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Protein

Coiled-coil domain-containing protein 81

Gene

CCDC81

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 81
Gene namesi
Name:CCDC81
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26281. CCDC81.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394704.

Polymorphism and mutation databases

BioMutaiCCDC81.
DMDMi148841312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 652652Coiled-coil domain-containing protein 81PRO_0000288877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061PhosphoserineBy similarity
Modified residuei275 – 2751PhosphoserineBy similarity
Modified residuei296 – 2961PhosphoserineBy similarity
Modified residuei417 – 4171PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZN84.
PeptideAtlasiQ6ZN84.
PRIDEiQ6ZN84.

PTM databases

iPTMnetiQ6ZN84.
PhosphoSiteiQ6ZN84.

Expressioni

Gene expression databases

BgeeiQ6ZN84.
CleanExiHS_CCDC81.
ExpressionAtlasiQ6ZN84. baseline and differential.
GenevisibleiQ6ZN84. HS.

Organism-specific databases

HPAiHPA040745.
HPA040827.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili436 – 49358Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE6A. Eukaryota.
ENOG410XPAP. LUCA.
GeneTreeiENSGT00390000011985.
HOGENOMiHOG000007608.
HOVERGENiHBG103116.
InParanoidiQ6ZN84.
OMAiEGCVKET.
OrthoDBiEOG7HHWRP.
PhylomeDBiQ6ZN84.
TreeFamiTF336185.

Family and domain databases

InterProiIPR026295. Coiled-coil_dom_cont_p_81.
IPR028034. DUF4496.
[Graphical view]
PANTHERiPTHR14362. PTHR14362. 1 hit.
PfamiPF14908. DUF4496. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZN84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLDTIARALQ DLGRQVLPTL PSLSQEEVSI IWGNVSEFVR RQLTLHKGVQ
60 70 80 90 100
IPAFGTFTFI RQKLEVGNNK FILIQRPVFI MVEKLVQIHG LKQNKVYTPG
110 120 130 140 150
EIPIVPLNFV MISLEGPFNR DVVEGCVKET LLFLSRSISM KQNVEFTFKG
160 170 180 190 200
IGVLMIRDSK VKMRFYKDFL CTMDGSGALA KALANRPGTV DSVLSSREAL
210 220 230 240 250
RKWPSSVLAF PRIELKEMEN KLPMETLVEE CGENRERKCK LKDQSDKEEG
260 270 280 290 300
TRDISSPKRL RDRQALFPAK VTNVSLLEKF ERSESGGKIM TPESLSYPSC
310 320 330 340 350
LKHDSEMKPQ TSPACQDHNK AGQEMCYVCL QRAQRNSLLY YSEERRREIE
360 370 380 390 400
DERLIQQYQM LKDQEALFRH QMKSLATREQ NQKNAAYNLG VAEAIRNHKN
410 420 430 440 450
EKPEFYKSFL FDKRPLSPAL NALKQEEYSR SLLKQMDNRQ ENEIKQRQYR
460 470 480 490 500
ELMDRLEQVQ LTEELAAQRA KFLKDKMEET QCYKRALDAQ IKNKPSRLPP
510 520 530 540 550
FEPDSSEPIF GKNEGELMVE KQKREQNYMK HQLEAAANHK RKAILHQLVD
560 570 580 590 600
QRRDLQMLQR TQREHLADRT AELERVNRVN QCLQEDWERS AAMKKQRDLE
610 620 630 640 650
DKAFERASDK LFLLDQCEKY RRCKQCQRRT SNVGESNLWP LNKFLPGSRL

LV
Length:652
Mass (Da):76,084
Last modified:May 29, 2007 - v2
Checksum:iBE258DA8038343AE
GO
Isoform 2 (identifier: Q6ZN84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-185: Missing.

Note: No experimental confirmation available.
Show »
Length:562
Mass (Da):66,064
Checksum:iABDE53FCC03FA2DD
GO
Isoform 3 (identifier: Q6ZN84-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-217: Missing.
     324-371: Missing.

