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Protein

Zinc finger protein 841

Gene

ZNF841

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degenerateAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2; degenerateAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3Add BLAST23
Zinc fingeri229 – 251C2H2-type 4Add BLAST23
Zinc fingeri257 – 279C2H2-type 5Add BLAST23
Zinc fingeri285 – 307C2H2-type 6Add BLAST23
Zinc fingeri313 – 335C2H2-type 7Add BLAST23
Zinc fingeri341 – 363C2H2-type 8Add BLAST23
Zinc fingeri369 – 391C2H2-type 9Add BLAST23
Zinc fingeri397 – 419C2H2-type 10Add BLAST23
Zinc fingeri425 – 447C2H2-type 11Add BLAST23
Zinc fingeri453 – 475C2H2-type 12Add BLAST23
Zinc fingeri481 – 503C2H2-type 13Add BLAST23
Zinc fingeri509 – 531C2H2-type 14Add BLAST23
Zinc fingeri537 – 559C2H2-type 15Add BLAST23
Zinc fingeri565 – 587C2H2-type 16; degenerateAdd BLAST23
Zinc fingeri593 – 615C2H2-type 17Add BLAST23
Zinc fingeri621 – 643C2H2-type 18Add BLAST23
Zinc fingeri649 – 671C2H2-type 19Add BLAST23
Zinc fingeri677 – 699C2H2-type 20Add BLAST23
Zinc fingeri705 – 727C2H2-type 21Add BLAST23
Zinc fingeri733 – 755C2H2-type 22Add BLAST23
Zinc fingeri761 – 783C2H2-type 23Add BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 841
Gene namesi
Name:ZNF841
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197608.11.
HGNCiHGNC:27611. ZNF841.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197608.
PharmGKBiPA162410839.

Polymorphism and mutation databases

BioMutaiZNF841.
DMDMi74758703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003346771 – 808Zinc finger protein 841Add BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki137Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki554Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki579Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki791Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ6ZN19.
MaxQBiQ6ZN19.
PaxDbiQ6ZN19.
PeptideAtlasiQ6ZN19.
PRIDEiQ6ZN19.

PTM databases

iPTMnetiQ6ZN19.
PhosphoSitePlusiQ6ZN19.

Expressioni

Gene expression databases

BgeeiENSG00000197608.
CleanExiHS_ZNF841.
ExpressionAtlasiQ6ZN19. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000374185.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN19.
SMRiQ6ZN19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degenerateAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2; degenerateAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3Add BLAST23
Zinc fingeri229 – 251C2H2-type 4Add BLAST23
Zinc fingeri257 – 279C2H2-type 5Add BLAST23
Zinc fingeri285 – 307C2H2-type 6Add BLAST23
Zinc fingeri313 – 335C2H2-type 7Add BLAST23
Zinc fingeri341 – 363C2H2-type 8Add BLAST23
Zinc fingeri369 – 391C2H2-type 9Add BLAST23
Zinc fingeri397 – 419C2H2-type 10Add BLAST23
Zinc fingeri425 – 447C2H2-type 11Add BLAST23
Zinc fingeri453 – 475C2H2-type 12Add BLAST23
Zinc fingeri481 – 503C2H2-type 13Add BLAST23
Zinc fingeri509 – 531C2H2-type 14Add BLAST23
Zinc fingeri537 – 559C2H2-type 15Add BLAST23
Zinc fingeri565 – 587C2H2-type 16; degenerateAdd BLAST23
Zinc fingeri593 – 615C2H2-type 17Add BLAST23
Zinc fingeri621 – 643C2H2-type 18Add BLAST23
Zinc fingeri649 – 671C2H2-type 19Add BLAST23
Zinc fingeri677 – 699C2H2-type 20Add BLAST23
Zinc fingeri705 – 727C2H2-type 21Add BLAST23
Zinc fingeri733 – 755C2H2-type 22Add BLAST23
Zinc fingeri761 – 783C2H2-type 23Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000140787.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZN19.
KOiK09228.
OMAiVMLEGHE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ZN19.
TreeFamiTF343410.

