Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ETS translocation variant 3-like protein

Gene

ETV3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi39 – 12082ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 3-like protein
Gene namesi
Name:ETV3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:33834. ETV3L.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385461.

Polymorphism and mutation databases

BioMutaiETV3L.
DMDMi74749565.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361ETS translocation variant 3-like proteinPRO_0000325822Add
BLAST

Proteomic databases

PaxDbiQ6ZN32.
PRIDEiQ6ZN32.

PTM databases

PhosphoSiteiQ6ZN32.

Expressioni

Gene expression databases

BgeeiQ6ZN32.
CleanExiHS_ETV3L.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000430271.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN32.
SMRiQ6ZN32. Positions 34-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi234 – 28754Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000112407.
InParanoidiQ6ZN32.
OMAiGAWHFPG.
OrthoDBiEOG70ZZN1.
PhylomeDBiQ6ZN32.
TreeFamiTF351065.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR032929. ETV3.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11849:SF30. PTHR11849:SF30. 1 hit.
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZN32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCSCLAEGI PANPGNWISG LAFPDWAYKA ESSPGSRQIQ LWHFILELLQ
60 70 80 90 100
KEEFRHVIAW QQGEYGEFVI KDPDEVARLW GRRKCKPQMN YDKLSRALRY
110 120 130 140 150
YYNKRILHKT KGKRFTYKFN FSKLIVVNYP LWEVRAPPSP HLLLGAPALC
160 170 180 190 200
RPALVPVGVQ SELLHSMLFA HQAMVEQLTG QQTPRGPPET SGDKKGSSSS
210 220 230 240 250
VYRLGSAPGP CRLGLCCHLG SVQGELPGVA SFTPPLPPPL PSNWTCLSGP
260 270 280 290 300
FLPPLPSEQQ LPGAFKPDIL LPGPRSLPGA WHFPGLPLLA GLGQGAGERL
310 320 330 340 350
WLLSLRPEGL EVKPAPMMEA KGGLDPREVF CPETRRLKTG EESLTSPNLE
360
NLKAVWPLDP P
Length:361
Mass (Da):39,948
Last modified:July 5, 2004 - v1
Checksum:i5E45866DC31585C9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191S → A.
Corresponds to variant rs16838078 [ dbSNP | Ensembl ].
VAR_039928
Natural varianti151 – 1511R → W.
Corresponds to variant rs12083811 [ dbSNP | Ensembl ].
VAR_048949
Natural varianti263 – 2631G → A.
Corresponds to variant rs12136960 [ dbSNP | Ensembl ].
VAR_039929
Natural varianti318 – 3181M → V.
Corresponds to variant rs12126791 [ dbSNP | Ensembl ].
VAR_039930

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131392 mRNA. Translation: BAD18543.1.
CCDSiCCDS30893.1.
RefSeqiNP_001004341.1. NM_001004341.2.
UniGeneiHs.127138.

Genome annotation databases

EnsembliENST00000454449; ENSP00000430271; ENSG00000253831.
GeneIDi440695.
KEGGihsa:440695.
UCSCiuc001fqq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131392 mRNA. Translation: BAD18543.1.
CCDSiCCDS30893.1.
RefSeqiNP_001004341.1. NM_001004341.2.
UniGeneiHs.127138.

3D structure databases

ProteinModelPortaliQ6ZN32.
SMRiQ6ZN32. Positions 34-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000430271.

PTM databases

PhosphoSiteiQ6ZN32.

Polymorphism and mutation databases

BioMutaiETV3L.
DMDMi74749565.

Proteomic databases

PaxDbiQ6ZN32.
PRIDEiQ6ZN32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000454449; ENSP00000430271; ENSG00000253831.
GeneIDi440695.
KEGGihsa:440695.
UCSCiuc001fqq.3. human.

Organism-specific databases

CTDi440695.
GeneCardsiETV3L.
HGNCiHGNC:33834. ETV3L.
neXtProtiNX_Q6ZN32.
PharmGKBiPA162385461.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000112407.
InParanoidiQ6ZN32.
OMAiGAWHFPG.
OrthoDBiEOG70ZZN1.
PhylomeDBiQ6ZN32.
TreeFamiTF351065.

Miscellaneous databases

GenomeRNAii440695.
NextBioi109452.
PROiQ6ZN32.

Gene expression databases

BgeeiQ6ZN32.
CleanExiHS_ETV3L.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR032929. ETV3.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11849:SF30. PTHR11849:SF30. 1 hit.
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Subthalamic nucleus.

Entry informationi

Entry nameiETV3L_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.