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Protein

Zinc finger protein 841

Gene

ZNF841

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 16; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri649 – 67123C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri677 – 69923C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri733 – 75523C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri761 – 78323C2H2-type 23PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 841
Gene namesi
Name:ZNF841
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:27611. ZNF841.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410839.

Polymorphism and mutation databases

BioMutaiZNF841.
DMDMi74758703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 808808Zinc finger protein 841PRO_0000334677Add
BLAST

Proteomic databases

EPDiQ6ZN19.
MaxQBiQ6ZN19.
PaxDbiQ6ZN19.
PRIDEiQ6ZN19.

PTM databases

PhosphoSiteiQ6ZN19.

Expressioni

Gene expression databases

BgeeiQ6ZN19.
CleanExiHS_ZNF841.
ExpressionAtlasiQ6ZN19. baseline and differential.

Organism-specific databases

HPAiHPA060901.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000374185.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN19.
SMRiQ6ZN19. Positions 76-786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 23 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 16; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri649 – 67123C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri677 – 69923C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri733 – 75523C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri761 – 78323C2H2-type 23PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZN19.
KOiK09228.
OMAiVMLEGHE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZN19.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 23 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 22 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 20 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZN19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEGHESYDT ENFYFREIRK NLQEVDFQWK DGEINYKEGP MTHKNNLTGQ
60 70 80 90 100
RVRHSQGDVE NKHMENQLIL RFQSGLGELQ KFQTAEKIYG CNQIERTVNN
110 120 130 140 150
CFLASPLQRI FPGVQTNISR KYGNDFLQLS LPTQDEKTHI REKPYIGNEC
160 170 180 190 200
GKAFRVSSSL INHQMIHTTE KPYRCNESGK AFHRGSLLTV HQIVHTRGKP
210 220 230 240 250
YQCDVCGRIF RQNSDLVNHR RSHTGDKPYI CNECGKSFSK SSHLAVHQRI
260 270 280 290 300
HTGEKPYKCN RCGKCFSQSS SLATHQTVHT GDKPYKCNEC GKTFKRNSSL
310 320 330 340 350
TAHHIIHAGK KPYTCDVCGK VFYQNSQLVR HQIIHTGETP YKCNECGKVF
360 370 380 390 400
FQRSRLAGHR RIHTGEKPYK CNECGKVFSQ HSHLAVHQRV HTGEKPYKCN
410 420 430 440 450
ECGKAFNWGS LLTVHQRIHT GEKPYKCNVC GKVFNYGGYL SVHMRCHTGE
460 470 480 490 500
KPLHCNKCGM VFTYYSCLAR HQRMHTGEKP YKCNVCGKVF IDSGNLSIHR
510 520 530 540 550
RSHTGEKPFQ CNECGKVFSY YSCLARHRKI HTGEKPYKCN DCGKAYTQRS
560 570 580 590 600
SLTKHLVIHT GENPYHCNEF GEAFIQSSKL ARYHRNPTGE KPHKCSECGR
610 620 630 640 650
TFSHKTSLVY HQRRHTGEMP YKCIECGKVF NSTTTLARHR RIHTGEKPYK
660 670 680 690 700
CNECGKVFRY RSGLARHWSI HTGEKPYKCN ECGKAFRVRS ILLNHQMMHT
710 720 730 740 750
GEKPYKCNEC GKAFIERSNL VYHQRNHTGE KPYKCMECGK AFGRRSCLTK
760 770 780 790 800
HQRIHSSEKP YKCNECGKSY ISRSGLTKHQ IKHAGENLTT KLNVERPLDV

VLTSGIPK
Length:808
Mass (Da):93,148
Last modified:July 5, 2004 - v1
Checksum:iBD06B2DEE9F14BCE
GO
Isoform 2 (identifier: Q6ZN19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-647: Missing.

