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Protein

Putative C-mannosyltransferase DPY19L2P2

Gene

DPY19L2P2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.By similarity

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative C-mannosyltransferase DPY19L2P2 (EC:2.4.1.-)
Alternative name(s):
Dpy-19-like protein 2 pseudogene 2
Protein dpy-19 homolog 2-like 2
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:21764 DPY19L2P2
neXtProtiNX_Q6ZN68

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi187471076

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003329651 – 376Putative C-mannosyltransferase DPY19L2P2Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiQ6ZN68
PRIDEiQ6ZN68

Expressioni

Tissue specificityi

Fibroblast, lung, lymphoblast, spleen and testis.1 Publication

Structurei

3D structure databases

SMRiQ6ZN68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ6ZN68
PhylomeDBiQ6ZN68

Family and domain databases

InterProiView protein in InterPro
IPR018732 Dpy-19/Dpy-19-like
PANTHERiPTHR31488 PTHR31488, 1 hit
PfamiView protein in Pfam
PF10034 Dpy19, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZN68-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADSRRVIIA SWYRTFMGIV NLFGLETKTC WNVTRIEPLN EVQSCEGLRD
60 70 80 90 100
PACFYVGVIF ILNGLMMGLF FIYGTYLSGT ELGGLITVLC FFFNHGEATC
110 120 130 140 150
VMWTPPLRES FSYPFLVLQM YVLTLILRTS SNDRRPFIAL CLSNVAFMLP
160 170 180 190 200
WQFAQFILFT QIASLFPMYV VGYIEPSKFQ KIIYMNMISV TLSFILMFGN
210 220 230 240 250
SMYLSSYYSS SLLMTWAIIL KRNEIQKLGV SKLNCWLIQG SAWWCGTIIL
260 270 280 290 300
KFLTSKILGV SDHICLSDLI AAGILRYTDF DTLKYTCSPE FDFMEKATLL
310 320 330 340 350
IYTKTLLLPV VMVITCFIFK KTVGDISRVL ATNVYLRCCL CRCHAYNGKC
360 370
QAVYTSSHCE SSTLRRCRLE AWLQHA
Length:376
Mass (Da):43,060
Last modified:April 29, 2008 - v2
Checksum:i40C668C279E43609
GO
Isoform 2 (identifier: Q6ZN68-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     338-376: CCLCRCHAYN...CRLEAWLQHA → KQLLEHSELA...MCVMASLICS

Show »
Length:318
Mass (Da):36,385
Checksum:i8B0937B0B6EFE915
GO
Isoform 3 (identifier: Q6ZN68-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-147: Missing.
     338-376: CCLCRCHAYN...CRLEAWLQHA → KQLLEHSELA...MCVMASLICS

Show »
Length:236
Mass (Da):27,059
Checksum:i7CD66E53ED010D13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti274I → T in BAD18507 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04300966M → V. Corresponds to variant dbSNP:rs7796589Ensembl.1
Natural variantiVAR_043010333N → I. Corresponds to variant dbSNP:rs17136078Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0333991 – 147Missing in isoform 3. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_0334001 – 65Missing in isoform 2. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_033401338 – 376CCLCR…WLQHA → KQLLEHSELAFHTLQLLAFT ALAILILRLKLFLTQHMCVM ASLICS in isoform 2 and isoform 3. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093485 mRNA Translation: BAC04183.1
AK131353 mRNA Translation: BAD18507.1
AL834175 mRNA Translation: CAD38872.1
CH471070 Genomic DNA Translation: EAW83318.1
UniGeneiHs.732579

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiD19P2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN68
Secondary accession number(s): Q8N9V4, Q8ND62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: February 28, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health