Show »
Length:387
Mass (Da):45,500
Checksum:i5CB80F53B48F4349
GO

Sequence cautioni

The sequence BAD96888.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831E → G in BAD18491 (PubMed:14702039).Curated
Sequence conflicti407 – 4071K → I in BAB15681 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti449 – 4491Y → C.
Corresponds to variant rs3741005 [ dbSNP | Ensembl ].
VAR_032524

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 217217Missing in isoform 3. 2 PublicationsVSP_025805Add
BLAST
Alternative sequencei96 – 18590Missing in isoform 2. 1 PublicationVSP_025806Add
BLAST
Alternative sequencei324 – 37148Missing in isoform 3. 2 PublicationsVSP_025807Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027167 mRNA. Translation: BAB15681.1.
AK131331 mRNA. Translation: BAD18491.1.
AK223168 mRNA. Translation: BAD96888.1. Different initiation.
BC126412 mRNA. Translation: AAI26413.1.
CCDSiCCDS53691.1. [Q6ZN84-1]
CCDS8276.1. [Q6ZN84-2]
RefSeqiNP_001149946.1. NM_001156474.1. [Q6ZN84-1]
NP_068599.3. NM_021827.4. [Q6ZN84-2]
UniGeneiHs.144913.

Genome annotation databases

EnsembliENST00000354755; ENSP00000346800; ENSG00000149201. [Q6ZN84-2]
ENST00000445632; ENSP00000415528; ENSG00000149201. [Q6ZN84-1]
ENST00000528728; ENSP00000437165; ENSG00000149201. [Q6ZN84-3]
GeneIDi60494.
KEGGihsa:60494.
UCSCiuc001pbw.3. human. [Q6ZN84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027167 mRNA. Translation: BAB15681.1.
AK131331 mRNA. Translation: BAD18491.1.
AK223168 mRNA. Translation: BAD96888.1. Different initiation.
BC126412 mRNA. Translation: AAI26413.1.
CCDSiCCDS53691.1. [Q6ZN84-1]
CCDS8276.1. [Q6ZN84-2]
RefSeqiNP_001149946.1. NM_001156474.1. [Q6ZN84-1]
NP_068599.3. NM_021827.4. [Q6ZN84-2]
UniGeneiHs.144913.

3D structure databases

ProteinModelPortaliQ6ZN84.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6ZN84.
PhosphoSiteiQ6ZN84.

Polymorphism and mutation databases

BioMutaiCCDC81.
DMDMi148841312.

Proteomic databases

PaxDbiQ6ZN84.
PeptideAtlasiQ6ZN84.
PRIDEiQ6ZN84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354755; ENSP00000346800; ENSG00000149201. [Q6ZN84-2]
ENST00000445632; ENSP00000415528; ENSG00000149201. [Q6ZN84-1]
ENST00000528728; ENSP00000437165; ENSG00000149201. [Q6ZN84-3]
GeneIDi60494.
KEGGihsa:60494.
UCSCiuc001pbw.3. human. [Q6ZN84-1]

Organism-specific databases

CTDi60494.
GeneCardsiCCDC81.
HGNCiHGNC:26281. CCDC81.
HPAiHPA040745.
HPA040827.
neXtProtiNX_Q6ZN84.
PharmGKBiPA128394704.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE6A. Eukaryota.
ENOG410XPAP. LUCA.
GeneTreeiENSGT00390000011985.
HOGENOMiHOG000007608.
HOVERGENiHBG103116.
InParanoidiQ6ZN84.
OMAiEGCVKET.
OrthoDBiEOG7HHWRP.
PhylomeDBiQ6ZN84.
TreeFamiTF336185.

Miscellaneous databases

GenomeRNAii60494.
PROiQ6ZN84.

Gene expression databases

BgeeiQ6ZN84.
CleanExiHS_CCDC81.
ExpressionAtlasiQ6ZN84. baseline and differential.
GenevisibleiQ6ZN84. HS.

Family and domain databases

InterProiIPR026295. Coiled-coil_dom_cont_p_81.
IPR028034. DUF4496.
[Graphical view]
PANTHERiPTHR14362. PTHR14362. 1 hit.
PfamiPF14908. DUF4496. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Lung and Testis.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  4. "Proteomic analysis of mammalian sperm cells identifies new components of the centrosome."
    Firat-Karalar E.N., Sante J., Elliott S., Stearns T.
    J. Cell Sci. 127:4128-4133(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCCD81_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN84
Secondary accession number(s): A0AVL7, Q53FW3, Q9H5E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: July 6, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.