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Protein

Netrin receptor UNC5A

Gene

UNC5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-HSA-373752. Netrin-1 signaling.
R-HSA-418886. Netrin mediated repulsion signals.
R-HSA-418889. Ligand-independent caspase activation via DCC.
SIGNORiQ6ZN44.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin receptor UNC5A
Alternative name(s):
Protein unc-5 homolog 1
Protein unc-5 homolog A
Gene namesi
Name:UNC5A
Synonyms:KIAA1976, UNC5H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:12567. UNC5A.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Membrane raft By similarity
  • Cell projection By similarity

  • Note: The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones. Detected in neurites.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 306281ExtracellularSequence analysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence analysisAdd
BLAST
Topological domaini328 – 842515CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37204.

Polymorphism and mutation databases

BioMutaiUNC5A.
DMDMi296453000.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 842817Netrin receptor UNC5APRO_0000036068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi65 ↔ 126Combined sources
Disulfide bondi77 ↔ 124Combined sources
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence analysis
Disulfide bondi170 ↔ 221Combined sources
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence analysisCombined sources
Disulfide bondi254 ↔ 288Combined sources
Disulfide bondi258 ↔ 293Combined sources
Disulfide bondi266 ↔ 278Combined sources
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylated on cytoplasmic tyrosine residues (By similarity). Phosphorylated by PKC in vitro (By similarity).By similarity
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei340 – 3412Cleavage; by caspase-3By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ6ZN44.
PaxDbiQ6ZN44.
PeptideAtlasiQ6ZN44.
PRIDEiQ6ZN44.

PTM databases

iPTMnetiQ6ZN44.
PhosphoSiteiQ6ZN44.

Expressioni

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiQ6ZN44.
CleanExiHS_UNC5A.
ExpressionAtlasiQ6ZN44. baseline and differential.
GenevisibleiQ6ZN44. HS.

Interactioni

Subunit structurei

Homodimer and homooligomer. Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC (By similarity). Interacts (via extracellular domain) with FLRT2 (via extracellular domain) (PubMed:25374360). Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi124683. 3 interactions.
STRINGi9606.ENSP00000332737.

Structurei

Secondary structure

1
842
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi45 – 484Combined sources
Beta strandi61 – 699Combined sources
Beta strandi71 – 777Combined sources
Turni84 – 863Combined sources
Beta strandi88 – 936Combined sources
Beta strandi95 – 984Combined sources
Beta strandi100 – 1089Combined sources
Helixi110 – 1156Combined sources
Beta strandi118 – 1203Combined sources
Beta strandi123 – 1297Combined sources
Beta strandi134 – 1363Combined sources
Beta strandi158 – 1636Combined sources
Beta strandi166 – 1683Combined sources
Beta strandi180 – 1856Combined sources
Turni192 – 1943Combined sources
Beta strandi196 – 2005Combined sources
Beta strandi206 – 2083Combined sources
Beta strandi211 – 2144Combined sources
Beta strandi216 – 2249Combined sources
Beta strandi229 – 2313Combined sources
Beta strandi235 – 2417Combined sources
Helixi256 – 2583Combined sources
Beta strandi259 – 2635Combined sources
Beta strandi282 – 2876Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V2AX-ray2.40A1-303[»]
ProteinModelPortaliQ6ZN44.
SMRiQ6ZN44. Positions 43-239, 241-289, 445-831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 14198Ig-likeAdd
BLAST
Domaini155 – 23480Ig-like C2-typeAdd
BLAST
Domaini242 – 29453TSP type-1PROSITE-ProRule annotationAdd
BLAST
Domaini439 – 545107ZU5PROSITE-ProRule annotationAdd
BLAST
Domaini761 – 84181DeathAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni605 – 62319Interaction with DCCBy similarityAdd
BLAST

