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Protein

Zinc finger protein 2 homolog

Gene

ZFP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri102 – 12423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri130 – 15223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri158 – 18023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 2 homolog
Short name:
Zfp-2
Alternative name(s):
Zinc finger protein 751
Gene namesi
Name:ZFP2
Synonyms:ZNF751
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26138. ZFP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670528.

Polymorphism and mutation databases

BioMutaiZFP2.
DMDMi74758715.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Zinc finger protein 2 homologPRO_0000291967Add
BLAST

Proteomic databases

MaxQBiQ6ZN57.
PaxDbiQ6ZN57.
PeptideAtlasiQ6ZN57.
PRIDEiQ6ZN57.

PTM databases

iPTMnetiQ6ZN57.
PhosphoSiteiQ6ZN57.

Expressioni

Gene expression databases

BgeeiQ6ZN57.
ExpressionAtlasiQ6ZN57. baseline and differential.
GenevisibleiQ6ZN57. HS.

Organism-specific databases

HPAiHPA023364.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BCDIN3DQ7Z5W33EBI-7236323,EBI-10257921
GOLGA2Q083793EBI-7236323,EBI-618309
KRT40Q6A1623EBI-7236323,EBI-10171697
MTUS2Q5JR593EBI-7236323,EBI-742948
TRIM41Q8WV443EBI-7236323,EBI-725997
ZAKQ9NYL2-23EBI-7236323,EBI-10255081

Protein-protein interaction databases

BioGridi123115. 11 interactions.
IntActiQ6ZN57. 8 interactions.
MINTiMINT-1199669.
STRINGi9606.ENSP00000354453.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN57.
SMRiQ6ZN57. Positions 36-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri102 – 12423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri130 – 15223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri158 – 18023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZN57.
OMAiGGNEFER.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZN57.
TreeFamiTF350858.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 11 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZN57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEREGIWHST LGETWEPNNW LEGQQDSHLS QVGVTHKETF TEMRVCGGNE
60 70 80 90 100
FERCSSQDSI LDTQQSIPMV KRPHNCNSHG EDATQNSELI KTQRMFVGKK
110 120 130 140 150
IYECNQCSKT FSQSSSLLKH QRIHTGEKPY KCNVCGKHFI ERSSLTVHQR
160 170 180 190 200
IHTGEKPYKC NECGKAFSQS MNLTVHQRTH TGEKPYQCKE CGKAFHKNSS
210 220 230 240 250
LIQHERIHTG EKPYKCNECG KAFTQSMNLT VHQRTHTGEK PYECNECGKA
260 270 280 290 300
FSQSMHLIVH QRSHTGEKPY ECSQCGKAFS KSSTLTLHQR NHTGEKPYKC
310 320 330 340 350
NKCGKSFSQS TYLIEHQRLH SGVKPFECNE CGKAFSKNSS LTQHRRIHTG
360 370 380 390 400
EKPYECMVCG KHFTGRSSLT VHQVIHTGEK PYECNECGKA FSQSAYLIEH
410 420 430 440 450
QRIHTGEKPY ECDQCGKAFI KNSSLTVHQR THTGEKPYQC NECGKAFSRS
460
TNLTRHQRTH T
Length:461
Mass (Da):52,740
Last modified:July 5, 2004 - v1
Checksum:i1448D86C81C7FC22
GO

Sequence cautioni

The sequence BAB15104.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131Q → H.
Corresponds to variant rs28678700 [ dbSNP | Ensembl ].
VAR_032904
Natural varianti142 – 1421R → G.
Corresponds to variant rs11956147 [ dbSNP | Ensembl ].
VAR_032905

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025281 mRNA. Translation: BAB15104.1. Different initiation.
AK131367 mRNA. Translation: BAD18518.1.
BC132779 mRNA. Translation: AAI32780.1.
BC132781 mRNA. Translation: AAI32782.1.
BC142989 mRNA. Translation: AAI42990.1.
BC144216 mRNA. Translation: AAI44217.1.
CCDSiCCDS4440.1.
RefSeqiNP_085116.2. NM_030613.3.
UniGeneiHs.654533.

Genome annotation databases

EnsembliENST00000361362; ENSP00000354453; ENSG00000198939.
ENST00000520301; ENSP00000430980; ENSG00000198939.
ENST00000523286; ENSP00000430531; ENSG00000198939.
GeneIDi80108.
KEGGihsa:80108.
UCSCiuc003mjn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025281 mRNA. Translation: BAB15104.1. Different initiation.
AK131367 mRNA. Translation: BAD18518.1.
BC132779 mRNA. Translation: AAI32780.1.
BC132781 mRNA. Translation: AAI32782.1.
BC142989 mRNA. Translation: AAI42990.1.
BC144216 mRNA. Translation: AAI44217.1.
CCDSiCCDS4440.1.
RefSeqiNP_085116.2. NM_030613.3.
UniGeneiHs.654533.

3D structure databases

ProteinModelPortaliQ6ZN57.
SMRiQ6ZN57. Positions 36-461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123115. 11 interactions.
IntActiQ6ZN57. 8 interactions.
MINTiMINT-1199669.
STRINGi9606.ENSP00000354453.

PTM databases

iPTMnetiQ6ZN57.
PhosphoSiteiQ6ZN57.

Polymorphism and mutation databases

BioMutaiZFP2.
DMDMi74758715.

Proteomic databases

MaxQBiQ6ZN57.
PaxDbiQ6ZN57.
PeptideAtlasiQ6ZN57.
PRIDEiQ6ZN57.

Protocols and materials databases

DNASUi80108.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361362; ENSP00000354453; ENSG00000198939.
ENST00000520301; ENSP00000430980; ENSG00000198939.
ENST00000523286; ENSP00000430531; ENSG00000198939.
GeneIDi80108.
KEGGihsa:80108.
UCSCiuc003mjn.2. human.

Organism-specific databases

CTDi80108.
GeneCardsiZFP2.
HGNCiHGNC:26138. ZFP2.
HPAiHPA023364.
neXtProtiNX_Q6ZN57.
PharmGKBiPA142670528.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZN57.
OMAiGGNEFER.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZN57.
TreeFamiTF350858.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii80108.
PROiQ6ZN57.

Gene expression databases

BgeeiQ6ZN57.
ExpressionAtlasiQ6ZN57. baseline and differential.
GenevisibleiQ6ZN57. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 11 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum and Colon.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZFP2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN57
Secondary accession number(s): A5PLN5, B7ZM23, Q9H6Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.