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Protein

Metastasis-associated in colon cancer protein 1

Gene

MACC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Growth factor, Mitogen

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:G66-33577-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-associated in colon cancer protein 1
Alternative name(s):
SH3 domain-containing protein 7a5
Gene namesi
Name:MACC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:30215. MACC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi346389.
OpenTargetsiENSG00000183742.
PharmGKBiPA164722150.

Polymorphism and mutation databases

BioMutaiMACC1.
DMDMi182627616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290321 – 852Metastasis-associated in colon cancer protein 1Add BLAST852

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZN28.
MaxQBiQ6ZN28.
PaxDbiQ6ZN28.
PeptideAtlasiQ6ZN28.
PRIDEiQ6ZN28.

PTM databases

iPTMnetiQ6ZN28.
PhosphoSitePlusiQ6ZN28.

Expressioni

Tissue specificityi

Preferentially expressed in metastasizing tumors.1 Publication

Gene expression databases

BgeeiENSG00000183742.
GenevisibleiQ6ZN28. HS.

Organism-specific databases

HPAiCAB068194.
HPA020081.
HPA020103.
HPA029476.

Interactioni

Subunit structurei

Interacts with FASLG.1 Publication

Protein-protein interaction databases

BioGridi131381. 1 interactor.
IntActiQ6ZN28. 2 interactors.
STRINGi9606.ENSP00000328410.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN28.
SMRiQ6ZN28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini552 – 618SH3Add BLAST67

Sequence similaritiesi

Contains 1 SH3 domain.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410IHUQ. Eukaryota.
ENOG410YRKQ. LUCA.
GeneTreeiENSGT00390000013151.
HOGENOMiHOG000015297.
InParanoidiQ6ZN28.
OMAiDPFSQVM.
OrthoDBiEOG091G012M.
PhylomeDBiQ6ZN28.
TreeFamiTF105572.

Family and domain databases

InterProiIPR000906. ZU5_dom.
[Graphical view]
PfamiPF00791. ZU5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZN28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLITERKHFR SGRIAQSMSE ANLIDMEAGK LSKSCNITEC QDPDLLHNWP
60 70 80 90 100
DAFTLRGNNA SKVANPFWNQ LSASNPFLDD ITQLRNNRKR NNISILKEDP
110 120 130 140 150
FLFCREIENG NSFDSSGDEL DVHQLLRQTS SRNSGRSKSV SELLDILDDT
160 170 180 190 200
AHAHQSIHNS DQILLHDLEW LKNDREAYKM AWLSQRQLAR SCLDLNTISQ
210 220 230 240 250
SPGWAQTQLA EVTIACKVNH QGGSVQLPES DITVHVPQGH VAVGEFQEVS
260 270 280 290 300
LRAFLDPPHM LNHDLSCTVS PLLEIMLGNL NTMEALLLEM KIGAEVRKDP
310 320 330 340 350
FSQVMTEMVC LHSLGKEGPF KVLSNCYIYK DTIQVKLIDL SQVMYLVVAA
360 370 380 390 400
QAKALPSPAA TIWDYIHKTT SIGIYGPKYI HPSFTVVLTV CGHNYMPGQL
410 420 430 440 450
TISDIKKGGK NISPVVFQLW GKQSFLLDKP QDLSISIFSC DPDFEVKTEG
460 470 480 490 500
ERKEIKQKQL EAGEVVHQQF LFSLVEHREM HLFDFCVQVE PPNGEPVAQF
510 520 530 540 550
SITTPDPTPN LKRLSNLPGY LQKKEEIKSA PLSPKILVKY PTFQDKTLNF
560 570 580 590 600
SNYGVTLKAV LRQSKIDYFL EYFKGDTIAL LGEGKVKAIG QSKVKEWYVG
610 620 630 640 650
VLRGKIGLVH CKNVKVISKE QVMFMSDSVF TTRNLLEQIV LPLKKLTYIY
660 670 680 690 700
SVVLTLVSEK VYDWKVLADV LGYSHLSLED FDQIQADKES EKVSYVIKKL
710 720 730 740 750
KEDCHTERNT RKFLYELIVA LLKMDCQELV ARLIQEAAVL TSAVKLGKGW
760 770 780 790 800
RELAEKLVRL TKQQMEAYEI PHRGNTGDVA VEMMWKPAYD FLYTWSAHYG
810 820 830 840 850
NNYRDVLQDL QSALDRMKNP VTKHWRELTG VLILVNSLEV LRVTAFSTSE