Domaini

The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.By similarity

Sequence similaritiesi

Belongs to the unc-5 family.Curated
Contains 1 death domain.Curated
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 ZU5 domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1480. Eukaryota.
ENOG410XRS6. LUCA.
GeneTreeiENSGT00840000129679.
HOGENOMiHOG000060306.
HOVERGENiHBG056483.
InParanoidiQ6ZN44.
KOiK07521.
OMAiCTSELCI.
OrthoDBiEOG7BGHJX.
PhylomeDBiQ6ZN44.
TreeFamiTF316767.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000884. TSP1_rpt.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF07679. I-set. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
SM00409. IG. 1 hit.
SM00209. TSP1. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48726. SSF48726. 2 hits.
SSF82895. SSF82895. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZN44-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVRPGLWPA LLGIVLAAWL RGSGAQQSAT VANPVPGANP DLLPHFLVEP
60 70 80 90 100
EDVYIVKNKP VLLVCKAVPA TQIFFKCNGE WVRQVDHVIE RSTDGSSGLP
110 120 130 140 150
TMEVRINVSR QQVEKVFGLE EYWCQCVAWS SSGTTKSQKA YIRIAYLRKN
160 170 180 190 200
FEQEPLAKEV SLEQGIVLPC RPPEGIPPAE VEWLRNEDLV DPSLDPNVYI
210 220 230 240 250
TREHSLVVRQ ARLADTANYT CVAKNIVARR RSASAAVIVY VDGSWSPWSK
260 270 280 290 300
WSACGLDCTH WRSRECSDPA PRNGGEECQG TDLDTRNCTS DLCVHTASGP
310 320 330 340 350
EDVALYVGLI AVAVCLVLLL LVLILVYCRK KEGLDSDVAD SSILTSGFQP
360 370 380 390 400
VSIKPSKADN PHLLTIQPDL STTTTTYQGS LCPRQDGPSP KFQLTNGHLL
410 420 430 440 450
SPLGGGRHTL HHSSPTSEAE EFVSRLSTQN YFRSLPRGTS NMTYGTFNFL
460 470 480 490 500
GGRLMIPNTG ISLLIPPDAI PRGKIYEIYL TLHKPEDVRL PLAGCQTLLS
510 520 530 540 550
PIVSCGPPGV LLTRPVILAM DHCGEPSPDS WSLRLKKQSC EGSWEDVLHL
560 570 580 590 600
GEEAPSHLYY CQLEASACYV FTEQLGRFAL VGEALSVAAA KRLKLLLFAP
610 620 630 640 650
VACTSLEYNI RVYCLHDTHD ALKEVVQLEK QLGGQLIQEP RVLHFKDSYH
660 670 680 690 700
NLRLSIHDVP SSLWKSKLLV SYQEIPFYHI WNGTQRYLHC TFTLERVSPS
710 720 730 740 750
TSDLACKLWV WQVEGDGQSF SINFNITKDT RFAELLALES EAGVPALVGP
760 770 780 790 800
SAFKIPFLIR QKIISSLDPP CRRGADWRTL AQKLHLDSHL SFFASKPSPT
810 820 830 840
AMILNLWEAR HFPNGNLSQL AAAVAGLGQP DAGLFTVSEA EC
Note: No experimental confirmation available.
Length:842
Mass (Da):92,932
Last modified:May 18, 2010 - v3
Checksum:i7B209042977FE524
GO
Isoform 2 (identifier: Q6ZN44-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-301: TASGPE → SESSLP
     302-842: Missing.

Note: No experimental confirmation available.
Show »
Length:301
Mass (Da):33,342
Checksum:i255472A1B083799A
GO
Isoform 3 (identifier: Q6ZN44-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MAVRPGLWPA...VIERSTDGSS → MAGTSERSLI...PKPETFCGQT

Note: No experimental confirmation available.
Show »
Length:802
Mass (Da):88,640
Checksum:i122B6B66DBE9AE29
GO

Sequence cautioni

The sequence BAB85562.1 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971S → N in BAD18531 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797MAVRP…TDGSS → MAGTSERSLISSISQPKAIE CFEVKKKAFLTHGRYHGSGA TPPKTKDPKPETFCGQT in isoform 3. 1 PublicationVSP_011693Add
BLAST
Alternative sequencei296 – 3016TASGPE → SESSLP in isoform 2. 1 PublicationVSP_011694
Alternative sequencei302 – 842541Missing in isoform 2. 1 PublicationVSP_011695Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131380 mRNA. Translation: BAD18531.1.
AC027318 Genomic DNA. No translation available.
AC091897 Genomic DNA. No translation available.
AC091902 Genomic DNA. No translation available.
BC009333 mRNA. Translation: AAH09333.2.
BC033727 mRNA. No translation available.
BC157824 mRNA. Translation: AAI57825.1.
AB075856 mRNA. Translation: BAB85562.1. Sequence problems.
CCDSiCCDS34299.1. [Q6ZN44-1]
RefSeqiNP_588610.2. NM_133369.2. [Q6ZN44-1]
UniGeneiHs.33191.

