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Protein

Coiled-coil domain-containing protein 81

Gene

CCDC81

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 81
Gene namesi
Name:CCDC81
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149201.9.
HGNCiHGNC:26281. CCDC81.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149201.
PharmGKBiPA128394704.

Polymorphism and mutation databases

BioMutaiCCDC81.
DMDMi148841312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888771 – 652Coiled-coil domain-containing protein 81Add BLAST652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206PhosphoserineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei417PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZN84.
PeptideAtlasiQ6ZN84.
PRIDEiQ6ZN84.

PTM databases

iPTMnetiQ6ZN84.
PhosphoSitePlusiQ6ZN84.

Expressioni

Gene expression databases

BgeeiENSG00000149201.
CleanExiHS_CCDC81.
ExpressionAtlasiQ6ZN84. baseline and differential.
GenevisibleiQ6ZN84. HS.

Organism-specific databases

HPAiHPA040745.
HPA040827.

Interactioni

Protein-protein interaction databases

IntActiQ6ZN84. 1 interactor.
STRINGi9606.ENSP00000415528.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili436 – 493Sequence analysisAdd BLAST58

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE6A. Eukaryota.
ENOG410XPAP. LUCA.
GeneTreeiENSGT00390000011985.
HOGENOMiHOG000007608.
HOVERGENiHBG103116.
InParanoidiQ6ZN84.
OMAiNQKNAAY.
OrthoDBiEOG091G09MH.
PhylomeDBiQ6ZN84.
TreeFamiTF336185.

Family and domain databases

Gene3Di4.10.520.10. 1 hit.
InterProiView protein in InterPro
IPR026295. Coiled-coil_dom_cont_p_81.
IPR028034. DUF4496.
IPR010992. IHF-like_DNA-bd_dom.
PANTHERiPTHR14362. PTHR14362. 1 hit.
PfamiView protein in Pfam
PF14908. DUF4496. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZN84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLDTIARALQ DLGRQVLPTL PSLSQEEVSI IWGNVSEFVR RQLTLHKGVQ
60 70 80 90 100
IPAFGTFTFI RQKLEVGNNK FILIQRPVFI MVEKLVQIHG LKQNKVYTPG
110 120 130 140 150
EIPIVPLNFV MISLEGPFNR DVVEGCVKET LLFLSRSISM KQNVEFTFKG
160 170 180 190 200
IGVLMIRDSK VKMRFYKDFL CTMDGSGALA KALANRPGTV DSVLSSREAL
210 220 230 240 250
RKWPSSVLAF PRIELKEMEN KLPMETLVEE CGENRERKCK LKDQSDKEEG
260 270 280 290 300
TRDISSPKRL RDRQALFPAK VTNVSLLEKF ERSESGGKIM TPESLSYPSC
310 320 330 340 350
LKHDSEMKPQ TSPACQDHNK AGQEMCYVCL QRAQRNSLLY YSEERRREIE
360 370 380 390 400
DERLIQQYQM LKDQEALFRH QMKSLATREQ NQKNAAYNLG VAEAIRNHKN
410 420 430 440 450
EKPEFYKSFL FDKRPLSPAL NALKQEEYSR SLLKQMDNRQ ENEIKQRQYR
460 470 480 490 500
ELMDRLEQVQ LTEELAAQRA KFLKDKMEET QCYKRALDAQ IKNKPSRLPP
510 520 530 540 550
FEPDSSEPIF GKNEGELMVE KQKREQNYMK HQLEAAANHK RKAILHQLVD
560 570 580 590 600
QRRDLQMLQR TQREHLADRT AELERVNRVN QCLQEDWERS AAMKKQRDLE
610 620 630 640 650
DKAFERASDK LFLLDQCEKY RRCKQCQRRT SNVGESNLWP LNKFLPGSRL

LV
Length:652
Mass (Da):76,084
Last modified:May 29, 2007 - v2
Checksum:iBE258DA8038343AE
GO
Isoform 2 (identifier: Q6ZN84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-185: Missing.

Note: No experimental confirmation available.
Show »
Length:562
Mass (Da):66,064
Checksum:iABDE53FCC03FA2DD
GO
Isoform 3 (identifier: Q6ZN84-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-217: Missing.
     324-371: Missing.

Show »
Length:387
Mass (Da):45,500
Checksum:i5CB80F53B48F4349
GO

Sequence cautioni

Q6ZN84: The sequence BAD96888 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83E → G in BAD18491 (PubMed:14702039).Curated1
Sequence conflicti407K → I in BAB15681 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032524449Y → C. Corresponds to variant dbSNP:rs3741005Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0258051 – 217Missing in isoform 3. 2 PublicationsAdd BLAST217
Alternative sequenceiVSP_02580696 – 185Missing in isoform 2. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_025807324 – 371Missing in isoform 3. 2 PublicationsAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027167 mRNA. Translation: BAB15681.1.
AK131331 mRNA. Translation: BAD18491.1.
AK223168 mRNA. Translation: BAD96888.1. Different initiation.
BC126412 mRNA. Translation: AAI26413.1.
CCDSiCCDS53691.1. [Q6ZN84-1]
CCDS8276.1. [Q6ZN84-2]
RefSeqiNP_001149946.1. NM_001156474.1. [Q6ZN84-1]
NP_068599.3. NM_021827.4. [Q6ZN84-2]
UniGeneiHs.144913.

Genome annotation databases

EnsembliENST00000354755; ENSP00000346800; ENSG00000149201. [Q6ZN84-2]
ENST00000445632; ENSP00000415528; ENSG00000149201. [Q6ZN84-1]
ENST00000528728; ENSP00000437165; ENSG00000149201. [Q6ZN84-3]
GeneIDi60494.
KEGGihsa:60494.
UCSCiuc001pbw.3. human. [Q6ZN84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCD81_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN84
Secondary accession number(s): A0AVL7, Q53FW3, Q9H5E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: September 27, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations