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Q6ZN30 (BNC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein basonuclin-2
Gene names
Name:BNC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1099 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. Ref.4

Subcellular location

Nucleus Ref.3.

Tissue specificity

Highly expressed in testis, uterus and small intestine, and weakly expressed in colon and prostate. Also expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa and HEK293 cells. Not detected in blood, thymus, spleen or Hep-G2 cells. Ref.3 Ref.4

Sequence similarities

Contains 4 C2H2-type zinc fingers.

Sequence caution

The sequence AAR99389.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA90908.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB15269.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC03837.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.3 (identifier: Q6ZN30-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZN30-2)

The sequence of this isoform differs from the canonical sequence as follows:
     881-903: HSANINLHRKLLTKELDDMGLDS → YWEKSNEQNGLLVSWGETLSSLK
     904-1099: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10991099Zinc finger protein basonuclin-2
PRO_0000046934

Regions

Zinc finger441 – 46424C2H2-type 1
Zinc finger833 – 85624C2H2-type 2
Zinc finger1035 – 105824C2H2-type 3
Zinc finger1063 – 109028C2H2-type 4
Compositional bias534 – 61481Pro-rich

Amino acid modifications

Modified residue5611Phosphoserine Ref.5

Natural variations

Alternative sequence881 – 90323HSANI…MGLDS → YWEKSNEQNGLLVSWGETLS SLK in isoform 2.
VSP_051873
Alternative sequence904 – 1099196Missing in isoform 2.
VSP_051874
Natural variant5501L → V.
Corresponds to variant rs4961490 [ dbSNP | Ensembl ].
VAR_052707
Natural variant7821T → A.
Corresponds to variant rs3739714 [ dbSNP | Ensembl ].
VAR_033543

Experimental info

Sequence conflict5601F → L in BAC03837. Ref.1
Sequence conflict6301K → T in BAC03837. Ref.1
Sequence conflict7971G → E in BAB15269. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B1601EACD158D3D3

FASTA1,099122,330
        10         20         30         40         50         60 
MAHLGPTPPP HSLNYKSEDR LSEQDWPAYF KVPCCGVDTS QIESEEAEVD VRERETQRDR 

        70         80         90        100        110        120 
EPKRARDLTL RDSCTDNSMQ FGTRTTTAEP GFMGTWQNAD TNLLFRMSQQ AIRCTLVNCT 

       130        140        150        160        170        180 
CECFQPGKIN LRTCDQCKHG WVAHALDKLS TQHLYHPTQV EIVQSNVVFD ISSLMLYGTQ 

       190        200        210        220        230        240 
AVPVRLKILL DRLFSVLKQE EVLHILHGLG WTLRDYVRGY ILQDAAGKVL DRWAIMSREE 

       250        260        270        280        290        300 
EIITLQQFLR FGETKSIVEL MAIQEKEGQA VAVPSSKTDS DIRTFIESNN RTRSPSLLAH 

       310        320        330        340        350        360 
LENSNPSSIH HFENIPNSLA FLLPFQYINP VSAPLLGLPP NGLLLEQPGL RLREPSLSTQ 

       370        380        390        400        410        420 
NEYNESSESE VSPTPYKNDQ TPNRNALTSI TNVEPKTEPA CVSPIQNSAP VSDLTKTEHP 

       430        440        450        460        470        480 
KSSFRIHRMR RMGSASRKGR VFCNACGKTF YDKGTLKIHY NAVHLKIKHR CTIEGCNMVF 

       490        500        510        520        530        540 
SSLRSRNRHS ANPNPRLHMP MLRNNRDKDL IRATSGAATP VIASTKSNLA LTSPGRPPMG 

       550        560        570        580        590        600 
FTTPPLDPVL QNPLPSQLVF SGLKTVQPVP PFYRSLLTPG EMVSPPTSLP TSPIIPTSGT 

       610        620        630        640        650        660 
IEQHPPPPSE PVVPAVMMAT HEPSADLAPK KKPRKSSMPV KIEKEIIDTA DEFDDEDDDP 

       670        680        690        700        710        720 
NDGGAVVNDM SHDNHCHSQE EMSPGMSVKD FSKHNRTRCI SRTEIRRADS MTSEDQEPER 

       730        740        750        760        770        780 
DYENESESSE PKLGEESMEG DEHIHSEVSE KVLMNSERPD ENHSEPSHQD VIKVKEEFTD 

