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Protein

Zinc finger protein basonuclin-2

Gene

BNC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri441 – 464C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri833 – 856C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1035 – 1058C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1063 – 1090C2H2-type 4PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein basonuclin-2
Gene namesi
Name:BNC2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:30988. BNC2.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54796.
OpenTargetsiENSG00000173068.
PharmGKBiPA134953132.

Polymorphism and mutation databases

BioMutaiBNC2.
DMDMi74762393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000469341 – 1099Zinc finger protein basonuclin-2Add BLAST1099

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei561PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZN30.
MaxQBiQ6ZN30.
PaxDbiQ6ZN30.
PeptideAtlasiQ6ZN30.
PRIDEiQ6ZN30.

PTM databases

iPTMnetiQ6ZN30.
PhosphoSitePlusiQ6ZN30.

Expressioni

Tissue specificityi

Highly expressed in testis, uterus and small intestine, and weakly expressed in colon and prostate. Also expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa and HEK293 cells. Not detected in blood, thymus, spleen or Hep-G2 cells.2 Publications

Gene expression databases

BgeeiENSG00000173068.
CleanExiHS_BNC2.
ExpressionAtlasiQ6ZN30. baseline and differential.
GenevisibleiQ6ZN30. HS.

Organism-specific databases

HPAiHPA018525.

Interactioni

Protein-protein interaction databases

BioGridi120155. 3 interactors.
IntActiQ6ZN30. 2 interactors.
STRINGi9606.ENSP00000370047.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi534 – 614Pro-richSequence analysisAdd BLAST81

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri441 – 464C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri833 – 856C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1035 – 1058C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1063 – 1090C2H2-type 4PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE3V. Eukaryota.
ENOG410YN2D. LUCA.
GeneTreeiENSGT00390000005844.
HOGENOMiHOG000049098.
HOVERGENiHBG050706.
InParanoidiQ6ZN30.
OMAiVPGCNMM.
OrthoDBiEOG091G01CA.
PhylomeDBiQ6ZN30.
TreeFamiTF350399.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6ZN30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHLGPTPPP HSLNYKSEDR LSEQDWPAYF KVPCCGVDTS QIESEEAEVD
60 70 80 90 100
VRERETQRDR EPKRARDLTL RDSCTDNSMQ FGTRTTTAEP GFMGTWQNAD
110 120 130 140 150
TNLLFRMSQQ AIRCTLVNCT CECFQPGKIN LRTCDQCKHG WVAHALDKLS
160 170 180 190 200
TQHLYHPTQV EIVQSNVVFD ISSLMLYGTQ AVPVRLKILL DRLFSVLKQE
210 220 230 240 250
EVLHILHGLG WTLRDYVRGY ILQDAAGKVL DRWAIMSREE EIITLQQFLR
260 270 280 290 300
FGETKSIVEL MAIQEKEGQA VAVPSSKTDS DIRTFIESNN RTRSPSLLAH
310 320 330 340 350
LENSNPSSIH HFENIPNSLA FLLPFQYINP VSAPLLGLPP NGLLLEQPGL
360 370 380 390 400
RLREPSLSTQ NEYNESSESE VSPTPYKNDQ TPNRNALTSI TNVEPKTEPA
410 420 430 440 450
CVSPIQNSAP VSDLTKTEHP KSSFRIHRMR RMGSASRKGR VFCNACGKTF
460 470 480 490 500
YDKGTLKIHY NAVHLKIKHR CTIEGCNMVF SSLRSRNRHS ANPNPRLHMP
510 520 530 540 550
MLRNNRDKDL IRATSGAATP VIASTKSNLA LTSPGRPPMG FTTPPLDPVL
560 570 580 590 600
QNPLPSQLVF SGLKTVQPVP PFYRSLLTPG EMVSPPTSLP TSPIIPTSGT
610 620 630 640 650
IEQHPPPPSE PVVPAVMMAT HEPSADLAPK KKPRKSSMPV KIEKEIIDTA
660 670 680 690 700
DEFDDEDDDP NDGGAVVNDM SHDNHCHSQE EMSPGMSVKD FSKHNRTRCI
710 720 730 740 750
SRTEIRRADS MTSEDQEPER DYENESESSE PKLGEESMEG DEHIHSEVSE
760 770 780 790 800
KVLMNSERPD ENHSEPSHQD VIKVKEEFTD PTYDMFYMSQ YGLYNGGGAS
810 820 830 840 850
MAALHESFTS SLNYGSPQKF SPEGDLCSSP DPKICYVCKK SFKSSYSVKL
860 870 880 890 900
HYRNVHLKEM HVCTVAGCNA AFPSRRSRDR HSANINLHRK LLTKELDDMG
910 920 930 940 950
LDSSQPSLSK DLRDEFLVKI YGAQHPMGLD VREDASSPAG TEDSHLNGYG
960 970 980 990 1000
RGMAEDYMVL DLSTTSSLQS SSSIHSSRES DAGSDEGILL DDIDGASDSG
1010 1020 1030 1040 1050
ESAHKAEAPA LPGSLGAEVS GSLMFSSLSG SNGGIMCNIC HKMYSNKGTL
1060 1070 1080 1090
RVHYKTVHLR EMHKCKVPGC NMMFSSVRSR NRHSQNPNLH KNIPFTSVD
Length:1,099
Mass (Da):122,330
Last modified:July 5, 2004 - v1
Checksum:iB1601EACD158D3D3
GO
Isoform 2Curated (identifier: Q6ZN30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     881-903: HSANINLHRKLLTKELDDMGLDS → YWEKSNEQNGLLVSWGETLSSLK
     904-1099: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:903
Mass (Da):101,333
Checksum:iCDE800F776B4644F
GO

