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Protein

Zinc finger protein 836

Gene

ZNF836

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri218 – 24023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri526 – 54823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri554 – 57623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri582 – 60423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri610 – 63223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri638 – 66023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri666 – 68823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri694 – 71623C2H2-type 18; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri722 – 74423C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri750 – 77223C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri778 – 80023C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri806 – 82823C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri834 – 85623C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri862 – 88423C2H2-type 24PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri890 – 91223C2H2-type 25PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 836
Gene namesi
Name:ZNF836
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:34333. ZNF836.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410788.

Polymorphism and mutation databases

BioMutaiZNF836.
DMDMi172046146.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 936936Zinc finger protein 836PRO_0000319434Add
BLAST

Proteomic databases

EPDiQ6ZNA1.
PaxDbiQ6ZNA1.
PeptideAtlasiQ6ZNA1.
PRIDEiQ6ZNA1.

PTM databases

iPTMnetiQ6ZNA1.
PhosphoSiteiQ6ZNA1.

Expressioni

Gene expression databases

BgeeiQ6ZNA1.
CleanExiHS_ZNF836.
ExpressionAtlasiQ6ZNA1. baseline and differential.
GenevisibleiQ6ZNA1. HS.

Organism-specific databases

HPAiHPA060901.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000325038.

Structurei

3D structure databases

ProteinModelPortaliQ6ZNA1.
SMRiQ6ZNA1. Positions 125-915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8376KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 25 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri218 – 24023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri526 – 54823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri554 – 57623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri582 – 60423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri610 – 63223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri638 – 66023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri666 – 68823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri694 – 71623C2H2-type 18; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri722 – 74423C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri750 – 77223C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri778 – 80023C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri806 – 82823C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri834 – 85623C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri862 – 88423C2H2-type 24PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri890 – 91223C2H2-type 25PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZNA1.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZNA1.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 25 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 12 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 24 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 24 hits.
PS50157. ZINC_FINGER_C2H2_2. 25 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZNA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTQGPLTF RDVAIEFSQE EWKSLDPVQK ALYWDVMLEN YRNLVFLGIL
60 70 80 90 100
PKCMTKELPP IGNSNTGEKC QTVTLERHEC YDVENFYLRE IQKNLQDLEF
110 120 130 140 150
QWKDGEINYK EVPMTYKNNL NGKRGQHSQE DVENKCIENQ LTLSFQSRLT
160 170 180 190 200
ELQKFQTEGK IYECNQSEKT VNNSSLVSPL QRILPSVQTN ISKKYENEFL
210 220 230 240 250
QLSLPTQLEK THIREKPYMC KGCGKAFRVS SSLINHQMVH TTEKPYKCNE
260 270 280 290 300
CGKAFHRGSL LTIHQIVHTR GKPYQCGVCG KIFRQNSDLV NHRRSHTGEK
310 320 330 340 350
PYKCNECGKS FSQSYNLAIH QRIHTGEKPY KCNECGKTFK QGSCLTTHQI
360 370 380 390 400
IHTGEKPYQC DICGKVFRQN SNLVNHQRIH TGEKPYKCNI CGKSFSQSSN
410 420 430 440 450
LATHQTVHSG NKPYKCDECG KTFKRSSSLT THQIIHTGEK PYTCDVCDKV
460 470 480 490 500
FSQRSQLARH QRSHTGEKPY KCNECGKVFS QTSHLVGHRR IHTGEKPYKC
510 520 530 540 550
DKCGKAFKQG SLLTRHKIIH TREKRYQCGE CGKVFSENSC LVRHLRIHTG
560 570 580 590 600
EQPYKCNVCG KVFNYSGNLS IHKRIHTGEK PFQCNECGTV FRNYSCLARH
610 620 630 640 650
LRIHTGQKPY KCNVCGKVFN DSGNLSNHKR IHTGEKPFQC NECGKVFSYY
660 670 680 690 700
SCLARHRKIH TGEKPYKCND CGKAYTQRSS LTKHLIIHTG EKPYNCNEFG
710 720 730 740 750
GAFIQSSKLA RYHRNPTGEK PHKCSHCGRT FSHITGLTYH QRRHTGEMPY
760 770 780 790 800
KCIECGQVFN STSNLARHRR IHTGEKPYKC NECGKVFRHQ STLARHRSIH
810 820 830 840 850
TGEKPYVCNE CGKAFRVRSI LVNHQKMHTG DKPYKCNECG KAFIERSKLV
860 870 880 890 900
YHQRNHTGEK PYKCIECGKA FGRFSCLNKH QMIHSGEKPY KCNECGKSFI
910 920 930
SRSGLTKHQT KHTAESLKTK FNVEKPLDVL LTSGFK
Length:936
Mass (Da):107,717
Last modified:February 26, 2008 - v2
Checksum:i6C7FC8B639550732
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti434 – 4341I → V in BAD18474 (PubMed:14702039).Curated
Sequence conflicti463 – 4631S → G in BAD18474 (PubMed:14702039).Curated
Sequence conflicti576 – 5761H → R in BAD18474 (PubMed:14702039).Curated
Sequence conflicti661 – 6611T → A in BAD18474 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191M → I.1 Publication
Corresponds to variant rs1366245 [ dbSNP | Ensembl ].
VAR_039001
Natural varianti809 – 8091N → S.1 Publication
Corresponds to variant rs8113504 [ dbSNP | Ensembl ].
VAR_039002

