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Protein

Zinc finger protein 2 homolog

Gene

ZFP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 124C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri130 – 152C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri158 – 180C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 2 homolog
Short name:
Zfp-2
Alternative name(s):
Zinc finger protein 751
Gene namesi
Name:ZFP2
Synonyms:ZNF751
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000198939.7.
HGNCiHGNC:26138. ZFP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198939.
PharmGKBiPA142670528.

Polymorphism and mutation databases

BioMutaiZFP2.
DMDMi74758715.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002919671 – 461Zinc finger protein 2 homologAdd BLAST461

Proteomic databases

EPDiQ6ZN57.
MaxQBiQ6ZN57.
PaxDbiQ6ZN57.
PeptideAtlasiQ6ZN57.
PRIDEiQ6ZN57.

PTM databases

iPTMnetiQ6ZN57.
PhosphoSitePlusiQ6ZN57.

Expressioni

Gene expression databases

BgeeiENSG00000198939.
ExpressionAtlasiQ6ZN57. baseline and differential.
GenevisibleiQ6ZN57. HS.

Organism-specific databases

HPAiHPA023364.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123115. 11 interactors.
IntActiQ6ZN57. 10 interactors.
MINTiMINT-1199669.
STRINGi9606.ENSP00000354453.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN57.
SMRiQ6ZN57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 124C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri130 – 152C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri158 – 180C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139326.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZN57.
OMAiKKIYECN.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ZN57.
TreeFamiTF350858.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequencei

Sequence statusi: Complete.

Q6ZN57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEREGIWHST LGETWEPNNW LEGQQDSHLS QVGVTHKETF TEMRVCGGNE
60 70 80 90 100
FERCSSQDSI LDTQQSIPMV KRPHNCNSHG EDATQNSELI KTQRMFVGKK
110 120 130 140 150
IYECNQCSKT FSQSSSLLKH QRIHTGEKPY KCNVCGKHFI ERSSLTVHQR
160 170 180 190 200
IHTGEKPYKC NECGKAFSQS MNLTVHQRTH TGEKPYQCKE CGKAFHKNSS
210 220 230 240 250
LIQHERIHTG EKPYKCNECG KAFTQSMNLT VHQRTHTGEK PYECNECGKA
260 270 280 290 300
FSQSMHLIVH QRSHTGEKPY ECSQCGKAFS KSSTLTLHQR NHTGEKPYKC
310 320 330 340 350
NKCGKSFSQS TYLIEHQRLH SGVKPFECNE CGKAFSKNSS LTQHRRIHTG
360 370 380 390 400
EKPYECMVCG KHFTGRSSLT VHQVIHTGEK PYECNECGKA FSQSAYLIEH
410 420 430 440 450
QRIHTGEKPY ECDQCGKAFI KNSSLTVHQR THTGEKPYQC NECGKAFSRS
460
TNLTRHQRTH T
Length:461
Mass (Da):52,740
Last modified:July 5, 2004 - v1
Checksum:i1448D86C81C7FC22
GO

Sequence cautioni

The sequence BAB15104 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032904113Q → H. Corresponds to variant dbSNP:rs28678700Ensembl.1
Natural variantiVAR_032905142R → G. Corresponds to variant dbSNP:rs11956147Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025281 mRNA. Translation: BAB15104.1. Different initiation.
AK131367 mRNA. Translation: BAD18518.1.
BC132779 mRNA. Translation: AAI32780.1.
BC132781 mRNA. Translation: AAI32782.1.
BC142989 mRNA. Translation: AAI42990.1.
BC144216 mRNA. Translation: AAI44217.1.
CCDSiCCDS4440.1.
RefSeqiNP_085116.2. NM_030613.3.
UniGeneiHs.654533.

Genome annotation databases

EnsembliENST00000361362; ENSP00000354453; ENSG00000198939.
ENST00000520301; ENSP00000430980; ENSG00000198939.
ENST00000523286; ENSP00000430531; ENSG00000198939.
GeneIDi80108.
KEGGihsa:80108.
UCSCiuc003mjn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZFP2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN57
Secondary accession number(s): A5PLN5, B7ZM23, Q9H6Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families