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Protein

Guanylate-binding protein 6

Gene

GBP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds GTP, GDP and GMP.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 528GTPBy similarity
Nucleotide bindingi67 – 693GTPBy similarity
Nucleotide bindingi97 – 1015GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate-binding protein 6
Alternative name(s):
GTP-binding protein 6
Short name:
GBP-6
Guanine nucleotide-binding protein 6
Gene namesi
Name:GBP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25395. GBP6.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134964409.

Polymorphism and mutation databases

BioMutaiGBP6.
DMDMi74749570.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633Guanylate-binding protein 6PRO_0000313811Add
BLAST

Proteomic databases

MaxQBiQ6ZN66.
PaxDbiQ6ZN66.
PeptideAtlasiQ6ZN66.
PRIDEiQ6ZN66.

PTM databases

iPTMnetiQ6ZN66.
PhosphoSiteiQ6ZN66.

Expressioni

Gene expression databases

BgeeiENSG00000183347.
CleanExiHS_GBP6.

Organism-specific databases

HPAiHPA027744.

Interactioni

Protein-protein interaction databases

BioGridi127864. 3 interactions.
STRINGi9606.ENSP00000359485.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN66.
SMRiQ6ZN66. Positions 7-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 277243GB1/RHD3-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 310310GTPase domain (Globular)By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi38 – 414Poly-Val

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00550000074475.
HOGENOMiHOG000266974.
HOVERGENiHBG001979.
InParanoidiQ6ZN66.
OMAiQNDWLHE.
OrthoDBiEOG091G03P3.
PhylomeDBiQ6ZN66.
TreeFamiTF331602.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF02841. GBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZN66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESGPKMLAP VCLVENNNEQ LLVNQQAIQI LEKISQPVVV VAIVGLYRTG
60 70 80 90 100
KSYLMNHLAG QNHGFPLGST VQSETKGIWM WCVPHPSKPN HTLVLLDTEG
110 120 130 140 150
LGDVEKGDPK NDSWIFALAV LLCSTFVYNS MSTINHQALE QLHYVTELTE
160 170 180 190 200
LIKAKSSPRP DGVEDSTEFV SFFPDFLWTV RDFTLELKLN GHPITEDEYL
210 220 230 240 250
ENALKLIQGN NPRVQTSNFP RECIRRFFPK RKCFVFDRPT NDKDLLANIE
260 270 280 290 300
KVSEKQLDPK FQEQTNIFCS YIFTHARTKT LREGITVTGN RLGTLAVTYV
310 320 330 340 350
EAINSGAVPC LENAVITLAQ RENSAAVQRA ADYYSQQMAQ RVKLPTDTLQ
360 370 380 390 400
ELLDMHAACE REAIAIFMEH SFKDENQEFQ KKFMETTMNK KGDFLLQNEE
410 420 430 440 450
SSVQYCQAKL NELSKGLMES ISAGSFSVPG GHKLYMETKE RIEQDYWQVP
460 470 480 490 500
RKGVKAKEVF QRFLESQMVI EESILQSDKA LTDREKAVAV DRAKKEAAEK
510 520 530 540 550
EQELLKQKLQ EQQQQMEAQD KSRKENIAQL KEKLQMEREH LLREQIMMLE
560 570 580 590 600
HTQKVQNDWL HEGFKKKYEE MNAEISQFKR MIDTTKNDDT PWIARTLDNL
610 620 630
ADELTAILSA PAKLIGHGVK GVSSLFKKHK LPF
Length:633
Mass (Da):72,427
Last modified:July 5, 2004 - v1
Checksum:iD3487659300D5678
GO
Isoform 2 (identifier: Q6ZN66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-337: Missing.

Show »
Length:296
Mass (Da):34,494
Checksum:i3A1A17E856C484B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131L → Q in CAD97917 (PubMed:17974005).Curated
Sequence conflicti313 – 3131N → D in CAD97917 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti278 – 2781T → I.
Corresponds to variant rs4582772 [ dbSNP | Ensembl ].
VAR_037750
Natural varianti331 – 3311A → S.2 Publications
Corresponds to variant rs4658359 [ dbSNP | Ensembl ].
VAR_037751
Natural varianti344 – 3441L → F.3 Publications
Corresponds to variant rs4658360 [ dbSNP | Ensembl ].
VAR_037752
Natural varianti355 – 3551M → V.3 Publications
Corresponds to variant rs4658146 [ dbSNP | Ensembl ].
VAR_037753
Natural varianti520 – 5201D → V.3 Publications
Corresponds to variant rs959460 [ dbSNP | Ensembl ].
VAR_037754

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 337337Missing in isoform 2. 1 PublicationVSP_030155Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131329 mRNA. Translation: BAD18489.1.
AK131356 mRNA. Translation: BAD18509.1.
BX537949 mRNA. Translation: CAD97917.1.
AL691464 Genomic DNA. Translation: CAI22141.1.
BC131713 mRNA. Translation: AAI31714.1.
CCDSiCCDS723.1. [Q6ZN66-1]
RefSeqiNP_940862.2. NM_198460.2. [Q6ZN66-1]
XP_011539137.1. XM_011540835.2. [Q6ZN66-1]
UniGeneiHs.254338.

Genome annotation databases

EnsembliENST00000370456; ENSP00000359485; ENSG00000183347. [Q6ZN66-1]
GeneIDi163351.
KEGGihsa:163351.
UCSCiuc001dnf.3. human. [Q6ZN66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131329 mRNA. Translation: BAD18489.1.
AK131356 mRNA. Translation: BAD18509.1.
BX537949 mRNA. Translation: CAD97917.1.
AL691464 Genomic DNA. Translation: CAI22141.1.
BC131713 mRNA. Translation: AAI31714.1.
CCDSiCCDS723.1. [Q6ZN66-1]
RefSeqiNP_940862.2. NM_198460.2. [Q6ZN66-1]
XP_011539137.1. XM_011540835.2. [Q6ZN66-1]
UniGeneiHs.254338.

3D structure databases

ProteinModelPortaliQ6ZN66.
SMRiQ6ZN66. Positions 7-579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127864. 3 interactions.
STRINGi9606.ENSP00000359485.

PTM databases

iPTMnetiQ6ZN66.
PhosphoSiteiQ6ZN66.

Polymorphism and mutation databases

BioMutaiGBP6.
DMDMi74749570.

Proteomic databases

MaxQBiQ6ZN66.
PaxDbiQ6ZN66.
PeptideAtlasiQ6ZN66.
PRIDEiQ6ZN66.

Protocols and materials databases

DNASUi163351.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370456; ENSP00000359485; ENSG00000183347. [Q6ZN66-1]
GeneIDi163351.
KEGGihsa:163351.
UCSCiuc001dnf.3. human. [Q6ZN66-1]

Organism-specific databases

CTDi163351.
GeneCardsiGBP6.
H-InvDBHIX0000767.
HGNCiHGNC:25395. GBP6.
HPAiHPA027744.
MIMi612467. gene.
neXtProtiNX_Q6ZN66.
PharmGKBiPA134964409.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00550000074475.
HOGENOMiHOG000266974.
HOVERGENiHBG001979.
InParanoidiQ6ZN66.
OMAiQNDWLHE.
OrthoDBiEOG091G03P3.
PhylomeDBiQ6ZN66.
TreeFamiTF331602.

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

GenomeRNAii163351.
PROiQ6ZN66.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183347.
CleanExiHS_GBP6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF02841. GBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBP6_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN66
Secondary accession number(s): A2RRM3, Q6ZN86, Q7Z3F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.