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010320 Genomic DNA. No translation available.
AC011468 Genomic DNA. No translation available.
AK131308 mRNA. Translation: BAD18474.1.
CCDSiCCDS46162.1.
RefSeqiNP_001096127.1. NM_001102657.1.
XP_011524860.1. XM_011526558.1.
XP_011524861.1. XM_011526559.1.
UniGeneiHs.631584.

Genome annotation databases

EnsembliENST00000597252; ENSP00000470239; ENSG00000196267.
GeneIDi162962.
KEGGihsa:162962.
UCSCiuc010ydi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010320 Genomic DNA. No translation available.
AC011468 Genomic DNA. No translation available.
AK131308 mRNA. Translation: BAD18474.1.
CCDSiCCDS46162.1.
RefSeqiNP_001096127.1. NM_001102657.1.
XP_011524860.1. XM_011526558.1.
XP_011524861.1. XM_011526559.1.
UniGeneiHs.631584.

3D structure databases

ProteinModelPortaliQ6ZNA1.
SMRiQ6ZNA1. Positions 125-915.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000325038.

PTM databases

iPTMnetiQ6ZNA1.
PhosphoSiteiQ6ZNA1.

Polymorphism and mutation databases

BioMutaiZNF836.
DMDMi172046146.

Proteomic databases

EPDiQ6ZNA1.
PaxDbiQ6ZNA1.
PeptideAtlasiQ6ZNA1.
PRIDEiQ6ZNA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000597252; ENSP00000470239; ENSG00000196267.
GeneIDi162962.
KEGGihsa:162962.
UCSCiuc010ydi.3. human.

Organism-specific databases

CTDi162962.
GeneCardsiZNF836.
HGNCiHGNC:34333. ZNF836.
HPAiHPA060901.
neXtProtiNX_Q6ZNA1.
PharmGKBiPA162410788.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZNA1.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZNA1.
TreeFamiTF343410.

Miscellaneous databases

ChiTaRSiZNF836. human.
GenomeRNAii162962.
PROiQ6ZNA1.

Gene expression databases

BgeeiQ6ZNA1.
CleanExiHS_ZNF836.
ExpressionAtlasiQ6ZNA1. baseline and differential.
GenevisibleiQ6ZNA1. HS.

Family and domain databases

Gene3Di3.30.160.60. 25 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 12 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 24 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 24 hits.
PS50157. ZINC_FINGER_C2H2_2. 25 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-891, VARIANTS ILE-219 AND SER-809.
    Tissue: Brain.

Entry informationi

Entry nameiZN836_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 6, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.