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Q6ZN30

- BNC2_HUMAN

UniProt

Q6ZN30 - BNC2_HUMAN

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Protein

Zinc finger protein basonuclin-2

Gene
BNC2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri441 – 46424C2H2-type 1Add
BLAST
Zinc fingeri833 – 85624C2H2-type 2Add
BLAST
Zinc fingeri1035 – 105824C2H2-type 3Add
BLAST
Zinc fingeri1063 – 109028C2H2-type 4Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. endochondral bone growth Source: Ensembl
  2. mesenchyme development Source: Ensembl
  3. palate development Source: Ensembl
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. tongue development Source: Ensembl
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein basonuclin-2
Gene namesi
Name:BNC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:30988. BNC2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
  3. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10991099Zinc finger protein basonuclin-2PRO_0000046934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei561 – 5611Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZN30.
PRIDEiQ6ZN30.

PTM databases

PhosphoSiteiQ6ZN30.

Expressioni

Tissue specificityi

Highly expressed in testis, uterus and small intestine, and weakly expressed in colon and prostate. Also expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa and HEK293 cells. Not detected in blood, thymus, spleen or Hep-G2 cells.2 Publications

Gene expression databases

ArrayExpressiQ6ZN30.
BgeeiQ6ZN30.
CleanExiHS_BNC2.
GenevestigatoriQ6ZN30.

Organism-specific databases

HPAiHPA018525.

Interactioni

Protein-protein interaction databases

BioGridi120155. 2 interactions.
IntActiQ6ZN30. 1 interaction.
STRINGi9606.ENSP00000370047.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN30.
SMRiQ6ZN30. Positions 437-490, 822-895, 1029-1066.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi534 – 61481Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG82846.
HOGENOMiHOG000049098.
HOVERGENiHBG050706.
InParanoidiQ6ZN30.
OMAiKVPGCNM.
OrthoDBiEOG7SV0TM.
PhylomeDBiQ6ZN30.
TreeFamiTF350399.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q6ZN30-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAHLGPTPPP HSLNYKSEDR LSEQDWPAYF KVPCCGVDTS QIESEEAEVD     50
VRERETQRDR EPKRARDLTL RDSCTDNSMQ FGTRTTTAEP GFMGTWQNAD 100
TNLLFRMSQQ AIRCTLVNCT CECFQPGKIN LRTCDQCKHG WVAHALDKLS 150
TQHLYHPTQV EIVQSNVVFD ISSLMLYGTQ AVPVRLKILL DRLFSVLKQE 200
EVLHILHGLG WTLRDYVRGY ILQDAAGKVL DRWAIMSREE EIITLQQFLR 250
FGETKSIVEL MAIQEKEGQA VAVPSSKTDS DIRTFIESNN RTRSPSLLAH 300
LENSNPSSIH HFENIPNSLA FLLPFQYINP VSAPLLGLPP NGLLLEQPGL 350
RLREPSLSTQ NEYNESSESE VSPTPYKNDQ TPNRNALTSI TNVEPKTEPA 400
CVSPIQNSAP VSDLTKTEHP KSSFRIHRMR RMGSASRKGR VFCNACGKTF 450
YDKGTLKIHY NAVHLKIKHR CTIEGCNMVF SSLRSRNRHS ANPNPRLHMP 500
MLRNNRDKDL IRATSGAATP VIASTKSNLA LTSPGRPPMG FTTPPLDPVL 550
QNPLPSQLVF SGLKTVQPVP PFYRSLLTPG EMVSPPTSLP TSPIIPTSGT 600
IEQHPPPPSE PVVPAVMMAT HEPSADLAPK KKPRKSSMPV KIEKEIIDTA 650
DEFDDEDDDP NDGGAVVNDM SHDNHCHSQE EMSPGMSVKD FSKHNRTRCI 700
SRTEIRRADS MTSEDQEPER DYENESESSE PKLGEESMEG DEHIHSEVSE 750
KVLMNSERPD ENHSEPSHQD VIKVKEEFTD PTYDMFYMSQ YGLYNGGGAS 800
MAALHESFTS SLNYGSPQKF SPEGDLCSSP DPKICYVCKK SFKSSYSVKL 850
HYRNVHLKEM HVCTVAGCNA AFPSRRSRDR HSANINLHRK LLTKELDDMG 900
LDSSQPSLSK DLRDEFLVKI YGAQHPMGLD VREDASSPAG TEDSHLNGYG 950
RGMAEDYMVL DLSTTSSLQS SSSIHSSRES DAGSDEGILL DDIDGASDSG 1000
ESAHKAEAPA LPGSLGAEVS GSLMFSSLSG SNGGIMCNIC HKMYSNKGTL 1050
RVHYKTVHLR EMHKCKVPGC NMMFSSVRSR NRHSQNPNLH KNIPFTSVD 1099
Length:1,099
Mass (Da):122,330
Last modified:July 5, 2004 - v1
Checksum:iB1601EACD158D3D3
GO
Isoform 2 (identifier: Q6ZN30-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     881-903: HSANINLHRKLLTKELDDMGLDS → YWEKSNEQNGLLVSWGETLSSLK
     904-1099: Missing.

Note: No experimental confirmation available.

