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Protein

Zinc finger protein 705A

Gene

ZNF705A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 705A
Gene namesi
Name:ZNF705A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000196946.9
HGNCiHGNC:32281 ZNF705A
neXtProtiNX_Q6ZN79

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi440077
OpenTargetsiENSG00000196946
PharmGKBiPA142670502

Polymorphism and mutation databases

BioMutaiZNF705A
DMDMi74758719

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332831 – 300Zinc finger protein 705AAdd BLAST300

Proteomic databases

PaxDbiQ6ZN79
PeptideAtlasiQ6ZN79
PRIDEiQ6ZN79

PTM databases

iPTMnetiQ6ZN79
PhosphoSitePlusiQ6ZN79

Expressioni

Gene expression databases

BgeeiENSG00000196946
CleanExiHS_ZNF705A
ExpressionAtlasiQ6ZN79 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352233

Structurei

3D structure databases

ProteinModelPortaliQ6ZN79
SMRiQ6ZN79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 78KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00830000128291
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6ZN79
KOiK09228
OMAiISMHPIR
OrthoDBiEOG091G0C5V
PhylomeDBiQ6ZN79
TreeFamiTF338497

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q6ZN79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSLKKVTFE DVAIDFTQEE WAMMDTSKRK LYRDVMLENI SHLVSLGYQI
60 70 80 90 100
SKSYIILQLE QGKELWREGR EFLQDQNPDR ESALKKKHMI SMHPITRKDA
110 120 130 140 150
STSMTMENSL ILEDPFECND SGEDCTHSST ITQRLLTHSG KKPYVSKQCG
160 170 180 190 200
KSLRNLFSPK PHKQIHTKGK SYQCNLCEKA YTNCFRLRRH KMTHTGERPY
210 220 230 240 250
ACHLCGKAFT QCSHLRRHEK THTGERPYKC HQCGKAFIQS FNLRRHERTH
260 270 280 290 300
LGKKCYECDK SGKAFSQSSG FRGNKIIHTG EKPHACLLCG KAFSLSSDLR
Length:300
Mass (Da):34,734
Last modified:July 5, 2004 - v1
Checksum:i88D49C592D7D8AA7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059929126T → A. Corresponds to variant dbSNP:rs10743251Ensembl.1
Natural variantiVAR_059930134R → C. Corresponds to variant dbSNP:rs10743252Ensembl.1
Natural variantiVAR_033595142K → Q. Corresponds to variant dbSNP:rs10743253Ensembl.1
Natural variantiVAR_059931186R → H. Corresponds to variant dbSNP:rs11043758Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131339 mRNA Translation: BAD18496.1
CCDSiCCDS31737.1
RefSeqiNP_001004328.1, NM_001004328.2
UniGeneiHs.438536

Genome annotation databases

EnsembliENST00000359286; ENSP00000352233; ENSG00000196946
ENST00000610508; ENSP00000481663; ENSG00000196946
GeneIDi440077
KEGGihsa:440077
UCSCiuc001qud.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZ705A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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