Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6ZN28

- MACC1_HUMAN

UniProt

Q6ZN28 - MACC1_HUMAN

Protein

Metastasis-associated in colon cancer protein 1

Gene

MACC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (08 Apr 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.1 Publication

    GO - Biological processi

    1. positive regulation of cell division Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Growth factor, Mitogen

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metastasis-associated in colon cancer protein 1
    Alternative name(s):
    SH3 domain-containing protein 7a5
    Gene namesi
    Name:MACC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:30215. MACC1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Mainly found in the cytoplasm in non-metastasizing tumors.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164722150.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 852852Metastasis-associated in colon cancer protein 1PRO_0000329032Add
    BLAST

    Proteomic databases

    MaxQBiQ6ZN28.
    PaxDbiQ6ZN28.
    PRIDEiQ6ZN28.

    PTM databases

    PhosphoSiteiQ6ZN28.

    Expressioni

    Tissue specificityi

    Preferentially expressed in metastasizing tumors.1 Publication

    Gene expression databases

    BgeeiQ6ZN28.
    GenevestigatoriQ6ZN28.

    Organism-specific databases

    HPAiHPA020081.
    HPA020103.
    HPA029476.

    Interactioni

    Subunit structurei

    Interacts with FASLG.1 Publication

    Protein-protein interaction databases

    BioGridi131381. 1 interaction.
    IntActiQ6ZN28. 2 interactions.
    STRINGi9606.ENSP00000328410.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZN28.
    SMRiQ6ZN28. Positions 744-819.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini552 – 61867SH3Add
    BLAST

    Sequence similaritiesi

    Contains 1 SH3 domain.Curated

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG39995.
    HOGENOMiHOG000015297.
    InParanoidiQ6ZN28.
    OMAiDPFSQVM.
    OrthoDBiEOG7GJ6C4.
    PhylomeDBiQ6ZN28.
    TreeFamiTF105572.

    Family and domain databases

    InterProiIPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZN28-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLITERKHFR SGRIAQSMSE ANLIDMEAGK LSKSCNITEC QDPDLLHNWP    50
    DAFTLRGNNA SKVANPFWNQ LSASNPFLDD ITQLRNNRKR NNISILKEDP 100
    FLFCREIENG NSFDSSGDEL DVHQLLRQTS SRNSGRSKSV SELLDILDDT 150
    AHAHQSIHNS DQILLHDLEW LKNDREAYKM AWLSQRQLAR SCLDLNTISQ 200
    SPGWAQTQLA EVTIACKVNH QGGSVQLPES DITVHVPQGH VAVGEFQEVS 250
    LRAFLDPPHM LNHDLSCTVS PLLEIMLGNL NTMEALLLEM KIGAEVRKDP 300
    FSQVMTEMVC LHSLGKEGPF KVLSNCYIYK DTIQVKLIDL SQVMYLVVAA 350
    QAKALPSPAA TIWDYIHKTT SIGIYGPKYI HPSFTVVLTV CGHNYMPGQL 400
    TISDIKKGGK NISPVVFQLW GKQSFLLDKP QDLSISIFSC DPDFEVKTEG 450
    ERKEIKQKQL EAGEVVHQQF LFSLVEHREM HLFDFCVQVE PPNGEPVAQF 500
    SITTPDPTPN LKRLSNLPGY LQKKEEIKSA PLSPKILVKY PTFQDKTLNF 550
    SNYGVTLKAV LRQSKIDYFL EYFKGDTIAL LGEGKVKAIG QSKVKEWYVG 600
    VLRGKIGLVH CKNVKVISKE QVMFMSDSVF TTRNLLEQIV LPLKKLTYIY 650
    SVVLTLVSEK VYDWKVLADV LGYSHLSLED FDQIQADKES EKVSYVIKKL 700
    KEDCHTERNT RKFLYELIVA LLKMDCQELV ARLIQEAAVL TSAVKLGKGW 750
    RELAEKLVRL TKQQMEAYEI PHRGNTGDVA VEMMWKPAYD FLYTWSAHYG 800
    NNYRDVLQDL QSALDRMKNP VTKHWRELTG VLILVNSLEV LRVTAFSTSE 850
    EV 852
    Length:852
    Mass (Da):96,639
    Last modified:April 8, 2008 - v2
    Checksum:i9272110E1F91489A
    GO