Note: No experimental confirmation available.
Show »
Length:500
Mass (Da):57,630
Checksum:i94C29F61F23F51C6
GO
Isoform 3 (identifier: Q6ZN19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MALPQGSLTF...NTGEKFQAVM

Show »
Length:924
Mass (Da):106,101
Checksum:i1BC02AE07FE5FE16
GO

Sequence cautioni

The sequence BAC04190.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD18493.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti748 – 7481L → P in BAC04190 (PubMed:14702039).Curated
Sequence conflicti778 – 7781K → N in BAC85253 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MALPQGSLTFRDVAVEFSQE EWKCLDPVQKALYRDVMLEN YRNLGFLGLCLPDLNIISML EQGKEPWTVVSQVKIARNPN CGECMKGVITGISPKCVIKE LPPIQNSNTGEKFQAVM in isoform 3. 1 PublicationVSP_040752
Alternative sequencei340 – 647308Missing in isoform 2. 1 PublicationVSP_033755Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093512 mRNA. Translation: BAC04190.1. Different initiation.
AK129938 mRNA. Translation: BAC85253.1.
AK131334 mRNA. Translation: BAD18493.1. Different initiation.
AK131409 mRNA. Translation: BAD18556.1.
AC011468 Genomic DNA. No translation available.
BC136254 mRNA. Translation: AAI36255.1.
CCDSiCCDS46161.1. [Q6ZN19-3]
RefSeqiNP_001129971.1. NM_001136499.1. [Q6ZN19-3]
XP_011525137.1. XM_011526835.1. [Q6ZN19-1]
UniGeneiHs.665751.

Genome annotation databases

EnsembliENST00000389534; ENSP00000374185; ENSG00000197608. [Q6ZN19-3]
ENST00000426391; ENSP00000415453; ENSG00000197608. [Q6ZN19-1]
ENST00000594295; ENSP00000470746; ENSG00000197608. [Q6ZN19-3]
GeneIDi284371.
KEGGihsa:284371.
UCSCiuc002pyl.1. human. [Q6ZN19-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093512 mRNA. Translation: BAC04190.1. Different initiation.
AK129938 mRNA. Translation: BAC85253.1.
AK131334 mRNA. Translation: BAD18493.1. Different initiation.
AK131409 mRNA. Translation: BAD18556.1.
AC011468 Genomic DNA. No translation available.
BC136254 mRNA. Translation: AAI36255.1.
CCDSiCCDS46161.1. [Q6ZN19-3]
RefSeqiNP_001129971.1. NM_001136499.1. [Q6ZN19-3]
XP_011525137.1. XM_011526835.1. [Q6ZN19-1]
UniGeneiHs.665751.

3D structure databases

ProteinModelPortaliQ6ZN19.
SMRiQ6ZN19. Positions 76-786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000374185.

PTM databases

PhosphoSiteiQ6ZN19.

Polymorphism and mutation databases

BioMutaiZNF841.
DMDMi74758703.

Proteomic databases

EPDiQ6ZN19.
MaxQBiQ6ZN19.
PaxDbiQ6ZN19.
PRIDEiQ6ZN19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389534; ENSP00000374185; ENSG00000197608. [Q6ZN19-3]
ENST00000426391; ENSP00000415453; ENSG00000197608. [Q6ZN19-1]
ENST00000594295; ENSP00000470746; ENSG00000197608. [Q6ZN19-3]
GeneIDi284371.
KEGGihsa:284371.
UCSCiuc002pyl.1. human. [Q6ZN19-1]

Organism-specific databases

CTDi284371.
GeneCardsiZNF841.
HGNCiHGNC:27611. ZNF841.
HPAiHPA060901.
neXtProtiNX_Q6ZN19.
PharmGKBiPA162410839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZN19.
KOiK09228.
OMAiVMLEGHE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZN19.
TreeFamiTF343410.

Miscellaneous databases

ChiTaRSiZNF841. human.
GenomeRNAii284371.
NextBioi94804.
PROiQ6ZN19.

Gene expression databases

BgeeiQ6ZN19.
CleanExiHS_ZNF841.
ExpressionAtlasiQ6ZN19. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 23 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 22 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 20 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney and Testis.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Heart and Lung.

Entry informationi

Entry nameiZN841_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN19
Secondary accession number(s): B9EG58
, Q6ZN82, Q6ZP71, Q8N9U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.