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Protein

Metastasis-associated in colon cancer protein 1

Gene

MACC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.1 Publication

GO - Biological processi

  1. positive regulation of cell division Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Growth factor, Mitogen

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-associated in colon cancer protein 1
Alternative name(s):
SH3 domain-containing protein 7a5
Gene namesi
Name:MACC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:30215. MACC1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Mainly found in the cytoplasm in non-metastasizing tumors.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164722150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 852852Metastasis-associated in colon cancer protein 1PRO_0000329032Add
BLAST

Proteomic databases

MaxQBiQ6ZN28.
PaxDbiQ6ZN28.
PRIDEiQ6ZN28.

PTM databases

PhosphoSiteiQ6ZN28.

Expressioni

Tissue specificityi

Preferentially expressed in metastasizing tumors.1 Publication

Gene expression databases

BgeeiQ6ZN28.
GenevestigatoriQ6ZN28.

Organism-specific databases

HPAiHPA020081.
HPA020103.
HPA029476.

Interactioni

Subunit structurei

Interacts with FASLG.1 Publication

Protein-protein interaction databases

BioGridi131381. 1 interaction.
IntActiQ6ZN28. 2 interactions.
STRINGi9606.ENSP00000328410.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN28.
SMRiQ6ZN28. Positions 744-819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini552 – 61867SH3Add
BLAST

Sequence similaritiesi

Contains 1 SH3 domain.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG39995.
GeneTreeiENSGT00390000013151.
HOGENOMiHOG000015297.
InParanoidiQ6ZN28.
OMAiDPFSQVM.
OrthoDBiEOG7GJ6C4.
PhylomeDBiQ6ZN28.
TreeFamiTF105572.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZN28-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLITERKHFR SGRIAQSMSE ANLIDMEAGK LSKSCNITEC QDPDLLHNWP
60 70 80 90 100
DAFTLRGNNA SKVANPFWNQ LSASNPFLDD ITQLRNNRKR NNISILKEDP
110 120 130 140 150
FLFCREIENG NSFDSSGDEL DVHQLLRQTS SRNSGRSKSV SELLDILDDT
160 170 180 190 200
AHAHQSIHNS DQILLHDLEW LKNDREAYKM AWLSQRQLAR SCLDLNTISQ
210 220 230 240 250
SPGWAQTQLA EVTIACKVNH QGGSVQLPES DITVHVPQGH VAVGEFQEVS
260 270 280 290 300
LRAFLDPPHM LNHDLSCTVS PLLEIMLGNL NTMEALLLEM KIGAEVRKDP
310 320 330 340 350
FSQVMTEMVC LHSLGKEGPF KVLSNCYIYK DTIQVKLIDL SQVMYLVVAA
360 370 380 390 400
QAKALPSPAA TIWDYIHKTT SIGIYGPKYI HPSFTVVLTV CGHNYMPGQL
410 420 430 440 450
TISDIKKGGK NISPVVFQLW GKQSFLLDKP QDLSISIFSC DPDFEVKTEG
460 470 480 490 500
ERKEIKQKQL EAGEVVHQQF LFSLVEHREM HLFDFCVQVE PPNGEPVAQF
510 520 530 540 550
SITTPDPTPN LKRLSNLPGY LQKKEEIKSA PLSPKILVKY PTFQDKTLNF
560 570 580 590 600
SNYGVTLKAV LRQSKIDYFL EYFKGDTIAL LGEGKVKAIG QSKVKEWYVG
610 620 630 640 650
VLRGKIGLVH CKNVKVISKE QVMFMSDSVF TTRNLLEQIV LPLKKLTYIY
660 670 680 690 700
SVVLTLVSEK VYDWKVLADV LGYSHLSLED FDQIQADKES EKVSYVIKKL
710 720 730 740 750
KEDCHTERNT RKFLYELIVA LLKMDCQELV ARLIQEAAVL TSAVKLGKGW
760 770 780 790 800
RELAEKLVRL TKQQMEAYEI PHRGNTGDVA VEMMWKPAYD FLYTWSAHYG
810 820 830 840 850
NNYRDVLQDL QSALDRMKNP VTKHWRELTG VLILVNSLEV LRVTAFSTSE

EV
Length:852
Mass (Da):96,639
Last modified:April 8, 2008 - v2
Checksum:i9272110E1F91489A
GO

