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Protein

Differentially expressed in FDCP 8 homolog

Gene

DEF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri199 – 25052Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 48961Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Differentially expressed in FDCP 8 homolog
Short name:
DEF-8
Gene namesi
Name:DEF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25969. DEF8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383526.

Polymorphism and mutation databases

BioMutaiDEF8.
DMDMi239938619.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Differentially expressed in FDCP 8 homologPRO_0000321913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei501 – 5011PhosphoserineBy similarity
Isoform 2 (identifier: Q6ZN54-2)
Modified residuei1 – 11N-acetylmethionineCombined sources
Isoform 3 (identifier: Q6ZN54-3)
Modified residuei1 – 11N-acetylmethionineCombined sources
Isoform 5 (identifier: Q6ZN54-5)
Modified residuei1 – 11N-acetylmethionineCombined sources
Isoform 6 (identifier: Q6ZN54-6)
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6ZN54.
PaxDbiQ6ZN54.
PRIDEiQ6ZN54.

PTM databases

iPTMnetiQ6ZN54.
PhosphoSiteiQ6ZN54.

Expressioni

Gene expression databases

BgeeiQ6ZN54.
CleanExiHS_DEF8.
ExpressionAtlasiQ6ZN54. baseline and differential.
GenevisibleiQ6ZN54. HS.

Organism-specific databases

HPAiHPA041745.
HPA049434.

Interactioni

Protein-protein interaction databases

BioGridi120199. 30 interactions.
IntActiQ6ZN54. 1 interaction.
STRINGi9606.ENSP00000268676.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN54.
SMRiQ6ZN54. Positions 192-251, 449-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DEF8 family.Curated
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri199 – 25052Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 48961Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1829. Eukaryota.
ENOG410XP8S. LUCA.
GeneTreeiENSGT00550000074570.
HOVERGENiHBG107807.
InParanoidiQ6ZN54.
OMAiAYICEIC.
OrthoDBiEOG75F4D3.
PhylomeDBiQ6ZN54.
TreeFamiTF317067.

Family and domain databases

InterProiIPR002219. PE/DAG-bd.
IPR025258. Zf-RING_9.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF13901. zf-RING_9. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM01175. DUF4206. 1 hit.
[Graphical view]
PROSITEiPS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZN54-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAILSLRAPG PWQAMQVWAD RTLLTPHTGV TSQVLGVAAA VMTPLPGGHA
60 70 80 90 100
AGRTREARWD AMEYDEKLAR FRQAHLNPFN KQSGPRQHEQ GPGEEVPDVT
110 120 130 140 150
PEEALPELPP GEPEFRCPER VMDLGLSEDH FSRPVGLFLA SDVQQLRQAI
160 170 180 190 200
EECKQVILEL PEQSEKQKDA VVRLIHLRLK LQELKDPNED EPNIRVLLEH
210 220 230 240 250
RFYKEKSKSV KQTCDKCNTI IWGLIQTWYT CTGCYYRCHS KCLNLISKPC
260 270 280 290 300
VSSKVSHQAE YELNICPETG LDSQDYRCAE CRAPISLRGV PSEARQCDYT
310 320 330 340 350
GQYYCSHCHW NDLAVIPARV VHNWDFEPRK VSRCSMRYLA LMVSRPVLRL
360 370 380 390 400
REINPLLFSY VEELVEIRKL RQDILLMKPY FITCREAMEA RLLLQLQDRQ
410 420 430 440 450
HFVENDEMYS VQDLLDVHAG RLGCSLTEIH TLFAKHIKLD CERCQAKGFV
460 470 480 490 500
CELCREGDVL FPFDSHTSVC ADCSAVFHRD CYYDNSTTCP KCARLSLRKQ
510
SLFQEPGPDV EA
Length:512
Mass (Da):58,710
Last modified:June 16, 2009 - v2
Checksum:i2909333CBD68F5C7
GO
Isoform 2 (identifier: Q6ZN54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     234-258: CYYRCHSKCLNLISKPCVSSKVSHQ → GPRPRRGVRNERDQSSCLRWAHIQM
     259-512: Missing.

Show »
Length:197
Mass (Da):22,976
Checksum:iE2CAF588BBFD4DD1
GO
Isoform 3 (identifier: Q6ZN54-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     136-145: Missing.

Show »
Length:441
Mass (Da):51,222
Checksum:i21559BD6630D5EB3
GO
Isoform 4 (identifier: Q6ZN54-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.

Show »
Length:391
Mass (Da):45,388
Checksum:iFC519A19A9343287
GO
Isoform 5 (identifier: Q6ZN54-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:451
Mass (Da):52,281
Checksum:i74283C0DFBB04B5E
GO
Isoform 6 (identifier: Q6ZN54-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     395-411: Missing.

