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Protein

Zinc finger protein 705A

Gene

ZNF705A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32161-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 705A
Gene namesi
Name:ZNF705A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:32281. ZNF705A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196946.
PharmGKBiPA142670502.

Polymorphism and mutation databases

BioMutaiZNF705A.
DMDMi74758719.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332831 – 300Zinc finger protein 705AAdd BLAST300

Proteomic databases

PaxDbiQ6ZN79.
PeptideAtlasiQ6ZN79.
PRIDEiQ6ZN79.

PTM databases

iPTMnetiQ6ZN79.
PhosphoSitePlusiQ6ZN79.

Expressioni

Gene expression databases

BgeeiENSG00000196946.
CleanExiHS_ZNF705A.
ExpressionAtlasiQ6ZN79. baseline and differential.

Organism-specific databases

HPAiCAB005417.
CAB012406.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352233.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN79.
SMRiQ6ZN79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 78KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128291.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZN79.
KOiK09228.
OMAiNAFSKYS.
OrthoDBiEOG091G0C5V.
PhylomeDBiQ6ZN79.
TreeFamiTF338497.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZN79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSLKKVTFE DVAIDFTQEE WAMMDTSKRK LYRDVMLENI SHLVSLGYQI
60 70 80 90 100
SKSYIILQLE QGKELWREGR EFLQDQNPDR ESALKKKHMI SMHPITRKDA
110 120 130 140 150
STSMTMENSL ILEDPFECND SGEDCTHSST ITQRLLTHSG KKPYVSKQCG
160 170 180 190 200
KSLRNLFSPK PHKQIHTKGK SYQCNLCEKA YTNCFRLRRH KMTHTGERPY
210 220 230 240 250
ACHLCGKAFT QCSHLRRHEK THTGERPYKC HQCGKAFIQS FNLRRHERTH
260 270 280 290 300
LGKKCYECDK SGKAFSQSSG FRGNKIIHTG EKPHACLLCG KAFSLSSDLR
Length:300
Mass (Da):34,734
Last modified:July 5, 2004 - v1
Checksum:i88D49C592D7D8AA7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059929126T → A.Corresponds to variant rs10743251dbSNPEnsembl.1
Natural variantiVAR_059930134R → C.Corresponds to variant rs10743252dbSNPEnsembl.1
Natural variantiVAR_033595142K → Q.Corresponds to variant rs10743253dbSNPEnsembl.1
Natural variantiVAR_059931186R → H.Corresponds to variant rs11043758dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131339 mRNA. Translation: BAD18496.1.
CCDSiCCDS31737.1.
RefSeqiNP_001004328.1. NM_001004328.2.
UniGeneiHs.438536.

Genome annotation databases

EnsembliENST00000359286; ENSP00000352233; ENSG00000196946.
ENST00000610508; ENSP00000481663; ENSG00000196946.
GeneIDi440077.
KEGGihsa:440077.
UCSCiuc001qud.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131339 mRNA. Translation: BAD18496.1.
CCDSiCCDS31737.1.
RefSeqiNP_001004328.1. NM_001004328.2.
UniGeneiHs.438536.

3D structure databases

ProteinModelPortaliQ6ZN79.
SMRiQ6ZN79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352233.

PTM databases

iPTMnetiQ6ZN79.
PhosphoSitePlusiQ6ZN79.

Polymorphism and mutation databases

BioMutaiZNF705A.
DMDMi74758719.

Proteomic databases

PaxDbiQ6ZN79.
PeptideAtlasiQ6ZN79.
PRIDEiQ6ZN79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359286; ENSP00000352233; ENSG00000196946.
ENST00000610508; ENSP00000481663; ENSG00000196946.
GeneIDi440077.
KEGGihsa:440077.
UCSCiuc001qud.2. human.

Organism-specific databases

CTDi440077.
GeneCardsiZNF705A.
HGNCiHGNC:32281. ZNF705A.
HPAiCAB005417.
CAB012406.
neXtProtiNX_Q6ZN79.
OpenTargetsiENSG00000196946.
PharmGKBiPA142670502.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128291.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZN79.
KOiK09228.
OMAiNAFSKYS.
OrthoDBiEOG091G0C5V.
PhylomeDBiQ6ZN79.
TreeFamiTF338497.

Enzyme and pathway databases

BioCyciZFISH:G66-32161-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF705A. human.
GenomeRNAii440077.
PROiQ6ZN79.

Gene expression databases

BgeeiENSG00000196946.
CleanExiHS_ZNF705A.
ExpressionAtlasiQ6ZN79. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ705A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.