNA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTQGPLTF RDVAIEFSQE EWKSLDPVQK ALYWDVMLEN YRNLVFLGIL
60 70 80 90 100
PKCMTKELPP IGNSNTGEKC QTVTLERHEC YDVENFYLRE IQKNLQDLEF
110 120 130 140 150
QWKDGEINYK EVPMTYKNNL NGKRGQHSQE DVENKCIENQ LTLSFQSRLT
160 170 180 190 200
ELQKFQTEGK IYECNQSEKT VNNSSLVSPL QRILPSVQTN ISKKYENEFL
210 220 230 240 250
QLSLPTQLEK THIREKPYMC KGCGKAFRVS SSLINHQMVH TTEKPYKCNE
260 270 280 290 300
CGKAFHRGSL LTIHQIVHTR GKPYQCGVCG KIFRQNSDLV NHRRSHTGEK
310 320 330 340 350
PYKCNECGKS FSQSYNLAIH QRIHTGEKPY KCNECGKTFK QGSCLTTHQI
360 370 380 390 400
IHTGEKPYQC DICGKVFRQN SNLVNHQRIH TGEKPYKCNI CGKSFSQSSN
410 420 430 440 450
LATHQTVHSG NKPYKCDECG KTFKRSSSLT THQIIHTGEK PYTCDVCDKV
460 470 480 490 500
FSQRSQLARH QRSHTGEKPY KCNECGKVFS QTSHLVGHRR IHTGEKPYKC
510 520 530 540 550
DKCGKAFKQG SLLTRHKIIH TREKRYQCGE CGKVFSENSC LVRHLRIHTG
560 570 580 590 600
EQPYKCNVCG KVFNYSGNLS IHKRIHTGEK PFQCNECGTV FRNYSCLARH
610 620 630 640 650
LRIHTGQKPY KCNVCGKVFN DSGNLSNHKR IHTGEKPFQC NECGKVFSYY
660 670 680 690 700
SCLARHRKIH TGEKPYKCND CGKAYTQRSS LTKHLIIHTG EKPYNCNEFG
710 720 730 740 750
GAFIQSSKLA RYHRNPTGEK PHKCSHCGRT FSHITGLTYH QRRHTGEMPY
760 770 780 790 800
KCIECGQVFN STSNLARHRR IHTGEKPYKC NECGKVFRHQ STLARHRSIH
810 820 830 840 850
TGEKPYVCNE CGKAFRVRSI LVNHQKMHTG DKPYKCNECG KAFIERSKLV
860 870 880 890 900
YHQRNHTGEK PYKCIECGKA FGRFSCLNKH QMIHSGEKPY KCNECGKSFI
910 920 930
SRSGLTKHQT KHTAESLKTK FNVEKPLDVL LTSGFK
Length:936
Mass (Da):107,717
Last modified:February 26, 2008 - v2
Checksum:i6C7FC8B639550732
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti434I → V in BAD18474 (PubMed:14702039).Curated1
Sequence conflicti463S → G in BAD18474 (PubMed:14702039).Curated1
Sequence conflicti576H → R in BAD18474 (PubMed:14702039).Curated1
Sequence conflicti661T → A in BAD18474 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039001219M → I1 PublicationCorresponds to variant dbSNP:rs1366245Ensembl.1
Natural variantiVAR_039002809N → S1 PublicationCorresponds to variant dbSNP:rs8113504Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010320 Genomic DNA No translation available.
AC011468 Genomic DNA No translation available.
AK131308 mRNA Translation: BAD18474.1
CCDSiCCDS46162.1
RefSeqiNP_001096127.1, NM_001102657.1
XP_011524860.1, XM_011526558.2
XP_011524861.1, XM_011526559.2
UniGeneiHs.631584

Genome annotation databases

EnsembliENST00000597252; ENSP00000470239; ENSG00000196267
GeneIDi162962
KEGGihsa:162962
UCSCiuc010ydi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN836_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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