Sequence cautioni

The sequence AAR99389 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA90908 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15269 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03837 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti560F → L in BAC03837 (PubMed:14702039).Curated1
Sequence conflicti630K → T in BAC03837 (PubMed:14702039).Curated1
Sequence conflicti797G → E in BAB15269 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052707550L → V.Corresponds to variant rs4961490dbSNPEnsembl.1
Natural variantiVAR_033543782T → A.Corresponds to variant rs3739714dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051873881 – 903HSANI…MGLDS → YWEKSNEQNGLLVSWGETLS SLK in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_051874904 – 1099Missing in isoform 2. 1 PublicationAdd BLAST196

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000050 mRNA. Translation: BAA90908.1. Different initiation.
AK025882 mRNA. Translation: BAB15269.1. Different initiation.
AK092247 mRNA. Translation: BAC03837.1. Different initiation.
AK131398 mRNA. Translation: BAD18545.1.
AL450105, AL449983, AL450003 Genomic DNA. Translation: CAM21221.1.
AY438376 mRNA. Translation: AAR99389.1. Different initiation.
CCDSiCCDS6482.2. [Q6ZN30-1]
RefSeqiNP_060107.3. NM_017637.5. [Q6ZN30-1]
UniGeneiHs.656581.
Hs.693436.
Hs.740070.

Genome annotation databases

EnsembliENST00000380672; ENSP00000370047; ENSG00000173068. [Q6ZN30-1]
ENST00000484726; ENSP00000431516; ENSG00000173068. [Q6ZN30-2]
GeneIDi54796.
KEGGihsa:54796.
UCSCiuc003zml.4. human. [Q6ZN30-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000050 mRNA. Translation: BAA90908.1. Different initiation.
AK025882 mRNA. Translation: BAB15269.1. Different initiation.
AK092247 mRNA. Translation: BAC03837.1. Different initiation.
AK131398 mRNA. Translation: BAD18545.1.
AL450105, AL449983, AL450003 Genomic DNA. Translation: CAM21221.1.
AY438376 mRNA. Translation: AAR99389.1. Different initiation.
CCDSiCCDS6482.2. [Q6ZN30-1]
RefSeqiNP_060107.3. NM_017637.5. [Q6ZN30-1]
UniGeneiHs.656581.
Hs.693436.
Hs.740070.

3D structure databases

ProteinModelPortaliQ6ZN30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120155. 3 interactors.
IntActiQ6ZN30. 2 interactors.
STRINGi9606.ENSP00000370047.

PTM databases

iPTMnetiQ6ZN30.
PhosphoSitePlusiQ6ZN30.

Polymorphism and mutation databases

BioMutaiBNC2.
DMDMi74762393.

Proteomic databases

EPDiQ6ZN30.
MaxQBiQ6ZN30.
PaxDbiQ6ZN30.
PeptideAtlasiQ6ZN30.
PRIDEiQ6ZN30.

Protocols and materials databases

DNASUi54796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380672; ENSP00000370047; ENSG00000173068. [Q6ZN30-1]
ENST00000484726; ENSP00000431516; ENSG00000173068. [Q6ZN30-2]
GeneIDi54796.
KEGGihsa:54796.
UCSCiuc003zml.4. human. [Q6ZN30-1]

Organism-specific databases

CTDi54796.
DisGeNETi54796.
GeneCardsiBNC2.
HGNCiHGNC:30988. BNC2.
HPAiHPA018525.
MIMi608669. gene.
neXtProtiNX_Q6ZN30.
OpenTargetsiENSG00000173068.
PharmGKBiPA134953132.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE3V. Eukaryota.
ENOG410YN2D. LUCA.
GeneTreeiENSGT00390000005844.
HOGENOMiHOG000049098.
HOVERGENiHBG050706.
InParanoidiQ6ZN30.
OMAiVPGCNMM.
OrthoDBiEOG091G01CA.
PhylomeDBiQ6ZN30.
TreeFamiTF350399.

Miscellaneous databases

ChiTaRSiBNC2. human.
GeneWikiiBNC2.
GenomeRNAii54796.
PROiQ6ZN30.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173068.
CleanExiHS_BNC2.
ExpressionAtlasiQ6ZN30. baseline and differential.
GenevisibleiQ6ZN30. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBNC2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN30
Secondary accession number(s): B1APG9
, Q6T3A3, Q8NAR2, Q9H6J0, Q9NXV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.