Note: No experimental confirmation available. Gene prediction based on cDNA data.Combined sources
Show »
Length:434
Mass (Da):50,161
Checksum:iA1356F61B3642E90
GO

Sequence cautioni

The sequence BAC04802.1 differs from that shown.Unlikely isoform. Aberrant splice sites.Curated
The sequence BAG64541.1 differs from that shown.Unlikely isoform. Aberrant splice sites.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti283 – 2831A → V in BAD18521 (PubMed:14702039).Curated
Sequence conflicti293 – 2931E → A in BAG52977 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901Q → E.
Corresponds to variant rs7194844 [ dbSNP | Ensembl ].
VAR_061485

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 121121Missing in isoform 4. 1 PublicationVSP_037523Add
BLAST
Alternative sequencei1 – 6161Missing in isoform 2, isoform 3, isoform 5 and isoform 6. 2 PublicationsVSP_031821Add
BLAST
Alternative sequencei136 – 14510Missing in isoform 3. 1 PublicationVSP_031822
Alternative sequencei234 – 25825CYYRC…KVSHQ → GPRPRRGVRNERDQSSCLRW AHIQM in isoform 2. 2 PublicationsVSP_031823Add
BLAST
Alternative sequencei259 – 512254Missing in isoform 2. 2 PublicationsVSP_031824Add
BLAST
Alternative sequencei395 – 41117Missing in isoform 6. CuratedVSP_047179Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000193 mRNA. Translation: BAA91000.1.
AK095051 mRNA. Translation: BAG52977.1.
AK096485 mRNA. Translation: BAC04802.1. Sequence problems.
AK131370 mRNA. Translation: BAD18521.1.
AK295880 mRNA. Translation: BAH12212.1.
AK296410 mRNA. Translation: BAG59074.1.
AK303510 mRNA. Translation: BAG64541.1. Sequence problems.
AC092143 Genomic DNA. No translation available.
CH471184 Genomic DNA. Translation: EAW66667.1.
BC015482 mRNA. Translation: AAH15482.1.
BC105592 mRNA. Translation: AAI05593.1.
CCDSiCCDS10989.1. [Q6ZN54-1]
CCDS45555.1. [Q6ZN54-2]
CCDS58493.1. [Q6ZN54-5]
CCDS58494.1. [Q6ZN54-6]
CCDS58495.1. [Q6ZN54-3]
CCDS58496.1. [Q6ZN54-4]
RefSeqiNP_001229745.1. NM_001242816.1. [Q6ZN54-3]
NP_001229746.1. NM_001242817.1. [Q6ZN54-4]
NP_001229747.1. NM_001242818.1. [Q6ZN54-5]
NP_001229748.1. NM_001242819.1. [Q6ZN54-6]
NP_001229749.1. NM_001242820.1. [Q6ZN54-5]
NP_001229750.1. NM_001242821.1. [Q6ZN54-2]
NP_001229751.1. NM_001242822.1. [Q6ZN54-2]
NP_060172.1. NM_017702.3. [Q6ZN54-2]
NP_997397.1. NM_207514.2. [Q6ZN54-1]
XP_005256375.2. XM_005256318.2. [Q6ZN54-6]
XP_011521468.1. XM_011523166.1. [Q6ZN54-5]
UniGeneiHs.62771.