Show »
Length:903
Mass (Da):101,333
Checksum:iCDE800F776B4644F
GO

Sequence cautioni

The sequence AAR99389.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA90908.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB15269.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC03837.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti550 – 5501L → V.
Corresponds to variant rs4961490 [ dbSNP | Ensembl ].
VAR_052707
Natural varianti782 – 7821T → A.
Corresponds to variant rs3739714 [ dbSNP | Ensembl ].
VAR_033543

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei881 – 90323HSANI…MGLDS → YWEKSNEQNGLLVSWGETLS SLK in isoform 2. VSP_051873Add
BLAST
Alternative sequencei904 – 1099196Missing in isoform 2. VSP_051874Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti560 – 5601F → L in BAC03837. 1 Publication
Sequence conflicti630 – 6301K → T in BAC03837. 1 Publication
Sequence conflicti797 – 7971G → E in BAB15269. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000050 mRNA. Translation: BAA90908.1. Different initiation.
AK025882 mRNA. Translation: BAB15269.1. Different initiation.
AK092247 mRNA. Translation: BAC03837.1. Different initiation.
AK131398 mRNA. Translation: BAD18545.1.
AL450105, AL449983, AL450003 Genomic DNA. Translation: CAM21221.1.
AY438376 mRNA. Translation: AAR99389.1. Different initiation.
CCDSiCCDS6482.2. [Q6ZN30-1]
RefSeqiNP_060107.3. NM_017637.5. [Q6ZN30-1]
UniGeneiHs.656581.
Hs.693436.
Hs.740070.

Genome annotation databases

EnsembliENST00000380666; ENSP00000370041; ENSG00000173068. [Q6ZN30-2]
ENST00000380672; ENSP00000370047; ENSG00000173068. [Q6ZN30-1]
ENST00000484726; ENSP00000431516; ENSG00000173068. [Q6ZN30-2]
GeneIDi54796.
KEGGihsa:54796.
UCSCiuc003zmi.3. human. [Q6ZN30-1]

Polymorphism databases

DMDMi74762393.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000050 mRNA. Translation: BAA90908.1 . Different initiation.
AK025882 mRNA. Translation: BAB15269.1 . Different initiation.
AK092247 mRNA. Translation: BAC03837.1 . Different initiation.
AK131398 mRNA. Translation: BAD18545.1 .
AL450105 , AL449983 , AL450003 Genomic DNA. Translation: CAM21221.1 .
AY438376 mRNA. Translation: AAR99389.1 . Different initiation.
CCDSi CCDS6482.2. [Q6ZN30-1 ]
RefSeqi NP_060107.3. NM_017637.5. [Q6ZN30-1 ]
UniGenei Hs.656581.
Hs.693436.
Hs.740070.

3D structure databases

ProteinModelPortali Q6ZN30.
SMRi Q6ZN30. Positions 437-490, 822-895, 1029-1066.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120155. 2 interactions.
IntActi Q6ZN30. 1 interaction.
STRINGi 9606.ENSP00000370047.

PTM databases

PhosphoSitei Q6ZN30.

Polymorphism databases

DMDMi 74762393.

Proteomic databases

PaxDbi Q6ZN30.
PRIDEi Q6ZN30.

Protocols and materials databases

DNASUi 54796.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380666 ; ENSP00000370041 ; ENSG00000173068 . [Q6ZN30-2 ]
ENST00000380672 ; ENSP00000370047 ; ENSG00000173068 . [Q6ZN30-1 ]
ENST00000484726 ; ENSP00000431516 ; ENSG00000173068 . [Q6ZN30-2 ]
GeneIDi 54796.
KEGGi hsa:54796.
UCSCi uc003zmi.3. human. [Q6ZN30-1 ]

Organism-specific databases

CTDi 54796.
GeneCardsi GC09M016410.
HGNCi HGNC:30988. BNC2.
HPAi HPA018525.
MIMi 608669. gene.
neXtProti NX_Q6ZN30.
PharmGKBi PA134953132.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82846.
HOGENOMi HOG000049098.
HOVERGENi HBG050706.
InParanoidi Q6ZN30.
OMAi KVPGCNM.
OrthoDBi EOG7SV0TM.
PhylomeDBi Q6ZN30.
TreeFami TF350399.

Miscellaneous databases

ChiTaRSi BNC2. human.
GeneWikii BNC2.
GenomeRNAii 54796.
NextBioi 57475.
PROi Q6ZN30.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6ZN30.
Bgeei Q6ZN30.
CleanExi HS_BNC2.
Genevestigatori Q6ZN30.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Colon, Kidney epithelium, Teratocarcinoma and Tongue.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Identification of Basonuclin2, a DNA-binding zinc-finger protein expressed in germ tissues and skin keratinocytes."
    Romano R.-A., Li H., Tummala R., Maul R., Sinha S.
    Genomics 83:821-833(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-1099 (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Basonuclin 2: an extremely conserved homolog of the zinc finger protein basonuclin."
    Vanhoutteghem A., Djian P.
    Proc. Natl. Acad. Sci. U.S.A. 101:3468-3473(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROBABLE FUNCTION, TISSUE SPECIFICITY.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiBNC2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN30
Secondary accession number(s): B1APG9
, Q6T3A3, Q8NAR2, Q9H6J0, Q9NXV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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