Genome annotation databases

EnsembliENST00000329542; ENSP00000332737; ENSG00000113763. [Q6ZN44-1]
GeneIDi90249.
KEGGihsa:90249.
UCSCiuc003mey.4. human. [Q6ZN44-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131380 mRNA. Translation: BAD18531.1.
AC027318 Genomic DNA. No translation available.
AC091897 Genomic DNA. No translation available.
AC091902 Genomic DNA. No translation available.
BC009333 mRNA. Translation: AAH09333.2.
BC033727 mRNA. No translation available.
BC157824 mRNA. Translation: AAI57825.1.
AB075856 mRNA. Translation: BAB85562.1. Sequence problems.
CCDSiCCDS34299.1. [Q6ZN44-1]
RefSeqiNP_588610.2. NM_133369.2. [Q6ZN44-1]
UniGeneiHs.33191.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V2AX-ray2.40A1-303[»]
ProteinModelPortaliQ6ZN44.
SMRiQ6ZN44. Positions 43-239, 241-289, 445-831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124683. 3 interactions.
STRINGi9606.ENSP00000332737.

PTM databases

iPTMnetiQ6ZN44.
PhosphoSiteiQ6ZN44.

Polymorphism and mutation databases

BioMutaiUNC5A.
DMDMi296453000.

Proteomic databases

EPDiQ6ZN44.
PaxDbiQ6ZN44.
PeptideAtlasiQ6ZN44.
PRIDEiQ6ZN44.

Protocols and materials databases

DNASUi90249.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329542; ENSP00000332737; ENSG00000113763. [Q6ZN44-1]
GeneIDi90249.
KEGGihsa:90249.
UCSCiuc003mey.4. human. [Q6ZN44-1]

Organism-specific databases

CTDi90249.
GeneCardsiUNC5A.
H-InvDBHIX0005448.
HGNCiHGNC:12567. UNC5A.
MIMi607869. gene.
neXtProtiNX_Q6ZN44.
PharmGKBiPA37204.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1480. Eukaryota.
ENOG410XRS6. LUCA.
GeneTreeiENSGT00840000129679.
HOGENOMiHOG000060306.
HOVERGENiHBG056483.
InParanoidiQ6ZN44.
KOiK07521.
OMAiCTSELCI.
OrthoDBiEOG7BGHJX.
PhylomeDBiQ6ZN44.
TreeFamiTF316767.

Enzyme and pathway databases

ReactomeiR-HSA-373752. Netrin-1 signaling.
R-HSA-418886. Netrin mediated repulsion signals.
R-HSA-418889. Ligand-independent caspase activation via DCC.
SIGNORiQ6ZN44.

Miscellaneous databases

ChiTaRSiUNC5A. human.
GeneWikiiUNC5A.
GenomeRNAii90249.
PROiQ6ZN44.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZN44.
CleanExiHS_UNC5A.
ExpressionAtlasiQ6ZN44. baseline and differential.
GenevisibleiQ6ZN44. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000884. TSP1_rpt.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF07679. I-set. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
SM00409. IG. 1 hit.
SM00209. TSP1. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48726. SSF48726. 2 hits.
SSF82895. SSF82895. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-404 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 302-842 (ISOFORMS 1/2/3).
    Tissue: Brain.
  4. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 624-728.
    Tissue: Brain.
  5. Cited for: INDUCTION.
  6. "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment."
    Thiebault K., Mazelin L., Pays L., Llambi F., Joly M.-O., Scoazec J.-Y., Saurin J.-C., Romeo G., Mehlen P.
    Proc. Natl. Acad. Sci. U.S.A. 100:4173-4178(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOWN-REGULATION IN CANCER.
  7. "FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development."
    Seiradake E., del Toro D., Nagel D., Cop F., Haertl R., Ruff T., Seyit-Bremer G., Harlos K., Border E.C., Acker-Palmer A., Jones E.Y., Klein R.
    Neuron 84:370-385(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 1-303, DISULFIDE BONDS, GLYCOSYLATION AT ASN-218, INTERACTION WITH FLRT2.

Entry informationi

Entry nameiUNC5A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN44
Secondary accession number(s): B2RXE6, Q8TF26, Q96GP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.