Genome annotation databases

EnsembliENST00000268676; ENSP00000268676; ENSG00000140995. [Q6ZN54-1]
ENST00000418391; ENSP00000412784; ENSG00000140995. [Q6ZN54-2]
ENST00000563594; ENSP00000458019; ENSG00000140995. [Q6ZN54-5]
ENST00000563795; ENSP00000457627; ENSG00000140995. [Q6ZN54-6]
ENST00000567874; ENSP00000456095; ENSG00000140995. [Q6ZN54-4]
ENST00000569453; ENSP00000456501; ENSG00000140995. [Q6ZN54-5]
ENST00000570182; ENSP00000456799; ENSG00000140995. [Q6ZN54-3]
ENST00000610455; ENSP00000480073; ENSG00000140995. [Q6ZN54-2]
ENST00000617948; ENSP00000482524; ENSG00000140995. [Q6ZN54-5]
GeneIDi54849.
KEGGihsa:54849.
UCSCiuc002fpl.4. human. [Q6ZN54-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000193 mRNA. Translation: BAA91000.1.
AK095051 mRNA. Translation: BAG52977.1.
AK096485 mRNA. Translation: BAC04802.1. Sequence problems.
AK131370 mRNA. Translation: BAD18521.1.
AK295880 mRNA. Translation: BAH12212.1.
AK296410 mRNA. Translation: BAG59074.1.
AK303510 mRNA. Translation: BAG64541.1. Sequence problems.
AC092143 Genomic DNA. No translation available.
CH471184 Genomic DNA. Translation: EAW66667.1.
BC015482 mRNA. Translation: AAH15482.1.
BC105592 mRNA. Translation: AAI05593.1.
CCDSiCCDS10989.1. [Q6ZN54-1]
CCDS45555.1. [Q6ZN54-2]
CCDS58493.1. [Q6ZN54-5]
CCDS58494.1. [Q6ZN54-6]
CCDS58495.1. [Q6ZN54-3]
CCDS58496.1. [Q6ZN54-4]
RefSeqiNP_001229745.1. NM_001242816.1. [Q6ZN54-3]
NP_001229746.1. NM_001242817.1. [Q6ZN54-4]
NP_001229747.1. NM_001242818.1. [Q6ZN54-5]
NP_001229748.1. NM_001242819.1. [Q6ZN54-6]
NP_001229749.1. NM_001242820.1. [Q6ZN54-5]
NP_001229750.1. NM_001242821.1. [Q6ZN54-2]
NP_001229751.1. NM_001242822.1. [Q6ZN54-2]
NP_060172.1. NM_017702.3. [Q6ZN54-2]
NP_997397.1. NM_207514.2. [Q6ZN54-1]
XP_005256375.2. XM_005256318.2. [Q6ZN54-6]
XP_011521468.1. XM_011523166.1. [Q6ZN54-5]
UniGeneiHs.62771.

3D structure databases

ProteinModelPortaliQ6ZN54.
SMRiQ6ZN54. Positions 192-251, 449-491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120199. 30 interactions.
IntActiQ6ZN54. 1 interaction.
STRINGi9606.ENSP00000268676.

PTM databases

iPTMnetiQ6ZN54.
PhosphoSiteiQ6ZN54.

Polymorphism and mutation databases

BioMutaiDEF8.
DMDMi239938619.

Proteomic databases

MaxQBiQ6ZN54.
PaxDbiQ6ZN54.
PRIDEiQ6ZN54.

Protocols and materials databases

DNASUi54849.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268676; ENSP00000268676; ENSG00000140995. [Q6ZN54-1]
ENST00000418391; ENSP00000412784; ENSG00000140995. [Q6ZN54-2]
ENST00000563594; ENSP00000458019; ENSG00000140995. [Q6ZN54-5]
ENST00000563795; ENSP00000457627; ENSG00000140995. [Q6ZN54-6]
ENST00000567874; ENSP00000456095; ENSG00000140995. [Q6ZN54-4]
ENST00000569453; ENSP00000456501; ENSG00000140995. [Q6ZN54-5]
ENST00000570182; ENSP00000456799; ENSG00000140995. [Q6ZN54-3]
ENST00000610455; ENSP00000480073; ENSG00000140995. [Q6ZN54-2]
ENST00000617948; ENSP00000482524; ENSG00000140995. [Q6ZN54-5]
GeneIDi54849.
KEGGihsa:54849.
UCSCiuc002fpl.4. human. [Q6ZN54-1]

Organism-specific databases

CTDi54849.
GeneCardsiDEF8.
HGNCiHGNC:25969. DEF8.
HPAiHPA041745.
HPA049434.
neXtProtiNX_Q6ZN54.
PharmGKBiPA162383526.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1829. Eukaryota.
ENOG410XP8S. LUCA.
GeneTreeiENSGT00550000074570.
HOVERGENiHBG107807.
InParanoidiQ6ZN54.
OMAiAYICEIC.
OrthoDBiEOG75F4D3.
PhylomeDBiQ6ZN54.
TreeFamiTF317067.

Miscellaneous databases

ChiTaRSiDEF8. human.
GenomeRNAii54849.
PROiQ6ZN54.

Gene expression databases

BgeeiQ6ZN54.
CleanExiHS_DEF8.
ExpressionAtlasiQ6ZN54. baseline and differential.
GenevisibleiQ6ZN54. HS.

Family and domain databases

InterProiIPR002219. PE/DAG-bd.
IPR025258. Zf-RING_9.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF13901. zf-RING_9. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM01175. DUF4206. 1 hit.
[Graphical view]
PROSITEiPS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
    Tissue: Brain, Cerebellum, Colon mucosa, Hippocampus, Thalamus and Thymus.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Pancreas and Skin.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORMS 2; 3; 5 AND 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDEFI8_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN54
Secondary accession number(s): B3KT65
, B4DK62, B4E0S9, B7Z3H6, H3BUG7, Q8N8N3, Q9NXL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 16, 2009
Last modified: June 8, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.