Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ETS translocation variant 3-like protein

Gene

ETV3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi39 – 120ETSPROSITE-ProRule annotationAdd BLAST82

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 3-like protein
Gene namesi
Name:ETV3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000253831.1
HGNCiHGNC:33834 ETV3L
neXtProtiNX_Q6ZN32

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000253831
PharmGKBiPA162385461

Polymorphism and mutation databases

BioMutaiETV3L
DMDMi74749565

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258221 – 361ETS translocation variant 3-like proteinAdd BLAST361

Proteomic databases

PaxDbiQ6ZN32
PeptideAtlasiQ6ZN32
PRIDEiQ6ZN32

PTM databases

iPTMnetiQ6ZN32
PhosphoSitePlusiQ6ZN32

Expressioni

Gene expression databases

BgeeiENSG00000253831
CleanExiHS_ETV3L

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000430271

Structurei

3D structure databases

ProteinModelPortaliQ6ZN32
SMRiQ6ZN32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi234 – 287Pro-richAdd BLAST54

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000112407
InParanoidiQ6ZN32
OMAiGAWHFPG
OrthoDBiEOG091G05C7
PhylomeDBiQ6ZN32
TreeFamiTF351065

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR032929 ETV3
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11849:SF261 PTHR11849:SF261, 1 hit
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZN32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCSCLAEGI PANPGNWISG LAFPDWAYKA ESSPGSRQIQ LWHFILELLQ
60 70 80 90 100
KEEFRHVIAW QQGEYGEFVI KDPDEVARLW GRRKCKPQMN YDKLSRALRY
110 120 130 140 150
YYNKRILHKT KGKRFTYKFN FSKLIVVNYP LWEVRAPPSP HLLLGAPALC
160 170 180 190 200
RPALVPVGVQ SELLHSMLFA HQAMVEQLTG QQTPRGPPET SGDKKGSSSS
210 220 230 240 250
VYRLGSAPGP CRLGLCCHLG SVQGELPGVA SFTPPLPPPL PSNWTCLSGP
260 270 280 290 300
FLPPLPSEQQ LPGAFKPDIL LPGPRSLPGA WHFPGLPLLA GLGQGAGERL
310 320 330 340 350
WLLSLRPEGL EVKPAPMMEA KGGLDPREVF CPETRRLKTG EESLTSPNLE
360
NLKAVWPLDP P
Length:361
Mass (Da):39,948
Last modified:July 5, 2004 - v1
Checksum:i5E45866DC31585C9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03992819S → A. Corresponds to variant dbSNP:rs16838078Ensembl.1
Natural variantiVAR_048949151R → W. Corresponds to variant dbSNP:rs12083811Ensembl.1
Natural variantiVAR_039929263G → A. Corresponds to variant dbSNP:rs12136960Ensembl.1
Natural variantiVAR_039930318M → V. Corresponds to variant dbSNP:rs12126791Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131392 mRNA Translation: BAD18543.1
CCDSiCCDS30893.1
RefSeqiNP_001004341.1, NM_001004341.2
UniGeneiHs.127138

Genome annotation databases

EnsembliENST00000454449; ENSP00000430271; ENSG00000253831
GeneIDi440695
KEGGihsa:440695
UCSCiuc001fqq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiETV3L_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health