Family and domain databases

InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 22 hits.
SUPFAMiSSF57667. SSF57667. 12 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 20 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZN19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEGHESYDT ENFYFREIRK NLQEVDFQWK DGEINYKEGP MTHKNNLTGQ
60 70 80 90 100
RVRHSQGDVE NKHMENQLIL RFQSGLGELQ KFQTAEKIYG CNQIERTVNN
110 120 130 140 150
CFLASPLQRI FPGVQTNISR KYGNDFLQLS LPTQDEKTHI REKPYIGNEC
160 170 180 190 200
GKAFRVSSSL INHQMIHTTE KPYRCNESGK AFHRGSLLTV HQIVHTRGKP
210 220 230 240 250
YQCDVCGRIF RQNSDLVNHR RSHTGDKPYI CNECGKSFSK SSHLAVHQRI
260 270 280 290 300
HTGEKPYKCN RCGKCFSQSS SLATHQTVHT GDKPYKCNEC GKTFKRNSSL
310 320 330 340 350
TAHHIIHAGK KPYTCDVCGK VFYQNSQLVR HQIIHTGETP YKCNECGKVF
360 370 380 390 400
FQRSRLAGHR RIHTGEKPYK CNECGKVFSQ HSHLAVHQRV HTGEKPYKCN
410 420 430 440 450
ECGKAFNWGS LLTVHQRIHT GEKPYKCNVC GKVFNYGGYL SVHMRCHTGE
460 470 480 490 500
KPLHCNKCGM VFTYYSCLAR HQRMHTGEKP YKCNVCGKVF IDSGNLSIHR
510 520 530 540 550
RSHTGEKPFQ CNECGKVFSY YSCLARHRKI HTGEKPYKCN DCGKAYTQRS
560 570 580 590 600
SLTKHLVIHT GENPYHCNEF GEAFIQSSKL ARYHRNPTGE KPHKCSECGR
610 620 630 640 650
TFSHKTSLVY HQRRHTGEMP YKCIECGKVF NSTTTLARHR RIHTGEKPYK
660 670 680 690 700
CNECGKVFRY RSGLARHWSI HTGEKPYKCN ECGKAFRVRS ILLNHQMMHT
710 720 730 740 750
GEKPYKCNEC GKAFIERSNL VYHQRNHTGE KPYKCMECGK AFGRRSCLTK
760 770 780 790 800
HQRIHSSEKP YKCNECGKSY ISRSGLTKHQ IKHAGENLTT KLNVERPLDV

VLTSGIPK
Length:808
Mass (Da):93,148
Last modified:July 5, 2004 - v1
Checksum:iBD06B2DEE9F14BCE
GO
Isoform 2 (identifier: Q6ZN19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-647: Missing.

Note: No experimental confirmation available.
Show »
Length:500
Mass (Da):57,630
Checksum:i94C29F61F23F51C6
GO
Isoform 3 (identifier: Q6ZN19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MALPQGSLTF...NTGEKFQAVM

Show »
Length:924
Mass (Da):106,101
Checksum:i1BC02AE07FE5FE16
GO

Sequence cautioni

The sequence BAC04190 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD18493 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti748L → P in BAC04190 (PubMed:14702039).Curated1
Sequence conflicti778K → N in BAC85253 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0407521M → MALPQGSLTFRDVAVEFSQE EWKCLDPVQKALYRDVMLEN YRNLGFLGLCLPDLNIISML EQGKEPWTVVSQVKIARNPN CGECMKGVITGISPKCVIKE LPPIQNSNTGEKFQAVM in isoform 3. 1 Publication1
Alternative sequenceiVSP_033755340 – 647Missing in isoform 2. 1 PublicationAdd BLAST308

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093512 mRNA. Translation: BAC04190.1. Different initiation.
AK129938 mRNA. Translation: BAC85253.1.
AK131334 mRNA. Translation: BAD18493.1. Different initiation.
AK131409 mRNA. Translation: BAD18556.1.
AC011468 Genomic DNA. No translation available.
BC136254 mRNA. Translation: AAI36255.1.
CCDSiCCDS46161.1. [Q6ZN19-3]
CCDS82388.1. [Q6ZN19-1]
RefSeqiNP_001129971.1. NM_001136499.1. [Q6ZN19-3]
NP_001308278.1. NM_001321349.1. [Q6ZN19-1]
XP_016882145.1. XM_017026656.1. [Q6ZN19-3]
XP_016882146.1. XM_017026657.1.
UniGeneiHs.665751.
Hs.678513.

Genome annotation databases

EnsembliENST00000389534; ENSP00000374185; ENSG00000197608. [Q6ZN19-3]
ENST00000426391; ENSP00000415453; ENSG00000197608. [Q6ZN19-1]
ENST00000594295; ENSP00000470746; ENSG00000197608. [Q6ZN19-3]
GeneIDi284371.
KEGGihsa:284371.
UCSCiuc002pyl.1. human. [Q6ZN19-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN841_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN19
Secondary accession number(s): B9EG58
, Q6ZN82, Q6ZP71, Q8N9U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families