Q6ZN64 (Q6ZN64_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
NIMA (Never in mitosis gene a)-related kinase 3, isoform CRA_a EMBL EAX08905.1

Submitted name:
Serine/threonine-protein kinase Nek3 Ensembl ENSP00000404197
Submitted name:
cDNA FLJ16392 fis, clone TRACH2020048, moderately similar to Mus musculus serine/threonine-protein kinase NEK3 (Nek3) mRNA EMBL BAD18511.1

Gene names

Name:	NEK3 Ensembl ENSP00000404197 EMBL EAX08905.1
ORF Names:	hCG_29120 EMBL EAX08905.1

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAD18511.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase EMBL BAD18511.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6ZN64 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B7E3328C7B740FA4	FASTA	510	58,030
	10 20 30 40 50 60 MQFGRAHGDC VSGAQLCGCP SMDDYMVLRM IGEGSFGRAL LVQHESSNQM FAMKEIRLPK 70 80 90 100 110 120 SFSNTQNSRK EAVLLAKMKH PNIVAFKESF EAEGHLYIVM EYCDGGDLMQ KIKQQKGKLF 130 140 150 160 170 180 PEDMILNWFT QMCLGVNHIH KKRVLHRDIK SKNIFLTQNG KVKLGDFGSA RLLSNPMAFA 190 200 210 220 230 240 CTYVGTPYYV PPEIWENLPY NNKSDIWSLG CILYELCTLK HPFQANSWKN LILKVCQGCI 250 260 270 280 290 300 SPLPSHYSYE LQFLVKQMFK RNPSHRPSAT TLLSRGIVAR LVQKCLPPEI IMEYGEEVLE 310 320 330 340 350 360 EIKNSKHNTP RKKQEEEQDR KGSHTDLESI NENLVESALR RVNREEKGNK SVHLRKASSP 370 380 390 400 410 420 NLHRRQWEKN VPNTALTALE NASILTSSLT AEDDRGGSVI KYSKNTTRKQ WLKETPDTLL 430 440 450 460 470 480 NILKNADLSL AFQTYTIYRP GSEGFLKGPL SEETEASDSV DGGHDSVILD PERLEPGLDE 490 500 510 EDTDFEEEDD NPDWVSELKK RAGWQGLCDR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project." Kanehori K., Ishibashi T., Chiba Y., Fujimori K., Hiraoka S., Tanai H., Watanabe S., Ishida S., Ono Y., Hotuta T., Watanabe M., Sugiyama T., Irie R., Otsuki T., Sato H., Ota T., Wakamatsu A., Ishii S. , Yamamoto J., Isono Y., Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Trachea EMBL BAD18511.1.
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL139082 Genomic DNA. No translation available. AK131359 mRNA. Translation: BAD18511.1. CH471075 Genomic DNA. Translation: EAX08905.1.
IPI	IPI00465101.
RefSeq	NP_689933.1. NM_152720.2.
UniGene	Hs.409989.
3D structure databases
SMR	Q6ZN64. Positions 21-374.
ModBase	Search...
Proteomic databases
PRIDE	Q6ZN64.
Protocols and materials databases
DNASU	4752.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000452082; ENSP00000404197; ENSG00000136098.
GeneID	4752.
KEGG	hsa:4752.
UCSC	uc001vgh.3. human.
Organism-specific databases
CTD	4752.
HGNC	HGNC:7746. NEK3.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000261617.
HOVERGEN	HBG003063.
KO	K08857.
OMA	SFEAEGH.
Gene expression databases
ArrayExpress	Q6ZN64.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4752.
NextBio	18314.

Entry information

Entry name

Q6ZN64_HUMAN

Accession

Primary (citable) accession number: Q6ZN64

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.