Sequence cautioni

The sequence BAC87646.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EAW93719.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711L → P in BAD18547. (PubMed:14702039)Curated
Sequence conflicti264 – 2641D → N in BAD18547. (PubMed:14702039)Curated
Sequence conflicti383 – 3831S → N in BAD18547. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311L → V.1 Publication
Corresponds to variant rs4721888 [ dbSNP | Ensembl ].
VAR_042620
Natural varianti50 – 501P → L.
Corresponds to variant rs17142503 [ dbSNP | Ensembl ].
VAR_042621
Natural varianti515 – 5151S → L.1 Publication
Corresponds to variant rs975263 [ dbSNP | Ensembl ].
VAR_042622
Natural varianti728 – 7281E → A.
Corresponds to variant rs12671170 [ dbSNP | Ensembl ].
VAR_042623
Natural varianti804 – 8041R → T.1 Publication
Corresponds to variant rs3735615 [ dbSNP | Ensembl ].
VAR_042624

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313524 mRNA. Translation: CAC86408.1.
AK128850 mRNA. Translation: BAC87646.1. Different initiation.
AK131400 mRNA. Translation: BAD18547.1.
CH236948 Genomic DNA. Translation: EAL24276.1.
AC007001 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93719.1. Sequence problems.
BC137090 mRNA. Translation: AAI37091.1.
CCDSiCCDS5369.1.
RefSeqiNP_877439.3. NM_182762.3.
UniGeneiHs.598388.

Genome annotation databases

EnsembliENST00000332878; ENSP00000328410; ENSG00000183742.
ENST00000400331; ENSP00000383185; ENSG00000183742.
ENST00000589011; ENSP00000466864; ENSG00000183742.
GeneIDi346389.
KEGGihsa:346389.
UCSCiuc003sus.4. human.

Polymorphism databases

DMDMi182627616.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313524 mRNA. Translation: CAC86408.1.
AK128850 mRNA. Translation: BAC87646.1. Different initiation.
AK131400 mRNA. Translation: BAD18547.1.
CH236948 Genomic DNA. Translation: EAL24276.1.
AC007001 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93719.1. Sequence problems.
BC137090 mRNA. Translation: AAI37091.1.
CCDSiCCDS5369.1.
RefSeqiNP_877439.3. NM_182762.3.
UniGeneiHs.598388.

3D structure databases

ProteinModelPortaliQ6ZN28.
SMRiQ6ZN28. Positions 744-819.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131381. 1 interaction.
IntActiQ6ZN28. 2 interactions.
STRINGi9606.ENSP00000328410.

PTM databases

PhosphoSiteiQ6ZN28.

Polymorphism databases

DMDMi182627616.

Proteomic databases

MaxQBiQ6ZN28.
PaxDbiQ6ZN28.
PRIDEiQ6ZN28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332878; ENSP00000328410; ENSG00000183742.
ENST00000400331; ENSP00000383185; ENSG00000183742.
ENST00000589011; ENSP00000466864; ENSG00000183742.
GeneIDi346389.
KEGGihsa:346389.
UCSCiuc003sus.4. human.

Organism-specific databases

CTDi346389.
GeneCardsiGC07M020140.
H-InvDBHIX0025430.
HGNCiHGNC:30215. MACC1.
HPAiHPA020081.
HPA020103.
HPA029476.
MIMi612646. gene.
neXtProtiNX_Q6ZN28.
PharmGKBiPA164722150.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39995.
GeneTreeiENSGT00390000013151.
HOGENOMiHOG000015297.
InParanoidiQ6ZN28.
OMAiDPFSQVM.
OrthoDBiEOG7GJ6C4.
PhylomeDBiQ6ZN28.
TreeFamiTF105572.

Miscellaneous databases

GenomeRNAii346389.
NextBioi98956.
PROiQ6ZN28.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZN28.
GenevestigatoriQ6ZN28.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis."
    Stein U., Walther W., Arlt F., Schwabe H., Smith J., Fichtner I., Birchmeier W., Schlag P.M.
    Nat. Med. 15:59-67(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Colon carcinoma and Trachea.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-31; LEU-515 AND THR-804.
    Tissue: Tongue.
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.

Entry informationi

Entry nameiMACC1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN28
Secondary accession number(s): A8MUS5
, B2RNR9, Q6ZQN8, Q7Z5A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 7, 2015
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.