    Sequence cautioni

    The sequence BAC87646.1 differs from that shown. Reason: Erroneous initiation.
    The sequence EAW93719.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti171 – 1711L → P in BAD18547. (PubMed:14702039)Curated
    Sequence conflicti264 – 2641D → N in BAD18547. (PubMed:14702039)Curated
    Sequence conflicti383 – 3831S → N in BAD18547. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311L → V.1 Publication
    Corresponds to variant rs4721888 [ dbSNP | Ensembl ].
    VAR_042620
    Natural varianti50 – 501P → L.
    Corresponds to variant rs17142503 [ dbSNP | Ensembl ].
    VAR_042621
    Natural varianti515 – 5151S → L.1 Publication
    Corresponds to variant rs975263 [ dbSNP | Ensembl ].
    VAR_042622
    Natural varianti728 – 7281E → A.
    Corresponds to variant rs12671170 [ dbSNP | Ensembl ].
    VAR_042623
    Natural varianti804 – 8041R → T.1 Publication
    Corresponds to variant rs3735615 [ dbSNP | Ensembl ].
    VAR_042624

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ313524 mRNA. Translation: CAC86408.1.
    AK128850 mRNA. Translation: BAC87646.1. Different initiation.
    AK131400 mRNA. Translation: BAD18547.1.
    CH236948 Genomic DNA. Translation: EAL24276.1.
    AC007001 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93719.1. Sequence problems.
    BC137090 mRNA. Translation: AAI37091.1.
    CCDSiCCDS5369.1.
    RefSeqiNP_877439.3. NM_182762.3.
    UniGeneiHs.598388.

    Genome annotation databases

    EnsembliENST00000332878; ENSP00000328410; ENSG00000183742.
    ENST00000400331; ENSP00000383185; ENSG00000183742.
    ENST00000589011; ENSP00000466864; ENSG00000183742.
    GeneIDi346389.
    KEGGihsa:346389.
    UCSCiuc003sus.4. human.

    Polymorphism databases

    DMDMi182627616.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ313524 mRNA. Translation: CAC86408.1 .
    AK128850 mRNA. Translation: BAC87646.1 . Different initiation.
    AK131400 mRNA. Translation: BAD18547.1 .
    CH236948 Genomic DNA. Translation: EAL24276.1 .
    AC007001 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93719.1 . Sequence problems.
    BC137090 mRNA. Translation: AAI37091.1 .
    CCDSi CCDS5369.1.
    RefSeqi NP_877439.3. NM_182762.3.
    UniGenei Hs.598388.

    3D structure databases

    ProteinModelPortali Q6ZN28.
    SMRi Q6ZN28. Positions 744-819.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131381. 1 interaction.
    IntActi Q6ZN28. 2 interactions.
    STRINGi 9606.ENSP00000328410.

    PTM databases

    PhosphoSitei Q6ZN28.

    Polymorphism databases

    DMDMi 182627616.

    Proteomic databases

    MaxQBi Q6ZN28.
    PaxDbi Q6ZN28.
    PRIDEi Q6ZN28.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332878 ; ENSP00000328410 ; ENSG00000183742 .
    ENST00000400331 ; ENSP00000383185 ; ENSG00000183742 .
    ENST00000589011 ; ENSP00000466864 ; ENSG00000183742 .
    GeneIDi 346389.
    KEGGi hsa:346389.
    UCSCi uc003sus.4. human.

    Organism-specific databases

    CTDi 346389.
    GeneCardsi GC07M020140.
    H-InvDB HIX0025430.
    HGNCi HGNC:30215. MACC1.
    HPAi HPA020081.
    HPA020103.
    HPA029476.
    MIMi 612646. gene.
    neXtProti NX_Q6ZN28.
    PharmGKBi PA164722150.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39995.
    HOGENOMi HOG000015297.
    InParanoidi Q6ZN28.
    OMAi DPFSQVM.
    OrthoDBi EOG7GJ6C4.
    PhylomeDBi Q6ZN28.
    TreeFami TF105572.

    Miscellaneous databases

    GenomeRNAii 346389.
    NextBioi 98956.
    PROi Q6ZN28.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZN28.
    Genevestigatori Q6ZN28.

    Family and domain databases

    InterProi IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis."
      Stein U., Walther W., Arlt F., Schwabe H., Smith J., Fichtner I., Birchmeier W., Schlag P.M.
      Nat. Med. 15:59-67(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Colon carcinoma and Trachea.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-31; LEU-515 AND THR-804.
      Tissue: Tongue.
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    7. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
      Voss M., Lettau M., Janssen O.
      BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FASLG.

    Entry informationi

    Entry nameiMACC1_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZN28
    Secondary accession number(s): A8MUS5
    , B2RNR9, Q6ZQN8, Q7Z5A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3