EV
Length:852
Mass (Da):96,639
Last modified:April 8, 2008 - v2
Checksum:i9272110E1F91489A
GO

Sequence cautioni

The sequence BAC87646 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW93719 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171L → P in BAD18547 (PubMed:14702039).Curated1
Sequence conflicti264D → N in BAD18547 (PubMed:14702039).Curated1
Sequence conflicti383S → N in BAD18547 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04262031L → V.1 PublicationCorresponds to variant rs4721888dbSNPEnsembl.1
Natural variantiVAR_04262150P → L.Corresponds to variant rs17142503dbSNPEnsembl.1
Natural variantiVAR_042622515S → L.1 PublicationCorresponds to variant rs975263dbSNPEnsembl.1
Natural variantiVAR_042623728E → A.Corresponds to variant rs12671170dbSNPEnsembl.1
Natural variantiVAR_042624804R → T.1 PublicationCorresponds to variant rs3735615dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313524 mRNA. Translation: CAC86408.1.
AK128850 mRNA. Translation: BAC87646.1. Different initiation.
AK131400 mRNA. Translation: BAD18547.1.
CH236948 Genomic DNA. Translation: EAL24276.1.
AC007001 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93719.1. Sequence problems.
BC137090 mRNA. Translation: AAI37091.1.
CCDSiCCDS5369.1.
RefSeqiNP_877439.3. NM_182762.3.
UniGeneiHs.598388.

Genome annotation databases

EnsembliENST00000332878; ENSP00000328410; ENSG00000183742.
ENST00000400331; ENSP00000383185; ENSG00000183742.
ENST00000589011; ENSP00000466864; ENSG00000183742.
GeneIDi346389.
KEGGihsa:346389.
UCSCiuc003sus.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313524 mRNA. Translation: CAC86408.1.
AK128850 mRNA. Translation: BAC87646.1. Different initiation.
AK131400 mRNA. Translation: BAD18547.1.
CH236948 Genomic DNA. Translation: EAL24276.1.
AC007001 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93719.1. Sequence problems.
BC137090 mRNA. Translation: AAI37091.1.
CCDSiCCDS5369.1.
RefSeqiNP_877439.3. NM_182762.3.
UniGeneiHs.598388.

3D structure databases

ProteinModelPortaliQ6ZN28.
SMRiQ6ZN28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131381. 1 interactor.
IntActiQ6ZN28. 2 interactors.
STRINGi9606.ENSP00000328410.

PTM databases

iPTMnetiQ6ZN28.
PhosphoSitePlusiQ6ZN28.

Polymorphism and mutation databases

BioMutaiMACC1.
DMDMi182627616.

Proteomic databases

EPDiQ6ZN28.
MaxQBiQ6ZN28.
PaxDbiQ6ZN28.
PeptideAtlasiQ6ZN28.
PRIDEiQ6ZN28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332878; ENSP00000328410; ENSG00000183742.
ENST00000400331; ENSP00000383185; ENSG00000183742.
ENST00000589011; ENSP00000466864; ENSG00000183742.
GeneIDi346389.
KEGGihsa:346389.
UCSCiuc003sus.5. human.

Organism-specific databases

CTDi346389.
DisGeNETi346389.
GeneCardsiMACC1.
H-InvDBHIX0025430.
HGNCiHGNC:30215. MACC1.
HPAiCAB068194.
HPA020081.
HPA020103.
HPA029476.
MIMi612646. gene.
neXtProtiNX_Q6ZN28.
OpenTargetsiENSG00000183742.
PharmGKBiPA164722150.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHUQ. Eukaryota.
ENOG410YRKQ. LUCA.
GeneTreeiENSGT00390000013151.
HOGENOMiHOG000015297.
InParanoidiQ6ZN28.
OMAiDPFSQVM.
OrthoDBiEOG091G012M.
PhylomeDBiQ6ZN28.
TreeFamiTF105572.

Enzyme and pathway databases

BioCyciZFISH:G66-33577-MONOMER.

Miscellaneous databases

GenomeRNAii346389.
PROiQ6ZN28.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183742.
GenevisibleiQ6ZN28. HS.

Family and domain databases

InterProiIPR000906. ZU5_dom.
[Graphical view]
PfamiPF00791. ZU5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMACC1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN28
Secondary accession number(s): A8MUS5
, B2RNR9, Q6ZQN8, Q7Z5A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.