       790        800        810        820        830        840 
PTYDMFYMSQ YGLYNGGGAS MAALHESFTS SLNYGSPQKF SPEGDLCSSP DPKICYVCKK 

       850        860        870        880        890        900 
SFKSSYSVKL HYRNVHLKEM HVCTVAGCNA AFPSRRSRDR HSANINLHRK LLTKELDDMG 

       910        920        930        940        950        960 
LDSSQPSLSK DLRDEFLVKI YGAQHPMGLD VREDASSPAG TEDSHLNGYG RGMAEDYMVL 

       970        980        990       1000       1010       1020 
DLSTTSSLQS SSSIHSSRES DAGSDEGILL DDIDGASDSG ESAHKAEAPA LPGSLGAEVS 

      1030       1040       1050       1060       1070       1080 
GSLMFSSLSG SNGGIMCNIC HKMYSNKGTL RVHYKTVHLR EMHKCKVPGC NMMFSSVRSR 

      1090 
NRHSQNPNLH KNIPFTSVD 

« Hide

Isoform 2 [UniParc].

Checksum: CDE800F776B4644F
Show »

FASTA903101,333

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Colon, Kidney epithelium, Teratocarcinoma and Tongue.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Identification of Basonuclin2, a DNA-binding zinc-finger protein expressed in germ tissues and skin keratinocytes."
Romano R.-A., Li H., Tummala R., Maul R., Sinha S.
Genomics 83:821-833(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-1099 (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]"Basonuclin 2: an extremely conserved homolog of the zinc finger protein basonuclin."
Vanhoutteghem A., Djian P.
Proc. Natl. Acad. Sci. U.S.A. 101:3468-3473(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROBABLE FUNCTION, TISSUE SPECIFICITY.
[5]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK000050 mRNA. Translation: BAA90908.1. Different initiation.
AK025882 mRNA. Translation: BAB15269.1. Different initiation.
AK092247 mRNA. Translation: BAC03837.1. Different initiation.
AK131398 mRNA. Translation: BAD18545.1.
AL450105, AL449983, AL450003 Genomic DNA. Translation: CAM21221.1.
AY438376 mRNA. Translation: AAR99389.1. Different initiation.
CCDSCCDS6482.2. [Q6ZN30-1]
RefSeqNP_060107.3. NM_017637.5. [Q6ZN30-1]
UniGeneHs.656581.
Hs.693436.
Hs.740070.

3D structure databases

ProteinModelPortalQ6ZN30.
SMRQ6ZN30. Positions 437-490, 822-895, 1029-1066.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120155. 2 interactions.
IntActQ6ZN30. 1 interaction.
STRING9606.ENSP00000370047.

PTM databases

PhosphoSiteQ6ZN30.

Polymorphism databases

DMDM74762393.

Proteomic databases

PaxDbQ6ZN30.
PRIDEQ6ZN30.

Protocols and materials databases

DNASU54796.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380666; ENSP00000370041; ENSG00000173068. [Q6ZN30-2]
ENST00000380672; ENSP00000370047; ENSG00000173068. [Q6ZN30-1]
ENST00000484726; ENSP00000431516; ENSG00000173068. [Q6ZN30-2]
GeneID54796.
KEGGhsa:54796.
UCSCuc003zmi.3. human. [Q6ZN30-1]

Organism-specific databases

CTD54796.
GeneCardsGC09M016410.
HGNCHGNC:30988. BNC2.
HPAHPA018525.
MIM608669. gene.
neXtProtNX_Q6ZN30.
PharmGKBPA134953132.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG82846.
HOGENOMHOG000049098.
HOVERGENHBG050706.
InParanoidQ6ZN30.
OMAKVPGCNM.
OrthoDBEOG7SV0TM.
PhylomeDBQ6ZN30.
TreeFamTF350399.

Gene expression databases

ArrayExpressQ6ZN30.
BgeeQ6ZN30.
CleanExHS_BNC2.
GenevestigatorQ6ZN30.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBNC2. human.
GeneWikiBNC2.
GenomeRNAi54796.
NextBio57475.
PROQ6ZN30.
SOURCESearch...

Entry information

Entry nameBNC2_HUMAN
AccessionPrimary (citable) accession number: Q6ZN30
Secondary accession number(s): B1APG9 expand/collapse secondary AC list , Q6T3A3, Q8NAR2, Q9H6J0, Q9NXV0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM